GREMLIN Database
RMLA - Glucose-1-phosphate thymidylyltransferase
UniProt: P39629 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 246 (229)
Sequences: 22970 (14480)
Seq/√Len: 956.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_K185_E3.4061.00
31_Y39_M3.0141.00
35_Y64_L2.6721.00
146_E155_R2.6201.00
146_E156_S2.6131.00
127_K211_T2.5211.00
48_D74_T2.4791.00
84_S88_D2.4491.00
135_E167_N2.3521.00
148_D153_R2.3471.00
58_M62_Y2.3311.00
183_Y207_N2.2751.00
135_E214_V2.2031.00
48_D76_T2.2021.00
133_L212_Y2.1471.00
101_S177_D2.1461.00
183_Y203_L2.1231.00
122_F130_K2.0911.00
148_D155_R2.0371.00
3_G46_I2.0271.00
53_S58_M2.0021.00
127_K209_Q1.9641.00
3_G41_L1.9611.00
38_I49_I1.9311.00
153_R211_T1.9301.00
58_M79_V1.8921.00
91_S94_K1.8891.00
203_L207_N1.8831.00
78_Q92_Y1.8121.00
202_N206_E1.7921.00
101_S123_E1.7731.00
7_A51_L1.7621.00
15_M19_K1.7191.00
121_R213_D1.7161.00
41_L105_L1.7071.00
90_L104_L1.6991.00
125_Q211_T1.6991.00
59_P63_K1.6891.00
35_Y39_M1.6801.00
4_V93_A1.6691.00
168_L214_V1.6611.00
116_K120_E1.6461.00
146_E166_T1.6451.00
156_S202_N1.6421.00
220_V230_L1.6421.00
128_G177_D1.6091.00
21_V27_P1.5871.00
21_V60_Q1.5801.00
147_I168_L1.5661.00
203_L206_E1.5561.00
50_L96_F1.5381.00
150_K153_R1.5371.00
154_I210_L1.5361.00
76_T96_F1.5281.00
32_P35_Y1.5061.00
138_D141_R1.5051.00
62_Y79_V1.5031.00
42_Q73_V1.4861.00
154_I212_Y1.4741.00
50_L78_Q1.4461.00
97_T102_F1.4311.00
199_D202_N1.4301.00
88_D92_Y1.3931.00
228_L232_S1.3901.00
117_P120_E1.3871.00
49_I73_V1.3851.00
60_Q63_K1.3741.00
68_G71_L1.3491.00
188_S191_K1.3401.00
121_R125_Q1.3261.00
145_A154_I1.3231.00
120_E124_Q1.3161.00
133_L145_A1.3161.00
25_L60_Q1.3151.00
153_R209_Q1.2991.00
229_Y233_Q1.2971.00
160_K164_P1.2741.00
129_A176_Y1.2651.00
100_E178_A1.2521.00
91_S185_E1.2441.00
218_W234_L1.2401.00
102_F178_A1.2231.00
186_Q203_L1.2191.00
146_E158_I1.2141.00
57_H60_Q1.2131.00
224_T227_S1.1901.00
101_S178_A1.1831.00
179_E182_S1.1811.00
53_S62_Y1.1811.00
147_I212_Y1.1781.00
66_G77_Y1.1651.00
128_G209_Q1.1641.00
106_L172_G1.1601.00
222_A231_A1.1521.00
158_I165_P1.1431.00
53_S79_V1.1371.00
183_Y200_V1.1351.00
118_Y132_L1.1351.00
88_D91_S1.1291.00
50_L93_A1.1261.00
10_N83_A1.1231.00
117_P121_R1.1151.00
133_L168_L1.1141.00
148_D151_N1.1141.00
98_K101_S1.1141.00
114_S117_P1.1071.00
34_I65_L1.1051.00
220_V234_L1.1031.00
176_Y201_N1.1021.00
103_I175_M1.0921.00
118_Y175_M1.0901.00
227_S230_L1.0721.00
186_Q207_N1.0671.00
187_I191_K1.0621.00
