GREMLIN Database
PTAS - Phosphate acetyltransferase
UniProt: P39646 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 323 (319)
Sequences: 3027 (1651)
Seq/√Len: 92.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
224_A233_L4.1441.00
81_L117_L4.0251.00
19_I120_G3.7101.00
174_D177_D3.6931.00
219_D222_K3.5301.00
50_E54_Q3.2011.00
102_L111_M2.9791.00
81_L112_L2.7921.00
18_K43_N2.7821.00
37_A67_V2.6081.00
83_Q95_E2.5821.00
36_L315_A2.5491.00
222_K226_E2.5271.00
45_I118_A2.4921.00
87_E90_K2.4551.00
35_K312_Y2.3041.00
16_D43_N2.2941.00
21_F315_A2.2411.00
18_K45_I2.2381.00
175_S219_D2.2351.00
113_V118_A2.1901.00
49_N71_D2.1671.00
165_A265_V2.1411.00
176_Q223_I2.1041.00
183_I228_A2.0431.00
77_G117_L2.0341.00
84_A115_K2.0311.00
84_A114_Y2.0241.00
197_R260_D2.0211.00
172_A216_K2.0081.00
201_L274_I1.9861.00
225_K233_L1.9611.00
77_G80_D1.9541.00
79_E99_R1.9361.00
120_G318_T1.8871.00
232_T256_E1.8681.00
112_L117_L1.8461.00
187_N228_A1.8451.00
25_L52_E1.8321.00
80_D115_K1.8131.00
200_M221_V1.8091.00
164_F279_A1.8071.00
176_Q219_D1.7991.00
179_A223_I1.7461.00
86_V90_K1.7291.00
34_S38_G1.7211.00
133_V169_I1.7131.00
45_I68_K1.7001.00
36_L42_L1.6911.00
81_L115_K1.6861.00
203_F211_S1.6751.00
84_A87_E1.6751.00
245_P249_E1.6671.00
180_E227_K1.6571.00
109_G121_L1.6481.00
85_F101_A1.6241.00
84_A111_M1.6241.00
172_A213_E1.6171.00
140_I299_V1.6131.00
27_E56_K1.6021.00
183_I227_K1.5981.00
95_E99_R1.5931.00
275_G278_I1.5901.00
215_E218_A1.5891.00
88_R114_Y1.5881.00
27_E60_L1.5701.00
56_K60_L1.5701.00
18_K68_K1.5461.00
123_S132_T1.5391.00
225_K256_E1.5361.00
244_V281_R1.5151.00
82_V86_V1.4991.00
27_E31_E1.4741.00
80_D117_L1.4591.00
48_G53_I1.4521.00
271_A274_I1.4511.00
223_I227_K1.4511.00
34_S62_L1.4270.99
85_F138_Q1.4150.99
43_N68_K1.4060.99
224_A231_L1.3980.99
200_M224_A1.3890.99
122_V314_L1.3810.99
97_Q100_K1.3800.99
79_E83_Q1.3760.99
172_A212_D1.3660.99
82_V99_R1.3650.99
77_G81_L1.3510.99
24_G46_V1.3510.99
64_L67_V1.3490.99
300_N318_T1.3480.99
173_P181_I1.3480.99
73_H103_L1.3290.99
183_I224_A1.3270.99
50_E71_D1.3270.99
56_K59_E1.3240.99
175_S221_V1.3230.99
57_A64_L1.3230.99
114_Y297_M1.3170.99
78_M82_V1.3100.99
20_V113_V1.3040.99
148_K177_D1.3020.99
16_D319_A1.2960.99
157_R285_F1.2940.99
143_K187_N1.2800.99
200_M233_L1.2710.99
239_F264_F1.2700.99
182_A200_M1.2680.99
9_Q316_L1.2630.99
271_A275_G1.2610.99
268_S271_A1.2600.99
243_F264_F1.2440.98
75_Y108_F1.2420.98
239_F278_I1.2380.98
47_I70_Y1.2360.98
50_E74_T1.2300.98
178_L217_V1.2280.98
164_F266_F1.2190.98
