GREMLIN Database
BACD - Alanine-anticapsin ligase BacD
UniProt: P39641 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 472 (384)
Sequences: 18319 (10428)
Seq/√Len: 532.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
169_E194_T3.9401.00
165_R198_E3.3051.00
94_K98_M3.2901.00
193_D196_T3.2661.00
31_V53_V3.1521.00
160_T163_D3.0061.00
292_E296_K2.9241.00
154_K227_E2.8761.00
117_K133_E2.8551.00
88_V91_Q2.8501.00
293_A296_K2.8301.00
30_L102_D2.6951.00
117_K121_R2.6941.00
288_K292_E2.6711.00
254_D257_Y2.6671.00
315_M319_E2.6521.00
173_T194_T2.6351.00
295_K299_E2.6251.00
447_N450_D2.6081.00
445_G450_D2.5421.00
97_E122_L2.4741.00
352_D358_K2.3811.00
192_T196_T2.3571.00
156_K170_E2.3441.00
60_D76_W2.2351.00
113_A136_R2.2111.00
284_E288_K2.2081.00
147_K300_G2.1751.00
143_D147_K2.1571.00
145_F297_A2.1271.00
118_A122_L2.0791.00
192_T230_Q2.0751.00
167_A170_E2.0431.00
140_K143_D2.0051.00
278_T341_V2.0041.00
289_K319_E2.0031.00
283_D286_A1.9881.00
194_T198_E1.9811.00
293_A320_P1.9781.00
348_Q352_D1.9621.00
446_S450_D1.9581.00
230_Q316_K1.9021.00
252_M298_N1.8911.00
93_V122_L1.8631.00
349_L361_D1.8561.00
377_C455_I1.8331.00
89_V118_A1.8271.00
198_E202_N1.8031.00
190_L228_F1.7811.00
93_V97_E1.7531.00
104_I124_L1.7351.00
296_K299_E1.7311.00
205_N221_A1.7101.00
50_K348_Q1.7051.00
422_A425_T1.6951.00
165_R194_T1.6911.00
161_L202_N1.6811.00
398_V426_S1.6681.00
47_L50_K1.6591.00
133_E140_K1.6421.00
166_A170_E1.6411.00
167_A171_I1.6361.00
119_C124_L1.6351.00
161_L198_E1.6241.00
343_G370_E1.6221.00
286_A289_K1.6171.00
91_Q94_K1.5911.00
120_E129_V1.5851.00
128_G131_A1.5771.00
46_A49_E1.5751.00
90_E118_A1.5751.00
42_A70_H1.5731.00
144_A300_G1.5651.00
289_K292_E1.5541.00
161_L165_R1.5291.00
53_V73_S1.5201.00
75_Y95_V1.5161.00
60_D63_K1.5141.00
118_A121_R1.5031.00
416_V419_S1.4911.00
148_A300_G1.4881.00
134_N144_A1.4881.00
143_D146_N1.4761.00
199_D203_R1.4621.00
95_V99_F1.4551.00
139_N143_D1.4521.00
428_D433_E1.4421.00
166_A169_E1.4391.00
156_K167_A1.4311.00
286_A314_L1.4251.00
161_L201_F1.4231.00
180_T222_P1.4161.00
340_K444_K1.4081.00
94_K97_E1.3991.00
457_Q461_H1.3901.00
48_I54_A1.3881.00
376_D440_A1.3741.00
425_T428_D1.3671.00
165_R169_E1.3641.00
120_E128_G1.3611.00
227_E321_G1.3581.00
73_S99_F1.3571.00
130_Q134_N1.3571.00
231_G316_K1.3501.00
144_A148_A1.3501.00
229_L323_I1.3491.00
380_Y436_N1.3481.00
340_K442_E1.3441.00
89_V93_V1.3401.00
32_S52_S1.3321.00
449_Q453_E1.3261.00
