GREMLIN Database
YWFI - Putative heme-dependent peroxidase YwfI
UniProt: P39645 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 254 (219)
Sequences: 780 (450)
Seq/√Len: 30.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
144_S210_D5.6241.00
19_A193_T3.9831.00
175_R179_L3.3001.00
76_F104_T3.1131.00
187_K214_Q3.0621.00
172_N226_E3.0371.00
180_I225_D3.0051.00
84_T87_E2.8121.00
45_E99_R2.7801.00
53_W91_I2.6381.00
95_F104_T2.6211.00
85_M111_V2.5681.00
146_Y241_N2.4370.99
86_E145_K2.4360.99
52_K94_E2.3690.99
27_D105_I2.3680.99
221_E224_F2.2680.99
169_E172_N2.2520.99
46_F100_L2.2480.99
164_M229_A2.2420.99
46_F49_L2.0850.98
173_L227_V1.9750.97
200_D236_S1.9700.97
32_K35_S1.9680.97
219_V232_G1.9500.97
172_N176_S1.9120.96
195_S199_D1.8980.96
47_T51_E1.8900.96
183_S221_E1.8320.95
154_K174_M1.8320.95
244_S247_T1.8220.95
145_K241_N1.7640.94
148_C197_G1.7490.94
176_S226_E1.7210.93
173_L231_Y1.7100.93
25_T105_I1.7000.93
47_T245_L1.6770.92
85_M212_V1.6640.92
44_H48_G1.6600.92
113_V213_L1.6530.92
203_W237_F1.6510.92
95_F101_A1.6390.92
188_V218_L1.6380.92
225_D231_Y1.6370.92
185_A221_E1.6260.91
86_E146_Y1.5880.90
165_L222_M1.5820.90
40_Q44_H1.5810.90
156_R235_G1.5310.88
212_V239_V1.5280.88
182_R185_A1.5120.88
172_N175_R1.4880.87
90_Q94_E1.4840.87
171_R182_R1.4300.85
21_H112_S1.4260.85
99_R248_L1.3990.83
85_M198_F1.3800.83
197_G222_M1.3700.82
50_L245_L1.3600.82
110_Y195_S1.3580.82
49_L95_F1.3220.80
112_S204_G1.3100.79
184_Y221_E1.3000.79
18_Y213_L1.2850.78
134_R138_Y1.2680.77
77_M147_V1.2660.77
176_S225_D1.2600.76
49_L53_W1.2590.76
110_Y199_D1.2490.76
171_R175_R1.2470.76
52_K76_F1.2400.75
168_E171_R1.2280.74
70_V93_L1.2280.74
66_L98_S1.2210.74
198_F212_V1.2190.74
110_Y238_F1.2150.74
180_I221_E1.2140.74
156_R232_G1.2130.74
155_R232_G1.1950.72
214_Q217_K1.1870.72
52_K55_V1.1860.72
176_S180_I1.1370.69
53_W98_S1.1250.68
79_M191_I1.1170.67
42_I99_R1.1060.66
148_C195_S1.0960.66
206_T215_F1.0960.66
220_Y224_F1.0880.65
140_E189_K1.0780.64
110_Y204_G1.0730.64
117_S154_K1.0720.64
166_S172_N1.0640.63
54_G142_P1.0610.63
19_A76_F1.0420.62
166_S169_E1.0270.61
45_E98_S1.0200.60
50_L66_L1.0060.59
42_I104_T1.0040.59
22_D109_S1.0000.58
34_L46_F0.9930.58
113_V198_F0.9920.58
54_G250_Q0.9860.57
85_M146_Y0.9800.57
178_G237_F0.9790.57
112_S194_G0.9780.57
114_V191_I0.9770.57
90_Q244_S0.9680.56
33_L37_D0.9630.56
42_I103_F0.9570.55