116_G297_M1.2110.98
16_D40_K1.2070.98
54_Q58_K1.2000.98
106_N123_S1.1970.98
7_T11_K1.1950.98
136_A299_V1.1870.98
10_E13_A1.1810.98
279_A283_G1.1780.98
31_E308_A1.1770.98
20_V112_L1.1660.98
152_V188_T1.1540.98
234_D256_E1.1470.97
264_F278_I1.1340.97
215_E219_D1.1300.97
188_T293_Q1.1230.97
241_A247_V1.1210.97
197_R232_T1.1160.97
187_N190_K1.1110.97
30_L62_L1.1080.97
186_A231_L1.0970.97
221_V225_K1.0900.96
85_F102_L1.0890.96
206_K237_F1.0890.96
189_A194_I1.0870.96
26_D126_A1.0770.96
94_T97_Q1.0760.96
176_Q227_K1.0710.96
78_M103_L1.0700.96
234_D255_S1.0680.96
86_V95_E1.0670.96
153_F167_C1.0650.96
288_V313_N1.0620.96
157_R160_E1.0620.96
35_K309_E1.0590.96
239_F243_F1.0570.96
234_D237_F1.0540.96
49_N73_H1.0440.96
163_V189_A1.0420.95
203_F270_E1.0360.95
36_L41_V1.0340.95
123_S127_H1.0330.95
49_N52_E1.0330.95
223_I226_E1.0310.95
228_A231_L1.0160.95
165_A185_S1.0140.95
55_A59_E1.0100.95
57_A62_L1.0090.95
136_A295_L1.0070.95
212_D215_E1.0050.94
218_A222_K1.0040.94
20_V118_A1.0000.94
190_K195_E1.0000.94
146_V184_E0.9980.94
42_L315_A0.9940.94
248_A258_K0.9920.94
9_Q39_N0.9910.94
83_Q87_E0.9880.94
211_S214_T0.9860.94
111_M115_K0.9760.94
232_T258_K0.9700.93
210_K215_E0.9620.93
302_L311_V0.9610.93
207_G236_E0.9560.93
82_V95_E0.9470.93
71_D74_T0.9460.92
190_K196_P0.9450.92
178_L181_I0.9430.92
152_V163_V0.9400.92
237_F252_A0.9390.92
19_I315_A0.9380.92
186_A198_V0.9360.92
17_V119_D0.9340.92
151_G292_L0.9320.92
222_K225_K0.9320.92
246_S250_K0.9290.92
4_L154_I0.9200.91
209_A214_T0.9150.91
199_A261_A0.9110.91
149_T295_L0.9090.91
206_K252_A0.9050.91
135_P141_K0.9020.91
24_G30_L0.9010.91
34_S67_V0.8990.90
147_K176_Q0.8950.90
126_A250_K0.8950.90
35_K38_G0.8920.90
53_I69_I0.8890.90
30_L56_K0.8880.90
38_G63_T0.8820.90
248_A254_D0.8810.90
114_Y139_I0.8800.89
257_I260_D0.8780.89
147_K180_E0.8750.89
155_M164_F0.8750.89
140_I296_N0.8730.89
35_K39_N0.8710.89
31_E62_L0.8710.89
178_L220_A0.8670.89
148_K181_I0.8650.89
78_M99_R0.8640.89
21_F122_V0.8590.88
171_I211_S0.8580.88
51_N55_A0.8580.88
141_K296_N0.8580.88
179_A224_A0.8570.88
17_V322_A0.8500.88
175_S216_K0.8470.88
28_R125_A0.8440.87
105_E127_H0.8430.87
104_D131_D0.8410.87
152_V165_A0.8380.87
200_M217_V0.8360.87
49_N53_I0.8360.87
29_I311_V0.8270.86
232_T257_I0.8230.86
276_Y287_A0.8230.86
255_S258_K0.8230.86
278_I283_G0.8170.86
26_D125_A0.8120.85
151_G167_C0.8080.85
148_K170_N0.8030.85
134_R138_Q0.7950.84
312_Y316_L0.7950.84
150_S293_Q0.7930.84
203_F209_A0.7930.84
51_N54_Q0.7910.84
137_L149_T0.7890.84
140_I295_L0.7890.84
