GREMLIN Database
ROCC - Amino-acid permease RocC
UniProt: P39636 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 470 (424)
Sequences: 24717 (16067)
Seq/√Len: 780.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
137_F343_L4.4681.00
325_F337_N4.4021.00
385_F389_R3.4741.00
54_G248_L3.2541.00
377_M415_F3.2121.00
328_R337_N3.1291.00
234_K238_K3.0231.00
13_K230_E2.9101.00
231_S234_K2.7871.00
78_Q319_N2.7331.00
229_S235_T2.7061.00
18_F242_N2.6301.00
94_G316_L2.6241.00
169_G257_V2.5971.00
317_S327_T2.5951.00
330_T336_M2.5471.00
130_L347_G2.5461.00
325_F328_R2.5241.00
285_F289_I2.4191.00
14_S242_N2.3961.00
167_V171_A2.3361.00
227_G318_S2.3221.00
82_T90_G2.2411.00
66_E387_R2.1931.00
228_E311_R2.1781.00
138_L142_L2.1761.00
340_L344_G2.1711.00
314_W318_S2.1581.00
436_Y440_P2.1311.00
134_I347_G2.1271.00
380_C414_G2.1221.00
14_S235_T2.0931.00
17_L229_S2.0881.00
137_F339_L2.0811.00
145_R149_E2.0621.00
412_I416_C2.0491.00
276_A279_D2.0421.00
14_S18_F2.0261.00
238_K242_N2.0261.00
141_A336_M2.0061.00
129_C350_L2.0051.00
18_F246_R2.0051.00
187_F190_N2.0041.00
82_T87_Q1.9901.00
266_T280_Q1.9701.00
156_S160_A1.9661.00
85_L385_F1.9571.00
130_L350_L1.9531.00
37_T46_A1.9411.00
13_K16_H1.9271.00
326_L341_I1.9251.00
440_P443_I1.9241.00
63_C380_C1.9231.00
446_Y450_H1.9151.00
55_F59_L1.9121.00
447_A451_L1.8741.00
98_W342_T1.8701.00
8_L329_L1.8641.00
263_P266_T1.8571.00
320_Q324_S1.8571.00
85_L381_A1.8471.00
276_A280_Q1.8321.00
241_R245_W1.7741.00
231_S235_T1.7481.00
134_I343_L1.7371.00
81_A93_I1.7201.00
86_G89_T1.7051.00
330_T334_V1.6841.00
409_L413_L1.6771.00
16_H152_F1.6771.00
140_N303_N1.6721.00
141_A340_L1.6611.00
160_A164_L1.6511.00
444_F448_Y1.6451.00
93_I378_S1.6441.00
385_F388_R1.6121.00
332_K336_M1.6091.00
21_A243_V1.6031.00
105_V346_S1.5801.00
440_P444_F1.5781.00
49_A208_T1.5651.00
12_M16_H1.5631.00
279_D287_A1.5591.00
245_W249_F1.5531.00
188_L191_F1.5431.00
109_L302_A1.5371.00
85_L89_T1.5331.00
445_C448_Y1.5291.00
442_I446_Y1.5141.00
133_G346_S1.5131.00
9_Q333_G1.5041.00
56_L417_L1.4991.00
381_A415_F1.4981.00
416_C420_C1.4951.00
225_A307_Y1.4801.00
142_L332_K1.4751.00
381_A385_F1.4741.00
116_M128_W1.4661.00
53_G212_V1.4651.00
59_L413_L1.4581.00
443_I447_A1.4571.00
313_M338_A1.4521.00
170_G257_V1.4471.00
309_A342_T1.4431.00
130_L134_I1.4371.00
337_N341_I1.4351.00
231_S238_K1.4341.00
314_W329_L1.4311.00
432_R435_L1.4131.00
133_G343_L1.4121.00
61_M244_I1.4081.00
324_S327_T1.4061.00
161_A293_V1.4041.00
431_Q434_G1.3881.00
310_S339_L1.3871.00
81_A378_S1.3791.00
438_G442_I1.3711.00
74_A227_G1.3631.00
137_F340_L1.3601.00
8_L314_W1.3571.00
187_F191_F1.3561.00
88_S449_Y1.3541.00
324_S328_R1.3511.00
