SPSG - BACSU - GREMLIN Contacts

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SPSG - Spore coat polysaccharide biosynthesis protein SpsG

UniProt:	P39627	Sequences: MHVGIFADGGYEKGMGHVVRMKRLAEGLKQRCLITFYTNQDSEAFLHEEHWQVIVKPELQQHEFILREIKSKKLDLLLFDILGAPAELLKKIKTETDAKIVLFEEKNGKSIQYSDAVINGIYGDIRSRVYVQGNTRIYEGPDYLILHPAFQAAREDYTLKKDCRNILVALGGSDPKQLIFKVLAAADQVPDIKDKNMMFVMGSASPHQEAVRRRIEKKPQYKMIEQTNDMAGLMKQADAAIVAGGISLYEAICIGVPCLVLSQVEHQTATAKTFADQGAALDLGLGELVPDETLIYQMSRIMSSYPLRLSLHKGGRPLVDGKGIIRVTAILQDLYEQEI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	339 (299)
Sequences:	18616 (14987)
Seq/√Len:	866.7

ECOLI - MURG
BACSU - SPSG MURG YJIC YDHE YOJK UGTP YKON
SULSO - Q97VW9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
188_Q	295_I	3.155	1.00
310_S	313_K	3.057	1.00
244_G	260_V	3.040	1.00
274_F	280_A	2.819	1.00
7_A	10_G	2.753	1.00
27_G	30_Q	2.655	1.00
5_I	25_A	2.584	1.00
295_I	299_S	2.456	1.00
308_R	312_H	2.442	1.00
275_A	282_D	2.420	1.00
27_G	31_R	2.407	1.00
272_K	276_D	2.397	1.00
260_V	271_A	2.394	1.00
281_L	300_R	2.389	1.00
259_L	301_I	2.360	1.00
184_A	291_D	2.351	1.00
240_A	251_A	2.350	1.00
27_G	325_I	2.248	1.00
251_A	258_C	2.247	1.00
315_G	319_V	2.226	1.00
35_T	54_I	2.221	1.00
66_L	94_T	2.164	1.00
309_L	313_K	2.113	1.00
310_S	314_G	2.098	1.00
43_E	47_H	2.086	1.00
35_T	72_K	2.055	1.00
285_L	288_L	2.046	1.00
300_R	304_S	2.043	1.00
79_F	100_I	2.013	1.00
248_L	274_F	2.009	1.00
300_R	307_L	1.974	1.00
6_F	10_G	1.928	1.00
281_L	297_Q	1.926	1.00
314_G	317_P	1.891	1.00
312_H	315_G	1.875	1.00
67_R	71_S	1.864	1.00
229_D	232_G	1.853	1.00
176_K	180_F	1.844	1.00
242_V	258_C	1.825	1.00
115_D	119_N	1.791	1.00
293_T	297_Q	1.787	1.00
239_A	301_I	1.742	1.00
307_L	310_S	1.735	1.00
224_I	227_T	1.728	1.00
121_I	124_D	1.725	1.00
124_D	127_S	1.724	1.00
299_S	303_S	1.722	1.00
121_I	125_I	1.685	1.00
322_K	326_R	1.669	1.00
27_G	324_I	1.659	1.00
122_Y	125_I	1.656	1.00
313_K	317_P	1.651	1.00
265_E	268_T	1.620	1.00
311_L	314_G	1.600	1.00
272_K	275_A	1.595	1.00
121_I	126_R	1.593	1.00
180_F	184_A	1.591	1.00
167_L	237_A	1.583	1.00
33_L	52_Q	1.563	1.00
239_A	298_M	1.555	1.00
116_A	120_G	1.545	1.00
281_L	307_L	1.534	1.00
122_Y	126_R	1.530	1.00
240_A	256_V	1.492	1.00
322_K	325_I	1.489	1.00
240_A	247_S	1.484	1.00
307_L	311_L	1.479	1.00
