ROCA - BACSU - GREMLIN Contacts

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ROCA - 1-pyrroline-5-carboxylate dehydrogenase

UniProt:	P39634	Sequences: MTVTYAHEPFTDFTEAKNKTAFGESLAFVNTQLGKHYPLVINGEKIETDRKIISINPANKEEIIGYASTADQELAEKAMQAALQAFDSWKKQRPEHRANILFKAAAILRRRKHEFSSYLVKEAGKPWKEADADTAEAIDFLEFYARQMLKLKEGAPVKSRAGEVNQYHYEALGVGIVISPFNFPLAIMAGTAVAAIVTGNTILLKPADAAPVVAAKFVEVMEEAGLPNGVLNYIPGDGAEIGDFLVEHPKTRFVSFTGSRAVGCRIYERAAKVQPGQKWLKRVIAEMGGKDTVLVDKDADLDLAASSIVYSAFGYSGQKCSAGSRAVIHQDVYDEVVEKAVALTKTLTVGNPEDPDTYMGPVIHEASYNKVMKYIEIGKSEGKLLAGGEGDDSKGYFIQPTIFADVDENARLMQEEIFGPVVAICKARDFDHMLEIANNTEYGLTGALLTKNRAHIERAREDFHVGNLYFNRGCTGAIVGYQPFGGFNMSGTDSKAGGPDYLILHMQAKTTSEAF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	515 (463)
Sequences:	35959 (21761)
Seq/√Len:	1011.3

ECOLI - PUUC GABD ALDB ABDH FEAB BETB ALDA PUTA ASTD EUTE SAD PAAZ PROA
BACSU - ROCA ROCA2 ALDH4 ALDH1 ALDH5 IOLA BETB ALDY GABD ALDH3 ALDH2 PROA
HALSA - Q9HQZ2 Q9HMJ6 Q9HRB5 Q9HR91
SULSO - Q97YT9 KGSDH GAPN Q97XS9 Q97XA5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
330_Q	428_R	5.115	1.00
268_E	272_K	3.899	1.00
330_Q	426_K	3.208	1.00
302_D	339_K	3.121	1.00
333_Y	426_K	2.855	1.00
407_D	410_A	2.794	1.00
389_E	399_Q	2.794	1.00
53_I	66_Y	2.739	1.00
83_L	250_K	2.736	1.00
297_K	329_H	2.733	1.00
59_N	62_E	2.708	1.00
365_E	369_N	2.679	1.00
377_I	411_R	2.550	1.00
337_V	424_I	2.549	1.00
306_S	343_L	2.524	1.00
109_R	142_E	2.447	1.00
376_E	380_S	2.443	1.00
216_K	219_E	2.436	1.00
297_K	331_D	2.413	1.00
111_R	114_E	2.359	1.00
375_I	398_I	2.332	1.00
83_L	252_R	2.281	1.00
53_I	63_I	2.246	1.00
450_T	456_I	2.234	1.00
71_D	74_L	2.207	1.00
42_N	84_Q	2.204	1.00
104_A	221_M	2.129	1.00
39_L	70_A	2.108	1.00
222_E	228_N	2.098	1.00
372_M	376_E	2.088	1.00
383_K	405_D	2.072	1.00
112_K	135_A	2.064	1.00
377_I	381_E	2.062	1.00
430_F	455_H	2.041	1.00
107_I	223_E	2.024	1.00
362_V	371_V	2.021	1.00
372_M	390_G	2.020	1.00
170_E	509_K	1.969	1.00
341_V	345_K	1.954	1.00
243_D	247_E	1.949	1.00
209_A	364_H	1.945	1.00
441_E	489_M	1.937	1.00
247_E	269_R	1.911	1.00
100_I	226_L	1.891	1.00
372_M	398_I	1.888	1.00
458_R	462_D	1.868	1.00
293_V	308_I	1.863	1.00
335_E	339_K	1.846	1.00
114_E	216_K	1.832	1.00
40_V	222_E	1.831	1.00
46_I	77_K	1.828	1.00
385_L	404_A	1.804	1.00
403_F	412_L	1.800	1.00
113_H	131_D	1.794	1.00
107_I	224_A	1.788	1.00
298_D	455_H	1.787	1.00
430_F	458_R	1.776	1.00
379_K	384_L	1.766	1.00
169_Y	503_I	1.760	1.00
265_R	268_E	1.756	1.00
80_Q	250_K	1.752	1.00
169_Y	506_M	1.743	1.00
