GREMLIN Database
SPSE - Spore coat polysaccharide biosynthesis protein SpsE
UniProt: P39625 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 373 (331)
Sequences: 2124 (1647)
Seq/√Len: 90.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
177_A232_L4.0741.00
18_F104_I3.7821.00
95_L99_R3.5661.00
39_D101_K3.2651.00
312_I349_A3.2081.00
313_Q352_D2.9731.00
140_K341_E2.9601.00
39_D97_Y2.9301.00
116_D141_Y2.7601.00
119_Q126_F2.7471.00
75_V83_S2.7321.00
128_I142_V2.5361.00
339_F342_L2.5211.00
35_F93_P2.3161.00
18_F48_A2.3061.00
42_A101_K2.2761.00
195_S271_L2.2411.00
258_K262_D2.2341.00
314_K352_D2.2301.00
190_E269_A2.2191.00
308_T359_I2.2081.00
349_A353_I2.1991.00
35_F97_Y2.1471.00
198_P228_L2.1381.00
165_W176_I2.1361.00
149_M168_I2.0831.00
308_T312_I2.0701.00
316_E322_N2.0671.00
313_Q316_E2.0671.00
318_F322_N2.0281.00
53_M107_S2.0071.00
241_K253_N1.9871.00
92_L96_D1.9771.00
311_P354_P1.9681.00
351_R363_D1.9571.00
162_H166_R1.9561.00
326_L356_D1.9421.00
87_P90_W1.9321.00
310_A321_D1.9031.00
163_E338_R1.8871.00
306_I325_V1.8841.00
17_V268_E1.8611.00
58_R113_G1.8581.00
126_F147_R1.8181.00
136_L167_T1.8161.00
308_T353_I1.8121.00
220_E266_K1.8001.00
57_D78_F1.7851.00
312_I316_E1.7791.00
115_A141_Y1.7611.00
224_A267_T1.7481.00
140_K170_A1.7331.00
40_A43_E1.7321.00
318_F349_A1.7261.00
33_Q243_L1.7181.00
41_A237_F1.7131.00
38_I94_L1.7091.00
199_M203_A1.7051.00
97_Y101_K1.6891.00
159_S162_H1.6861.00
311_P355_A1.6861.00
139_L168_I1.6691.00
142_V149_M1.6591.00
97_Y100_E1.6431.00
222_P260_M1.6431.00
96_D100_E1.6371.00
162_H203_A1.6331.00
191_Y294_I1.6291.00
141_Y145_L1.6001.00
189_P266_K1.5921.00
162_H204_F1.5791.00
208_V231_K1.5631.00
150_I179_M1.5591.00
317_A348_R1.5551.00
192_S215_S1.5401.00
177_A208_V1.5061.00
265_R268_E1.5001.00
312_I322_N1.4801.00
119_Q145_L1.4761.00
57_D82_Q1.4600.99
19_I261_V1.4530.99
241_K256_E1.4480.99
159_S203_A1.4410.99
305_G328_P1.4400.99
61_Q326_L1.4380.99
112_E141_Y1.4340.99
115_A142_V1.4270.99
310_A322_N1.4240.99
20_I232_L1.4190.99
56_A85_E1.4050.99
221_A270_E1.3870.99
42_A103_V1.3830.99
178_I200_L1.3810.99
51_F105_F1.3610.99
259_E263_G1.3530.99
166_R170_A1.3290.99
140_K171_E1.3210.99
223_C267_T1.3200.99
43_E258_K1.3050.99
111_D114_S1.3020.99
293_A296_G1.2990.99
168_I173_N1.2940.99
178_I204_F1.2910.99
351_R357_T1.2830.99
46_A103_V1.2750.99
75_V79_S1.2750.99
79_S82_Q1.2740.99
36_A39_D1.2730.99
223_C263_G1.2660.99
237_F257_L1.2620.99
104_I125_A1.2610.99
316_E349_A1.2540.98
119_Q147_R1.2300.98
198_P201_A1.2250.98
264_I268_E1.2250.98
59_M81_V1.2190.98
23_A37_L1.2170.98
95_L105_F1.2150.98
98_C103_V1.2130.98
23_A49_V1.2050.98
43_E101_K1.2020.98
