GREMLIN Database
RMLB - dTDP-glucose 4,6-dehydratase
UniProt: P39630 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 315 (287)
Sequences: 60677 (41794)
Seq/√Len: 2467.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_G32_V3.1661.00
4_S29_R2.8291.00
256_V300_E2.7141.00
21_L225_R2.6341.00
226_A242_I2.5681.00
238_E286_K2.4731.00
68_D114_K2.4171.00
99_T103_M2.4041.00
240_Y290_E2.3481.00
123_I227_I2.2781.00
77_G231_L2.2771.00
80_H122_H2.1511.00
33_L59_G2.1311.00
93_Q96_P2.1221.00
259_K300_E2.1211.00
298_T301_E2.1071.00
8_T80_H2.0901.00
119_K172_P2.0891.00
21_L25_E2.0461.00
63_V66_D2.0401.00
21_L228_K2.0051.00
79_I231_L1.9921.00
182_Y302_G1.9881.00
288_K294_R1.9571.00
225_R296_E1.9531.00
4_S31_T1.9171.00
251_K255_S1.8921.00
6_L75_Y1.8871.00
140_T143_T1.8791.00
260_H304_A1.8731.00
7_I19_T1.8481.00
178_C227_I1.8451.00
31_T55_R1.8271.00
25_E232_E1.8211.00
59_G66_D1.8191.00
256_V259_K1.8011.00
221_E305_R1.7951.00
31_T75_Y1.7881.00
225_R229_L1.7541.00
162_V173_A1.7471.00
29_R55_R1.7281.00
249_T252_E1.7141.00
176_T230_I1.6721.00
31_T57_V1.6651.00
18_F224_C1.6531.00
245_G288_K1.6251.00
106_Y161_L1.6161.00
18_F79_I1.5991.00
62_S99_T1.5901.00
124_S128_V1.5871.00
106_Y110_E1.5791.00
219_F305_R1.5751.00
36_L56_F1.5421.00
64_Q110_E1.5341.00
68_D111_A1.5341.00
25_E228_K1.5321.00
197_R201_Q1.5301.00
103_M106_Y1.4891.00
98_I157_S1.4871.00
21_L24_R1.4731.00
18_F81_F1.4661.00
228_K232_E1.4631.00
287_L291_L1.4571.00
156_A160_L1.4491.00
141_E286_K1.4471.00
5_Y28_A1.4451.00
256_V260_H1.4431.00
178_C223_H1.4331.00
204_P268_A1.4311.00
219_F302_G1.4191.00
14_I181_N1.4091.00
21_L224_C1.4031.00
76_D118_K1.3991.00
284_A288_K1.3951.00
105_T158_S1.3921.00
113_L169_H1.3901.00
95_E99_T1.3881.00
129_Y241_N1.3831.00
151_Y155_K1.3781.00
176_T227_I1.3751.00
119_K174_I1.3651.00
80_H105_T1.3561.00
81_F123_I1.3511.00
229_L233_K1.3511.00
79_I227_I1.3441.00
252_E255_S1.3381.00
123_I178_C1.3351.00
78_V112_V1.3291.00
145_L156_A1.3211.00
220_A224_C1.3201.00
19_T32_V1.3111.00
179_S282_I1.3091.00
101_N154_S1.3081.00
64_Q107_R1.3031.00
68_D115_G1.3011.00
28_A232_E1.2801.00
25_E28_A1.2681.00
251_K269_H1.2601.00
160_L163_L1.2491.00
198_H203_L1.2481.00
218_L223_H1.2371.00
20_K185_Y1.2301.00
10_G19_T1.2201.00
301_E304_A1.2181.00
206_P268_A1.2151.00
108_L120_L1.2051.00
64_Q68_D1.2041.00
66_D69_R1.2001.00
177_R239_V1.1961.00
301_E305_R1.1931.00
214_I247_E1.1891.00
216_D245_G1.1781.00
110_E113_L1.1651.00
122_H158_S1.1591.00
109_A165_Y1.1511.00
22_M228_K1.1501.00
61_I104_G1.1461.00
140_T283_N1.1461.00
11_A34_D1.1391.00
163_L175_I1.1291.00
110_E114_K1.1171.00
5_Y22_M1.1151.00
284_A295_Q1.1081.00
23_L54_F1.1071.00
71_F75_Y1.1071.00
159_D177_R1.1061.00
153_A157_S1.1011.00
72_D115_G1.0971.00
61_I82_A1.0961.00
112_V120_L1.0901.00
69_R72_D1.0861.00
13_F183_G1.0801.00
71_F78_V1.0781.00
17_T221_E1.0761.00
20_K24_R1.0751.00
6_L33_L1.0751.00
248_R299_F1.0741.00
21_L221_E1.0731.00
226_A287_L1.0721.00
238_E290_E1.0691.00
172_P236_D1.0661.00
32_V54_F1.0651.00
121_I176_T1.0651.00
163_L239_V1.0601.00
136_D140_T1.0591.00
