GREMLIN Database
BACA - Bacilysin biosynthesis protein BacA
UniProt: P39638 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 204 (167)
Sequences: 129 (107)
Seq/√Len: 8.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_F78_P3.2030.91
76_I194_L3.0450.89
129_H190_M2.8540.86
127_V164_Y2.7930.84
32_S152_T2.6050.80
32_S195_F2.4540.75
99_F151_S2.2720.69
79_H191_S2.2100.67
80_A151_S2.1350.64
24_N67_T2.1130.63
152_T195_F2.0590.61
132_P190_M2.0280.60
60_F170_N2.0230.60
80_A88_Y2.0210.60
132_P170_N1.9870.58
104_P195_F1.9550.57
32_S106_Y1.9390.57
192_W195_F1.8900.55
28_P31_T1.8600.53
33_S77_V1.7890.50
80_A99_F1.7560.49
106_Y152_T1.6990.47
24_N57_H1.6830.46
31_T103_T1.6720.45
103_T156_A1.6580.45
23_V83_G1.6500.45
78_P89_M1.6430.44
132_P173_A1.6320.44
159_V195_F1.5800.42
156_A173_A1.5540.41
89_M188_I1.5380.40
28_P56_L1.5360.40
87_F104_P1.5340.40
89_M106_Y1.5120.39
33_S192_W1.4990.38
103_T106_Y1.4620.37
60_F192_W1.4490.36
103_T165_D1.4470.36
24_N72_L1.4440.36
136_I170_N1.4320.36
56_L165_D1.4160.35
146_F182_V1.4120.35
130_P190_M1.3910.34
151_S169_T1.3850.34
89_M190_M1.3820.34
78_P192_W1.3780.34
77_V192_W1.3640.33
59_T131_S1.3410.32
29_E45_T1.3360.32
54_L66_R1.3110.31
88_Y152_T1.3040.31
62_S112_P1.2980.31
132_P188_I1.2970.31
58_D66_R1.2230.28
34_E88_Y1.2180.28
71_P163_L1.1980.27
55_S111_R1.1970.27
39_H43_N1.1890.27
80_A89_M1.1820.27
63_C78_P1.1800.27
78_P159_V1.1670.26
22_T73_E1.1630.26
32_S192_W1.1610.26
31_T56_L1.1580.26
159_V192_W1.1560.26
40_F192_W1.1550.26
34_E56_L1.1530.26
78_P170_N1.1450.26
107_G152_T1.1410.26
89_M152_T1.1370.25
32_S188_I1.1340.25
32_S132_P1.1220.25
80_A104_P1.1120.25
132_P153_S1.1070.24
106_Y195_F1.1000.24
131_S190_M1.0990.24
77_V159_V1.0840.24
23_V38_K1.0780.24
107_G167_A1.0720.23
35_Y101_C1.0670.23
173_A179_L1.0610.23
23_V53_K1.0570.23
39_H101_C1.0500.23
129_H132_P1.0450.23
167_A181_F1.0400.22
23_V116_F1.0370.22
60_F80_A1.0230.22
32_S159_V1.0200.22
153_S156_A1.0130.22
33_S195_F1.0120.22
103_T109_A1.0030.21
22_T53_K1.0000.21
33_S194_L0.9990.21
24_N73_E0.9980.21
32_S88_Y0.9970.21
132_P195_F0.9960.21
93_L154_Q0.9960.21
33_S191_S0.9930.21
23_V29_E0.9730.21
23_V95_L0.9590.20
79_H106_Y0.9540.20
89_M104_P0.9540.20
60_F77_V0.9440.20
61_E194_L0.9390.20
81_Y156_A0.9380.20
170_N195_F0.9350.20
128_S164_Y0.9260.19
126_I133_I0.9240.19
152_T188_I0.9200.19
61_E75_T0.9050.19
32_S104_P0.8990.19
32_S107_G0.8950.19
98_I191_S0.8930.19
33_S60_F0.8930.19
57_H135_L0.8930.19
107_G169_T0.8920.18
145_R175_Q0.8900.18
88_Y188_I0.8890.18
69_Q116_F0.8880.18
35_Y105_M0.8680.18
132_P156_A0.8660.18
77_V80_A0.8610.18
42_S50_L0.8570.18
156_A179_L0.8560.18
79_H107_G0.8560.18
81_Y173_A0.8530.18
78_P88_Y0.8520.17
106_Y167_A0.8490.17
30_G34_E0.8490.17
34_E165_D0.8460.17
54_L136_I0.8460.17
88_Y153_S0.8450.17
79_H168_L0.8420.17
