GREMLIN Database
SPSG - Spore coat polysaccharide biosynthesis protein SpsG
UniProt: P39627 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 339 (299)
Sequences: 18616 (14987)
Seq/√Len: 866.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
188_Q295_I3.1551.00
310_S313_K3.0571.00
244_G260_V3.0401.00
274_F280_A2.8191.00
7_A10_G2.7531.00
27_G30_Q2.6551.00
5_I25_A2.5841.00
295_I299_S2.4561.00
308_R312_H2.4421.00
275_A282_D2.4201.00
27_G31_R2.4071.00
272_K276_D2.3971.00
260_V271_A2.3941.00
281_L300_R2.3891.00
259_L301_I2.3601.00
184_A291_D2.3511.00
240_A251_A2.3501.00
27_G325_I2.2481.00
251_A258_C2.2471.00
315_G319_V2.2261.00
35_T54_I2.2211.00
66_L94_T2.1641.00
309_L313_K2.1131.00
310_S314_G2.0981.00
43_E47_H2.0861.00
35_T72_K2.0551.00
285_L288_L2.0461.00
300_R304_S2.0431.00
79_F100_I2.0131.00
248_L274_F2.0091.00
300_R307_L1.9741.00
6_F10_G1.9281.00
281_L297_Q1.9261.00
314_G317_P1.8911.00
312_H315_G1.8751.00
67_R71_S1.8641.00
229_D232_G1.8531.00
176_K180_F1.8441.00
242_V258_C1.8251.00
115_D119_N1.7911.00
293_T297_Q1.7871.00
239_A301_I1.7421.00
307_L310_S1.7351.00
224_I227_T1.7281.00
121_I124_D1.7251.00
124_D127_S1.7241.00
299_S303_S1.7221.00
121_I125_I1.6851.00
322_K326_R1.6691.00
27_G324_I1.6591.00
122_Y125_I1.6561.00
313_K317_P1.6511.00
265_E268_T1.6201.00
311_L314_G1.6001.00
272_K275_A1.5951.00
121_I126_R1.5931.00
180_F184_A1.5911.00
167_L237_A1.5831.00
33_L52_Q1.5631.00
239_A298_M1.5551.00
116_A120_G1.5451.00
281_L307_L1.5341.00
122_Y126_R1.5301.00
240_A256_V1.4921.00
322_K325_I1.4891.00
240_A247_S1.4841.00
307_L311_L1.4791.00
188_Q291_D1.4761.00
165_N196_N1.4661.00
304_S307_L1.4221.00
181_K291_D1.4191.00
123_G126_R1.3991.00
166_I241_I1.3891.00
64_F67_R1.3881.00
235_K254_I1.3741.00
116_A119_N1.3601.00
259_L297_Q1.3591.00
255_G316_R1.3581.00
199_F202_G1.3481.00
189_V299_S1.3451.00
163_C196_N1.3351.00
166_I239_A1.3311.00
44_A48_E1.3181.00
316_R320_D1.3161.00
4_G74_L1.3131.00
3_V28_L1.3091.00
305_Y309_L1.2961.00
4_G37_Y1.2951.00
185_A295_I1.2821.00
291_D295_I1.2821.00
314_G318_L1.2811.00
312_H316_R1.2771.00
296_Y300_R1.2731.00
210_A214_R1.2681.00
275_A281_L1.2681.00
115_D120_G1.2651.00
290_P293_T1.2491.00
160_K196_N1.2471.00
26_E49_E1.2471.00
121_I127_S1.2381.00
297_Q300_R1.2341.00
281_L301_I1.2271.00
273_T276_D1.2191.00
3_V10_G1.2101.00
274_F279_A1.2091.00
3_V6_F1.2021.00
123_G127_S1.1981.00
209_E212_R1.1981.00