464_H	488_N	1.741	1.00
327_V	436_I	1.740	1.00
76_E	244_F	1.736	1.00
327_V	433_M	1.734	1.00
264_C	489_M	1.724	1.00
107_I	110_R	1.714	1.00
111_R	223_E	1.688	1.00
107_I	220_V	1.678	1.00
76_E	80_Q	1.677	1.00
408_E	436_I	1.676	1.00
329_H	427_A	1.675	1.00
344_T	402_I	1.665	1.00
413_M	425_C	1.659	1.00
341_V	385_L	1.635	1.00
383_K	404_A	1.625	1.00
308_I	336_V	1.620	1.00
432_H	435_E	1.606	1.00
102_F	142_E	1.599	1.00
118_Y	216_K	1.598	1.00
86_F	90_K	1.584	1.00
218_V	233_Y	1.583	1.00
411_R	415_E	1.575	1.00
338_E	342_A	1.562	1.00
333_Y	337_V	1.560	1.00
326_A	422_V	1.554	1.00
301_L	339_K	1.544	1.00
201_T	230_V	1.543	1.00
141_L	193_V	1.529	1.00
106_A	110_R	1.528	1.00
63_I	66_Y	1.523	1.00
313_F	344_T	1.522	1.00
237_D	240_E	1.521	1.00
373_K	411_R	1.519	1.00
76_E	248_H	1.512	1.00
384_L	403_F	1.512	1.00
334_D	426_K	1.506	1.00
109_R	138_I	1.503	1.00
93_R	96_H	1.500	1.00
428_R	432_H	1.488	1.00
431_D	462_D	1.475	1.00
106_A	142_E	1.461	1.00
365_E	396_Y	1.454	1.00
339_K	342_A	1.449	1.00
102_F	149_L	1.448	1.00
297_K	455_H	1.447	1.00
103_K	106_A	1.429	1.00
96_H	99_N	1.427	1.00
305_A	339_K	1.426	1.00
376_E	379_K	1.421	1.00
446_G	465_V	1.405	1.00
296_D	455_H	1.400	1.00
219_E	223_E	1.398	1.00
44_E	228_N	1.397	1.00
62_E	394_K	1.396	1.00
307_S	449_L	1.388	1.00
335_E	338_E	1.386	1.00
343_L	346_T	1.385	1.00
113_H	117_S	1.382	1.00
333_Y	404_A	1.375	1.00
327_V	427_A	1.373	1.00
74_L	77_K	1.373	1.00
308_I	326_A	1.369	1.00
105_A	142_E	1.366	1.00
91_K	462_D	1.363	1.00
51_K	66_Y	1.363	1.00
147_Q	150_K	1.356	1.00
117_S	121_K	1.356	1.00
381_E	411_R	1.350	1.00
328_I	336_V	1.348	1.00
60_K	394_K	1.346	1.00
177_V	202_I	1.343	1.00
120_V	130_A	1.335	1.00
141_L	189_A	1.334	1.00
374_Y	417_I	1.329	1.00
168_H	461_E	1.323	1.00
371_V	419_G	1.311	1.00
432_H	436_I	1.306	1.00
267_Y	492_T	1.305	1.00
92_Q	96_H	1.302	1.00
296_D	427_A	1.302	1.00
86_F	201_T	1.298	1.00
348_T	356_D	1.294	1.00
117_S	353_E	1.288	1.00
218_V	231_L	1.275	1.00
342_A	345_K	1.270	1.00
368_Y	398_I	1.269	1.00
56_N	59_N	1.268	1.00
434_L	459_A	1.267	1.00
111_R	216_K	1.266	1.00
55_I	63_I	1.264	1.00
253_F	284_I	1.260	1.00
369_N	373_K	1.254	1.00
427_A	436_I	1.253	1.00
50_R	69_T	1.252	1.00
188_M	204_L	1.251	1.00
345_K	386_A	1.251	1.00
368_Y	372_M	1.241	1.00
40_V	45_K	1.240	1.00
296_D	459_A	1.238	1.00
429_D	432_H	1.234	1.00
334_D	338_E	1.232	1.00
221_M	231_L	1.221	1.00
105_A	109_R	1.215	1.00
127_W	131_D	1.212	1.00
115_F	216_K	1.211	1.00
368_Y	390_G	1.207	1.00
79_M	248_H	1.200	1.00
365_E	368_Y	1.198	1.00
337_V	341_V	1.197	1.00
