GREMLIN Database
DHE2 - Catabolic NAD-specific glutamate dehydrogenase RocG
UniProt: P39633 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 424 (367)
Sequences: 5506 (2596)
Seq/√Len: 135.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
240_M245_A4.4091.00
293_E315_N3.7911.00
226_I237_A3.6131.00
296_C318_A3.3971.00
225_I296_C3.3631.00
208_I322_V3.1611.00
270_D274_S2.9751.00
295_D317_Q2.9501.00
335_K339_E2.8801.00
112_Y359_Y2.6181.00
129_G133_R2.5841.00
122_D125_T2.5181.00
249_G291_L2.4411.00
337_L342_V2.4341.00
105_C355_V2.4311.00
223_R246_K2.4211.00
210_E213_K2.4121.00
338_N401_D2.3531.00
157_V304_I2.3521.00
210_E385_V2.3491.00
264_D267_Y2.3231.00
394_T398_H2.2911.00
237_A250_I2.2831.00
238_K242_D2.2601.00
72_H98_S2.2121.00
140_R170_E2.1761.00
57_M63_K2.1731.00
217_I222_A2.1431.00
214_K396_A2.1421.00
204_V324_A2.1261.00
224_I245_A2.1171.00
224_I240_M2.1121.00
207_C350_A2.0991.00
401_D404_L2.0801.00
388_F392_Y2.0581.00
412_R416_E2.0471.00
160_N163_I2.0461.00
223_R244_G2.0221.00
54_P137_G2.0181.00
310_A332_D2.0151.00
322_V350_A2.0091.00
393_Q397_T2.0021.00
329_T337_L1.9511.00
195_G373_E1.9261.00
394_T412_R1.9251.00
292_L299_L1.9141.00
345_V350_A1.8781.00
214_K392_Y1.8661.00
127_S130_E1.8601.00
210_E389_E1.8561.00
250_I268_L1.8461.00
313_A336_I1.8451.00
308_I329_T1.8411.00
206_I209_E1.8371.00
83_V167_M1.8221.00
121_C126_M1.8001.00
372_S375_E1.7701.00
219_L245_A1.7671.00
309_T312_N1.7611.00
348_I407_Y1.7601.00
79_T115_G1.7491.00
205_T243_A1.7481.00
375_E379_K1.7361.00
189_V416_E1.7351.00
70_S98_S1.7311.00
301_P325_A1.7151.00
400_V408_M1.7081.00
249_G294_K1.7021.00
76_V109_N1.6981.00
211_A320_I1.6831.00
287_T290_E1.6831.00
269_L273_D1.6801.00
90_N93_E1.6701.00
253_A272_R1.6671.00
140_R173_R1.6531.00
260_P284_D1.6401.00
308_I316_I1.6291.00
139_V167_M1.6061.00
214_K388_F1.6051.00
58_D127_S1.5871.00
336_I340_R1.5811.00
225_I249_G1.5751.00
145_I149_T1.5741.00
209_E243_A1.5321.00
107_I349_L1.5291.00
218_K221_N1.5061.00
143_S175_R1.4761.00
238_K269_L1.4761.00
212_V298_I1.4621.00
400_V405_A1.4601.00
325_A328_P1.4591.00
165_A187_P1.4561.00
209_E381_R1.4501.00
170_E173_R1.4401.00
211_A345_V1.4401.00
72_H102_T1.4161.00
74_D79_T1.3921.00
224_I300_V1.3841.00
206_I381_R1.3801.00
56_K129_G1.3721.00
331_I334_T1.3711.00
236_L300_V1.3681.00
128_F132_E1.3631.00
204_V322_V1.3531.00
140_R174_L1.3461.00
86_H304_I1.3361.00
349_L391_I1.3311.00
67_G138_Y1.3281.00
127_S131_L1.3161.00
322_V345_V1.3101.00
386_S390_T1.2891.00
121_C134_L1.2851.00
217_I319_S1.2851.00
310_A336_I1.2821.00
377_A381_R1.2771.00
137_G140_R1.2771.00
214_K389_E1.2751.00
232_A324_A1.2721.00
132_E136_R1.2651.00
314_H336_I1.2601.00
267_Y281_L1.2531.00
388_F402_M1.2481.00
206_I377_A1.2371.00
128_F162_Q1.2341.00
53_I137_G1.2331.00
212_V219_L1.2301.00
389_E393_Q1.2231.00
382_S386_S1.2211.00
161_S197_E1.2141.00
215_K319_S1.2131.00
254_N277_M1.2021.00
299_L316_I1.1991.00
103_L348_I1.1941.00
208_I300_V1.1840.99