188_Q	291_D	1.476	1.00
165_N	196_N	1.466	1.00
304_S	307_L	1.422	1.00
181_K	291_D	1.419	1.00
123_G	126_R	1.399	1.00
166_I	241_I	1.389	1.00
64_F	67_R	1.388	1.00
235_K	254_I	1.374	1.00
116_A	119_N	1.360	1.00
259_L	297_Q	1.359	1.00
255_G	316_R	1.358	1.00
199_F	202_G	1.348	1.00
189_V	299_S	1.345	1.00
163_C	196_N	1.335	1.00
166_I	239_A	1.331	1.00
44_A	48_E	1.318	1.00
316_R	320_D	1.316	1.00
4_G	74_L	1.313	1.00
3_V	28_L	1.309	1.00
305_Y	309_L	1.296	1.00
4_G	37_Y	1.295	1.00
185_A	295_I	1.282	1.00
291_D	295_I	1.282	1.00
314_G	318_L	1.281	1.00
312_H	316_R	1.277	1.00
296_Y	300_R	1.273	1.00
210_A	214_R	1.268	1.00
275_A	281_L	1.268	1.00
115_D	120_G	1.265	1.00
290_P	293_T	1.249	1.00
160_K	196_N	1.247	1.00
26_E	49_E	1.247	1.00
121_I	127_S	1.238	1.00
297_Q	300_R	1.234	1.00
281_L	301_I	1.227	1.00
273_T	276_D	1.219	1.00
3_V	10_G	1.210	1.00
274_F	279_A	1.209	1.00
3_V	6_F	1.202	1.00
123_G	127_S	1.198	1.00
209_E	212_R	1.198	1.00
117_V	120_G	1.198	1.00
122_Y	127_S	1.192	1.00
15_M	19_V	1.182	1.00
67_R	70_K	1.176	1.00
268_T	285_L	1.176	1.00
211_V	214_R	1.175	1.00
25_A	51_W	1.168	1.00
26_E	51_W	1.166	1.00
313_K	316_R	1.159	1.00
3_V	76_L	1.155	1.00
63_E	66_L	1.153	1.00
188_Q	292_E	1.152	1.00
268_T	272_K	1.142	1.00
77_L	92_I	1.141	1.00
40_Q	55_V	1.141	1.00
165_N	198_M	1.140	1.00
115_D	118_I	1.135	1.00
320_D	326_R	1.133	1.00
44_A	47_H	1.131	1.00
154_R	157_Y	1.127	1.00
63_E	67_R	1.126	1.00
153_A	156_D	1.121	1.00
293_T	296_Y	1.114	1.00
21_M	36_F	1.112	1.00
26_E	29_K	1.112	1.00
16_G	20_R	1.107	1.00
124_D	128_R	1.096	1.00
66_L	70_K	1.095	1.00
181_K	184_A	1.080	1.00
316_R	319_V	1.072	1.00
184_A	187_D	1.071	1.00
3_V	7_A	1.057	1.00
309_L	312_H	1.056	1.00
189_V	195_K	1.056	1.00
153_A	157_Y	1.049	1.00
89_L	100_I	1.043	1.00
279_A	314_G	1.042	1.00
165_N	237_A	1.040	1.00
122_Y	128_R	1.029	1.00
255_G	311_L	1.028	1.00
301_I	307_L	1.027	1.00
283_L	297_Q	1.026	1.00
181_K	185_A	1.019	1.00
272_K	282_D	1.018	1.00
76_L	101_V	1.018	1.00
218_K	221_Y	1.017	1.00
164_R	238_D	1.014	1.00
5_I	78_L	1.013	1.00
114_S	118_I	1.011	1.00
138_Y	141_P	1.008	1.00
185_A	294_L	1.008	1.00
161_K	196_N	1.002	1.00
125_I	128_R	1.000	1.00
64_F	68_E	0.998	1.00
50_H	53_V	0.997	1.00
167_L	229_D	0.992	1.00
90_K	94_T	0.992	1.00
90_K	93_K	0.988	1.00
306_P	309_L	0.985	1.00
38_T	42_S	0.984	1.00