159_T163_D1.3221.00
117_K130_Q1.3171.00
288_K291_V1.3071.00
134_N140_K1.2931.00
162_E166_A1.2891.00
96_A124_L1.2871.00
31_V55_V1.2801.00
139_N157_R1.2771.00
343_G368_D1.2741.00
146_N154_K1.2731.00
159_T222_P1.2671.00
173_T193_D1.2671.00
144_A147_K1.2671.00
75_Y99_F1.2581.00
104_I119_C1.2541.00
128_G304_Q1.2521.00
31_V73_S1.2521.00
329_F346_M1.2381.00
141_M145_F1.2351.00
168_L173_T1.2341.00
142_R226_E1.2331.00
135_A325_S1.2301.00
163_D166_A1.2281.00
168_L175_L1.2271.00
46_A50_K1.2181.00
285_E289_K1.2141.00
175_L225_A1.2001.00
158_V167_A1.2001.00
34_I45_A1.1981.00
287_K291_V1.1941.00
284_E287_K1.1901.00
298_N301_L1.1891.00
450_D454_S1.1841.00
58_D63_K1.1821.00
96_A104_I1.1801.00
202_N206_D1.1761.00
398_V425_T1.1731.00
32_S351_L1.1731.00
56_I67_D1.1731.00
371_P374_V1.1711.00
456_R460_Q1.1691.00
256_E304_Q1.1671.00
125_R356_F1.1661.00
32_S48_I1.1571.00
414_E417_S1.1551.00
115_M119_C1.1501.00
445_G454_S1.1481.00
162_E165_R1.1381.00
195_E199_D1.1261.00
291_V295_K1.1251.00
289_K293_A1.1231.00
157_R222_P1.1231.00
146_N152_S1.1201.00
33_F57_K1.1181.00
120_E304_Q1.1121.00
69_E422_A1.1121.00
74_I77_A1.1121.00
34_I44_H1.1101.00
47_L348_Q1.1101.00
93_V118_A1.1081.00
422_A426_S1.0881.00
441_F462_A1.0881.00
443_L455_I1.0861.00
189_T204_V1.0821.00
154_K171_I1.0811.00
452_A456_R1.0751.00
250_G310_T1.0731.00
457_Q460_Q1.0691.00
142_R152_S1.0681.00
454_S457_Q1.0661.00
344_L349_L1.0641.00
292_E295_K1.0561.00
177_L223_F1.0561.00
250_G290_I1.0521.00
72_D75_Y1.0511.00
90_E94_K1.0431.00
370_E444_K1.0381.00
199_D202_N1.0371.00
441_F458_I1.0371.00
164_F197_A1.0341.00
146_N156_K1.0321.00
453_E457_Q1.0301.00
169_E198_E1.0291.00
145_F322_L1.0271.00
316_K319_E1.0211.00
57_K77_A1.0211.00
379_L459_Q1.0211.00
283_D318_R1.0201.00
404_I462_A1.0191.00
45_A49_E1.0091.00
151_K293_A1.0081.00
401_A404_I1.0061.00
71_P74_I1.0011.00
400_E465_T1.0001.00
196_T199_D0.9991.00
143_D155_N0.9871.00
52_S356_F0.9851.00
45_A48_I0.9851.00
139_N180_T0.9841.00
117_K129_V0.9841.00
260_I362_L0.9801.00
110_L114_P0.9771.00
412_D415_I0.9761.00
282_L286_A0.9751.00
189_T203_R0.9731.00
137_D180_T0.9731.00
151_K319_E0.9701.00
201_F205_N0.9701.00
230_Q315_M0.9681.00
401_A465_T0.9671.00
49_E72_D0.9651.00
176_I190_L0.9551.00
164_F201_F0.9511.00
399_I421_A0.9481.00
105_T350_L0.9471.00
255_G299_E0.9451.00
285_E288_K0.9451.00
130_Q133_E0.9441.00
253_A307_A0.9431.00
415_I443_L0.9421.00
128_G302_G0.9411.00
422_A428_D0.9381.00
349_L352_D0.9361.00
