GREMLIN Database
AAT2 - Probable aspartate aminotransferase
UniProt: P39643 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 399 (351)
Sequences: 43372 (29632)
Seq/√Len: 1581.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
100_F106_G3.2361.00
161_D198_E3.1081.00
120_I141_E2.9821.00
348_A386_K2.9671.00
119_D169_K2.9341.00
299_K303_D2.8471.00
186_A190_A2.8291.00
316_K329_E2.7751.00
379_E383_R2.7191.00
304_F378_R2.7041.00
300_E374_Q2.6181.00
78_A285_S2.6161.00
115_L140_A2.4711.00
48_P52_E2.4021.00
253_G258_I2.3641.00
84_K90_T2.3521.00
74_F281_S2.3311.00
336_T339_Q2.2211.00
108_Y112_Q2.1741.00
248_M280_A2.1621.00
308_L381_V2.1571.00
190_A194_A2.1351.00
185_D188_F2.1131.00
379_E382_T2.0951.00
52_E56_E1.9681.00
158_E191_K1.9441.00
148_Y188_F1.9211.00
135_I140_A1.9181.00
200_N230_V1.9161.00
77_E81_A1.9021.00
120_I143_Y1.8861.00
81_A285_S1.8851.00
55_R60_N1.8591.00
154_L188_F1.8521.00
161_D191_K1.8521.00
196_A203_L1.8251.00
37_L380_F1.8101.00
159_K163_A1.7981.00
77_E93_P1.7951.00
110_L232_A1.7681.00
342_D346_E1.7591.00
170_L204_I1.7511.00
303_D307_A1.7421.00
156_D159_K1.7401.00
308_L382_T1.7381.00
208_A236_S1.7331.00
80_A93_P1.7281.00
120_I168_A1.6981.00
304_F308_L1.6981.00
204_I234_L1.6901.00
120_I165_L1.6691.00
308_L385_Q1.6591.00
103_G234_L1.6361.00
73_P77_E1.6351.00
305_F326_V1.6211.00
125_N144_E1.6201.00
312_E385_Q1.6061.00
56_E282_A1.6041.00
373_K376_D1.6001.00
120_I167_K1.5981.00
110_L204_I1.5941.00
96_E255_E1.5881.00
121_A135_I1.5811.00
191_K194_A1.5771.00
310_E317_M1.5701.00
337_S356_E1.5701.00
352_V366_V1.5691.00
159_K162_P1.5661.00
343_Y387_L1.5661.00
91_I252_V1.5491.00
306_T319_K1.5491.00
306_T310_E1.5311.00
79_I250_F1.5251.00
132_L136_T1.5011.00
111_T135_I1.4821.00
78_A81_A1.4811.00
83_Y252_V1.4791.00
194_A198_E1.4781.00
51_V55_R1.4611.00
74_F285_S1.4581.00
251_A261_V1.4521.00
308_L312_E1.4521.00
327_W355_G1.4461.00
187_A190_A1.4401.00
304_F374_Q1.4361.00
196_A201_I1.4361.00
157_F195_F1.4341.00
164_V195_F1.4161.00
161_D199_H1.4131.00
306_T326_V1.4131.00
94_E255_E1.4121.00
273_F276_L1.4041.00
237_F280_A1.3911.00
348_A383_R1.3861.00
125_N146_P1.3841.00
292_E296_R1.3801.00
307_A311_K1.3801.00
339_Q343_Y1.3781.00
98_A258_I1.3691.00
305_F381_V1.3531.00
232_A253_G1.3461.00
165_L168_A1.3431.00
79_I99_L1.3251.00
122_L168_A1.3201.00
78_A281_S1.3191.00
146_P159_K1.3191.00
339_Q342_D1.3171.00
157_F191_K1.3111.00
195_F199_H1.3081.00
292_E295_K1.3051.00
382_T386_K1.3021.00
297_I300_E1.3011.00
111_T172_F1.2761.00
52_E55_R1.2761.00
306_T317_M1.2721.00
53_A282_A1.2661.00
81_A85_R1.2621.00
221_F224_A1.2591.00
328_A368_I1.2531.00
378_R382_T1.2531.00
72_Y278_Q1.2471.00
297_I374_Q1.2451.00
105_A265_Q1.2441.00
195_F201_I1.2291.00
70_R262_N1.2281.00
296_R299_K1.2281.00
54_L279_A1.2271.00
83_Y250_F1.2251.00
54_L58_S1.2211.00