19_V	226_Q	0.984	1.00
307_L	314_G	0.983	1.00
119_N	122_Y	0.980	1.00
149_A	152_A	0.975	1.00
195_K	299_S	0.974	1.00
252_I	279_A	0.972	1.00
4_G	7_A	0.972	1.00
292_E	296_Y	0.968	1.00
167_L	233_L	0.963	1.00
31_R	325_I	0.960	1.00
5_I	21_M	0.956	1.00
260_V	280_A	0.952	1.00
260_V	274_F	0.952	1.00
273_T	277_Q	0.951	1.00
306_P	310_S	0.950	1.00
91_K	94_T	0.946	1.00
114_S	119_N	0.944	1.00
255_G	315_G	0.941	1.00
4_G	69_I	0.939	1.00
114_S	117_V	0.936	1.00
288_L	293_T	0.935	1.00
147_H	150_F	0.934	1.00
148_P	152_A	0.926	1.00
259_L	281_L	0.919	1.00
278_G	310_S	0.916	1.00
68_E	72_K	0.916	1.00
59_L	62_H	0.908	1.00
151_Q	156_D	0.906	1.00
197_M	200_V	0.903	1.00
227_T	233_L	0.893	1.00
54_I	71_S	0.892	1.00
185_A	189_V	0.889	1.00
196_N	202_G	0.889	1.00
43_E	53_V	0.889	1.00
6_F	9_G	0.888	1.00
248_L	270_T	0.886	1.00
68_E	71_S	0.882	1.00
174_D	178_L	0.881	1.00
151_Q	157_Y	0.879	1.00
308_R	314_G	0.878	1.00
241_I	261_L	0.872	1.00
198_M	201_M	0.870	1.00
201_M	204_A	0.866	1.00
120_G	125_I	0.865	1.00
114_S	120_G	0.863	1.00
244_G	271_A	0.858	1.00
253_C	319_V	0.857	1.00
69_I	72_K	0.856	1.00
305_Y	308_R	0.855	1.00
271_A	282_D	0.854	1.00
198_M	202_G	0.851	1.00
26_E	30_Q	0.850	1.00
151_Q	155_E	0.849	1.00
46_L	53_V	0.844	1.00
29_K	51_W	0.839	1.00
167_L	200_V	0.839	1.00
258_C	280_A	0.838	1.00
308_R	315_G	0.837	1.00
311_L	315_G	0.835	1.00
118_I	126_R	0.831	1.00
46_L	51_W	0.831	1.00
120_G	126_R	0.830	1.00
169_A	247_S	0.828	1.00
196_N	222_K	0.828	1.00
48_E	51_W	0.827	1.00
35_T	52_Q	0.827	1.00
102_L	105_E	0.825	1.00
241_I	294_L	0.822	1.00
221_Y	224_I	0.819	1.00
163_C	194_D	0.817	1.00
57_P	64_F	0.814	1.00
179_I	201_M	0.813	1.00
39_N	42_S	0.813	1.00
175_P	179_I	0.812	1.00
131_V	134_N	0.808	1.00
91_K	96_T	0.808	1.00
177_Q	180_F	0.803	1.00
307_L	315_G	0.802	1.00
180_F	210_A	0.799	1.00
198_M	233_L	0.798	1.00
308_R	311_L	0.794	1.00
52_Q	55_V	0.793	1.00
29_K	34_I	0.786	1.00
137_I	141_P	0.786	1.00
210_A	213_R	0.786	1.00
152_A	156_D	0.776	1.00
141_P	145_I	0.772	1.00
26_E	149_A	0.772	1.00
167_L	234_M	0.772	1.00
209_E	213_R	0.771	1.00
289_V	294_L	0.768	1.00
248_L	258_C	0.764	1.00
202_G	205_S	0.764	1.00
269_A	272_K	0.764	1.00
199_F	203_S	0.763	1.00
22_K	26_E	0.757	1.00
198_M	222_K	0.756	1.00
152_A	155_E	0.756	1.00
267_Q	270_T	0.756	1.00
23_R	26_E	0.750	1.00
130_Y	133_G	0.750	1.00