21_F33_V0.7890.84
249_E254_D0.7870.84
155_M287_A0.7870.84
78_M102_L0.7850.83
109_G299_V0.7820.83
30_L34_S0.7740.83
70_Y75_Y0.7740.83
106_N121_L0.7730.82
47_I109_G0.7710.82
86_V91_G0.7700.82
163_V185_S0.7680.82
84_A88_R0.7660.82
267_P274_I0.7660.82
143_K296_N0.7630.82
286_E313_N0.7620.82
234_D252_A0.7600.81
213_E268_S0.7570.81
77_G108_F0.7560.81
52_E55_A0.7550.81
75_Y78_M0.7550.81
182_A198_V0.7540.81
248_A257_I0.7520.81
107_Y135_P0.7470.80
86_V102_L0.7470.80
306_C310_D0.7470.80
221_V224_A0.7470.80
221_V233_L0.7460.80
269_L273_N0.7430.80
21_F36_L0.7420.80
300_N321_Q0.7380.79
44_P315_A0.7380.79
239_F282_L0.7370.79
17_V319_A0.7360.79
178_L200_M0.7360.79
291_I314_L0.7360.79
205_T241_A0.7340.79
18_K119_D0.7300.79
50_E69_I0.7270.78
152_V293_Q0.7260.78
19_I318_T0.7250.78
229_P233_L0.7240.78
195_E232_T0.7230.78
150_S181_I0.7220.78
5_F313_N0.7200.78
175_S179_A0.7160.77
189_A193_D0.7140.77
25_L56_K0.7120.77
169_I292_L0.7120.77
151_G165_A0.7110.77
152_V189_A0.7080.77
47_I108_F0.7070.76
83_Q86_V0.7060.76
157_R162_Y0.7060.76
46_V67_V0.7060.76
80_D84_A0.7050.76
151_G168_A0.7050.76
9_Q41_V0.7050.76
206_K254_D0.7040.76
10_E14_G0.7030.76
25_L105_E0.7030.76
6_S10_E0.7030.76
25_L126_A0.6990.76
201_L267_P0.6980.76
26_D46_V0.6940.75
110_T121_L0.6930.75
20_V47_I0.6880.74
9_Q13_A0.6840.74
93_A98_A0.6830.74
89_R92_K0.6800.74
83_Q99_R0.6800.74
238_Q305_G0.6780.73
75_Y81_L0.6740.73
318_T321_Q0.6740.73
18_K44_P0.6740.73
213_E270_E0.6730.73
162_Y243_F0.6730.73
106_N127_H0.6720.73
29_I125_A0.6700.73
27_E59_E0.6700.73
100_K103_L0.6660.72
40_K66_G0.6660.72
176_Q179_A0.6640.72
135_P138_Q0.6600.71
54_Q69_I0.6590.71
189_A263_V0.6580.71
283_G312_Y0.6580.71
31_E35_K0.6530.71
176_Q222_K0.6500.70
198_V263_V0.6500.70
184_E187_N0.6490.70
127_H131_D0.6440.70
19_I300_N0.6420.69
21_F44_P0.6420.69
55_A58_K0.6410.69
31_E60_L0.6380.69
190_K230_E0.6380.69
211_S215_E0.6360.69
30_L53_I0.6340.68
188_T291_I0.6280.68
57_A63_T0.6280.68
147_K177_D0.6280.68
238_Q273_N0.6280.68
168_A303_S0.6250.67
46_V53_I0.6240.67
190_K231_L0.6230.67
182_A224_A0.6210.67
210_K218_A0.6210.67
309_E313_N0.6190.67
239_F275_G0.6190.67
218_A221_V0.6170.66
144_E296_N0.6150.66
291_I317_I0.6140.66
37_A66_G0.6130.66
191_M194_I0.6110.66
26_D29_I0.6060.65
114_Y296_N0.6050.65
273_N276_Y0.6000.64
20_V45_I0.5970.64
75_Y112_L0.5960.64
35_K308_A0.5960.64
20_V109_G0.5950.63
85_F111_M0.5950.63
162_Y282_L0.5930.63
82_V102_L0.5910.63
110_T299_V0.5900.63
23_E125_A0.5890.63
52_E56_K0.5870.62
182_A263_V0.5850.62
208_S238_Q0.5850.62