188_F191_K1.2201.00
194_A197_K1.2181.00
123_V142_L1.2131.00
111_T115_L1.2111.00
70_R76_K1.2011.00
329_E365_H1.1971.00
122_L145_M1.1921.00
265_Q269_F1.1911.00
341_S352_V1.1851.00
148_Y156_D1.1831.00
79_I97_V1.1821.00
260_A263_E1.1821.00
32_A349_H1.1701.00
302_I306_T1.1691.00
101_G105_A1.1651.00
132_L144_E1.1621.00
161_D195_F1.1611.00
76_K80_A1.1601.00
235_Y250_F1.1481.00
329_E364_R1.1421.00
162_P166_E1.1341.00
115_L121_A1.1331.00
297_I301_R1.1331.00
296_R300_E1.1291.00
281_S285_S1.1191.00
74_F278_Q1.1191.00
112_Q138_A1.1171.00
344_L384_I1.1161.00
229_T254_N1.1091.00
92_N96_E1.1091.00
374_Q378_R1.1091.00
114_L170_L1.1041.00
187_A191_K1.0991.00
232_A251_A1.0981.00
171_M201_I1.0971.00
336_T363_K1.0961.00
113_C264_F1.0951.00
161_D165_L1.0931.00
282_A285_S1.0931.00
48_P51_V1.0841.00
301_R304_F1.0741.00
302_I370_M1.0671.00
135_I142_L1.0641.00
92_N255_E1.0621.00
337_S364_R1.0591.00
259_Q263_E1.0561.00
74_F77_E1.0531.00
73_P93_P1.0521.00
116_N119_D1.0511.00
53_A56_E1.0471.00
117_P139_R1.0471.00
80_A97_V1.0461.00
49_H286_G1.0461.00
338_H356_E1.0431.00
85_R288_P1.0391.00
80_A92_N1.0381.00
186_A223_E1.0331.00
308_L378_R1.0331.00
376_D379_E1.0331.00
73_P76_K1.0271.00
145_M163_A1.0241.00
186_A224_A1.0241.00
202_H232_A1.0231.00
51_V58_S1.0211.00
106_G251_A1.0201.00
131_Y172_F1.0101.00
150_E154_L1.0091.00
96_E258_I1.0081.00
340_F366_V1.0041.00
75_L99_L1.0041.00
308_L311_K1.0021.00
109_V265_Q1.0011.00
193_A203_L0.9961.00
344_L352_V0.9931.00
368_I380_F0.9921.00
106_G234_L0.9891.00
98_A261_V0.9881.00
114_L202_H0.9801.00
113_C261_V0.9761.00
343_Y346_E0.9741.00
215_D321_K0.9741.00
121_A170_L0.9701.00
197_K228_K0.9661.00
164_V201_I0.9661.00
202_H230_V0.9571.00
186_A219_A0.9541.00
97_V252_V0.9541.00
42_P298_Y0.9531.00
282_A286_G0.9501.00
209_Y325_Y0.9481.00
197_K229_T0.9461.00
165_L199_H0.9401.00
303_D319_K0.9401.00
193_A231_G0.9391.00
190_A227_A0.9371.00
101_G273_F0.9281.00
53_A57_A0.9231.00
220_S223_E0.9231.00
127_G174_N0.9181.00
148_Y159_K0.9151.00
213_E216_Q0.9151.00
33_H349_H0.9131.00
110_L261_V0.9111.00
307_A378_R0.9101.00
350_V384_I0.9091.00
343_Y348_A0.9081.00
82_F211_A0.9081.00
158_E162_P0.9041.00
164_V168_A0.9031.00
222_L233_E0.8981.00
155_P188_F0.8981.00
305_F308_L0.8951.00
122_L171_M0.8881.00
103_G208_A0.8871.00
234_L251_A0.8871.00
136_T142_L0.8861.00
315_W328_A0.8831.00
37_L377_L0.8821.00
315_W330_I0.8801.00
293_S296_R0.8791.00
158_E161_D0.8781.00
305_F377_L0.8761.00
202_H257_I0.8741.00
96_E228_K0.8721.00
226_D229_T0.8701.00
104_K130_E0.8681.00
157_F192_A0.8621.00
122_L163_A0.8551.00
115_L170_L0.8521.00
258_I262_N0.8501.00
255_E259_Q0.8501.00
304_F307_A0.8491.00
103_G236_S0.8441.00
302_I320_P0.8421.00
289_E293_S0.8421.00
207_F233_E0.8401.00
105_A269_F0.8361.00
221_F231_G0.8361.00
168_A201_I0.8321.00
203_L221_F0.8321.00
72_Y281_S0.8321.00
