GREMLIN Database
SPSK - Spore coat polysaccharide biosynthesis protein SpsK
UniProt: P39631 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 283 (265)
Sequences: 59964 (41701)
Seq/√Len: 2561.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
221_A268_R3.1121.00
9_A30_A2.9051.00
20_Q192_E2.5941.00
77_L81_I2.5011.00
193_A207_V2.4991.00
55_I198_F2.4411.00
100_I194_V2.4261.00
20_Q195_I2.4121.00
71_E74_K2.3311.00
225_E272_R2.3221.00
3_K27_E2.3181.00
203_G256_A2.3061.00
255_R259_E2.1441.00
266_H269_E2.1201.00
84_Y136_L2.0211.00
45_R92_R2.0201.00
3_K29_I1.9931.00
216_Y220_T1.9861.00
58_N99_H1.9691.00
115_R118_D1.9621.00
57_V198_F1.9271.00
214_S217_E1.9171.00
221_A224_E1.9141.00
192_E265_R1.9041.00
149_T194_V1.9001.00
224_E268_R1.8811.00
31_L36_M1.8621.00
36_M43_S1.8591.00
188_K273_E1.8241.00
29_I51_Y1.8201.00
147_I197_L1.8171.00
210_S258_E1.8161.00
20_Q24_A1.7731.00
40_D43_S1.7701.00
131_R135_E1.7641.00
192_E196_K1.7521.00
195_I199_S1.7401.00
24_A195_I1.7231.00
76_Y132_L1.7171.00
196_K200_H1.6991.00
45_R89_E1.6621.00
4_V26_Y1.6561.00
175_R233_L1.6501.00
7_T58_N1.6301.00
83_A133_G1.6261.00
81_I84_Y1.6221.00
258_E263_R1.6071.00
17_L191_A1.6041.00
84_Y88_L1.6011.00
254_H258_E1.5821.00
186_Y273_E1.5681.00
166_K170_T1.5221.00
24_A199_S1.5141.00
153_Y270_A1.5071.00
73_D77_L1.5011.00
17_L57_V1.5001.00
6_V18_C1.4981.00
221_A225_E1.4961.00
17_L59_S1.4931.00
41_Q88_L1.4871.00
181_I212_I1.4811.00
20_Q191_A1.4701.00
116_E256_A1.4651.00
257_I260_A1.4541.00
18_C30_A1.4371.00
20_Q23_Q1.4221.00
149_T190_L1.4221.00
120_L131_R1.3911.00
59_S100_I1.3871.00
41_Q85_Y1.3751.00
45_R93_I1.3721.00
56_V90_S1.3661.00
167_L172_Q1.3631.00
9_A18_C1.3541.00
41_Q45_R1.3521.00
135_E138_R1.3451.00
49_G93_I1.3441.00
43_S46_H1.3431.00
39_A77_L1.3421.00
138_R146_I1.3381.00
185_T190_L1.3311.00
26_Y199_S1.3311.00
13_L152_V1.3211.00
216_Y234_S1.3131.00
101_S105_V1.2961.00
100_I149_T1.2881.00
128_K132_L1.2781.00
87_A140_T1.2751.00
46_H50_H1.2741.00
99_H133_G1.2721.00
136_L139_L1.2661.00
147_I194_V1.2591.00
21_L195_I1.2501.00
187_T191_A1.2341.00
16_E187_T1.2331.00
19_R156_G1.2251.00
186_Y270_A1.2221.00
5_L31_L1.2161.00
90_S95_A1.2111.00
111_T115_R1.2091.00
150_S252_L1.2021.00
126_Y130_K1.2011.00
111_T118_D1.1971.00
57_V194_V1.1931.00
20_Q188_K1.1911.00
16_E188_K1.1911.00
269_E272_R1.1831.00
88_L91_T1.1751.00
217_E220_T1.1731.00
67_Q71_E1.1621.00
91_T144_S1.1521.00
114_Y118_D1.1491.00
269_E273_E1.1451.00
4_V21_L1.1221.00
5_L51_Y1.1111.00
213_C267_W1.1091.00
138_R204_I1.1031.00
79_N129_S1.0961.00
89_E93_I1.0871.00
98_V147_I1.0811.00
89_E92_R1.0751.00
193_A257_I1.0731.00
208_S252_L1.0701.00
88_L92_R1.0701.00
99_H146_I1.0651.00
46_H49_G1.0651.00
220_T223_M1.0641.00
38_I82_G1.0631.00
81_I85_Y1.0621.00
213_C217_E1.0611.00
212_I251_V1.0581.00
58_N83_A1.0561.00
99_H137_I1.0541.00
4_V55_I1.0521.00