117_V120_G1.1981.00
122_Y127_S1.1921.00
15_M19_V1.1821.00
67_R70_K1.1761.00
268_T285_L1.1761.00
211_V214_R1.1751.00
25_A51_W1.1681.00
26_E51_W1.1661.00
313_K316_R1.1591.00
3_V76_L1.1551.00
63_E66_L1.1531.00
188_Q292_E1.1521.00
268_T272_K1.1421.00
77_L92_I1.1411.00
40_Q55_V1.1411.00
165_N198_M1.1401.00
115_D118_I1.1351.00
320_D326_R1.1331.00
44_A47_H1.1311.00
154_R157_Y1.1271.00
63_E67_R1.1261.00
153_A156_D1.1211.00
293_T296_Y1.1141.00
21_M36_F1.1121.00
26_E29_K1.1121.00
16_G20_R1.1071.00
124_D128_R1.0961.00
66_L70_K1.0951.00
181_K184_A1.0801.00
316_R319_V1.0721.00
184_A187_D1.0711.00
3_V7_A1.0571.00
309_L312_H1.0561.00
189_V195_K1.0561.00
153_A157_Y1.0491.00
89_L100_I1.0431.00
279_A314_G1.0421.00
165_N237_A1.0401.00
122_Y128_R1.0291.00
255_G311_L1.0281.00
301_I307_L1.0271.00
283_L297_Q1.0261.00
181_K185_A1.0191.00
272_K282_D1.0181.00
76_L101_V1.0181.00
218_K221_Y1.0171.00
164_R238_D1.0141.00
5_I78_L1.0131.00
114_S118_I1.0111.00
138_Y141_P1.0081.00
185_A294_L1.0081.00
161_K196_N1.0021.00
125_I128_R1.0001.00
64_F68_E0.9981.00
50_H53_V0.9971.00
167_L229_D0.9921.00
90_K94_T0.9921.00
90_K93_K0.9881.00
306_P309_L0.9851.00
38_T42_S0.9841.00
19_V226_Q0.9841.00
307_L314_G0.9831.00
119_N122_Y0.9801.00
149_A152_A0.9751.00
195_K299_S0.9741.00
252_I279_A0.9721.00
4_G7_A0.9721.00
292_E296_Y0.9681.00
167_L233_L0.9631.00
31_R325_I0.9601.00
5_I21_M0.9561.00
260_V280_A0.9521.00
260_V274_F0.9521.00
273_T277_Q0.9511.00
306_P310_S0.9501.00
91_K94_T0.9461.00
114_S119_N0.9441.00
255_G315_G0.9411.00
4_G69_I0.9391.00
114_S117_V0.9361.00
288_L293_T0.9351.00
147_H150_F0.9341.00
148_P152_A0.9261.00
259_L281_L0.9191.00
278_G310_S0.9161.00
68_E72_K0.9161.00
59_L62_H0.9081.00
151_Q156_D0.9061.00
197_M200_V0.9031.00
227_T233_L0.8931.00
54_I71_S0.8921.00
185_A189_V0.8891.00
196_N202_G0.8891.00
43_E53_V0.8891.00
6_F9_G0.8881.00
248_L270_T0.8861.00
68_E71_S0.8821.00
174_D178_L0.8811.00
151_Q157_Y0.8791.00
308_R314_G0.8781.00
241_I261_L0.8721.00
198_M201_M0.8701.00
201_M204_A0.8661.00
120_G125_I0.8651.00
114_S120_G0.8631.00
244_G271_A0.8581.00
253_C319_V0.8571.00
69_I72_K0.8561.00
305_Y308_R0.8551.00
271_A282_D0.8541.00
198_M202_G0.8511.00
26_E30_Q0.8501.00
151_Q155_E0.8491.00
46_L53_V0.8441.00
29_K51_W0.8391.00
167_L200_V0.8391.00
258_C280_A0.8381.00
308_R315_G0.8371.00
311_L315_G0.8351.00
118_I126_R0.8311.00
46_L51_W0.8311.00
120_G126_R0.8301.00
169_A247_S0.8281.00
