GREMLIN Database
CYSL - HTH-type transcriptional regulator CysL
UniProt: P39647 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 299 (285)
Sequences: 79819 (58373)
Seq/√Len: 3457.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_Q74_L3.6051.00
15_E24_K3.4191.00
158_E290_K2.7331.00
96_A141_A2.6351.00
67_R81_E2.4451.00
231_V238_S2.3471.00
164_E242_R2.2351.00
11_A24_K2.2331.00
173_H189_E2.2261.00
162_E267_K2.2111.00
159_P162_E2.2101.00
92_E123_D2.1901.00
20_K23_E2.1601.00
92_E121_N2.1271.00
14_E69_K2.1161.00
159_P267_K2.1121.00
182_S185_D2.0731.00
8_T35_H2.0501.00
45_T60_T2.0381.00
10_I65_Y2.0171.00
112_Q288_M2.0061.00
162_E265_K1.9961.00
94_K123_D1.9961.00
67_R74_L1.9731.00
10_I69_K1.9361.00
169_A257_L1.9331.00
11_A14_E1.9191.00
8_T32_V1.9141.00
71_M75_Y1.9071.00
10_I14_E1.8891.00
232_I253_E1.8891.00
13_V57_T1.8881.00
192_V236_G1.8841.00
11_A15_E1.8841.00
18_F36_I1.8581.00
166_C242_R1.8501.00
65_Y69_K1.8311.00
49_N56_T1.7481.00
64_L78_A1.7261.00
190_A218_M1.7101.00
63_I81_E1.6931.00
166_C256_I1.6731.00
178_R185_D1.6681.00
157_I269_S1.6591.00
113_L285_F1.6531.00
135_R140_Q1.6371.00
14_E24_K1.6211.00
13_V65_Y1.6011.00
9_F65_Y1.5971.00
15_E20_K1.5871.00
156_E274_P1.5831.00
10_I68_A1.5821.00
8_T27_I1.5681.00
113_L120_L1.5461.00
19_T29_Q1.5421.00
88_Y119_E1.5351.00
134_E138_M1.5111.00
59_P62_D1.5091.00
5_V35_H1.5021.00
158_E272_H1.4691.00
28_S31_S1.4681.00
46_A49_N1.4621.00
5_V42_E1.4611.00
5_V38_N1.4481.00
278_N282_K1.4481.00
17_N20_K1.4441.00
10_I72_V1.4431.00
11_A25_L1.4391.00
67_R70_Q1.4341.00
201_R205_D1.4171.00
286_I290_K1.4031.00
146_I271_I1.4001.00
156_E272_H1.3921.00
71_M78_A1.3901.00
148_G269_S1.3881.00
171_N253_E1.3871.00
67_R77_Q1.3851.00
103_E225_Q1.3591.00
90_K119_E1.3501.00
137_R154_E1.3501.00
94_K125_M1.3451.00
270_Y286_I1.3371.00
272_H286_I1.3371.00
112_Q116_L1.3361.00
143_I282_K1.3291.00
284_I287_T1.3251.00
135_R141_A1.3161.00
136_V144_G1.3151.00
42_E79_K1.2961.00
163_D243_S1.2951.00
64_L79_K1.2911.00
51_S56_T1.2841.00
114_Q218_M1.2821.00
169_A237_L1.2821.00
189_E237_L1.2741.00
3_Y75_Y1.2711.00
227_V238_S1.2691.00
143_I270_Y1.2661.00
74_L77_Q1.2521.00
242_R246_R1.2491.00
116_L288_M1.2481.00
62_D66_Q1.2231.00
37_K41_K1.2221.00
66_Q70_Q1.2211.00
229_E232_I1.2201.00
242_R256_I1.2161.00
67_R78_A1.2021.00
114_Q190_A1.2001.00
63_I66_Q1.1981.00
171_N255_S1.1981.00
9_F48_L1.1911.00
159_P269_S1.1911.00
246_R250_I1.1901.00
111_A115_K1.1781.00
179_K255_S1.1771.00
157_I271_I1.1731.00
208_L213_L1.1731.00
174_P189_E1.1721.00
112_Q115_K1.1661.00
27_I31_S1.1491.00
192_V227_V1.1431.00
9_F47_L1.1341.00
9_F13_V1.1291.00
123_D220_T1.1261.00
93_L285_F1.1211.00
34_L38_N1.1201.00
33_S37_K1.1181.00
34_L37_K1.1181.00
111_A233_N1.1121.00
287_T290_K1.1121.00
113_L288_M1.1091.00
7_K76_E1.1011.00
168_A256_I1.0971.00
190_A216_K1.0961.00
117_Y284_I1.0941.00
221_I227_V1.0931.00
12_V21_A1.0921.00
18_F55_F1.0901.00
127_G135_R1.0891.00
70_Q77_Q1.0861.00
6_L68_A1.0831.00
11_A21_A1.0761.00
102_G126_I1.0731.00
180_E260_N1.0691.00