76_Y80_G1.0511.00
115_R253_S1.0461.00
88_L140_T1.0451.00
62_F78_I1.0431.00
223_M229_E1.0421.00
223_M230_T1.0411.00
183_S210_S1.0401.00
80_G132_L1.0341.00
181_I214_S1.0331.00
145_T197_L1.0191.00
196_K199_S1.0171.00
212_I249_Y1.0151.00
76_Y81_I1.0151.00
226_S275_L1.0131.00
7_T86_T1.0131.00
38_I60_A1.0121.00
268_R272_R1.0031.00
173_E231_A1.0001.00
85_Y88_L0.9981.00
90_S97_Y0.9961.00
87_A137_I0.9951.00
117_D256_A0.9921.00
10_G32_T0.9911.00
87_A97_Y0.9901.00
16_E19_R0.9881.00
132_L135_E0.9841.00
19_R23_Q0.9841.00
86_T97_Y0.9831.00
175_R235_V0.9801.00
45_R49_G0.9801.00
181_I249_Y0.9731.00
97_Y137_I0.9721.00
75_A129_S0.9681.00
225_E275_L0.9661.00
54_D96_Q0.9601.00
152_V190_L0.9541.00
254_H264_P0.9531.00
106_F206_H0.9511.00
225_E268_R0.9501.00
15_L156_G0.9381.00
255_R258_E0.9371.00
173_E233_L0.9351.00
192_E195_I0.9331.00
48_F89_E0.9281.00
12_Q187_T0.9231.00
12_Q154_G0.9221.00
192_E262_I0.9071.00
44_V89_E0.9041.00
91_T140_T0.9031.00
196_K260_A0.9031.00
256_A259_E0.9011.00
83_A137_I0.8981.00
146_I204_I0.8981.00
186_Y189_D0.8941.00
62_F74_K0.8901.00
189_D209_N0.8871.00
140_T144_S0.8861.00
148_R204_I0.8841.00
193_A262_I0.8831.00
3_K51_Y0.8791.00
59_S194_V0.8771.00
85_Y89_E0.8741.00
208_S254_H0.8681.00
160_F164_M0.8661.00
3_K54_D0.8661.00
211_G266_H0.8651.00
31_L47_S0.8601.00
47_S51_Y0.8571.00
16_E20_Q0.8571.00
17_L21_L0.8551.00
217_E221_A0.8541.00
78_I82_G0.8511.00
29_I50_H0.8481.00
163_T166_K0.8441.00
18_C28_V0.8441.00
22_K28_V0.8431.00
31_L43_S0.8431.00
42_R46_H0.8411.00
138_R142_K0.8411.00
141_T202_P0.8391.00
42_R45_R0.8361.00
163_T167_L0.8321.00
112_Q118_D0.8311.00
134_E148_R0.8261.00
74_K77_L0.8231.00
48_F93_I0.8231.00
72_L128_K0.8221.00
3_K26_Y0.8221.00
56_V86_T0.8211.00
147_I207_V0.8211.00
48_F56_V0.8181.00
48_F51_Y0.8171.00
91_T143_D0.8101.00
43_S47_S0.8081.00
13_L190_L0.8061.00
205_Y256_A0.8021.00
135_E139_L0.8011.00
4_V57_V0.7951.00
74_K78_I0.7951.00
41_Q92_R0.7931.00
7_T60_A0.7921.00
159_N162_E0.7921.00
58_N86_T0.7901.00
223_M228_L0.7871.00
4_V198_F0.7861.00
132_L136_L0.7851.00
153_Y186_Y0.7811.00
165_L169_E0.7791.00
196_K262_I0.7731.00
138_R141_T0.7671.00
152_V185_T0.7631.00
210_S254_H0.7571.00
166_K169_E0.7561.00
17_L194_V0.7481.00
31_L44_V0.7451.00
125_I128_K0.7411.00
168_A223_M0.7381.00
39_A78_I0.7321.00
16_E191_A0.7311.00
83_A87_A0.7271.00
62_F75_A0.7261.00
221_A267_W0.7201.00
149_T152_V0.7191.00
128_K135_E0.7191.00
103_D252_L0.7161.00
113_P253_S0.7151.00
191_A195_I0.7081.00
103_D150_S0.7071.00
148_R206_H0.7061.00
33_K37_N0.7041.00
141_T144_S0.7031.00
107_N121_D0.7031.00
136_L140_T0.7021.00
258_E264_P0.6891.00
197_L260_A0.6881.00
225_E271_L0.6841.00
98_V198_F0.6831.00
155_H186_Y0.6821.00
82_G85_Y0.6761.00
197_L257_I0.6761.00
223_M232_I0.6751.00
122_P127_G0.6741.00
101_S134_E0.6731.00
220_T224_E0.6721.00
76_Y129_S0.6701.00
37_N40_D0.6691.00