372_Y446_S0.9341.00
55_V59_K0.9331.00
158_V164_F0.9301.00
171_I175_L0.9261.00
250_G294_A0.9221.00
351_L356_F0.9201.00
176_I228_F0.9191.00
89_V115_M0.9181.00
189_T200_E0.9181.00
443_L458_I0.9151.00
44_H47_L0.9151.00
254_D259_P0.9101.00
421_A425_T0.9101.00
253_A349_L0.9071.00
31_V102_D0.8981.00
253_A353_V0.8961.00
44_H48_I0.8941.00
263_H367_L0.8921.00
227_E319_E0.8911.00
45_A70_H0.8841.00
181_Y220_E0.8791.00
201_F223_F0.8791.00
95_V101_A0.8781.00
294_A310_T0.8781.00
116_A120_E0.8771.00
414_E418_F0.8721.00
92_I119_C0.8681.00
120_E130_Q0.8651.00
314_L320_P0.8641.00
44_H105_T0.8621.00
78_H87_E0.8591.00
161_L205_N0.8571.00
250_G291_V0.8571.00
421_A424_G0.8541.00
33_F96_A0.8511.00
374_V451_V0.8511.00
195_E198_E0.8471.00
297_A300_G0.8441.00
191_I200_E0.8411.00
403_D463_K0.8361.00
363_P366_L0.8361.00
251_I353_V0.8351.00
54_A58_D0.8331.00
310_T325_S0.8321.00
189_T207_Y0.8311.00
458_I461_H0.8291.00
96_A119_C0.8271.00
289_K320_P0.8211.00
252_M257_Y0.8201.00
51_Y348_Q0.8181.00
56_I71_P0.8171.00
58_D74_I0.8131.00
372_Y444_K0.8121.00
173_T197_A0.8121.00
137_D222_P0.8121.00
203_R207_Y0.8091.00
177_L201_F0.8081.00
59_K63_K0.8031.00
53_V72_D0.8011.00
261_A291_V0.7981.00
360_A363_P0.7971.00
72_D76_W0.7951.00
60_D64_S0.7941.00
297_A301_L0.7901.00
93_V121_R0.7891.00
168_L201_F0.7881.00
139_N222_P0.7871.00
56_I59_K0.7861.00
55_V58_D0.7851.00
168_L197_A0.7841.00
258_F299_E0.7831.00
420_A425_T0.7811.00
175_L191_I0.7791.00
378_H381_P0.7791.00
261_A278_T0.7751.00
401_A423_P0.7731.00
203_R206_D0.7731.00
168_L172_G0.7721.00
117_K120_E0.7721.00
266_T280_S0.7691.00
116_A119_C0.7691.00
415_I419_S0.7671.00
164_F225_A0.7661.00
109_E112_I0.7661.00
415_I418_F0.7641.00
50_K345_D0.7631.00
277_I448_S0.7631.00
296_K300_G0.7601.00
146_N155_N0.7571.00
256_E361_D0.7541.00
424_G427_V0.7521.00
400_E463_K0.7511.00
401_A463_K0.7491.00
165_R202_N0.7491.00
251_I349_L0.7491.00
177_L200_E0.7471.00
445_G451_V0.7431.00
397_L400_E0.7401.00
377_C380_Y0.7391.00
229_L321_G0.7371.00
294_A312_I0.7371.00
417_S439_A0.7361.00
58_D61_Y0.7361.00
275_S377_C0.7351.00
381_P397_L0.7341.00
251_I260_I0.7331.00
57_K92_I0.7331.00
45_A50_K0.7321.00
131_A304_Q0.7311.00
169_E173_T0.7301.00
412_D458_I0.7291.00
154_K170_E0.7291.00
290_I320_P0.7251.00
177_L191_I0.7241.00
89_V114_P0.7231.00
42_A67_D0.7221.00
298_N308_T0.7221.00
156_K163_D0.7211.00
135_A301_L0.7201.00
163_D167_A0.7191.00
74_I78_H0.7191.00
73_S76_W0.7161.00
263_H369_Q0.7161.00