71_M74_L1.0681.00
283_E287_T1.0661.00
256_I259_I1.0601.00
109_L289_L1.0571.00
57_T61_G1.0571.00
170_P234_G1.0541.00
63_I67_R1.0461.00
181_I185_D1.0361.00
108_P233_N1.0351.00
35_H38_N1.0341.00
4_D7_K1.0331.00
158_E286_I1.0251.00
183_I261_N1.0221.00
137_R152_E1.0171.00
229_E233_N1.0151.00
79_K83_Y1.0011.00
8_T25_L1.0001.00
167_I237_L0.9971.00
247_K251_H0.9971.00
168_A245_L0.9971.00
76_E80_A0.9941.00
27_I32_V0.9901.00
76_E79_K0.9871.00
228_K232_I0.9811.00
13_V48_L0.9801.00
164_E265_K0.9801.00
202_E205_D0.9721.00
73_F77_Q0.9661.00
116_L291_S0.9641.00
64_L68_A0.9641.00
12_V18_F0.9591.00
113_L117_Y0.9551.00
169_A173_H0.9541.00
193_T217_S0.9491.00
9_F57_T0.9471.00
279_T282_K0.9411.00
135_R138_M0.9381.00
109_L288_M0.9371.00
221_I230_A0.9361.00
288_M291_S0.9361.00
45_T82_I0.9251.00
125_M135_R0.9231.00
48_L55_F0.9221.00
173_H190_A0.9211.00
96_A144_G0.9201.00
21_A32_V0.9201.00
9_F39_L0.9161.00
249_L252_R0.9151.00
154_E274_P0.9151.00
13_V61_G0.9111.00
173_H176_A0.9071.00
38_N41_K0.9001.00
141_A144_G0.8961.00
191_W215_P0.8931.00
202_E206_H0.8911.00
121_N216_K0.8881.00
96_A146_I0.8881.00
20_K24_K0.8861.00
66_Q69_K0.8771.00
155_L271_I0.8741.00
185_D188_N0.8691.00
177_G190_A0.8661.00
99_F223_S0.8641.00
120_L281_N0.8641.00
19_T23_E0.8611.00
16_K56_T0.8611.00
148_G267_K0.8601.00
190_A217_S0.8601.00
287_T291_S0.8581.00
51_S54_H0.8561.00
169_A174_P0.8551.00
273_S276_M0.8531.00
168_A238_S0.8511.00
95_I143_I0.8501.00
70_Q73_F0.8441.00
174_P179_K0.8401.00
25_L32_V0.8321.00
156_E159_P0.8311.00
125_M141_A0.8201.00
133_S137_R0.8171.00
278_N283_E0.8151.00
60_T82_I0.8121.00
37_K46_A0.8121.00
12_V36_I0.8101.00
16_K62_D0.8031.00
204_L208_L0.8011.00
207_V211_N0.8001.00
9_F64_L0.7981.00
184_S187_Q0.7971.00
29_Q33_S0.7931.00
13_V16_K0.7931.00
111_A235_M0.7911.00
91_G281_N0.7891.00
74_L78_A0.7861.00
170_P235_M0.7861.00
89_V117_Y0.7851.00
91_G120_L0.7851.00
164_E258_H0.7851.00
12_V48_L0.7831.00
75_Y78_A0.7791.00
14_E65_Y0.7761.00
4_D35_H0.7681.00
280_K284_I0.7651.00
15_E21_A0.7611.00
3_Y72_V0.7611.00
230_A235_M0.7591.00
143_I285_F0.7571.00
63_I85_H0.7551.00
83_Y86_H0.7541.00
77_Q81_E0.7541.00
164_E263_S0.7531.00
201_R220_T0.7531.00
114_Q235_M0.7511.00
16_K54_H0.7501.00
60_T63_I0.7461.00
182_S260_N0.7461.00
75_Y79_K0.7451.00
5_V8_T0.7421.00
116_L284_I0.7411.00
172_Q176_A0.7411.00
57_T62_D0.7401.00
60_T85_H0.7381.00
168_A240_L0.7361.00
137_R155_L0.7351.00
56_T62_D0.7341.00
94_K141_A0.7341.00
245_L249_L0.7321.00
31_S35_H0.7311.00
113_L284_I0.7271.00
68_A71_M0.7251.00
7_K11_A0.7251.00
78_A82_I0.7181.00
169_A255_S0.7131.00
18_F32_V0.7121.00
241_S244_V0.7121.00
12_V32_V0.7111.00
49_N58_T0.7111.00
145_L289_L0.7091.00
97_A102_G0.7081.00
170_P173_H0.7071.00
232_I251_H0.7061.00
176_A255_S0.7051.00
206_H210_S0.7041.00
223_S226_G0.6961.00
60_T64_L0.6941.00
112_Q291_S0.6921.00
180_E258_H0.6891.00
69_K73_F0.6881.00
40_E45_T0.6871.00
94_K142_D0.6871.00
187_Q213_L0.6861.00
247_K250_I0.6851.00
249_L256_I0.6821.00
173_H177_G0.6811.00
49_N54_H0.6791.00