191_I208_F0.9520.55
150_Y223_R0.9470.54
52_K99_R0.9440.54
65_T242_H0.9370.53
247_T250_Q0.9350.53
20_L111_V0.9330.53
181_G215_F0.9310.53
173_L176_S0.9240.52
185_A209_S0.9230.52
27_D42_I0.9160.52
77_M153_D0.8990.50
20_L106_P0.8970.50
174_M198_F0.8970.50
48_G51_E0.8940.50
51_E54_G0.8910.50
90_Q250_Q0.8900.50
179_L182_R0.8900.50
83_P95_F0.8880.50
215_F218_L0.8830.49
55_V247_T0.8780.49
14_L194_G0.8730.48
149_F207_L0.8660.48
246_D250_Q0.8630.48
64_Q236_S0.8600.47
188_V191_I0.8570.47
47_T246_D0.8510.47
226_E229_A0.8510.47
107_A238_F0.8500.47
19_A79_M0.8470.46
49_L94_E0.8440.46
20_L92_E0.8420.46
109_S148_C0.8390.46
42_I211_D0.8370.46
92_E106_P0.8360.45
179_L183_S0.8350.45
69_I109_S0.8330.45
88_L97_K0.8330.45
23_F77_M0.8250.45
119_Y154_K0.8230.44
49_L245_L0.8160.44
47_T244_S0.8130.44
50_L142_P0.8090.43
65_T178_G0.8090.43
173_L222_M0.8070.43
35_S38_E0.8060.43
37_D47_T0.8050.43
155_R230_R0.8030.43
53_W78_L0.8030.43
70_V248_L0.8020.43
238_F241_N0.7970.42
93_L251_F0.7960.42
66_L248_L0.7950.42
77_M212_V0.7930.42
180_I185_A0.7910.42
178_G203_W0.7880.42
98_S188_V0.7860.41
245_L248_L0.7830.41
89_N196_V0.7790.41
115_E216_K0.7770.41
78_L91_I0.7710.40
67_Y77_M0.7700.40
145_K244_S0.7700.40
42_I93_L0.7690.40
174_M220_Y0.7680.40
19_A80_I0.7660.40
80_I91_I0.7630.40
69_I229_A0.7610.40
66_L78_L0.7570.39
43_I47_T0.7560.39
112_S167_M0.7510.39
52_K102_E0.7500.39
41_S248_L0.7480.39
86_E241_N0.7470.39
21_H206_T0.7440.38
20_L88_L0.7410.38
48_G55_V0.7390.38
117_S167_M0.7340.38
27_D43_I0.7330.37
42_I45_E0.7320.37
12_K133_V0.7300.37
34_L38_E0.7280.37
32_K36_S0.7250.37
23_F107_A0.7220.37
44_H55_V0.7120.36
72_Q106_P0.7090.36
195_S224_F0.7060.35
156_R228_S0.7050.35
41_S55_V0.6990.35
97_K250_Q0.6950.35
190_Q205_V0.6940.35
41_S99_R0.6920.34
34_L99_R0.6890.34
122_S171_R0.6850.34
209_S214_Q0.6850.34
72_Q107_A0.6840.34
26_M93_L0.6830.34
48_G94_E0.6780.33
135_A238_F0.6760.33
147_V172_N0.6760.33
45_E100_L0.6750.33
174_M190_Q0.6750.33
11_A78_L0.6750.33
47_T61_K0.6720.33
176_S196_V0.6670.33
76_F137_L0.6640.32
164_M169_E0.6640.32
11_A196_V0.6640.32
150_Y163_Y0.6610.32
169_E209_S0.6610.32
11_A49_L0.6600.32
156_R229_A0.6600.32
51_E102_E0.6580.32
201_Y238_F0.6570.32
53_W63_S0.6560.32
123_G236_S0.6560.32
62_G82_R0.6550.32
178_G240_G0.6550.32
196_V220_Y0.6550.32
35_S40_Q0.6480.31
168_E195_S0.6480.31
67_Y79_M0.6460.31
21_H222_M0.6440.31
85_M112_S0.6440.31