259_P295_K0.7151.00
131_A302_G0.7131.00
426_S433_E0.7091.00
276_H337_N0.7081.00
336_P339_K0.7081.00
343_G366_L0.7071.00
150_V322_L0.7061.00
450_D453_E0.7061.00
75_Y78_H0.7051.00
376_D379_L0.7031.00
77_A95_V0.7031.00
54_A59_K0.7021.00
61_Y64_S0.7001.00
420_A424_G0.6971.00
49_E54_A0.6961.00
72_D77_A0.6951.00
273_E276_H0.6951.00
176_I188_V0.6951.00
379_L462_A0.6941.00
63_K66_A0.6931.00
48_I52_S0.6921.00
313_K323_I0.6921.00
339_K442_E0.6911.00
350_L354_L0.6911.00
257_Y298_N0.6901.00
449_Q452_A0.6881.00
253_A256_E0.6841.00
297_A325_S0.6821.00
218_T221_A0.6811.00
274_T380_Y0.6811.00
161_L197_A0.6751.00
125_R351_L0.6751.00
398_V401_A0.6721.00
168_L171_I0.6711.00
293_A312_I0.6711.00
443_L451_V0.6711.00
415_I420_A0.6701.00
349_L362_L0.6671.00
205_N223_F0.6651.00
119_C122_L0.6651.00
55_V60_D0.6651.00
423_P426_S0.6641.00
93_V124_L0.6641.00
143_D157_R0.6621.00
286_A318_R0.6621.00
115_M118_A0.6611.00
44_H50_K0.6611.00
336_P376_D0.6601.00
139_N224_I0.6591.00
420_A423_P0.6591.00
416_V420_A0.6581.00
421_A426_S0.6581.00
439_A442_E0.6571.00
35_P115_M0.6561.00
261_A369_Q0.6551.00
171_I227_E0.6551.00
168_L225_A0.6531.00
362_L367_L0.6511.00
439_A462_A0.6501.00
56_I60_D0.6491.00
264_D277_I0.6491.00
404_I461_H0.6481.00
417_S421_A0.6471.00
364_D367_L0.6451.00
402_I462_A0.6441.00
423_P428_D0.6421.00
191_I197_A0.6411.00
262_I280_S0.6391.00
142_R153_I0.6381.00
94_K122_L0.6371.00
103_A354_L0.6361.00
250_G308_T0.6351.00
177_L197_A0.6341.00
261_A341_V0.6321.00
31_V99_F0.6311.00
73_S77_A0.6301.00
153_I229_L0.6301.00
167_A225_A0.6301.00
110_L113_A0.6301.00
264_D280_S0.6301.00
417_S420_A0.6291.00
414_E454_S0.6261.00
31_V100_G0.6261.00
418_F422_A0.6221.00
410_K413_T0.6211.00
137_D140_K0.6211.00
403_D423_P0.6201.00
161_L164_F0.6171.00
186_I207_Y0.6161.00
71_P76_W0.6151.00
303_L308_T0.6141.00
342_F369_Q0.6131.00
414_E419_S0.6131.00
52_S55_V0.6121.00
206_D216_A0.6121.00
304_Q353_V0.6121.00
278_T337_N0.6081.00
249_E307_A0.6031.00
216_A219_F0.6031.00
362_L365_G0.6011.00
129_V133_E0.6001.00
324_E328_R0.5971.00
33_F101_A0.5951.00
341_V369_Q0.5951.00
175_L227_E0.5941.00
97_E124_L0.5931.00
260_I367_L0.5921.00
424_G428_D0.5910.99
282_L287_K0.5910.99
66_A422_A0.5900.99
269_I274_T0.5900.99
200_E204_V0.5890.99
397_L451_V0.5890.99
125_R304_Q0.5880.99
204_V223_F0.5870.99
248_I280_S0.5850.99
260_I263_H0.5850.99
264_D287_K0.5830.99
262_I265_K0.5820.99
289_K296_K0.5820.99
45_A54_A0.5790.99
253_A361_D0.5760.99