225_I294_K1.1700.99
136_R170_E1.1680.99
236_L302_A1.1670.99
248_I296_C1.1660.99
365_N370_Y1.1660.99
205_T240_M1.1590.99
373_E377_A1.1570.99
224_I298_I1.1470.99
208_I298_I1.1470.99
103_L414_S1.1450.99
68_Y120_I1.1440.99
102_T414_S1.1410.99
51_V142_I1.1320.99
394_T409_T1.1310.99
271_K275_F1.1280.99
276_G280_N1.1260.99
223_R297_D1.1210.99
256_G286_I1.1200.99
320_I343_L1.1180.99
397_T412_R1.1180.99
223_R260_P1.1180.99
335_K338_N1.1170.99
126_M134_L1.1050.99
70_S91_E1.1030.99
336_I339_E1.1010.99
66_T120_I1.0820.99
215_K343_L1.0770.99
209_E213_K1.0760.99
223_R295_D1.0740.99
224_I247_V1.0720.99
400_V404_L1.0720.99
381_R385_V1.0700.99
225_I248_I1.0680.99
240_M247_V1.0620.99
143_S174_L1.0610.99
271_K281_L1.0600.99
241_H266_P1.0560.99
143_S147_G1.0540.99
234_S273_D1.0530.99
202_Q239_F1.0460.99
54_P64_V1.0450.99
334_T403_R1.0420.99
108_A356_T1.0400.99
248_I258_Y1.0350.99
267_Y270_D1.0340.99
235_F238_K1.0320.99
73_N418_S1.0260.99
204_V300_V1.0250.99
85_F159_T1.0170.98
209_E219_L1.0150.98
85_F135_S1.0130.98
308_I337_L1.0120.98
144_Q176_E1.0120.98
143_S146_V1.0100.98
87_P122_D1.0090.98
137_G141_A1.0060.98
256_G288_N1.0040.98
310_A314_H1.0030.98
265_I269_L0.9980.98
211_A322_V0.9920.98
283_T286_I0.9910.98
204_V208_I0.9900.98
159_T164_M0.9890.98
241_H265_I0.9800.98
396_A399_K0.9780.98
234_S269_L0.9720.98
128_F131_L0.9680.98
137_G170_E0.9670.98
398_H408_M0.9660.98
411_I414_S0.9650.98
51_V67_G0.9610.98
236_L240_M0.9580.98
263_L268_L0.9520.98
204_V302_A0.9490.98
170_E174_L0.9480.98
108_A352_A0.9460.97
127_S132_E0.9420.97
146_V149_T0.9420.97
290_E293_E0.9410.97
246_K261_D0.9400.97
378_E382_S0.9360.97
369_Y375_E0.9330.97
187_P190_L0.9330.97
197_E235_F0.9310.97
259_N281_L0.9280.97
286_I290_E0.9230.97
372_S382_S0.9220.97
135_S139_V0.9130.97
150_K176_E0.9120.97
202_Q377_A0.9110.97
299_L307_Q0.9110.97
356_T360_F0.9080.97
86_H157_V0.9040.97
271_K280_N0.9020.97
394_T408_M0.9010.97
252_D272_R0.8970.97
392_Y396_A0.8960.96
208_I320_I0.8930.96
237_A247_V0.8920.96
311_K314_H0.8910.96
92_E95_K0.8900.96
75_A414_S0.8880.96
88_E93_E0.8850.96
378_E381_R0.8840.96
300_V322_V0.8820.96
126_M130_E0.8810.96
143_S149_T0.8710.96
237_A268_L0.8700.96
226_I245_A0.8670.96
285_V288_N0.8660.96
334_T338_N0.8650.96
83_V138_Y0.8630.96
395_A400_V0.8610.96
393_Q396_A0.8610.96
283_T288_N0.8590.96
316_I321_V0.8570.95
175_R178_D0.8550.95
229_F250_I0.8530.95
308_I313_A0.8520.95
369_Y372_S0.8480.95
204_V236_L0.8470.95
241_H264_D0.8450.95
214_K393_Q0.8450.95
109_N383_V0.8410.95
76_V106_G0.8400.95
368_G372_S0.8400.95
57_M65_F0.8370.95
98_S102_T0.8350.95
358_S361_E0.8350.95
384_M387_S0.8310.95
207_C391_I0.8300.95
240_M300_V0.8280.95
142_I145_I0.8100.94
356_T384_M0.8080.94
385_V389_E0.8080.94
257_L268_L0.8070.94
391_I394_T0.8070.94
83_V153_P0.8050.94
85_F119_I0.8040.94
355_V358_S0.8000.94
116_K200_T0.8000.94
116_K326_N0.7990.93
56_K63_K0.7970.93
321_V337_L0.7960.93
167_M170_E0.7960.93
258_Y294_K0.7930.93
241_H247_V0.7860.93