46_F78_L0.6430.31
115_E217_K0.6400.31
216_K234_F0.6390.31
55_V248_L0.6380.31
68_S89_N0.6370.31
45_E56_A0.6370.31
190_Q234_F0.6350.30
117_S120_L0.6350.30
205_V219_V0.6350.30
181_G207_L0.6330.30
173_L196_V0.6300.30
38_E41_S0.6290.30
208_F236_S0.6290.30
90_Q99_R0.6270.30
36_S47_T0.6250.30
117_S193_T0.6230.30
36_S77_M0.6220.30
182_R221_E0.6200.29
150_Y202_E0.6160.29
47_T54_G0.6140.29
46_F84_T0.6080.29
49_L52_K0.6050.28
168_E179_L0.6000.28
163_Y223_R0.5990.28
33_L41_S0.5950.28
51_E55_V0.5950.28
27_D76_F0.5950.28
189_K218_L0.5930.28
118_N227_V0.5920.28
133_V148_C0.5920.28
73_K222_M0.5850.27
202_E223_R0.5850.27
23_F74_A0.5840.27
25_T145_K0.5810.27
42_I139_P0.5760.27
37_D43_I0.5750.27
88_L111_V0.5740.26
22_D92_E0.5720.26
135_A138_Y0.5680.26
190_Q207_L0.5650.26
12_K122_S0.5630.26
181_G190_Q0.5620.26
63_S78_L0.5600.26
146_Y224_F0.5590.26
123_G191_I0.5570.25
51_E242_H0.5550.25
38_E42_I0.5530.25
35_S42_I0.5520.25
48_G99_R0.5500.25
192_I196_V0.5490.25
53_W245_L0.5450.25
41_S183_S0.5440.25
146_Y251_F0.5440.25
111_V195_S0.5430.25
146_Y215_F0.5430.25
155_R231_Y0.5400.24
94_E98_S0.5400.24
117_S174_M0.5390.24
76_F103_F0.5390.24
194_G204_G0.5370.24
33_L36_S0.5370.24
44_H47_T0.5330.24
149_F229_A0.5320.24
118_N230_R0.5320.24
19_A242_H0.5320.24
115_E234_F0.5310.24
13_T82_R0.5300.24
20_L138_Y0.5290.24
156_R231_Y0.5290.24
208_F212_V0.5270.24
32_K102_E0.5260.24
135_A220_Y0.5260.24
36_S50_L0.5240.23
123_G134_R0.5230.23
88_L209_S0.5210.23
217_K222_M0.5210.23
37_D51_E0.5210.23
203_W222_M0.5210.23
155_R233_E0.5200.23
168_E172_N0.5180.23
244_S250_Q0.5180.23
94_E99_R0.5150.23
32_K87_E0.5110.23
69_I110_Y0.5100.23
27_D106_P0.5100.23
115_E219_V0.5090.23
13_T116_L0.5080.23
24_R188_V0.5080.23
13_T92_E0.5070.23
137_L195_S0.5070.23
90_Q249_P0.5060.22
144_S238_F0.5050.22
218_L225_D0.5040.22
16_G22_D0.5010.22
56_A212_V0.5010.22
62_G137_L0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1t0tV 5 0.9567 100 0.085 Contact Map
4wwsA 3 0.9606 100 0.089 Contact Map
1vdhA 3 0.9724 100 0.1 Contact Map
3nn1A 3 0.9252 100 0.195 Contact Map
3dtzA 3 0.8661 100 0.216 Contact Map
2vxhA 3 0.8976 100 0.23 Contact Map
3qpiA 1 0.6575 100 0.507 Contact Map
2zbcA 6 0.315 87.2 0.946 Contact Map
2cviA 2 0.3228 73.1 0.954 Contact Map
2djwA 6 0.311 71.9 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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