16_H148_A1.3501.00
434_G438_G1.3391.00
407_Y411_P1.3381.00
328_R336_M1.3321.00
249_F253_L1.3311.00
12_M17_L1.3301.00
109_L133_G1.3291.00
270_I276_A1.3241.00
55_F413_L1.3211.00
71_M83_K1.3141.00
173_V260_A1.3111.00
288_D292_F1.3091.00
159_V163_I1.3071.00
112_A295_L1.3001.00
235_T238_K1.2961.00
112_A132_F1.2901.00
84_F382_S1.2851.00
61_M240_I1.2841.00
63_C411_P1.2821.00
14_S238_K1.2671.00
60_V380_C1.2641.00
232_P237_P1.2631.00
414_G418_Y1.2571.00
15_R19_M1.2521.00
47_I256_F1.2501.00
136_I302_A1.2401.00
166_I253_L1.2391.00
441_I445_C1.2381.00
279_D284_P1.2281.00
126_W130_L1.2251.00
272_S276_A1.2231.00
62_L241_R1.2211.00
426_I429_P1.2181.00
408_P412_I1.2151.00
73_V79_A1.2151.00
25_V247_T1.2081.00
430_D434_G1.2081.00
108_E301_V1.2011.00
430_D433_I1.2011.00
391_L400_L1.1951.00
124_P127_I1.1831.00
79_A83_K1.1801.00
44_L205_V1.1781.00
186_P189_S1.1761.00
420_C424_S1.1701.00
431_Q435_L1.1661.00
433_I440_P1.1651.00
32_L111_S1.1641.00
313_M322_G1.1631.00
433_I436_Y1.1621.00
86_G90_G1.1621.00
165_F169_G1.1601.00
12_M148_A1.1541.00
430_D444_F1.1541.00
21_A222_V1.1361.00
122_S125_I1.1281.00
201_G204_A1.1241.00
169_G261_I1.1191.00
398_N401_E1.1181.00
230_E235_T1.1151.00
406_L410_V1.1141.00
170_G174_F1.1121.00
151_E303_N1.1071.00
446_Y449_Y1.1061.00
64_L77_F1.1051.00
164_L168_I1.1041.00
17_L239_S1.1041.00
397_V400_L1.1021.00
20_I225_A1.1021.00
139_I150_M1.1001.00
406_L409_L1.0981.00
186_P190_N1.0941.00
150_M154_F1.0921.00
127_I131_V1.0901.00
383_Q411_P1.0901.00
70_A400_L1.0901.00
318_S327_T1.0881.00
98_W313_M1.0841.00
83_K390_F1.0841.00
73_V83_K1.0801.00
187_F192_M1.0681.00
388_R391_L1.0661.00
11_S230_E1.0641.00
38_I46_A1.0611.00
149_E153_W1.0591.00
81_A89_T1.0571.00
419_G423_I1.0541.00
415_F419_G1.0511.00
22_L246_R1.0451.00
91_F95_W1.0451.00
422_L425_L1.0421.00
163_I167_V1.0411.00
68_A80_Y1.0381.00
409_L412_I1.0361.00
337_N340_L1.0351.00
131_V135_V1.0321.00
445_C449_Y1.0311.00
329_L333_G1.0201.00
22_L247_T1.0201.00
435_L438_G1.0191.00
113_G128_W1.0131.00
51_I252_V1.0111.00
391_L397_V1.0101.00
144_V307_Y1.0091.00
78_Q315_S1.0081.00
185_T188_L1.0061.00
70_A398_N1.0051.00
137_F141_A1.0021.00
439_V443_I1.0011.00
384_F412_I1.0011.00
41_A44_L1.0001.00
442_I445_C0.9991.00
263_P280_Q0.9941.00
444_F450_H0.9941.00
154_F300_S0.9921.00
66_E69_V0.9871.00
116_M120_L0.9851.00
141_A334_V0.9821.00
123_V127_I0.9801.00
380_C415_F0.9741.00
390_F397_V0.9731.00
432_R436_Y0.9721.00
171_A175_G0.9711.00
134_I138_L0.9661.00
377_M419_G0.9661.00
387_R391_L0.9651.00
436_Y443_I0.9581.00
444_F451_L0.9551.00
344_G348_C0.9521.00
206_M420_C0.9501.00
388_R408_P0.9501.00
282_G286_S0.9471.00
284_P288_D0.9421.00
159_V250_F0.9411.00
135_V299_L0.9211.00