297_D319_S0.7860.93
135_S138_Y0.7820.93
314_H340_R0.7780.93
267_Y271_K0.7780.93
117_G138_Y0.7760.92
168_M179_S0.7740.92
235_F239_F0.7700.92
126_M131_L0.7690.92
76_V113_G0.7680.92
215_K320_I0.7670.92
329_T344_L0.7640.92
257_L278_V0.7620.92
368_G375_E0.7530.91
219_L224_I0.7490.91
278_V285_V0.7470.91
94_V98_S0.7400.91
376_V379_K0.7400.91
308_I347_D0.7370.90
343_L402_M0.7370.90
258_Y284_D0.7330.90
321_V329_T0.7330.90
238_K266_P0.7320.90
277_M280_N0.7310.90
256_G293_E0.7310.90
68_Y91_E0.7300.90
295_D318_A0.7280.90
124_R253_A0.7280.90
80_K355_V0.7270.90
352_A356_T0.7220.89
200_T354_G0.7200.89
385_V388_F0.7180.89
337_L344_L0.7170.89
390_T393_Q0.7170.89
166_W169_D0.7150.89
310_A334_T0.7130.89
363_V369_Y0.7120.89
310_A333_A0.7110.89
229_F265_I0.7060.88
240_M298_I0.7060.88
266_P269_L0.7060.88
201_A236_L0.7050.88
104_K326_N0.7050.88
397_T400_V0.7020.88
268_L281_L0.7020.88
237_A265_I0.6990.88
398_H412_R0.6970.88
139_V183_I0.6960.88
148_P179_S0.6950.88
237_A281_L0.6950.88
293_E312_N0.6910.87
89_V118_G0.6900.87
106_G410_G0.6890.87
239_F243_A0.6870.87
124_R272_R0.6860.87
63_K125_T0.6830.87
318_A342_V0.6800.87
409_T413_K0.6780.86
149_T366_N0.6770.86
139_V170_E0.6760.86
289_E293_E0.6740.86
329_T333_A0.6730.86
286_I294_K0.6720.86
117_G135_S0.6690.86
202_Q381_R0.6690.86
392_Y395_A0.6670.85
246_K264_D0.6660.85
239_F377_A0.6650.85
379_K384_M0.6630.85
252_D277_M0.6620.85
321_V333_A0.6620.85
55_V65_F0.6620.85
249_G256_G0.6590.85
318_A321_V0.6590.85
155_P196_R0.6580.85
144_Q148_P0.6560.85
344_L347_D0.6560.85
137_G173_R0.6560.85
71_Q150_K0.6530.84
75_A102_T0.6520.84
164_M167_M0.6520.84
212_V320_I0.6490.84
298_I320_I0.6480.84
259_N283_T0.6480.84
57_M61_S0.6470.84
316_I337_L0.6470.84
226_I250_I0.6470.84
58_D133_R0.6470.84
395_A402_M0.6420.83
133_R136_R0.6420.83
168_M172_S0.6400.83
158_Y232_A0.6390.83
193_S371_W0.6380.83
411_I415_A0.6370.83
269_L272_R0.6370.83
379_K382_S0.6370.83
300_V324_A0.6350.83
233_G252_D0.6350.83
100_W327_G0.6350.83
109_N386_S0.6330.82
207_C322_V0.6320.82
268_L278_V0.6320.82
271_K282_F0.6320.82
271_K276_G0.6300.82
259_N263_L0.6280.82
146_V167_M0.6250.82
124_R127_S0.6240.81
232_A253_A0.6240.81
199_A231_N0.6240.81
229_F268_L0.6220.81
359_Y363_V0.6200.81
70_S115_G0.6180.81
248_I294_K0.6160.81
63_K126_M0.6160.81
75_A418_S0.6150.81
308_I321_V0.6140.80
394_T405_A0.6140.80
162_Q165_A0.6130.80
374_E378_E0.6130.80
164_M190_L0.6120.80
209_E385_V0.6120.80
123_P131_L0.6120.80
164_M183_I0.6090.80
309_T329_T0.6080.80
321_V342_V0.6080.80
379_K383_V0.6070.80
188_L194_Q0.6060.80
267_Y272_R0.6060.80
274_S280_N0.6050.79
283_T287_T0.6040.79
270_D273_D0.6040.79
229_F325_A0.6040.79
388_F391_I0.6030.79
167_M183_I0.6030.79
383_V386_S0.6010.79
229_F301_P0.6010.79
53_I134_L0.5990.79
275_F280_N0.5980.79
384_M388_F0.5970.79
393_Q399_K0.5970.79
251_S292_L0.5960.78
148_P180_P0.5960.78
310_A337_L0.5960.78
207_C345_V0.5940.78
292_L315_N0.5930.78
305_S327_G0.5930.78
268_L272_R0.5920.78
309_T330_T0.5920.78