329_H	429_D	1.186	1.00
247_E	272_K	1.183	1.00
329_H	332_V	1.175	1.00
243_D	269_R	1.167	1.00
80_Q	84_Q	1.163	1.00
294_L	433_M	1.161	1.00
169_Y	508_A	1.158	1.00
351_N	354_D	1.157	1.00
381_E	410_A	1.157	1.00
166_Q	457_E	1.155	1.00
500_D	503_I	1.154	1.00
350_G	357_T	1.143	1.00
348_T	358_Y	1.142	1.00
69_T	237_D	1.141	1.00
75_A	241_I	1.140	1.00
104_A	220_V	1.138	1.00
414_Q	439_N	1.136	1.00
409_N	414_Q	1.135	1.00
378_G	403_F	1.134	1.00
340_A	422_V	1.132	1.00
499_P	503_I	1.131	1.00
446_G	468_L	1.131	1.00
332_V	335_E	1.130	1.00
117_S	127_W	1.127	1.00
243_D	265_R	1.126	1.00
120_V	352_P	1.124	1.00
408_E	439_N	1.124	1.00
192_A	231_L	1.123	1.00
347_L	359_M	1.123	1.00
373_K	377_I	1.122	1.00
92_Q	100_I	1.120	1.00
336_V	340_A	1.119	1.00
103_K	107_I	1.116	1.00
208_D	237_D	1.114	1.00
79_M	250_K	1.111	1.00
104_A	226_L	1.111	1.00
208_D	239_A	1.108	1.00
104_A	141_L	1.107	1.00
460_R	511_T	1.106	1.00
414_Q	441_E	1.104	1.00
56_N	351_N	1.104	1.00
262_V	265_R	1.103	1.00
342_A	346_T	1.103	1.00
337_V	404_A	1.098	1.00
244_F	248_H	1.086	1.00
431_D	458_R	1.084	1.00
456_I	470_F	1.079	1.00
294_L	459_A	1.077	1.00
339_K	343_L	1.073	1.00
337_V	385_L	1.072	1.00
177_V	255_S	1.069	1.00
500_D	508_A	1.068	1.00
58_A	352_P	1.066	1.00
79_M	251_T	1.064	1.00
391_D	399_Q	1.062	1.00
265_R	269_R	1.060	1.00
65_G	212_V	1.060	1.00
434_L	462_D	1.056	1.00
155_A	499_P	1.054	1.00
300_D	451_K	1.046	1.00
341_V	386_A	1.046	1.00
112_K	131_D	1.044	1.00
267_Y	283_V	1.044	1.00
72_Q	244_F	1.044	1.00
345_K	399_Q	1.044	1.00
111_R	220_V	1.043	1.00
102_F	146_R	1.041	1.00
110_R	223_E	1.037	1.00
431_D	435_E	1.037	1.00
52_I	69_T	1.034	1.00
215_A	235_P	1.033	1.00
115_F	220_V	1.030	1.00
430_F	459_A	1.029	1.00
293_V	323_G	1.026	1.00
294_L	437_A	1.025	1.00
172_L	253_F	1.023	1.00
60_K	396_Y	1.021	1.00
379_K	403_F	1.020	1.00
261_A	265_R	1.019	1.00
192_A	202_I	1.016	1.00
85_A	201_T	1.014	1.00
176_I	251_T	1.011	1.00
87_D	435_E	1.009	1.00
452_N	455_H	1.009	1.00
69_T	240_E	1.008	1.00
371_V	421_V	1.008	1.00
176_I	245_L	1.007	1.00
264_C	280_L	1.002	1.00
183_F	319_K	1.000	1.00
229_G	232_N	1.000	1.00
137_A	189_A	0.991	1.00
215_A	233_Y	0.990	1.00
368_Y	396_Y	0.989	1.00
387_G	399_Q	0.983	1.00
387_G	401_T	0.980	1.00
44_E	77_K	0.979	1.00
290_K	324_S	0.979	1.00
406_V	410_A	0.976	1.00
300_D	303_L	0.972	1.00
377_I	380_S	0.967	1.00
292_T	446_G	0.964	1.00
81_A	232_N	0.957	1.00
40_V	218_V	0.957	1.00
494_S	507_Q	0.957	1.00
87_D	464_H	0.956	1.00
42_N	81_A	0.952	1.00
168_H	511_T	0.952	1.00
208_D	238_G	0.949	1.00
87_D	91_K	0.947	1.00