122_H162_V1.0571.00
166_V173_A1.0531.00
286_K290_E1.0471.00
161_L164_S1.0431.00
136_D143_T1.0341.00
177_R241_N1.0291.00
139_F143_T1.0291.00
212_L251_K1.0281.00
258_L264_E1.0261.00
142_T286_K1.0241.00
81_F227_I1.0231.00
225_R293_W1.0121.00
219_F222_D1.0111.00
68_D72_D1.0071.00
222_D244_G1.0041.00
109_A120_L1.0031.00
5_Y77_G0.9941.00
182_Y219_F0.9931.00
122_H175_I0.9911.00
4_S76_D0.9901.00
204_P266_L0.9901.00
255_S258_L0.9901.00
191_M195_I0.9821.00
163_L173_A0.9791.00
16_L185_Y0.9791.00
300_E304_A0.9771.00
23_L53_R0.9751.00
17_T220_A0.9631.00
100_T104_G0.9621.00
4_S75_Y0.9601.00
164_S168_T0.9561.00
212_L249_T0.9551.00
112_V117_A0.9511.00
260_H307_I0.9491.00
84_E100_T0.9491.00
181_N223_H0.9431.00
243_G282_I0.9341.00
247_E279_R0.9341.00
8_T82_A0.9331.00
111_A115_G0.9311.00
261_L307_I0.9301.00
13_F220_A0.9291.00
247_E281_A0.9241.00
240_Y286_K0.9231.00
107_R110_E0.9231.00
229_L291_L0.9221.00
174_I230_I0.9221.00
97_F154_S0.9181.00
120_L162_V0.9161.00
33_L67_I0.9091.00
98_I102_V0.9061.00
124_S159_D0.9031.00
113_L171_L0.9011.00
67_I111_A0.8991.00
103_M107_R0.8981.00
57_V70_A0.8881.00
8_T108_L0.8871.00
65_E68_D0.8851.00
214_I249_T0.8841.00
36_L39_A0.8841.00
71_F111_A0.8811.00
163_L167_K0.8791.00
65_E69_R0.8791.00
31_T74_T0.8781.00
181_N218_L0.8771.00
248_R252_E0.8751.00
270_V273_R0.8721.00
66_D70_A0.8711.00
18_F22_M0.8711.00
197_R200_K0.8701.00
35_K60_D0.8701.00
109_A162_V0.8691.00
271_E274_K0.8671.00
4_S28_A0.8651.00
5_Y79_I0.8631.00
243_G284_A0.8551.00
226_A293_W0.8541.00
109_A161_L0.8461.00
27_D30_I0.8411.00
260_H303_I0.8411.00
17_T20_K0.8371.00
23_L30_I0.8351.00
190_K193_P0.8321.00
176_T242_I0.8311.00
19_T30_I0.8311.00
102_V157_S0.8301.00
98_I103_M0.8301.00
126_D179_S0.8301.00
230_I291_L0.8281.00
175_I239_V0.8251.00
111_A114_K0.8251.00
34_D56_F0.8241.00
37_T58_K0.8221.00
214_I279_R0.8171.00
229_L232_E0.8141.00
71_F115_G0.8131.00
64_Q114_K0.8101.00
33_L70_A0.8071.00
28_A76_D0.8051.00
36_L58_K0.8031.00
77_G119_K0.8021.00
260_H300_E0.8021.00
157_S160_L0.8021.00
235_T238_E0.7991.00
17_T21_L0.7971.00
258_L263_C0.7911.00
225_R228_K0.7871.00
194_T198_H0.7871.00
33_L66_D0.7861.00
5_Y231_L0.7801.00
118_K172_P0.7771.00
107_R111_A0.7761.00
194_T197_R0.7741.00
17_T224_C0.7701.00
230_I287_L0.7701.00
62_S100_T0.7691.00
211_G251_K0.7691.00
255_S259_K0.7591.00
105_T162_V0.7571.00
245_G284_A0.7561.00
248_R253_L0.7541.00
71_F112_V0.7521.00
6_L59_G0.7501.00
285_S288_K0.7491.00
235_T290_E0.7461.00
128_V159_D0.7451.00
14_I223_H0.7441.00
229_L292_G0.7431.00
18_F227_I0.7381.00
78_V108_L0.7381.00
147_P152_S0.7341.00
105_T109_A0.7341.00
113_L170_K0.7341.00
165_Y169_H0.7331.00
84_E96_P0.7291.00
141_E287_L0.7251.00
94_A153_A0.7211.00
199_A258_L0.7191.00
184_P305_R0.7151.00
229_L293_W0.7131.00
98_I154_S0.7131.00
96_P99_T0.7081.00
252_E256_V0.7071.00
80_H108_L0.7071.00
137_P143_T0.7051.00
160_L164_S0.7041.00
179_S243_G0.7001.00
104_G107_R0.6991.00
110_E165_Y0.6941.00
91_I150_P0.6931.00
206_P270_V0.6901.00
242_I287_L0.6901.00
84_E97_F0.6891.00
78_V120_L0.6871.00
246_N298_T0.6851.00
22_M231_L0.6841.00