115_R255_R0.6681.00
15_L19_R0.6671.00
24_A196_K0.6671.00
68_C75_A0.6651.00
18_C22_K0.6631.00
139_L143_D0.6611.00
196_K261_G0.6601.00
110_G118_D0.6561.00
87_A136_L0.6561.00
213_C218_F0.6551.00
55_I96_Q0.6551.00
162_E166_K0.6521.00
189_D192_E0.6501.00
234_S237_T0.6461.00
155_H273_E0.6421.00
16_E156_G0.6401.00
124_T127_G0.6391.00
76_Y128_K0.6391.00
158_S162_E0.6371.00
84_Y140_T0.6371.00
98_V194_V0.6351.00
109_K114_Y0.6341.00
26_Y55_I0.6331.00
44_V48_F0.6331.00
113_P251_V0.6301.00
56_V97_Y0.6291.00
213_C221_A0.6271.00
139_L142_K0.6261.00
72_L125_I0.6261.00
36_M44_V0.6251.00
55_I98_V0.6221.00
128_K139_L0.6211.00
21_L198_F0.6121.00
171_K228_L0.6121.00
69_E125_I0.6101.00
180_Q215_W0.6081.00
145_T205_Y0.6061.00
58_N97_Y0.6041.00
80_G84_Y0.6001.00
146_I202_P0.5991.00
10_G34_K0.5951.00
48_F90_S0.5941.00
150_S208_S0.5941.00
219_A223_M0.5941.00
151_W182_G0.5931.00
104_Y127_G0.5901.00
111_T116_E0.5881.00
120_L135_E0.5881.00
179_D214_S0.5871.00
159_N163_T0.5861.00
218_F267_W0.5861.00
165_L275_L0.5831.00
129_S133_G0.5831.00
207_V257_I0.5791.00
181_I251_V0.5781.00
116_E257_I0.5781.00
44_V85_Y0.5771.00
201_P205_Y0.5741.00
183_S212_I0.5731.00
223_M226_S0.5731.00
26_Y54_D0.5721.00
5_L56_V0.5721.00
147_I193_A0.5711.00
98_V197_L0.5661.00
17_L195_I0.5651.00
61_A79_N0.5631.00
265_R269_E0.5621.00
105_V120_L0.5611.00
10_G30_A0.5601.00
133_G137_I0.5571.00
122_P131_R0.5571.00
5_L47_S0.5561.00
102_T130_K0.5551.00
19_R188_K0.5551.00
175_R178_S0.5541.00
72_L76_Y0.5541.00
105_V134_E0.5541.00
40_D44_V0.5541.00
112_Q249_Y0.5541.00
165_L222_I0.5511.00
160_F168_A0.5481.00
221_A271_L0.5451.00
96_Q145_T0.5421.00
232_I235_V0.5411.00
174_L177_V0.5411.00
155_H188_K0.5371.00
47_S50_H0.5361.00
80_G136_L0.5321.00
195_I198_F0.5321.00
161_V164_M0.5301.00
183_S209_N0.5291.00
190_L207_V0.5291.00
221_A272_R0.5281.00
6_V21_L0.5281.00
247_P250_S0.5261.00
167_L171_K0.5251.00
205_Y257_I0.5231.00
19_R22_K0.5211.00
16_E155_H0.5201.00
21_L26_Y0.5201.00
233_L236_T0.5191.00
120_L204_I0.5181.00
137_I146_I0.5171.00
41_Q89_E0.5161.00
113_P116_E0.5151.00
133_G136_L0.5141.00
5_L48_F0.5131.00
145_T203_G0.5131.00
189_D265_R0.5081.00
254_H257_I0.5081.00
64_S67_Q0.5081.00
90_S93_I0.5061.00
48_F86_T0.5051.00
164_M168_A0.5041.00
108_G248_A0.5031.00
222_I271_L0.5021.00
158_S161_V0.5011.00
83_A99_H0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3sc6A 3 0.9859 100 0.172 Contact Map
1n2sA 2 0.9929 100 0.189 Contact Map
1vl0A 3 0.9859 100 0.201 Contact Map
1e6uA 2 0.9788 100 0.211 Contact Map
1rkxA 3 0.9682 100 0.211 Contact Map
1sb8A 2 0.9929 100 0.212 Contact Map
3rufA 2 0.9753 100 0.215 Contact Map
2c20A 2 0.9788 100 0.218 Contact Map
2ydyA 1 0.8763 100 0.218 Contact Map
2pzmA 2 0.9682 100 0.22 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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