267_Y	271_A	0.946	1.00
374_Y	377_I	0.937	1.00
98_A	149_L	0.934	1.00
56_N	121_K	0.933	1.00
427_A	433_M	0.933	1.00
334_D	337_V	0.928	1.00
154_G	157_V	0.926	1.00
174_V	251_T	0.926	1.00
148_M	197_V	0.925	1.00
485_G	494_S	0.925	1.00
252_R	464_H	0.921	1.00
447_A	473_G	0.919	1.00
174_V	201_T	0.917	1.00
72_Q	240_E	0.917	1.00
48_T	71_D	0.915	1.00
111_R	219_E	0.915	1.00
170_E	461_E	0.912	1.00
487_F	507_Q	0.911	1.00
302_D	335_E	0.909	1.00
219_E	222_E	0.906	1.00
172_L	282_R	0.903	1.00
90_K	464_H	0.902	1.00
259_S	262_V	0.901	1.00
311_S	323_G	0.898	1.00
121_K	353_E	0.898	1.00
114_E	117_S	0.897	1.00
83_L	87_D	0.892	1.00
374_Y	411_R	0.887	1.00
312_A	324_S	0.886	1.00
296_D	430_F	0.886	1.00
165_N	482_Q	0.886	1.00
56_N	62_E	0.881	1.00
433_M	436_I	0.877	1.00
408_E	425_C	0.877	1.00
105_A	145_A	0.877	1.00
309_V	343_L	0.874	1.00
305_A	340_A	0.874	1.00
108_L	137_A	0.874	1.00
371_V	417_I	0.874	1.00
435_E	439_N	0.873	1.00
39_L	235_P	0.873	1.00
75_A	176_I	0.872	1.00
125_K	133_D	0.871	1.00
102_F	145_A	0.870	1.00
98_A	145_A	0.870	1.00
333_Y	424_I	0.867	1.00
448_L	459_A	0.867	1.00
72_Q	76_E	0.867	1.00
123_A	210_A	0.863	1.00
425_C	436_I	0.863	1.00
373_K	376_E	0.859	1.00
175_G	253_F	0.859	1.00
94_P	98_A	0.857	1.00
301_L	305_A	0.856	1.00
305_A	343_L	0.853	1.00
457_E	461_E	0.853	1.00
378_G	417_I	0.851	1.00
295_V	336_V	0.848	1.00
388_G	401_T	0.848	1.00
98_A	102_F	0.847	1.00
282_R	507_Q	0.846	1.00
85_A	230_V	0.846	1.00
99_N	103_K	0.845	1.00
427_A	432_H	0.845	1.00
137_A	185_L	0.844	1.00
170_E	487_F	0.844	1.00
446_G	463_F	0.843	1.00
303_L	307_S	0.841	1.00
107_I	111_R	0.840	1.00
254_V	266_I	0.839	1.00
293_V	449_L	0.838	1.00
369_N	372_M	0.836	1.00
304_A	308_I	0.834	1.00
153_E	157_V	0.833	1.00
55_I	396_Y	0.831	1.00
305_A	336_V	0.829	1.00
296_D	450_T	0.824	1.00
172_L	200_N	0.821	1.00
172_L	507_Q	0.818	1.00
267_Y	270_A	0.814	1.00
209_A	366_A	0.814	1.00
434_L	438_N	0.813	1.00
204_L	214_A	0.811	1.00
264_C	268_E	0.810	1.00
375_I	421_V	0.810	1.00
482_Q	510_T	0.810	1.00
267_Y	280_L	0.808	1.00
91_K	461_E	0.806	1.00
73_E	76_E	0.802	1.00
52_I	237_D	0.800	1.00
305_A	309_V	0.798	1.00
226_L	231_L	0.792	1.00
77_K	81_A	0.792	1.00
42_N	228_N	0.792	1.00
108_L	138_I	0.792	1.00
382_G	410_A	0.788	1.00
188_M	192_A	0.787	1.00
254_V	270_A	0.786	1.00
453_R	456_I	0.785	1.00
333_Y	405_D	0.785	1.00
84_Q	87_D	0.785	1.00
101_L	197_V	0.783	1.00
349_V	391_D	0.782	1.00
58_A	397_F	0.779	1.00
73_E	77_K	0.777	1.00
39_L	68_S	0.777	1.00
304_A	336_V	0.775	1.00
371_V	398_I	0.775	1.00
116_S	131_D	0.773	1.00