32_S84_I0.8390.17
82_D108_L0.8350.17
76_I125_V0.8350.17
146_F175_Q0.8200.17
99_F170_N0.8170.17
33_S80_A0.8150.17
56_L156_A0.8100.17
28_P103_T0.8050.16
102_D187_S0.8000.16
81_Y195_F0.7970.16
94_Q108_L0.7880.16
159_V170_N0.7820.16
139_F183_K0.7790.16
107_G181_F0.7720.16
106_Y168_L0.7680.16
40_F189_P0.7660.16
80_A192_W0.7650.15
81_Y152_T0.7640.15
26_L54_L0.7630.15
135_L151_S0.7590.15
59_T150_N0.7530.15
156_A165_D0.7510.15
28_P37_A0.7480.15
65_E147_K0.7480.15
52_S80_A0.7440.15
45_T178_G0.7360.15
89_M129_H0.7310.15
132_P152_T0.7250.15
156_A167_A0.7250.15
42_S53_K0.7230.15
169_T172_L0.7180.14
78_P186_K0.7070.14
152_T192_W0.7060.14
111_R144_V0.7060.14
25_T28_P0.7000.14
68_L90_R0.6980.14
72_L75_T0.6930.14
59_T197_K0.6900.14
96_L115_E0.6860.14
24_N82_D0.6840.14
78_P132_P0.6790.14
59_T62_S0.6630.13
106_Y156_A0.6620.13
80_A152_T0.6620.13
123_T163_L0.6580.13
88_Y195_F0.6550.13
188_I195_F0.6540.13
76_I168_L0.6540.13
88_Y106_Y0.6510.13
114_F158_K0.6470.13
76_I149_V0.6440.13
145_R163_L0.6390.13
81_Y153_S0.6380.13
35_Y189_P0.6380.13
87_F136_I0.6340.13
99_F149_V0.6330.13
32_S89_M0.6320.13
79_H127_V0.6310.13
104_P152_T0.6280.13
41_I52_S0.6260.13
69_Q143_D0.6250.13
80_A195_F0.6240.13
30_G56_L0.6170.13
103_T155_A0.6160.13
23_V69_Q0.6150.12
147_K154_Q0.6130.12
60_F195_F0.6120.12
27_G31_T0.6120.12
106_Y192_W0.6110.12
77_V195_F0.6100.12
63_C67_T0.6080.12
54_L105_M0.6070.12
23_V175_Q0.6060.12
103_T162_G0.6020.12
71_P136_I0.5950.12
104_P192_W0.5940.12
135_L190_M0.5910.12
27_G192_W0.5900.12
79_H88_Y0.5900.12
67_T73_E0.5830.12
55_S110_V0.5820.12
104_P126_I0.5790.12
34_E156_A0.5750.12
69_Q157_R0.5700.12
28_P36_A0.5690.12
167_A195_F0.5670.12
174_R179_L0.5650.12
103_T130_P0.5650.12
129_H153_S0.5640.12
28_P156_A0.5610.12
135_L169_T0.5590.12
55_S92_D0.5570.11
102_D143_D0.5530.11
67_T197_K0.5520.11
23_V182_V0.5510.11
29_E53_K0.5480.11
89_M195_F0.5420.11
53_K142_K0.5410.11
63_C174_R0.5400.11
145_R178_G0.5360.11
63_C75_T0.5360.11
22_T147_K0.5330.11
24_N75_T0.5260.11
67_T142_K0.5240.11
51_N58_D0.5230.11
53_K145_R0.5230.11
57_H134_N0.5210.11
30_G127_V0.5190.11
79_H98_I0.5170.11
107_G151_S0.5170.11
84_I107_G0.5160.11
89_M132_P0.5160.11
170_N174_R0.5140.11
93_L108_L0.5120.11
168_L176_K0.5030.11
157_R182_V0.5010.11
88_Y167_A0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mwbA 3 0.848 99.8 0.711 Contact Map
2qmxA 3 0.8235 99.8 0.717 Contact Map
4lubA 2 0.4608 99.8 0.721 Contact Map
3luyA 2 0.8775 99.7 0.724 Contact Map
2qmwA 2 0.8382 99.7 0.731 Contact Map
2pfzA 1 0.8775 94 0.913 Contact Map
4pddA 1 0.8824 93.9 0.913 Contact Map
4magA 1 0.8824 93.8 0.914 Contact Map
3n5lA 2 0.8824 93.2 0.916 Contact Map
4gotA 1 0.8725 92.8 0.917 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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