220_E224_A1.2020.98
36_A40_A1.1970.98
219_T252_L1.1920.98
62_K356_D1.1900.98
225_A230_A1.1810.98
273_Q290_T1.1790.98
133_I164_A1.1710.98
115_A145_L1.1600.97
151_F164_A1.1580.97
220_E263_G1.1570.97
62_K355_A1.1520.97
31_L35_F1.1510.97
28_D245_G1.1490.97
335_L361_W1.1390.97
104_I124_S1.1380.97
35_F94_L1.1340.97
107_S118_L1.1330.97
226_V264_I1.1270.97
133_I156_A1.1230.97
343_L359_I1.1170.97
40_A239_I1.1090.97
46_A257_L1.1050.97
177_A231_K1.1020.96
322_N349_A1.1010.96
306_I340_F1.0950.96
32_D36_A1.0900.96
60_Y81_V1.0870.96
17_V264_I1.0820.96
310_A316_E1.0810.96
201_A209_I1.0810.96
263_G266_K1.0800.96
307_F358_G1.0750.96
323_I343_L1.0720.96
224_A227_R1.0690.96
126_F142_V1.0680.96
309_T326_L1.0680.96
319_S322_N1.0640.96
47_D265_R1.0600.96
360_V363_D1.0580.96
196_V289_K1.0490.95
312_I353_I1.0420.95
179_M232_L1.0390.95
353_I363_D1.0350.95
308_T318_F1.0300.95
160_D163_E1.0180.95
16_P47_D1.0150.94
91_I95_L1.0130.94
240_D243_L1.0110.94
37_L237_F1.0100.94
158_I203_A0.9940.94
197_I209_I0.9920.94
98_C105_F0.9920.94
115_A126_F0.9890.94
106_L125_A0.9810.93
17_V226_V0.9790.93
56_A78_F0.9780.93
48_A104_I0.9760.93
82_Q85_E0.9730.93
40_A257_L0.9730.93
296_G299_R0.9720.93
93_P96_D0.9670.93
43_E254_P0.9640.93
187_A192_S0.9600.93
160_D303_Y0.9540.92
178_I207_A0.9510.92
312_I318_F0.9480.92
122_S147_R0.9420.92
150_I232_L0.9370.92
116_D145_L0.9370.92
33_Q36_A0.9370.92
88_A120_S0.9350.92
201_A231_K0.9320.92
184_K188_P0.9250.91
35_F39_D0.9190.91
137_P340_F0.9170.91
61_Q309_T0.9160.91
157_E291_T0.9150.91
48_A125_A0.9140.91
115_A138_L0.9090.90
16_P265_R0.9060.90
91_I117_L0.9020.90
93_P97_Y0.9010.90
307_F326_L0.9000.90
199_M289_K0.8870.89
144_R171_E0.8870.89
273_Q288_Y0.8850.89
188_P191_Y0.8850.89
211_F221_A0.8820.89
165_W178_I0.8810.89
308_T322_N0.8780.89
40_A44_A0.8780.89
193_N272_K0.8770.89
92_L120_S0.8770.89
228_L271_L0.8710.88
195_S198_P0.8690.88
237_F254_P0.8650.88
305_G329_G0.8630.88
31_L93_P0.8620.88
48_A106_L0.8610.88
155_G303_Y0.8600.88
91_I121_T0.8580.88
40_A237_F0.8580.88
23_A51_F0.8570.88
222_P235_K0.8540.88
112_E320_E0.8510.87
339_F361_W0.8480.87
309_T324_A0.8460.87
354_P357_T0.8360.86
96_D99_R0.8340.86
169_R176_I0.8340.86
224_A270_E0.8330.86
219_T222_P0.8320.86
252_L257_L0.8310.86
71_A75_V0.8310.86
39_D100_E0.8300.86
219_T260_M0.8290.86
140_K167_T0.8280.86
151_F168_I0.8270.86
320_E340_F0.8260.86
41_A103_V0.8260.86
65_G68_K0.8260.86
308_T349_A0.8240.86
32_D35_F0.8230.86
76_S79_S0.8220.85
28_D33_Q0.8190.85
17_V265_R0.8160.85
196_V200_L0.8140.85
297_E300_N0.8120.85
161_V200_L0.8120.85
37_L238_T0.8100.85
240_D253_N0.8070.84
20_I150_I0.8040.84
168_I171_E0.8040.84
201_A208_V0.7990.84