25_L64_L1.0571.00
101_S175_M1.0571.00
53_S61_F1.0541.00
14_L26_L1.0471.00
53_S77_Y1.0341.00
50_L76_T1.0311.00
182_S185_E1.0181.00
33_M222_A1.0131.00
233_Q236_H1.0091.00
104_L176_Y1.0091.00
62_Y77_Y1.0081.00
46_I103_I1.0041.00
112_E218_W0.9981.00
210_L215_L0.9801.00
34_I51_L0.9771.00
85_G198_T0.9761.00
91_S184_I0.9741.00
8_G52_I0.9741.00
31_Y36_W0.9721.00
121_R211_T0.9681.00
143_G159_E0.9641.00
32_P64_L0.9611.00
4_V102_F0.9591.00
34_I61_F0.9521.00
170_V174_Y0.9491.00
182_S186_Q0.9471.00
140_E160_K0.9331.00
226_E230_L0.9301.00
5_I107_G0.9231.00
229_Y232_S0.9211.00
73_V76_T0.9201.00
35_Y68_G0.9181.00
31_Y35_Y0.9131.00
54_Q57_H0.9041.00
198_T202_N0.9031.00
105_L115_L0.8991.00
24_H107_G0.8991.00
121_R124_Q0.8931.00
59_P62_Y0.8921.00
39_M42_Q0.8881.00
183_Y186_Q0.8841.00
103_I119_T0.8781.00
122_F175_M0.8781.00
38_I65_L0.8741.00
141_R227_S0.8741.00
130_K134_K0.8601.00
73_V77_Y0.8571.00
39_M71_L0.8551.00
230_L233_Q0.8531.00
14_L18_T0.8531.00
94_K181_F0.8521.00
44_A116_K0.8521.00
27_P32_P0.8501.00
113_D116_K0.8481.00
33_M37_S0.8421.00
232_S236_H0.8361.00
201_N210_L0.8311.00
220_V231_A0.8271.00
78_Q96_F0.8121.00
144_I169_C0.8111.00
109_N219_W0.8101.00
155_R158_I0.7961.00
51_L75_I0.7931.00
126_G177_D0.7931.00
6_L106_L0.7921.00
43_E113_D0.7901.00
122_F177_D0.7891.00
120_E123_E0.7871.00
230_L234_L0.7861.00
42_Q49_I0.7801.00
211_T214_V0.7781.00
18_T26_L0.7741.00
86_I106_L0.7651.00
78_Q93_A0.7641.00
119_T123_E0.7621.00
42_Q47_K0.7551.00
62_Y66_G0.7501.00
36_W235_V0.7491.00
38_I75_I0.7491.00
29_G36_W0.7461.00
98_K178_A0.7441.00
156_S163_Q0.7431.00
130_K211_T0.7431.00
196_E200_V0.7401.00
47_K74_T0.7381.00
29_G232_S0.7381.00
99_K178_A0.7361.00
129_A210_L0.7361.00
26_L228_L0.7351.00
32_P36_W0.7341.00
46_I119_T0.7321.00
3_G49_I0.7311.00
51_L65_L0.7291.00
22_N60_Q0.7221.00
141_R160_K0.7161.00
179_E183_Y0.7141.00
187_I203_L0.7061.00
30_P36_W0.7031.00
118_Y213_D0.7021.00
157_I170_V0.7001.00
36_W39_M0.6991.00
131_V145_A0.6941.00
76_T79_V0.6921.00
40_K44_A0.6901.00
63_K66_G0.6901.00
129_A204_Y0.6901.00
200_V203_L0.6881.00
128_G179_E0.6871.00
90_L180_V0.6831.00
17_L21_V0.6811.00
119_T175_M0.6811.00
131_V136_V0.6751.00
133_L136_V0.6741.00
94_K182_S0.6731.00
4_V52_I0.6721.00
40_K113_D0.6701.00
110_I231_A0.6701.00
17_L225_H0.6671.00
158_I161_P0.6651.00
38_I73_V0.6631.00
42_Q74_T0.6621.00
147_I150_K0.6621.00
136_V139_P0.6601.00
68_G72_G0.6601.00
125_Q128_G0.6601.00
17_L20_A0.6581.00
127_K153_R0.6571.00