261_A295_K0.5760.99
68_F74_I0.5750.99
51_Y351_L0.5740.99
172_G194_T0.5720.99
140_K144_A0.5720.99
315_M321_G0.5700.99
216_A220_E0.5690.99
30_L53_V0.5680.99
397_L401_A0.5680.99
48_I351_L0.5670.99
153_I323_I0.5640.99
412_D418_F0.5630.99
451_V455_I0.5630.99
315_M318_R0.5620.99
132_A327_A0.5620.99
42_A66_A0.5620.99
303_L327_A0.5600.99
92_I104_I0.5570.99
229_L315_M0.5560.99
337_N340_K0.5550.99
180_T224_I0.5540.99
262_I287_K0.5540.99
173_T192_T0.5520.99
369_Q372_Y0.5510.99
296_K301_L0.5500.99
197_A201_F0.5500.99
411_G415_I0.5480.99
142_R146_N0.5450.99
263_H341_V0.5440.99
377_C459_Q0.5420.99
413_T418_F0.5420.99
362_L366_L0.5410.99
42_A45_A0.5390.99
52_S102_D0.5380.99
125_R256_E0.5380.99
399_I402_I0.5370.99
419_S422_A0.5360.99
283_D314_L0.5360.99
108_N111_F0.5360.99
351_L354_L0.5350.99
87_E114_P0.5340.99
420_A428_D0.5340.99
54_A57_K0.5320.99
141_M322_L0.5310.99
107_N111_F0.5300.99
421_A427_V0.5280.99
422_A427_V0.5280.99
188_V271_F0.5270.99
249_E263_H0.5260.99
134_N147_K0.5250.99
358_K362_L0.5240.99
253_A360_A0.5240.99
443_L454_S0.5230.99
45_A71_P0.5230.99
97_E121_R0.5230.99
196_T200_E0.5230.99
376_D380_Y0.5220.99
134_N327_A0.5220.99
192_T228_F0.5220.99
455_I459_Q0.5210.99
370_E446_S0.5190.99
373_Y448_S0.5180.99
376_D442_E0.5180.99
120_E125_R0.5150.99
191_I196_T0.5150.99
251_I307_A0.5140.99
177_L225_A0.5140.99
109_E184_S0.5130.99
460_Q463_K0.5130.99
34_I47_L0.5130.99
66_A70_H0.5120.99
290_I293_A0.5120.99
318_R321_G0.5120.99
102_D125_R0.5110.99
336_P440_A0.5110.99
96_A101_A0.5100.99
144_A301_L0.5100.99
335_I339_K0.5100.99
116_A129_V0.5080.98
149_G296_K0.5080.98
77_A86_E0.5070.98
162_E198_E0.5060.98
420_A427_V0.5060.98
277_I280_S0.5050.98
248_I294_A0.5050.98
404_I417_S0.5040.98
413_T416_V0.5040.98
264_D281_I0.5040.98
174_P228_F0.5040.98
165_R197_A0.5030.98
453_E456_R0.5030.98
71_P75_Y0.5020.98
95_V98_M0.5010.98
91_Q95_V0.5000.98
459_Q462_A0.5000.98
437_S442_E0.5000.98
287_K290_I0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dimA 1 0.8199 100 0.42 Contact Map
3votA 1 0.8623 100 0.428 Contact Map
3wnzA 2 0.8962 100 0.44 Contact Map
3n6rA 1 0.7267 100 0.452 Contact Map
3u9tA 3 0.8475 100 0.452 Contact Map
3va7A 1 0.7203 100 0.454 Contact Map
4rcnA 6 0.7881 100 0.463 Contact Map
1w96A 1 0.9174 100 0.463 Contact Map
2qf7A 4 0.7754 100 0.465 Contact Map
4qshA 4 0.75 100 0.468 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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