182_V	185_A	0.749	1.00
165_N	236_Q	0.746	1.00
252_I	311_L	0.744	1.00
147_H	151_Q	0.744	1.00
66_L	96_T	0.741	1.00
43_E	55_V	0.738	1.00
17_H	80_D	0.736	1.00
40_Q	57_P	0.735	1.00
237_A	256_V	0.732	1.00
242_V	247_S	0.729	1.00
203_S	225_E	0.728	1.00
123_G	128_R	0.726	1.00
38_T	53_V	0.725	1.00
174_D	179_I	0.722	1.00
315_G	318_L	0.721	1.00
170_L	173_S	0.719	1.00
201_M	206_P	0.718	1.00
261_L	289_V	0.712	1.00
183_L	199_F	0.711	1.00
178_L	182_V	0.711	1.00
121_I	128_R	0.708	1.00
196_N	199_F	0.707	1.00
206_P	225_E	0.706	1.00
181_K	289_V	0.706	1.00
20_R	246_I	0.705	1.00
195_K	202_G	0.705	1.00
296_Y	299_S	0.700	1.00
169_A	230_M	0.700	1.00
185_A	298_M	0.699	1.00
186_A	197_M	0.696	1.00
77_L	98_A	0.695	1.00
116_A	122_Y	0.693	1.00
152_A	157_Y	0.693	1.00
164_R	302_M	0.692	1.00
149_A	155_E	0.689	1.00
177_Q	286_G	0.688	1.00
79_F	86_A	0.685	1.00
258_C	274_F	0.684	1.00
230_M	254_I	0.684	1.00
146_L	150_F	0.681	1.00
158_T	161_K	0.673	1.00
318_L	321_G	0.673	1.00
145_I	149_A	0.671	1.00
146_L	149_A	0.670	1.00
185_A	291_D	0.670	1.00
64_F	72_K	0.669	1.00
323_G	326_R	0.667	1.00
234_M	240_A	0.666	1.00
47_H	53_V	0.665	1.00
196_N	200_V	0.663	1.00
137_I	140_G	0.662	1.00
52_Q	72_K	0.658	1.00
55_V	58_E	0.656	1.00
50_H	55_V	0.653	1.00
194_D	299_S	0.652	1.00
65_I	72_K	0.650	1.00
73_K	98_A	0.648	1.00
252_I	274_F	0.648	1.00
119_N	125_I	0.646	1.00
198_M	203_S	0.645	1.00
137_I	326_R	0.643	1.00
201_M	205_S	0.638	1.00
189_V	295_I	0.638	1.00
187_D	220_Q	0.636	1.00
151_Q	154_R	0.636	1.00
234_M	256_V	0.635	1.00
48_E	228_N	0.634	1.00
49_E	52_Q	0.634	1.00
145_I	148_P	0.633	1.00
242_V	251_A	0.633	1.00
168_V	186_A	0.632	1.00
200_V	204_A	0.631	1.00
230_M	250_E	0.631	1.00
35_T	74_L	0.631	1.00
94_T	97_D	0.631	1.00
200_V	203_S	0.627	1.00
242_V	260_V	0.623	1.00
112_Q	117_V	0.622	1.00
321_G	326_R	0.619	1.00
5_I	8_D	0.615	1.00
242_V	248_L	0.614	1.00
54_I	58_E	0.613	1.00
65_I	68_E	0.610	1.00
106_K	111_I	0.609	1.00
164_R	305_Y	0.607	1.00
183_L	187_D	0.604	1.00
146_L	253_C	0.604	1.00
112_Q	115_D	0.603	1.00
255_G	312_H	0.603	1.00
7_A	21_M	0.603	1.00
92_I	100_I	0.601	1.00
45_F	48_E	0.599	1.00
162_D	165_N	0.598	1.00
120_G	124_D	0.597	1.00
232_G	235_K	0.592	1.00
47_H	52_Q	0.591	1.00
43_E	46_L	0.590	1.00
47_H	50_H	0.588	1.00
28_L	32_C	0.587	1.00
135_T	139_E	0.587	1.00
25_A	34_I	0.586	1.00