248_L252_V0.9201.00
217_Q372_T0.9151.00
59_L410_V0.9121.00
190_N194_D0.9121.00
273_P278_L0.9061.00
19_M152_F0.9021.00
400_L403_R0.8981.00
136_I303_N0.8981.00
377_M381_A0.8971.00
226_A236_L0.8951.00
26_I29_G0.8891.00
11_S145_R0.8821.00
184_E188_L0.8811.00
283_I286_S0.8811.00
418_Y421_V0.8781.00
411_P414_G0.8771.00
166_I170_G0.8751.00
69_V401_E0.8751.00
436_Y447_A0.8731.00
166_I257_V0.8711.00
242_N246_R0.8671.00
113_G129_C0.8591.00
141_A330_T0.8581.00
202_V205_V0.8581.00
95_W322_G0.8571.00
47_I259_V0.8571.00
220_E224_I0.8571.00
377_M418_Y0.8531.00
85_L88_S0.8521.00
432_R446_Y0.8521.00
261_I277_V0.8521.00
420_C423_I0.8491.00
256_F260_A0.8481.00
82_T319_N0.8481.00
411_P415_F0.8471.00
326_L337_N0.8441.00
447_A450_H0.8431.00
306_L343_L0.8401.00
437_C440_P0.8381.00
184_E187_F0.8381.00
158_K297_A0.8371.00
128_W131_V0.8371.00
16_H149_E0.8341.00
330_T333_G0.8331.00
398_N403_R0.8331.00
75_G79_A0.8321.00
336_M340_L0.8311.00
70_A401_E0.8301.00
423_I427_F0.8301.00
86_G450_H0.8291.00
8_L311_R0.8261.00
270_I273_P0.8261.00
440_P447_A0.8241.00
97_Y101_W0.8191.00
58_Y62_L0.8191.00
107_L214_F0.8191.00
15_R152_F0.8181.00
75_G78_Q0.8151.00
8_L228_E0.8121.00
430_D436_Y0.8101.00
149_E152_F0.8101.00
54_G216_F0.8081.00
107_L365_I0.8061.00
138_L141_A0.8001.00
14_S239_S0.7941.00
126_W350_L0.7921.00
431_Q436_Y0.7921.00
322_G326_L0.7901.00
185_T191_F0.7871.00
112_A298_I0.7871.00
343_L347_G0.7871.00
117_Q121_P0.7861.00
116_M295_L0.7851.00
221_L308_A0.7841.00
89_T378_S0.7841.00
165_F278_L0.7831.00
207_F211_M0.7811.00
441_I449_Y0.7811.00
58_Y241_R0.7801.00
430_D443_I0.7791.00
110_T364_C0.7781.00
195_R199_P0.7771.00
384_F411_P0.7751.00
273_P277_V0.7731.00
171_A174_F0.7601.00
136_I306_L0.7521.00
59_L63_C0.7481.00
67_L383_Q0.7481.00
443_I446_Y0.7481.00
51_I55_F0.7471.00
344_G347_G0.7391.00
367_I371_V0.7391.00
186_P191_F0.7381.00
81_A382_S0.7381.00
25_V243_V0.7381.00
142_L146_S0.7371.00
384_F388_R0.7361.00
112_A299_L0.7351.00
421_V425_L0.7351.00
435_L439_V0.7311.00
11_S144_V0.7291.00
432_R438_G0.7291.00
440_P445_C0.7291.00
285_F288_D0.7271.00
109_L113_G0.7261.00
130_L351_L0.7251.00
43_P259_V0.7251.00
185_T189_S0.7211.00
390_F398_N0.7211.00
102_A345_I0.7211.00
48_A205_V0.7191.00
133_G350_L0.7161.00
173_V257_V0.7151.00
382_S386_F0.7141.00
67_L80_Y0.7131.00
170_G253_L0.7131.00
434_G440_P0.7111.00
15_R149_E0.7101.00
202_V206_M0.7101.00
425_L429_P0.7081.00
30_L254_A0.7081.00
433_I438_G0.7081.00
331_K336_M0.7061.00
18_F239_S0.7041.00
407_Y410_V0.7011.00
410_V414_G0.7001.00
217_Q376_W0.6991.00
434_G439_V0.6991.00
95_W440_P0.6991.00
126_W129_C0.6991.00
272_S275_V0.6971.00
88_S92_M0.6941.00
166_I254_A0.6941.00
448_Y451_L0.6941.00
444_F449_Y0.6911.00