167_T171_E0.7980.84
252_L260_M0.7940.83
30_K33_Q0.7890.83
31_L90_W0.7810.82
56_A82_Q0.7780.82
330_Q358_G0.7760.82
109_V118_L0.7740.82
71_A249_S0.7680.81
94_L98_C0.7670.81
139_L164_A0.7650.81
350_V362_D0.7650.81
322_N340_F0.7630.81
163_E167_T0.7580.80
88_A117_L0.7560.80
233_I264_I0.7530.80
136_L140_K0.7480.80
39_D43_E0.7430.79
136_L163_E0.7430.79
58_R88_A0.7430.79
65_G69_T0.7410.79
238_T245_G0.7380.79
129_A132_E0.7380.79
158_I162_H0.7350.78
353_I359_I0.7340.78
306_I323_I0.7280.78
125_A177_A0.7260.78
99_R103_V0.7240.77
160_D299_R0.7240.77
192_S221_A0.7240.77
318_F359_I0.7240.77
164_A167_T0.7210.77
187_A191_Y0.7210.77
125_A148_P0.7190.77
222_P225_A0.7180.77
34_A94_L0.7160.77
183_A298_I0.7130.76
318_F353_I0.7130.76
55_Q113_G0.7130.76
255_D262_D0.7110.76
42_A97_Y0.7100.76
311_P352_D0.7100.76
326_L355_A0.7090.76
42_A102_Q0.7080.76
169_R207_A0.7080.76
109_V115_A0.7030.75
172_G176_I0.7030.75
21_A41_A0.7030.75
41_A44_A0.7010.75
70_A73_K0.7000.75
92_L121_T0.6990.75
182_V187_A0.6990.75
260_M264_I0.6980.75
54_F81_V0.6960.75
158_I204_F0.6950.74
69_T73_K0.6940.74
78_F82_Q0.6940.74
173_N176_I0.6910.74
124_S148_P0.6890.74
124_S147_R0.6880.74
295_E303_Y0.6840.73
53_M117_L0.6830.73
182_V191_Y0.6830.73
309_T323_I0.6820.73
175_Q208_V0.6820.73
95_L121_T0.6820.73
322_N344_T0.6810.73
140_K144_R0.6810.73
155_G295_E0.6810.73
165_W169_R0.6690.72
37_L248_H0.6670.71
181_C212_S0.6670.71
39_D42_A0.6660.71
110_C302_A0.6650.71
180_H196_V0.6640.71
314_K348_R0.6630.71
141_Y144_R0.6620.71
140_K172_G0.6620.71
37_L46_A0.6610.71
19_I257_L0.6610.71
199_M202_A0.6600.71
110_C132_E0.6600.71
184_K297_E0.6560.70
86_M90_W0.6560.70
101_K104_I0.6530.70
131_Y183_A0.6530.70
38_I97_Y0.6520.70
219_T263_G0.6520.70
304_R326_L0.6520.70
262_D266_K0.6500.69
25_I246_A0.6500.69
64_P76_S0.6490.69
126_F145_L0.6490.69
198_P202_A0.6480.69
213_D327_R0.6470.69
359_I364_I0.6460.69
257_L260_M0.6440.69
77_I80_L0.6430.69
323_I340_F0.6380.68
308_T357_T0.6380.68
359_I363_D0.6380.68
15_A231_K0.6370.68
133_I161_V0.6370.68
25_I77_I0.6360.68
110_C129_A0.6330.67
189_P270_E0.6320.67
16_P268_E0.6310.67
38_I103_V0.6310.67
135_H304_R0.6290.67
168_I176_I0.6280.67
54_F327_R0.6280.67
349_A364_I0.6260.67
49_V98_C0.6260.67
54_F84_M0.6240.66
357_T363_D0.6210.66
329_G358_G0.6210.66
255_D259_E0.6180.66
24_G248_H0.6170.65
149_M164_A0.6160.65
49_V103_V0.6150.65
28_D243_L0.6130.65
226_V268_E0.6130.65
81_V250_F0.6120.65
233_I260_M0.6110.65
205_P209_I0.6110.65
90_W93_P0.6090.64
305_G334_G0.6090.64
188_P294_I0.6090.64
149_M173_N0.6070.64
16_P208_V0.6050.64
222_P252_L0.6050.64
291_T299_R0.6020.64
143_A171_E0.6020.64
213_D235_K0.6020.64