18_F54_H0.6781.00
188_N216_K0.6781.00
168_A249_L0.6771.00
142_D282_K0.6761.00
195_E220_T0.6761.00
97_A106_L0.6751.00
68_A72_V0.6741.00
206_H209_S0.6731.00
73_F76_E0.6721.00
62_D65_Y0.6711.00
219_F230_A0.6681.00
59_P63_I0.6641.00
207_V210_S0.6601.00
175_L178_R0.6581.00
77_Q80_A0.6581.00
93_L281_N0.6571.00
64_L82_I0.6551.00
194_R227_V0.6541.00
175_L189_E0.6541.00
167_I186_L0.6541.00
139_L273_S0.6541.00
184_S211_N0.6521.00
284_I288_M0.6511.00
169_A175_L0.6501.00
203_Y207_V0.6491.00
171_N252_R0.6491.00
172_Q175_L0.6481.00
172_Q255_S0.6471.00
40_E50_R0.6451.00
208_L215_P0.6451.00
204_L207_V0.6411.00
121_N220_T0.6401.00
191_W237_L0.6401.00
205_D209_S0.6371.00
23_E26_M0.6351.00
21_A25_L0.6351.00
36_I40_E0.6341.00
182_S261_N0.6331.00
136_V271_I0.6331.00
172_Q234_G0.6311.00
7_K10_I0.6311.00
161_M268_L0.6301.00
103_E229_E0.6251.00
99_F128_N0.6231.00
90_K121_N0.6211.00
126_I222_S0.6211.00
67_R71_M0.6201.00
12_V17_N0.6201.00
63_I82_I0.6101.00
4_D38_N0.6081.00
276_M279_T0.6071.00
175_L181_I0.6061.00
80_A84_A0.6051.00
156_E275_L0.6031.00
280_K283_E0.6011.00
93_L143_I0.6011.00
285_F289_L0.6001.00
167_I191_W0.5981.00
143_I286_I0.5971.00
106_L109_L0.5971.00
167_I239_V0.5951.00
57_T65_Y0.5901.00
96_A127_G0.5891.00
30_P34_L0.5871.00
227_V231_V0.5851.00
230_A236_G0.5841.00
126_I223_S0.5841.00
31_S34_L0.5831.00
136_V155_L0.5791.00
174_P178_R0.5721.00
43_F64_L0.5721.00
43_F82_I0.5721.00
28_S34_L0.5711.00
195_E222_S0.5711.00
202_E207_V0.5701.00
165_M239_V0.5671.00
110_L122_L0.5671.00
203_Y206_H0.5651.00
48_L57_T0.5651.00
221_I226_G0.5621.00
180_E185_D0.5611.00
163_D266_R0.5611.00
101_I105_I0.5611.00
108_P111_A0.5611.00
7_K72_V0.5601.00
45_T49_N0.5601.00
4_D8_T0.5601.00
147_E266_R0.5601.00
196_K220_T0.5591.00
66_Q81_E0.5531.00
108_P112_Q0.5531.00
96_A125_M0.5481.00
272_H283_E0.5471.00
43_F46_A0.5451.00
91_G119_E0.5451.00
8_T36_I0.5441.00
72_V75_Y0.5441.00
36_I48_L0.5431.00
259_I262_F0.5421.00
228_K245_L0.5401.00
72_V76_E0.5381.00
240_L245_L0.5361.00
160_F270_Y0.5361.00
67_R82_I0.5321.00
68_A75_Y0.5281.00
9_F61_G0.5271.00
117_Y120_L0.5271.00
145_L270_Y0.5271.00
205_D208_L0.5251.00
148_G157_I0.5241.00
224_N241_S0.5231.00
173_H237_L0.5191.00
282_K286_I0.5181.00
91_G117_Y0.5161.00
46_A60_T0.5161.00
103_E223_S0.5161.00
8_T21_A0.5141.00
18_F29_Q0.5131.00
6_L64_L0.5121.00
27_I35_H0.5121.00
18_F50_R0.5091.00
80_A83_Y0.5091.00
84_A89_V0.5091.00
272_H278_N0.5051.00
201_R207_V0.5051.00
105_I109_L0.5041.00
16_K55_F0.5011.00
150_T153_N0.5011.00
97_A124_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1al3A 1 0.7124 100 0.079 Contact Map
2esnA 3 0.9799 100 0.079 Contact Map
1ixcA 4 0.9766 100 0.079 Contact Map
1uthA 2 0.7592 100 0.08 Contact Map
2h98A 2 0.6923 100 0.082 Contact Map
3fzvA 4 0.9599 100 0.086 Contact Map
4x6gA 4 1 100 0.086 Contact Map
3fxqA 3 0.9766 100 0.086 Contact Map
2h9bA 2 0.6923 100 0.09 Contact Map
3szpA 3 0.9699 100 0.099 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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