239_A	243_D	0.766	1.00
123_A	363_I	0.764	1.00
100_I	224_A	0.762	1.00
120_V	127_W	0.761	1.00
403_F	406_V	0.759	1.00
103_K	224_A	0.759	1.00
194_A	501_Y	0.758	1.00
189_A	217_F	0.757	1.00
263_G	287_M	0.755	1.00
198_T	506_M	0.755	1.00
46_I	74_L	0.755	1.00
102_F	106_A	0.754	1.00
82_A	232_N	0.754	1.00
347_L	358_Y	0.752	1.00
309_V	340_A	0.752	1.00
292_T	437_A	0.751	1.00
128_K	358_Y	0.750	1.00
338_E	341_V	0.749	1.00
77_K	80_Q	0.749	1.00
81_A	229_G	0.748	1.00
379_K	389_E	0.745	1.00
176_I	254_V	0.742	1.00
236_G	241_I	0.740	1.00
89_W	230_V	0.739	1.00
215_A	219_E	0.738	1.00
116_S	127_W	0.735	1.00
45_K	222_E	0.735	1.00
206_P	235_P	0.734	1.00
177_V	191_T	0.734	1.00
404_A	426_K	0.734	1.00
291_D	324_S	0.733	1.00
465_V	468_L	0.732	1.00
116_S	120_V	0.731	1.00
95_E	149_L	0.731	1.00
87_D	90_K	0.729	1.00
329_H	430_F	0.729	1.00
263_G	285_A	0.728	1.00
70_A	74_L	0.728	1.00
191_T	495_K	0.727	1.00
256_F	262_V	0.727	1.00
246_V	269_R	0.726	1.00
340_A	402_I	0.724	1.00
374_Y	415_E	0.723	1.00
296_D	329_H	0.722	1.00
246_V	266_I	0.722	1.00
218_V	222_E	0.719	1.00
195_A	202_I	0.719	1.00
127_W	353_E	0.717	1.00
200_N	506_M	0.717	1.00
84_Q	88_S	0.715	1.00
226_L	230_V	0.710	1.00
88_S	92_Q	0.710	1.00
60_K	365_E	0.709	1.00
64_I	121_K	0.708	1.00
429_D	435_E	0.706	1.00
165_N	510_T	0.704	1.00
302_D	343_L	0.703	1.00
56_N	353_E	0.702	1.00
366_A	369_N	0.702	1.00
109_R	135_A	0.702	1.00
75_A	79_M	0.701	1.00
242_G	246_V	0.700	1.00
375_I	403_F	0.700	1.00
354_D	357_T	0.699	1.00
115_F	185_L	0.698	1.00
270_A	283_V	0.695	1.00
154_G	158_K	0.695	1.00
109_R	112_K	0.694	1.00
341_V	344_T	0.693	1.00
185_L	213_V	0.692	1.00
328_I	332_V	0.692	1.00
260_R	489_M	0.691	1.00
55_I	60_K	0.691	1.00
301_L	332_V	0.691	1.00
131_D	135_A	0.690	1.00
159_S	165_N	0.689	1.00
188_M	214_A	0.688	1.00
76_E	250_K	0.687	1.00
386_A	402_I	0.686	1.00
344_T	386_A	0.686	1.00
327_V	408_E	0.685	1.00
368_Y	391_D	0.684	1.00
264_C	272_K	0.683	1.00
365_E	390_G	0.682	1.00
176_I	242_G	0.681	1.00
70_A	78_A	0.680	1.00
351_N	357_T	0.678	1.00
89_W	100_I	0.676	1.00
204_L	231_L	0.675	1.00
460_R	470_F	0.675	1.00
209_A	363_I	0.675	1.00
94_P	148_M	0.673	1.00
398_I	401_T	0.672	1.00
172_L	252_R	0.671	1.00
246_V	254_V	0.670	1.00
451_K	454_A	0.668	1.00
119_L	122_E	0.667	1.00
344_T	347_L	0.667	1.00
240_E	243_D	0.666	1.00
118_Y	212_V	0.665	1.00
381_E	409_N	0.665	1.00
408_E	413_M	0.664	1.00
268_E	271_A	0.663	1.00
90_K	462_D	0.662	1.00
50_R	240_E	0.661	1.00
406_V	413_M	0.661	1.00
121_K	212_V	0.661	1.00
125_K	129_E	0.661	1.00
75_A	244_F	0.660	1.00