376_V381_R0.5920.78
204_V350_A0.5920.78
357_V376_V0.5920.78
395_A398_H0.5900.78
149_T368_G0.5900.78
324_A350_A0.5890.78
211_A343_L0.5880.78
71_Q79_T0.5870.77
386_S389_E0.5870.77
199_A380_L0.5850.77
196_R357_V0.5840.77
395_A399_K0.5830.77
99_I103_L0.5830.77
334_T344_L0.5810.77
376_V384_M0.5800.77
356_T383_V0.5800.77
52_R64_V0.5780.76
345_V402_M0.5770.76
76_V413_K0.5760.76
403_R407_Y0.5750.76
210_E214_K0.5750.76
198_T235_F0.5730.76
155_P231_N0.5700.75
139_V142_I0.5700.75
308_I344_L0.5690.75
205_T236_L0.5680.75
329_T334_T0.5670.75
135_S163_I0.5670.75
162_Q166_W0.5630.74
364_Q371_W0.5620.74
223_R248_I0.5610.74
392_Y402_M0.5610.74
77_G147_G0.5610.74
266_P270_D0.5600.74
80_K362_W0.5590.74
193_S357_V0.5590.74
284_D287_T0.5580.74
112_Y362_W0.5580.74
121_C127_S0.5570.74
408_M411_I0.5570.74
376_V387_S0.5570.74
107_I390_T0.5570.74
96_A327_G0.5560.74
275_F278_V0.5550.73
314_H339_E0.5550.73
255_G279_T0.5550.73
104_K116_K0.5550.73
225_I291_L0.5530.73
86_H89_V0.5530.73
56_K62_V0.5530.73
123_P126_M0.5520.73
394_T397_T0.5520.73
290_E312_N0.5510.73
205_T239_F0.5510.73
217_I297_D0.5500.73
299_L321_V0.5480.72
313_A337_L0.5480.72
196_R231_N0.5480.72
200_T231_N0.5480.72
227_Q307_Q0.5470.72
226_I240_M0.5470.72
94_V118_G0.5470.72
75_A417_A0.5470.72
225_I318_A0.5460.72
344_L403_R0.5460.72
318_A337_L0.5460.72
207_C349_L0.5450.72
113_G353_G0.5450.72
387_S391_I0.5450.72
238_K280_N0.5440.72
243_A265_I0.5440.72
174_L183_I0.5430.72
254_N285_V0.5420.72
330_T334_T0.5420.72
387_S390_T0.5400.71
223_R258_Y0.5400.71
131_L135_S0.5380.71
199_A357_V0.5380.71
410_G414_S0.5360.71
345_V388_F0.5360.71
122_D127_S0.5330.70
251_S288_N0.5320.70
196_R358_S0.5310.70
255_G278_V0.5310.70
225_I295_D0.5310.70
116_K154_A0.5300.70
394_T399_K0.5290.70
61_S64_V0.5270.70
200_T351_S0.5260.69
135_S167_M0.5250.69
55_V58_D0.5240.69
292_L307_Q0.5240.69
80_K112_Y0.5240.69
95_K98_S0.5220.69
401_D405_A0.5200.69
89_V93_E0.5200.69
65_F121_C0.5200.69
205_T208_I0.5200.69
383_V387_S0.5180.68
405_A408_M0.5180.68
367_Q375_E0.5150.68
213_K385_V0.5140.68
130_E136_R0.5130.67
204_V232_A0.5130.67
308_I314_H0.5110.67
302_A324_A0.5110.67
309_T315_N0.5110.67
136_R169_D0.5110.67
249_G263_L0.5090.67
208_I324_A0.5080.67
202_Q238_K0.5080.67
109_N390_T0.5080.67
252_D255_G0.5070.67
239_F242_D0.5070.67
256_G294_K0.5050.66
371_W374_E0.5040.66
141_A175_R0.5020.66
333_A338_N0.5020.66
211_A388_F0.5020.66
212_V222_A0.5000.66
381_R384_M0.5000.66
176_E179_S0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3r3jA 5 0.9976 100 0.088 Contact Map
4xgiA 6 0.9717 100 0.089 Contact Map
2yfqA 5 0.9222 100 0.089 Contact Map
4fccA 5 0.9976 100 0.09 Contact Map
2bmaA 5 0.9976 100 0.092 Contact Map
1bgvA 5 1 100 0.098 Contact Map
3k92A 5 0.9858 100 0.1 Contact Map
2tmgA 5 0.9575 100 0.101 Contact Map
1v9lA 4 0.967 100 0.103 Contact Map
3aoeE 3 0.9811 100 0.103 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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