128_V145_L0.6771.00
196_I200_K0.6761.00
60_D63_V0.6751.00
216_D244_G0.6751.00
126_D282_I0.6741.00
267_F270_V0.6741.00
138_A283_N0.6731.00
51_N54_F0.6661.00
125_T155_K0.6631.00
84_E101_N0.6621.00
16_L20_K0.6611.00
6_L78_V0.6611.00
256_V299_F0.6601.00
157_S161_L0.6591.00
222_D225_R0.6591.00
90_S97_F0.6581.00
266_L269_H0.6581.00
63_V67_I0.6571.00
149_N152_S0.6531.00
184_P219_F0.6531.00
253_L299_F0.6501.00
268_A271_E0.6491.00
4_S74_T0.6481.00
158_S162_V0.6461.00
288_K295_Q0.6441.00
29_R53_R0.6421.00
277_D280_Y0.6411.00
178_C181_N0.6371.00
224_C228_K0.6361.00
67_I107_R0.6351.00
154_S158_S0.6351.00
96_P100_T0.6341.00
147_P156_A0.6301.00
196_I307_I0.6301.00
180_N215_R0.6281.00
258_L265_E0.6271.00
25_E225_R0.6231.00
141_E241_N0.6201.00
196_I257_I0.6201.00
153_A160_L0.6191.00
113_L165_Y0.6191.00
133_K136_D0.6161.00
222_D296_E0.6151.00
132_L139_F0.6141.00
133_K143_T0.6131.00
213_Q250_N0.6081.00
98_I153_A0.6061.00
83_A101_N0.6051.00
25_E229_L0.6041.00
28_A77_G0.6041.00
101_N151_Y0.6021.00
216_D247_E0.6021.00
67_I71_F0.5981.00
77_G118_K0.5981.00
287_L290_E0.5981.00
6_L70_A0.5961.00
173_A237_G0.5911.00
125_T128_V0.5911.00
162_V175_I0.5911.00
105_T122_H0.5901.00
121_I231_L0.5881.00
94_A150_P0.5851.00
150_P153_A0.5821.00
153_A164_S0.5811.00
176_T226_A0.5801.00
202_G205_V0.5801.00
138_A281_A0.5791.00
6_L71_F0.5781.00
150_P154_S0.5781.00
246_N300_E0.5761.00
57_V66_D0.5721.00
214_I281_A0.5701.00
77_G121_I0.5671.00
130_G146_S0.5671.00
190_K194_T0.5661.00
80_H120_L0.5631.00
161_L165_Y0.5631.00
121_I227_I0.5601.00
127_E152_S0.5601.00
184_P188_S0.5591.00
193_P197_R0.5571.00
151_Y154_S0.5561.00
32_V56_F0.5561.00
155_K158_S0.5551.00
128_V177_R0.5551.00
258_L261_L0.5551.00
17_T185_Y0.5551.00
81_F178_C0.5511.00
254_A258_L0.5501.00
164_S167_K0.5501.00
248_R256_V0.5481.00
296_E301_E0.5461.00
182_Y244_G0.5461.00
121_I230_I0.5461.00
11_A36_L0.5461.00
223_H242_I0.5451.00
207_L269_H0.5411.00
256_V303_I0.5401.00
20_K221_E0.5391.00
31_T70_A0.5381.00
19_T23_L0.5371.00
70_A75_Y0.5361.00
199_A205_V0.5361.00
202_G263_C0.5341.00
184_P221_E0.5331.00
112_V115_G0.5311.00
140_T285_S0.5311.00
145_L160_L0.5311.00
18_F228_K0.5241.00
179_S216_D0.5241.00
219_F306_T0.5211.00
270_V274_K0.5191.00
240_Y287_L0.5191.00
36_L40_S0.5181.00
123_I176_T0.5171.00
7_I22_M0.5161.00
228_K231_L0.5151.00
192_I195_I0.5111.00
11_A32_V0.5101.00
195_I199_A0.5101.00
302_G305_R0.5091.00
145_L239_V0.5081.00
183_G220_A0.5071.00
109_A113_L0.5061.00
287_L295_Q0.5061.00
27_D53_R0.5041.00
234_G237_G0.5021.00
9_G12_G0.5001.00
174_I240_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sb8A 2 0.9841 100 0.173 Contact Map
3rufA 2 0.981 100 0.174 Contact Map
2hunA 2 0.9905 100 0.183 Contact Map
1orrA 3 0.9746 100 0.188 Contact Map
3m2pA 2 0.927 100 0.188 Contact Map
1oc2A 2 0.9841 100 0.191 Contact Map
1rpnA 4 0.9841 100 0.192 Contact Map
2q1sA 2 0.9397 100 0.192 Contact Map
1r6dA 2 0.9841 100 0.195 Contact Map
4wkgA 5 0.9714 100 0.196 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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