349_V	359_M	0.659	1.00
238_G	242_G	0.659	1.00
430_F	434_L	0.658	1.00
282_R	504_L	0.658	1.00
388_G	399_Q	0.657	1.00
364_H	367_S	0.656	1.00
113_H	127_W	0.655	1.00
327_V	413_M	0.654	1.00
203_L	232_N	0.653	1.00
326_A	336_V	0.653	1.00
106_A	109_R	0.650	1.00
298_D	450_T	0.649	1.00
83_L	86_F	0.649	1.00
316_S	359_M	0.647	1.00
221_M	226_L	0.647	1.00
90_K	170_E	0.646	1.00
370_K	373_K	0.642	1.00
308_I	340_A	0.642	1.00
42_N	232_N	0.641	1.00
367_S	370_K	0.641	1.00
372_M	375_I	0.639	1.00
164_V	457_E	0.639	1.00
464_H	487_F	0.639	1.00
436_I	439_N	0.638	1.00
42_N	77_K	0.638	1.00
208_D	370_K	0.637	1.00
295_V	304_A	0.637	1.00
309_V	347_L	0.636	1.00
384_L	401_T	0.634	1.00
453_R	457_E	0.633	1.00
340_A	424_I	0.632	1.00
450_T	455_H	0.631	1.00
90_K	171_A	0.630	1.00
70_A	234_I	0.628	1.00
267_Y	285_A	0.627	1.00
201_T	232_N	0.626	1.00
366_A	370_K	0.626	1.00
114_E	219_E	0.625	1.00
80_Q	83_L	0.625	1.00
241_I	244_F	0.623	1.00
88_S	91_K	0.621	1.00
188_M	217_F	0.621	1.00
67_A	211_P	0.620	1.00
68_S	235_P	0.619	1.00
456_I	460_R	0.618	1.00
82_A	201_T	0.618	1.00
108_L	217_F	0.616	1.00
362_V	367_S	0.614	1.00
284_I	504_L	0.613	1.00
179_S	188_M	0.611	1.00
134_T	138_I	0.610	1.00
372_M	379_K	0.610	1.00
41_I	78_A	0.608	1.00
503_I	508_A	0.608	1.00
503_I	506_M	0.607	1.00
269_R	272_K	0.606	1.00
105_A	138_I	0.605	1.00
87_D	462_D	0.604	1.00
301_L	335_E	0.604	1.00
185_L	217_F	0.603	1.00
155_A	500_D	0.603	1.00
168_H	509_K	0.602	1.00
406_V	412_L	0.602	1.00
151_L	506_M	0.601	1.00
125_K	183_F	0.601	1.00
236_G	242_G	0.601	1.00
45_K	219_E	0.599	1.00
108_L	141_L	0.599	1.00
417_I	421_V	0.597	1.00
85_A	88_S	0.596	1.00
54_S	65_G	0.596	1.00
119_L	213_V	0.596	1.00
293_V	326_A	0.596	1.00
94_P	197_V	0.595	1.00
192_A	204_L	0.594	1.00
165_N	512_S	0.593	1.00
43_G	222_E	0.593	1.00
341_V	402_I	0.593	1.00
208_D	265_R	0.592	1.00
216_K	220_V	0.592	1.00
54_S	122_E	0.591	1.00
131_D	355_P	0.590	1.00
390_G	399_Q	0.588	1.00
303_L	306_S	0.588	1.00
117_S	120_V	0.585	1.00
239_A	265_R	0.585	1.00
303_L	451_K	0.584	1.00
175_G	200_N	0.584	1.00
405_D	426_K	0.584	1.00
328_I	424_I	0.584	1.00
119_L	130_A	0.584	1.00
51_K	68_S	0.583	1.00
120_V	353_E	0.582	1.00
448_L	456_I	0.582	1.00
108_L	185_L	0.579	1.00
54_S	211_P	0.575	1.00
89_W	196_I	0.575	1.00
298_D	451_K	0.575	1.00
434_L	458_R	0.574	1.00
191_T	255_S	0.574	1.00
119_L	133_D	0.573	1.00
96_H	100_I	0.573	1.00
72_Q	247_E	0.573	1.00
100_I	104_A	0.573	1.00
186_A	190_G	0.572	1.00
112_K	116_S	0.572	1.00
246_V	279_W	0.572	1.00
330_Q	333_Y	0.571	1.00
350_G	354_D	0.570	1.00