239_F274_I0.5800.62
171_I203_F0.5790.61
203_F238_Q0.5770.61
70_Y112_L0.5740.61
85_F139_I0.5710.60
106_N132_T0.5680.60
33_V46_V0.5680.60
206_K236_E0.5680.60
134_R137_L0.5670.60
204_S207_G0.5660.60
173_P177_D0.5660.60
142_T149_T0.5630.59
8_V316_L0.5630.59
197_R261_A0.5630.59
179_A183_I0.5600.59
12_V17_V0.5580.59
266_F275_G0.5580.59
251_K303_S0.5560.58
79_E95_E0.5550.58
47_I112_L0.5550.58
58_K65_G0.5470.57
190_K228_A0.5460.57
129_T151_G0.5460.57
148_K169_I0.5440.57
101_A107_Y0.5420.56
162_Y285_F0.5410.56
220_A224_A0.5410.56
275_G279_A0.5400.56
157_R283_G0.5390.56
39_N312_Y0.5390.56
148_K151_G0.5390.56
224_A227_K0.5370.56
155_M217_V0.5370.56
28_R311_V0.5370.56
42_L316_L0.5360.56
305_G310_D0.5360.56
248_A259_G0.5350.55
116_G246_S0.5350.55
212_D218_A0.5340.55
175_S322_A0.5340.55
31_E307_N0.5330.55
102_L107_Y0.5330.55
37_A44_P0.5330.55
12_V320_A0.5320.55
101_A138_Q0.5320.55
36_L312_Y0.5310.55
234_D257_I0.5310.55
33_V67_V0.5310.55
156_A286_E0.5300.55
236_E282_L0.5300.55
85_F98_A0.5300.55
5_F9_Q0.5300.55
200_M231_L0.5290.55
83_Q90_K0.5280.54
110_T141_K0.5280.54
11_K193_D0.5280.54
152_V185_S0.5260.54
131_D134_R0.5260.54
34_S57_A0.5260.54
63_T66_G0.5250.54
47_I75_Y0.5250.54
224_A228_A0.5240.54
96_E100_K0.5240.54
47_I78_M0.5220.54
99_R103_L0.5210.54
160_E285_F0.5200.53
240_D277_K0.5200.53
201_L273_N0.5190.53
88_R111_M0.5190.53
265_V272_G0.5190.53
129_T303_S0.5180.53
125_A311_V0.5170.53
26_D56_K0.5170.53
247_V281_R0.5160.53
12_V316_L0.5150.53
24_G47_I0.5140.53
224_A229_P0.5130.52
177_D180_E0.5110.52
24_G45_I0.5110.52
154_I288_V0.5110.52
218_A237_F0.5110.52
7_T10_E0.5100.52
156_A288_V0.5100.52
88_R141_K0.5100.52
156_A161_Q0.5090.52
181_I184_E0.5090.52
239_F279_A0.5080.52
157_R282_L0.5070.52
71_D75_Y0.5070.52
53_I65_G0.5060.51
104_D123_S0.5060.51
33_V44_P0.5050.51
7_T193_D0.5050.51
228_A233_L0.5050.51
197_R259_G0.5050.51
46_V56_K0.5050.51
150_S170_N0.5030.51
101_A104_D0.5030.51
219_D223_I0.5020.51
241_A251_K0.5020.51
121_L295_L0.5010.51
153_F168_A0.5000.51
236_E278_I0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4e4rA 2 1 100 0.369 Contact Map
1td9A 3 1 100 0.387 Contact Map
1r5jA 4 1 100 0.401 Contact Map
2af4C 2 0.9907 100 0.405 Contact Map
1vmiA 2 0.9938 100 0.425 Contact Map
1ycoA 2 0.8297 100 0.472 Contact Map
3uf6A 2 0.87 100 0.488 Contact Map
4jqpA 2 0.8793 100 0.573 Contact Map
3lxyA 2 0.8793 100 0.596 Contact Map
1yxoA 2 0.87 100 0.6 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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