141_A339_L0.6891.00
57_M219_T0.6891.00
48_A52_I0.6891.00
431_Q444_F0.6881.00
311_R314_W0.6841.00
190_N193_T0.6841.00
148_A152_F0.6841.00
384_F408_P0.6831.00
237_P240_I0.6821.00
187_F193_T0.6821.00
435_L445_C0.6801.00
231_S237_P0.6801.00
84_F385_F0.6781.00
399_D403_R0.6771.00
435_L440_P0.6771.00
310_S338_A0.6731.00
436_Y441_I0.6721.00
326_L338_A0.6711.00
189_S192_M0.6711.00
60_V418_Y0.6691.00
436_Y439_V0.6681.00
335_P338_A0.6671.00
15_R18_F0.6661.00
141_A332_K0.6641.00
278_L281_I0.6641.00
24_G305_G0.6631.00
26_I158_K0.6621.00
430_D447_A0.6611.00
433_I443_I0.6591.00
27_G31_F0.6591.00
106_G364_C0.6581.00
404_T407_Y0.6551.00
432_R450_H0.6551.00
48_A51_I0.6551.00
118_R291_N0.6541.00
233_E401_E0.6531.00
433_I444_F0.6531.00
146_S149_E0.6511.00
390_F400_L0.6511.00
85_L90_G0.6501.00
24_G304_S0.6501.00
23_G155_S0.6481.00
104_T368_S0.6471.00
173_V176_L0.6451.00
424_S428_I0.6431.00
168_I172_A0.6431.00
313_M341_I0.6431.00
423_I426_I0.6421.00
267_A270_I0.6411.00
61_M219_T0.6411.00
325_F341_I0.6401.00
246_R249_F0.6391.00
436_Y448_Y0.6381.00
246_R250_F0.6381.00
96_L375_A0.6381.00
47_I51_I0.6361.00
64_L379_I0.6351.00
62_L410_V0.6351.00
430_D445_C0.6341.00
18_F21_A0.6341.00
140_N339_L0.6341.00
101_W305_G0.6341.00
11_S15_R0.6321.00
78_Q82_T0.6321.00
34_S255_M0.6301.00
411_P425_L0.6301.00
223_G240_I0.6301.00
70_A391_L0.6291.00
417_L421_V0.6281.00
113_G116_M0.6281.00
103_N367_I0.6261.00
383_Q387_R0.6231.00
104_T107_L0.6211.00
306_L310_S0.6211.00
273_P281_I0.6211.00
405_P409_L0.6201.00
132_F302_A0.6181.00
74_A314_W0.6171.00
102_A342_T0.6161.00
116_M132_F0.6161.00
253_L257_V0.6161.00
191_F194_D0.6151.00
59_L414_G0.6151.00
84_F386_F0.6151.00
100_S372_T0.6141.00
439_V442_I0.6141.00
46_A255_M0.6121.00
436_Y444_F0.6111.00
421_V424_S0.6101.00
185_T190_N0.6091.00
134_I137_F0.6091.00
65_G69_V0.6061.00
78_Q94_G0.6051.00
414_G417_L0.6031.00
431_Q438_G0.6021.00
108_E111_S0.6021.00
26_I31_F0.6001.00
36_F362_L0.5981.00
190_N197_L0.5981.00
67_L84_F0.5981.00
317_S326_L0.5981.00
432_R441_I0.5971.00
206_M424_S0.5971.00
157_I293_V0.5961.00
436_Y442_I0.5961.00
144_V225_A0.5951.00
309_A313_M0.5941.00
68_A223_G0.5921.00
85_L382_S0.5921.00
227_G314_W0.5911.00
136_I299_L0.5891.00
254_A274_F0.5891.00
40_Q43_P0.5871.00
236_L240_I0.5871.00
140_N307_Y0.5871.00
438_G441_I0.5851.00
157_I161_A0.5851.00
232_P235_T0.5831.00
224_I308_A0.5831.00
217_Q220_E0.5821.00
437_C441_I0.5781.00
77_F220_E0.5781.00
63_C414_G0.5781.00
434_G443_I0.5771.00
434_G437_C0.5771.00
115_L294_I0.5761.00
267_A273_P0.5761.00
190_N195_R0.5741.00
33_G365_I0.5731.00
440_P449_Y0.5731.00
434_G447_A0.5721.00
133_G347_G0.5711.00
432_R439_V0.5711.00
47_I252_V0.5711.00