349_V	358_Y	0.568	1.00
166_Q	511_T	0.567	1.00
362_V	398_I	0.567	1.00
298_D	452_N	0.565	1.00
78_A	234_I	0.563	1.00
154_G	500_D	0.562	1.00
151_L	502_L	0.562	1.00
434_L	463_F	0.562	1.00
134_T	185_L	0.560	1.00
104_A	107_I	0.560	1.00
454_A	458_R	0.559	1.00
454_A	457_E	0.559	1.00
64_I	212_V	0.559	1.00
413_M	436_I	0.557	1.00
105_A	141_L	0.557	1.00
243_D	246_V	0.557	1.00
299_A	304_A	0.557	1.00
253_F	504_L	0.556	1.00
381_E	407_D	0.556	1.00
311_S	473_G	0.555	1.00
375_I	401_T	0.554	1.00
198_T	502_L	0.554	1.00
177_V	192_A	0.549	1.00
319_K	322_A	0.548	1.00
146_R	149_L	0.547	1.00
326_A	424_I	0.545	1.00
272_K	279_W	0.545	1.00
261_A	366_A	0.544	1.00
40_V	43_G	0.544	1.00
115_F	134_T	0.543	1.00
133_D	183_F	0.543	1.00
176_I	203_L	0.542	1.00
312_A	422_V	0.540	1.00
50_R	71_D	0.540	1.00
297_K	427_A	0.540	1.00
463_F	468_L	0.539	1.00
48_T	74_L	0.539	1.00
468_L	509_K	0.538	1.00
293_V	447_A	0.538	1.00
217_F	221_M	0.538	1.00
108_L	115_F	0.538	1.00
143_F	147_Q	0.537	1.00
175_G	202_I	0.536	1.00
260_R	264_C	0.535	1.00
464_H	507_Q	0.534	1.00
39_L	74_L	0.533	1.00
291_D	445_T	0.530	1.00
286_E	444_L	0.529	1.00
292_T	465_V	0.529	1.00
313_F	347_L	0.528	1.00
81_A	228_N	0.526	1.00
244_F	247_E	0.525	1.00
301_L	304_A	0.525	1.00
144_Y	194_A	0.524	1.00
83_L	174_V	0.524	1.00
430_F	462_D	0.524	1.00
112_K	138_I	0.524	1.00
174_V	252_R	0.523	1.00
412_L	417_I	0.523	1.00
41_I	46_I	0.523	1.00
67_A	212_V	0.522	1.00
203_L	234_I	0.522	1.00
408_E	435_E	0.522	1.00
123_A	315_Y	0.521	1.00
384_L	387_G	0.519	1.00
323_G	447_A	0.519	1.00
81_A	85_A	0.518	1.00
136_E	186_A	0.514	1.00
469_Y	472_R	0.514	1.00
72_Q	243_D	0.514	1.00
135_A	138_I	0.511	1.00
116_S	134_T	0.510	1.00
408_E	414_Q	0.509	1.00
82_A	203_L	0.509	1.00
82_A	174_V	0.509	1.00
305_A	332_V	0.509	1.00
153_E	158_K	0.507	1.00
154_G	159_S	0.506	1.00
379_K	382_G	0.506	1.00
338_E	345_K	0.506	1.00
459_A	463_F	0.505	1.00
328_I	333_Y	0.505	1.00
170_E	464_H	0.505	1.00
389_E	392_D	0.504	1.00
332_V	427_A	0.503	1.00
116_S	130_A	0.501	1.00
448_L	470_F	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4nm9A	2	0.9981	100	0.068	Contact Map
1uzbA	5	0.9981	100	0.075	Contact Map
3qanA	2	0.9961	100	0.077	Contact Map
4jdcA	5	0.9786	100	0.092	Contact Map
4oe6A	5	0.9029	100	0.096	Contact Map
4pz2A	4	0.9165	100	0.097	Contact Map
4o5hA	4	0.967	100	0.097	Contact Map
4pxlA	4	0.9204	100	0.098	Contact Map
4yweA	5	0.9068	100	0.099	Contact Map
4lihA	5	0.9398	100	0.101	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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