304_F381_V0.8281.00
82_F241_F0.8261.00
157_F188_F0.8231.00
197_K230_V0.8171.00
253_G261_V0.8141.00
190_A224_A0.8131.00
265_Q272_M0.8121.00
49_H52_E0.8091.00
278_Q281_S0.8051.00
293_S297_I0.8051.00
122_L160_I0.8041.00
82_F87_Y0.8011.00
338_H342_D0.7991.00
340_F387_L0.7981.00
248_M272_M0.7951.00
121_A140_A0.7921.00
75_L79_I0.7921.00
331_P364_R0.7901.00
300_E303_D0.7891.00
313_L385_Q0.7881.00
104_K128_Y0.7851.00
211_A240_T0.7851.00
348_A387_L0.7841.00
49_H282_A0.7821.00
352_V368_I0.7811.00
330_I366_V0.7801.00
232_A257_I0.7751.00
111_T170_L0.7711.00
100_F251_A0.7691.00
307_A310_E0.7681.00
221_F225_E0.7611.00
120_I169_K0.7611.00
214_F299_K0.7611.00
305_F370_M0.7611.00
102_G247_R0.7601.00
143_Y165_L0.7601.00
157_F161_D0.7581.00
350_V383_R0.7581.00
124_P145_M0.7541.00
56_E61_P0.7511.00
47_P50_I0.7501.00
312_E382_T0.7491.00
341_S354_P0.7481.00
56_E60_N0.7481.00
81_A84_K0.7471.00
248_M276_L0.7461.00
124_P155_P0.7451.00
147_L177_N0.7451.00
115_L119_D0.7451.00
237_F250_F0.7401.00
71_G76_K0.7391.00
290_H294_L0.7391.00
124_P177_N0.7371.00
338_H354_P0.7351.00
33_H379_E0.7321.00
220_S224_A0.7301.00
36_N41_N0.7271.00
98_A251_A0.7261.00
31_G349_H0.7231.00
218_P222_L0.7231.00
375_E378_R0.7231.00
105_A109_V0.7211.00
160_I171_M0.7171.00
311_K378_R0.7171.00
310_E319_K0.7161.00
160_I195_F0.7151.00
149_E316_K0.7131.00
46_T49_H0.7101.00
72_Y277_Q0.7071.00
303_D306_T0.7051.00
178_N209_Y0.7041.00
193_A227_A0.7041.00
118_G141_E0.7031.00
289_E292_E0.7031.00
172_F204_I0.7031.00
123_V135_I0.7001.00
197_K227_A0.6991.00
125_N361_N0.6981.00
46_T51_V0.6961.00
164_V199_H0.6961.00
177_N180_T0.6951.00
304_F377_L0.6951.00
207_F220_S0.6931.00
156_D188_F0.6931.00
241_F288_P0.6931.00
143_Y168_A0.6921.00
337_S354_P0.6901.00
350_V380_F0.6891.00
186_A217_K0.6891.00
225_E228_K0.6861.00
331_P334_F0.6851.00
80_A91_I0.6831.00
63_F278_Q0.6791.00
171_M196_A0.6781.00
131_Y135_I0.6761.00
215_D302_I0.6751.00
33_H376_D0.6751.00
57_A279_A0.6711.00
219_A224_A0.6711.00
294_L298_Y0.6701.00
355_G365_H0.6691.00
133_S136_T0.6671.00
76_K93_P0.6651.00
213_E218_P0.6641.00
125_N359_G0.6621.00
229_T256_K0.6611.00
54_L275_G0.6601.00
109_V264_F0.6601.00
355_G358_F0.6591.00
290_H293_S0.6581.00
240_T291_T0.6581.00
149_E329_E0.6571.00
109_V261_V0.6541.00
183_V322_G0.6541.00
40_G209_Y0.6541.00
341_S366_V0.6511.00
300_E304_F0.6491.00
291_T295_K0.6491.00
99_L248_M0.6481.00
44_L297_I0.6471.00
307_A312_E0.6461.00
108_Y138_A0.6431.00
78_A284_L0.6421.00
228_K231_G0.6411.00
110_L234_L0.6391.00
87_Y210_G0.6381.00
305_F368_I0.6381.00
308_L313_L0.6371.00
107_L134_G0.6351.00
154_L185_D0.6341.00
328_A365_H0.6301.00
112_Q264_F0.6271.00
111_T140_A0.6261.00
327_W365_H0.6231.00
55_R58_S0.6231.00
372_S376_D0.6221.00
119_D167_K0.6201.00
145_M159_K0.6181.00
143_Y163_A0.6171.00
214_F322_G0.6171.00
301_R373_K0.6161.00