262_S	282_D	0.586	1.00
262_S	271_A	0.586	1.00
116_A	121_I	0.584	1.00
168_V	241_I	0.581	1.00
259_L	298_M	0.580	1.00
111_I	114_S	0.580	1.00
243_A	267_Q	0.579	1.00
130_Y	134_N	0.577	1.00
37_Y	65_I	0.571	1.00
251_A	260_V	0.568	1.00
179_I	185_A	0.568	1.00
54_I	57_P	0.565	1.00
159_L	165_N	0.565	1.00
150_F	154_R	0.565	1.00
198_M	237_A	0.565	1.00
131_V	141_P	0.563	1.00
195_K	198_M	0.563	1.00
126_R	129_V	0.562	1.00
119_N	123_G	0.559	1.00
147_H	152_A	0.558	1.00
229_D	234_M	0.558	1.00
272_K	277_Q	0.557	1.00
119_N	124_D	0.556	1.00
36_F	51_W	0.555	1.00
229_D	250_E	0.555	1.00
148_P	153_A	0.549	1.00
163_C	220_Q	0.548	1.00
174_D	182_V	0.547	1.00
83_G	86_A	0.545	1.00
66_L	72_K	0.544	1.00
195_K	200_V	0.544	1.00
278_G	306_P	0.543	1.00
197_M	202_G	0.541	1.00
34_I	51_W	0.540	1.00
89_L	93_K	0.539	1.00
278_G	314_G	0.538	1.00
244_G	248_L	0.537	1.00
106_K	110_S	0.536	1.00
118_I	122_Y	0.536	1.00
24_L	78_L	0.535	1.00
203_S	206_P	0.533	1.00
255_G	319_V	0.533	1.00
185_A	188_Q	0.533	1.00
93_K	97_D	0.531	1.00
112_Q	120_G	0.530	1.00
40_Q	43_E	0.530	1.00
292_E	295_I	0.528	1.00
232_G	236_Q	0.527	1.00
184_A	188_Q	0.525	1.00
51_W	59_L	0.525	1.00
271_A	275_A	0.525	1.00
125_I	129_V	0.523	1.00
177_Q	181_K	0.523	1.00
30_Q	325_I	0.522	1.00
81_I	84_A	0.522	1.00
4_G	9_G	0.522	1.00
239_A	259_L	0.521	1.00
311_L	318_L	0.520	1.00
146_L	156_D	0.520	1.00
166_I	197_M	0.520	1.00
149_A	156_D	0.515	1.00
289_V	293_T	0.514	1.00
200_V	227_T	0.513	1.00
80_D	105_E	0.513	1.00
182_V	186_A	0.513	1.00
21_M	80_D	0.512	1.00
54_I	68_E	0.512	1.00
54_I	72_K	0.511	1.00
146_L	151_Q	0.511	1.00
226_Q	229_D	0.511	1.00
82_L	265_E	0.510	1.00
120_G	123_G	0.507	1.00
169_A	173_S	0.506	1.00
145_I	150_F	0.503	1.00
195_K	302_M	0.503	1.00
168_V	197_M	0.501	1.00
51_W	57_P	0.500	1.00
119_N	126_R	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2iyaA	1	0.9322	100	0.365	Contact Map
3rscA	1	0.9351	100	0.37	Contact Map
2iyfA	1	0.9351	100	0.379	Contact Map
2p6pA	2	0.9233	100	0.38	Contact Map
3ia7A	2	0.9292	100	0.386	Contact Map
1rrvA	1	0.9233	100	0.389	Contact Map
2vchA	1	0.9528	100	0.389	Contact Map
3otiA	2	0.9056	100	0.398	Contact Map
2yjnA	2	0.9233	100	0.398	Contact Map
3wadA	2	0.9469	100	0.399	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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