188_S195_L0.6561.00
125_Q130_K0.6521.00
43_E116_K0.6521.00
183_Y204_Y0.6501.00
229_Y236_H0.6461.00
146_E165_P0.6441.00
4_V50_L0.6421.00
225_H229_Y0.6391.00
35_Y65_L0.6351.00
97_T181_F0.6351.00
29_G235_V0.6341.00
117_P213_D0.6341.00
149_E153_R0.6281.00
192_R196_E0.6271.00
115_L122_F0.6271.00
179_E209_Q0.6241.00
168_L212_Y0.6241.00
38_I51_L0.6241.00
5_I105_L0.6231.00
191_K196_E0.6231.00
129_A133_L0.6091.00
131_V135_E0.6091.00
118_Y122_F0.6091.00
85_G199_D0.6081.00
94_K102_F0.6081.00
135_E168_L0.6061.00
119_T122_F0.6061.00
52_I89_G0.6051.00
129_A201_N0.6041.00
6_L86_I0.6031.00
99_K179_E0.6001.00
116_K119_T0.6001.00
91_S195_L0.5991.00
65_L75_I0.5991.00
141_R224_T0.5981.00
178_A181_F0.5971.00
83_A88_D0.5961.00
40_K43_E0.5941.00
13_R23_K0.5941.00
52_I93_A0.5931.00
180_V204_Y0.5901.00
39_M68_G0.5881.00
118_Y130_K0.5871.00
221_D227_S0.5861.00
193_G196_E0.5861.00
151_N214_V0.5851.00
156_S206_E0.5851.00
17_L26_L0.5821.00
53_S57_H0.5811.00
111_F171_T0.5801.00
11_G23_K0.5761.00
41_L103_I0.5751.00
106_L109_N0.5741.00
151_N155_R0.5741.00
22_N57_H0.5731.00
199_D203_L0.5721.00
54_Q83_A0.5701.00
82_A88_D0.5691.00
179_E207_N0.5681.00
37_S40_K0.5661.00
179_E208_S0.5641.00
226_E229_Y0.5621.00
27_P30_P0.5601.00
5_I37_S0.5601.00
53_S59_P0.5581.00
182_S207_N0.5561.00
25_L61_F0.5541.00
40_K173_I0.5541.00
128_G132_L0.5521.00
151_N211_T0.5521.00
85_G194_E0.5521.00
80_Q89_G0.5491.00
105_L173_I0.5421.00
103_I115_L0.5381.00
52_I78_Q0.5351.00
80_Q83_A0.5331.00
36_W40_K0.5311.00
133_L214_V0.5301.00
93_A96_F0.5301.00
10_N15_M0.5301.00
55_K58_M0.5301.00
145_A212_Y0.5301.00
90_L181_F0.5271.00
9_G13_R0.5271.00
194_E198_T0.5271.00
86_I170_V0.5261.00
37_S105_L0.5261.00
196_E199_D0.5231.00
39_M43_E0.5181.00
122_F213_D0.5151.00
134_K169_C0.5141.00
187_I200_V0.5131.00
51_L77_Y0.5111.00
28_V232_S0.5111.00
188_S192_R0.5101.00
42_Q72_G0.5071.00
58_M61_F0.5061.00
190_S193_G0.5051.00
7_A34_I0.5031.00
41_L46_I0.5031.00
130_K133_L0.5031.00
115_L118_Y0.5021.00
204_Y208_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3jukA 3 0.9634 100 0.259 Contact Map
2e3dA 3 0.9878 100 0.265 Contact Map
1iimA 3 0.9959 100 0.267 Contact Map
1lvwA 3 0.9959 100 0.267 Contact Map
4ho4A 3 0.9959 100 0.269 Contact Map
1mc3A 3 0.9959 100 0.274 Contact Map
2ux8A 4 0.9919 100 0.277 Contact Map
4ecmA 3 0.9878 100 0.289 Contact Map
2pa4A 3 0.9919 100 0.297 Contact Map
3brkX 2 0.9512 100 0.312 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0093 seconds.