205_H233_E0.6151.00
148_Y154_L0.6141.00
168_A171_M0.6131.00
256_K259_Q0.6121.00
382_T385_Q0.6111.00
302_I319_K0.6091.00
111_T138_A0.6021.00
345_L351_V0.6021.00
123_V132_L0.6011.00
173_L189_Y0.6011.00
104_K270_V0.5991.00
83_Y233_E0.5991.00
43_D301_R0.5981.00
150_E188_F0.5971.00
316_K331_P0.5961.00
45_P51_V0.5961.00
214_F370_M0.5951.00
212_F295_K0.5941.00
108_Y134_G0.5941.00
175_Y207_F0.5931.00
214_F302_I0.5931.00
46_T290_H0.5931.00
215_D299_K0.5931.00
49_H288_P0.5931.00
99_L277_Q0.5901.00
46_T50_I0.5901.00
49_H290_H0.5871.00
288_P292_E0.5841.00
197_K226_D0.5831.00
196_A200_N0.5821.00
309_C328_A0.5811.00
82_F210_G0.5801.00
146_P163_A0.5771.00
98_A262_N0.5761.00
383_R386_K0.5731.00
334_F340_F0.5701.00
98_A253_G0.5691.00
253_G257_I0.5681.00
123_V144_E0.5671.00
184_A189_Y0.5671.00
47_P51_V0.5651.00
340_F344_L0.5651.00
53_A279_A0.5641.00
155_P160_I0.5631.00
31_G34_I0.5631.00
184_A188_F0.5601.00
49_H289_E0.5591.00
35_I379_E0.5581.00
176_P322_G0.5551.00
344_L387_L0.5541.00
237_F284_L0.5531.00
227_A231_G0.5511.00
337_S341_S0.5511.00
301_R374_Q0.5511.00
279_A282_A0.5501.00
38_G351_V0.5491.00
50_I283_A0.5491.00
155_P171_M0.5481.00
50_I243_M0.5471.00
101_G272_M0.5451.00
111_T134_G0.5451.00
313_L381_V0.5451.00
162_P165_L0.5391.00
295_K299_K0.5391.00
262_N265_Q0.5391.00
67_G72_Y0.5361.00
274_G278_Q0.5351.00
278_Q282_A0.5351.00
238_S247_R0.5341.00
182_A321_K0.5341.00
116_N169_K0.5331.00
299_K302_I0.5321.00
110_L170_L0.5311.00
189_Y205_H0.5301.00
259_Q262_N0.5291.00
227_A230_V0.5271.00
189_Y221_F0.5271.00
76_K262_N0.5251.00
379_E386_K0.5251.00
327_W367_R0.5251.00
336_T356_E0.5241.00
75_L280_A0.5241.00
243_M283_A0.5241.00
160_I192_A0.5231.00
68_P73_P0.5221.00
115_L169_K0.5211.00
203_L227_A0.5211.00
220_S233_E0.5191.00
121_A172_F0.5181.00
77_E285_S0.5181.00
107_L204_I0.5171.00
196_A199_H0.5161.00
35_I383_R0.5151.00
77_E80_A0.5131.00
277_Q281_S0.5131.00
146_P156_D0.5121.00
36_N39_Q0.5121.00
34_I351_V0.5121.00
171_M203_L0.5121.00
54_L57_A0.5111.00
317_M326_V0.5101.00
193_A196_A0.5091.00
210_G235_Y0.5091.00
102_G249_A0.5081.00
85_R285_S0.5081.00
84_K88_G0.5071.00
341_S345_L0.5061.00
67_G271_G0.5061.00
175_Y183_V0.5061.00
145_M155_P0.5061.00
178_N367_R0.5051.00
171_M195_F0.5041.00
154_L182_A0.5041.00
308_L377_L0.5011.00
337_S363_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xi9A 4 0.9649 100 0.28 Contact Map
3h14A 2 0.9223 100 0.283 Contact Map
3dydA 2 0.9298 100 0.288 Contact Map
2x5dA 3 0.9424 100 0.289 Contact Map
1b5pA 2 0.9474 100 0.295 Contact Map
4my5A 2 0.9549 100 0.296 Contact Map
1gd9A 2 0.9624 100 0.297 Contact Map
2o1bA 2 0.9398 100 0.298 Contact Map
1j32A 2 0.9674 100 0.298 Contact Map
3b46A 2 0.9724 100 0.303 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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