196_N222_K0.8281.00
48_E51_W0.8271.00
35_T52_Q0.8271.00
102_L105_E0.8251.00
241_I294_L0.8221.00
221_Y224_I0.8191.00
163_C194_D0.8171.00
57_P64_F0.8141.00
179_I201_M0.8131.00
39_N42_S0.8131.00
175_P179_I0.8121.00
131_V134_N0.8081.00
91_K96_T0.8081.00
177_Q180_F0.8031.00
307_L315_G0.8021.00
180_F210_A0.7991.00
198_M233_L0.7981.00
308_R311_L0.7941.00
52_Q55_V0.7931.00
29_K34_I0.7861.00
137_I141_P0.7861.00
210_A213_R0.7861.00
152_A156_D0.7761.00
141_P145_I0.7721.00
26_E149_A0.7721.00
167_L234_M0.7721.00
209_E213_R0.7711.00
289_V294_L0.7681.00
248_L258_C0.7641.00
202_G205_S0.7641.00
269_A272_K0.7641.00
199_F203_S0.7631.00
22_K26_E0.7571.00
198_M222_K0.7561.00
152_A155_E0.7561.00
267_Q270_T0.7561.00
23_R26_E0.7501.00
130_Y133_G0.7501.00
182_V185_A0.7491.00
165_N236_Q0.7461.00
252_I311_L0.7441.00
147_H151_Q0.7441.00
66_L96_T0.7411.00
43_E55_V0.7381.00
17_H80_D0.7361.00
40_Q57_P0.7351.00
237_A256_V0.7321.00
242_V247_S0.7291.00
203_S225_E0.7281.00
123_G128_R0.7261.00
38_T53_V0.7251.00
174_D179_I0.7221.00
315_G318_L0.7211.00
170_L173_S0.7191.00
201_M206_P0.7181.00
261_L289_V0.7121.00
183_L199_F0.7111.00
178_L182_V0.7111.00
121_I128_R0.7081.00
196_N199_F0.7071.00
206_P225_E0.7061.00
181_K289_V0.7061.00
20_R246_I0.7051.00
195_K202_G0.7051.00
296_Y299_S0.7001.00
169_A230_M0.7001.00
185_A298_M0.6991.00
186_A197_M0.6961.00
77_L98_A0.6951.00
116_A122_Y0.6931.00
152_A157_Y0.6931.00
164_R302_M0.6921.00
149_A155_E0.6891.00
177_Q286_G0.6881.00
79_F86_A0.6851.00
258_C274_F0.6841.00
230_M254_I0.6841.00
146_L150_F0.6811.00
158_T161_K0.6731.00
318_L321_G0.6731.00
145_I149_A0.6711.00
146_L149_A0.6701.00
185_A291_D0.6701.00
64_F72_K0.6691.00
323_G326_R0.6671.00
234_M240_A0.6661.00
47_H53_V0.6651.00
196_N200_V0.6631.00
137_I140_G0.6621.00
52_Q72_K0.6581.00
55_V58_E0.6561.00
50_H55_V0.6531.00
194_D299_S0.6521.00
65_I72_K0.6501.00
73_K98_A0.6481.00
252_I274_F0.6481.00
119_N125_I0.6461.00
198_M203_S0.6451.00
137_I326_R0.6431.00
201_M205_S0.6381.00
189_V295_I0.6381.00
187_D220_Q0.6361.00
151_Q154_R0.6361.00
234_M256_V0.6351.00
48_E228_N0.6341.00
49_E52_Q0.6341.00
145_I148_P0.6331.00
242_V251_A0.6331.00
168_V186_A0.6321.00
200_V204_A0.6311.00
230_M250_E0.6311.00
35_T74_L0.6311.00
94_T97_D0.6311.00
200_V203_S0.6271.00
242_V260_V0.6231.00
112_Q117_V0.6221.00
321_G326_R0.6191.00
5_I8_D0.6151.00
242_V248_L0.6141.00
54_I58_E0.6131.00
65_I68_E0.6101.00