324_A356_D0.6010.63
21_A237_F0.6000.63
54_F111_D0.5990.63
148_P175_Q0.5990.63
318_F364_I0.5980.63
54_F213_D0.5960.63
135_H325_V0.5940.63
353_I357_T0.5930.62
220_E270_E0.5920.62
28_D238_T0.5910.62
129_A138_L0.5910.62
81_V84_M0.5890.62
44_A257_L0.5880.62
312_I359_I0.5880.62
134_N303_Y0.5850.61
244_P248_H0.5810.61
309_T321_D0.5780.60
317_A320_E0.5780.60
348_R353_I0.5770.60
291_T296_G0.5760.60
305_G358_G0.5740.60
196_V199_M0.5740.60
243_L248_H0.5700.59
37_L49_V0.5690.59
336_H339_F0.5650.59
109_V142_V0.5640.59
226_V233_I0.5630.58
319_S344_T0.5630.58
159_S199_M0.5610.58
136_L341_E0.5610.58
313_Q349_A0.5600.58
205_P208_V0.5590.58
307_F356_D0.5580.58
25_I81_V0.5570.58
343_L364_I0.5550.57
306_I343_L0.5540.57
129_A135_H0.5540.57
350_V353_I0.5530.57
318_F344_T0.5530.57
220_E267_T0.5520.57
184_K294_I0.5520.57
323_I359_I0.5490.57
66_L297_E0.5470.56
261_V265_R0.5470.56
48_A124_S0.5470.56
25_I54_F0.5450.56
21_A46_A0.5440.56
161_V164_A0.5430.56
239_I243_L0.5430.56
84_M250_F0.5420.56
54_F58_R0.5420.56
240_D255_D0.5410.55
194_L197_I0.5410.55
152_S212_S0.5410.55
88_A113_G0.5400.55
33_Q239_I0.5400.55
357_T360_V0.5380.55
144_R167_T0.5380.55
64_P79_S0.5380.55
38_I49_V0.5370.55
98_C106_L0.5360.55
60_Y80_L0.5360.55
223_C227_R0.5350.55
131_Y302_A0.5350.55
31_L38_I0.5350.55
238_T248_H0.5340.54
59_M325_V0.5330.54
133_I151_F0.5330.54
215_S327_R0.5330.54
343_L349_A0.5330.54
41_A49_V0.5330.54
59_M78_F0.5320.54
19_I264_I0.5310.54
54_F85_E0.5300.54
165_W200_L0.5300.54
77_I302_A0.5290.54
18_F125_A0.5280.54
329_G337_P0.5250.53
38_I101_K0.5240.53
123_P126_F0.5230.53
340_F344_T0.5230.53
159_S202_A0.5220.53
352_D355_A0.5210.53
80_L246_A0.5190.52
323_I344_T0.5170.52
156_A235_K0.5160.52
133_I149_M0.5160.52
130_S153_T0.5150.52
259_E262_D0.5150.52
318_F347_V0.5120.51
123_P147_R0.5110.51
184_K191_Y0.5110.51
317_A346_G0.5100.51
189_P220_E0.5100.51
310_A355_A0.5100.51
28_D239_I0.5100.51
169_R173_N0.5090.51
256_E259_E0.5090.51
131_Y298_I0.5060.51
102_Q311_P0.5060.51
63_D356_D0.5050.51
200_L209_I0.5050.51
55_Q88_A0.5050.51
60_Y77_I0.5030.50
55_Q78_F0.5020.50
142_V168_I0.5020.50
112_E325_V0.5000.50
192_S211_F0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vliA 2 0.9598 100 0.173 Contact Map
2wqpA 2 0.9169 100 0.202 Contact Map
3g8rA 2 0.8874 100 0.245 Contact Map
1vr6A 4 0.6649 100 0.535 Contact Map
1vs1A 4 0.6515 100 0.537 Contact Map
4c1lA 4 0.6515 100 0.546 Contact Map
3nvtA 4 0.6488 100 0.549 Contact Map
3sz8A 4 0.689 100 0.549 Contact Map
1o60A 4 0.6917 100 0.557 Contact Map
2qkfA 4 0.6702 100 0.559 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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