155_S158_K0.5711.00
68_A236_L0.5701.00
50_Y215_S0.5691.00
119_W292_F0.5681.00
441_I448_Y0.5671.00
432_R449_Y0.5661.00
152_F156_S0.5661.00
421_V426_I0.5651.00
411_P418_Y0.5651.00
204_A207_F0.5621.00
254_A258_L0.5611.00
143_S146_S0.5581.00
411_P417_L0.5561.00
443_I449_Y0.5551.00
8_L11_S0.5541.00
148_A303_N0.5531.00
430_D449_Y0.5521.00
431_Q440_P0.5511.00
119_W291_N0.5501.00
292_F296_T0.5501.00
78_Q90_G0.5481.00
228_E335_P0.5481.00
386_F390_F0.5471.00
106_G349_S0.5461.00
433_I446_Y0.5441.00
108_E302_A0.5431.00
53_G213_N0.5421.00
269_V273_P0.5411.00
402_F405_P0.5411.00
436_Y446_Y0.5401.00
36_F40_Q0.5401.00
229_S236_L0.5381.00
30_L33_G0.5361.00
27_G251_F0.5361.00
21_A25_V0.5341.00
400_L404_T0.5341.00
289_I293_V0.5341.00
391_L398_N0.5321.00
242_N245_W0.5321.00
106_G109_L0.5321.00
115_L275_V0.5311.00
169_G173_V0.5301.00
347_G350_L0.5301.00
118_R121_P0.5301.00
37_T212_V0.5301.00
194_D197_L0.5281.00
40_Q207_F0.5281.00
313_M317_S0.5281.00
233_E399_D0.5281.00
348_C351_L0.5251.00
351_L354_V0.5251.00
406_L411_P0.5251.00
373_V418_Y0.5251.00
171_A176_L0.5251.00
329_L332_K0.5241.00
61_M65_G0.5231.00
297_A300_S0.5231.00
193_T197_L0.5231.00
153_W156_S0.5231.00
49_A52_I0.5221.00
188_L260_A0.5211.00
311_R329_L0.5211.00
108_E298_I0.5201.00
336_M339_L0.5201.00
47_I50_Y0.5191.00
98_W102_A0.5191.00
441_I444_F0.5181.00
437_C445_C0.5181.00
271_E275_V0.5181.00
168_I283_I0.5171.00
147_F307_Y0.5171.00
104_T108_E0.5171.00
77_F224_I0.5161.00
258_L274_F0.5161.00
274_F278_L0.5161.00
44_L197_L0.5151.00
431_Q441_I0.5151.00
432_R443_I0.5151.00
372_T375_A0.5151.00
371_V375_A0.5141.00
131_V134_I0.5141.00
441_I447_A0.5141.00
416_C419_G0.5131.00
193_T196_G0.5131.00
10_R230_E0.5111.00
52_I209_L0.5101.00
186_P192_M0.5101.00
112_A116_M0.5101.00
26_I250_F0.5091.00
415_F418_Y0.5091.00
53_G216_F0.5081.00
269_V272_S0.5081.00
134_I340_L0.5071.00
325_F329_L0.5051.00
43_P47_I0.5051.00
146_S150_M0.5051.00
275_V279_D0.5041.00
189_S193_T0.5041.00
386_F391_L0.5031.00
22_L155_S0.5031.00
151_E300_S0.5031.00
76_S223_G0.5031.00
111_S115_L0.5031.00
132_F299_L0.5031.00
362_L365_I0.5031.00
192_M195_R0.5021.00
217_Q368_S0.5011.00
418_Y422_L0.5011.00
96_L100_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.8872 100 0.307 Contact Map
4djkA 2 0.8766 100 0.36 Contact Map
3giaA 1 0.9021 100 0.371 Contact Map
3dh4A 3 0.917 99.1 0.848 Contact Map
2xq2A 2 0.9191 99.1 0.852 Contact Map
2jlnA 1 0.9 98.9 0.86 Contact Map
2a65A 2 0.9106 98.3 0.888 Contact Map
4xp4A 1 0.9362 98.1 0.892 Contact Map
4wgvA 2 0.7872 97.4 0.907 Contact Map
4us3A 1 0.8404 97.2 0.911 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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