106_K111_I0.6091.00
164_R305_Y0.6071.00
183_L187_D0.6041.00
146_L253_C0.6041.00
112_Q115_D0.6031.00
255_G312_H0.6031.00
7_A21_M0.6031.00
92_I100_I0.6011.00
45_F48_E0.5991.00
162_D165_N0.5981.00
120_G124_D0.5971.00
232_G235_K0.5921.00
47_H52_Q0.5911.00
43_E46_L0.5901.00
47_H50_H0.5881.00
28_L32_C0.5871.00
135_T139_E0.5871.00
25_A34_I0.5861.00
262_S282_D0.5861.00
262_S271_A0.5861.00
116_A121_I0.5841.00
168_V241_I0.5811.00
259_L298_M0.5801.00
111_I114_S0.5801.00
243_A267_Q0.5791.00
130_Y134_N0.5771.00
37_Y65_I0.5711.00
251_A260_V0.5681.00
179_I185_A0.5681.00
54_I57_P0.5651.00
159_L165_N0.5651.00
150_F154_R0.5651.00
198_M237_A0.5651.00
131_V141_P0.5631.00
195_K198_M0.5631.00
126_R129_V0.5621.00
119_N123_G0.5591.00
147_H152_A0.5581.00
229_D234_M0.5581.00
272_K277_Q0.5571.00
119_N124_D0.5561.00
36_F51_W0.5551.00
229_D250_E0.5551.00
148_P153_A0.5491.00
163_C220_Q0.5481.00
174_D182_V0.5471.00
83_G86_A0.5451.00
66_L72_K0.5441.00
195_K200_V0.5441.00
278_G306_P0.5431.00
197_M202_G0.5411.00
34_I51_W0.5401.00
89_L93_K0.5391.00
278_G314_G0.5381.00
244_G248_L0.5371.00
106_K110_S0.5361.00
118_I122_Y0.5361.00
24_L78_L0.5351.00
203_S206_P0.5331.00
255_G319_V0.5331.00
185_A188_Q0.5331.00
93_K97_D0.5311.00
112_Q120_G0.5301.00
40_Q43_E0.5301.00
292_E295_I0.5281.00
232_G236_Q0.5271.00
184_A188_Q0.5251.00
51_W59_L0.5251.00
271_A275_A0.5251.00
125_I129_V0.5231.00
177_Q181_K0.5231.00
30_Q325_I0.5221.00
81_I84_A0.5221.00
4_G9_G0.5221.00
239_A259_L0.5211.00
311_L318_L0.5201.00
146_L156_D0.5201.00
166_I197_M0.5201.00
149_A156_D0.5151.00
289_V293_T0.5141.00
200_V227_T0.5131.00
80_D105_E0.5131.00
182_V186_A0.5131.00
21_M80_D0.5121.00
54_I68_E0.5121.00
54_I72_K0.5111.00
146_L151_Q0.5111.00
226_Q229_D0.5111.00
82_L265_E0.5101.00
120_G123_G0.5071.00
169_A173_S0.5061.00
145_I150_F0.5031.00
195_K302_M0.5031.00
168_V197_M0.5011.00
51_W57_P0.5001.00
119_N126_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2iyaA 1 0.9322 100 0.365 Contact Map
3rscA 1 0.9351 100 0.37 Contact Map
2iyfA 1 0.9351 100 0.379 Contact Map
2p6pA 2 0.9233 100 0.38 Contact Map
3ia7A 2 0.9292 100 0.386 Contact Map
1rrvA 1 0.9233 100 0.389 Contact Map
2vchA 1 0.9528 100 0.389 Contact Map
3otiA 2 0.9056 100 0.398 Contact Map
2yjnA 2 0.9233 100 0.398 Contact Map
3wadA 2 0.9469 100 0.399 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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