SPSE - BACSU - GREMLIN Contacts

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SPSE - Spore coat polysaccharide biosynthesis protein SpsE

UniProt:	P39625	Sequences: MAAFQIANKTVGKDAPVFIIAEAGINHDGKLDQAFALIDAAAEAGADAVKFQMFQADRMYQKDPGLYKTAAGKDVSIFSLVQSMEMPAEWILPLLDYCREKQVIFLSTVCDEGSADLLQSTSPSAFKIASYEINHLPLLKYVARLNRPMIFSTAGAEISDVHEAWRTIRAEGNNQIAIMHCVAKYPAPPEYSNLSVIPMLAAAFPEAVIGFSDHSEHPTEAPCAAVRLGAKLIEKHFTIDKNLPGADHSFALNPDELKEMVDGIRKTEAELKQGITKPVSEKLLGSSYKTTTAIEGEIRNFAYRGIFTTAPIQKGEAFSEDNIAVLRPGQKPQGLHPRFFELLTSGVRAVRDIPADTGIVWDDILLKDSPFHE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	373 (331)
Sequences:	2124 (1647)
Seq/√Len:	90.5

BACSU - SPSE

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
177_A	232_L	4.074	1.00
18_F	104_I	3.782	1.00
95_L	99_R	3.566	1.00
39_D	101_K	3.265	1.00
312_I	349_A	3.208	1.00
313_Q	352_D	2.973	1.00
140_K	341_E	2.960	1.00
39_D	97_Y	2.930	1.00
116_D	141_Y	2.760	1.00
119_Q	126_F	2.747	1.00
75_V	83_S	2.732	1.00
128_I	142_V	2.536	1.00
339_F	342_L	2.521	1.00
35_F	93_P	2.316	1.00
18_F	48_A	2.306	1.00
42_A	101_K	2.276	1.00
195_S	271_L	2.241	1.00
258_K	262_D	2.234	1.00
314_K	352_D	2.230	1.00
190_E	269_A	2.219	1.00
308_T	359_I	2.208	1.00
349_A	353_I	2.199	1.00
35_F	97_Y	2.147	1.00
198_P	228_L	2.138	1.00
165_W	176_I	2.136	1.00
149_M	168_I	2.083	1.00
308_T	312_I	2.070	1.00
316_E	322_N	2.067	1.00
313_Q	316_E	2.067	1.00
318_F	322_N	2.028	1.00
53_M	107_S	2.007	1.00
241_K	253_N	1.987	1.00
92_L	96_D	1.977	1.00
311_P	354_P	1.968	1.00
351_R	363_D	1.957	1.00
162_H	166_R	1.956	1.00
326_L	356_D	1.942	1.00
87_P	90_W	1.932	1.00
310_A	321_D	1.903	1.00
163_E	338_R	1.887	1.00
306_I	325_V	1.884	1.00
17_V	268_E	1.861	1.00
58_R	113_G	1.858	1.00
126_F	147_R	1.818	1.00
136_L	167_T	1.816	1.00
308_T	353_I	1.812	1.00
220_E	266_K	1.800	1.00
57_D	78_F	1.785	1.00
312_I	316_E	1.779	1.00
115_A	141_Y	1.761	1.00
224_A	267_T	1.748	1.00
140_K	170_A	1.733	1.00
40_A	43_E	1.732	1.00
318_F	349_A	1.726	1.00
33_Q	243_L	1.718	1.00
41_A	237_F	1.713	1.00
38_I	94_L	1.709	1.00
199_M	203_A	1.705	1.00
97_Y	101_K	1.689	1.00
159_S	162_H	1.686	1.00
311_P	355_A	1.686	1.00
139_L	168_I	1.669	1.00
142_V	149_M	1.659	1.00
97_Y	100_E	1.643	1.00
222_P	260_M	1.643	1.00
96_D	100_E	1.637	1.00
162_H	203_A	1.633	1.00
191_Y	294_I	1.629	1.00
141_Y	145_L	1.600	1.00
189_P	266_K	1.592	1.00
162_H	204_F	1.579	1.00
208_V	231_K	1.563	1.00
150_I	179_M	1.559	1.00
317_A	348_R	1.555	1.00
192_S	215_S	1.540	1.00
177_A	208_V	1.506	1.00
265_R	268_E	1.500	1.00
312_I	322_N	1.480	1.00
119_Q	145_L	1.476	1.00
57_D	82_Q	1.460	0.99
19_I	261_V	1.453	0.99
241_K	256_E	1.448	0.99
159_S	203_A	1.441	0.99
305_G	328_P	1.440	0.99
61_Q	326_L	1.438	0.99
112_E	141_Y	1.434	0.99
115_A	142_V	1.427	0.99
310_A	322_N	1.424	0.99
20_I	232_L	1.419	0.99
56_A	85_E	1.405	0.99
221_A	270_E	1.387	0.99
42_A	103_V	1.383	0.99
178_I	200_L	1.381	0.99
51_F	105_F	1.361	0.99
259_E	263_G	1.353	0.99
166_R	170_A	1.329	0.99
140_K	171_E	1.321	0.99
223_C	267_T	1.320	0.99
43_E	258_K	1.305	0.99
111_D	114_S	1.302	0.99
293_A	296_G	1.299	0.99
168_I	173_N	1.294	0.99
178_I	204_F	1.291	0.99
351_R	357_T	1.283	0.99
46_A	103_V	1.275	0.99
75_V	79_S	1.275	0.99
79_S	82_Q	1.274	0.99
36_A	39_D	1.273	0.99
223_C	263_G	1.266	0.99
237_F	257_L	1.262	0.99
104_I	125_A	1.261	0.99
316_E	349_A	1.254	0.98
119_Q	147_R	1.230	0.98
198_P	201_A	1.225	0.98
264_I	268_E	1.225	0.98
59_M	81_V	1.219	0.98
23_A	37_L	1.217	0.98
95_L	105_F	1.215	0.98
98_C	103_V	1.213	0.98
23_A	49_V	1.205	0.98
43_E	101_K	1.202	0.98
220_E	224_A	1.202	0.98
36_A	40_A	1.197	0.98
219_T	252_L	1.192	0.98
62_K	356_D	1.190	0.98
225_A	230_A	1.181	0.98
273_Q	290_T	1.179	0.98
133_I	164_A	1.171	0.98
115_A	145_L	1.160	0.97
151_F	164_A	1.158	0.97
220_E	263_G	1.157	0.97
62_K	355_A	1.152	0.97
31_L	35_F	1.151	0.97
28_D	245_G	1.149	0.97
335_L	361_W	1.139	0.97
104_I	124_S	1.138	0.97
35_F	94_L	1.134	0.97
107_S	118_L	1.133	0.97
226_V	264_I	1.127	0.97
133_I	156_A	1.123	0.97
343_L	359_I	1.117	0.97
40_A	239_I	1.109	0.97
46_A	257_L	1.105	0.97
177_A	231_K	1.102	0.96
322_N	349_A	1.101	0.96
306_I	340_F	1.095	0.96
32_D	36_A	1.090	0.96
60_Y	81_V	1.087	0.96
17_V	264_I	1.082	0.96
310_A	316_E	1.081	0.96
201_A	209_I	1.081	0.96
263_G	266_K	1.080	0.96
307_F	358_G	1.075	0.96
323_I	343_L	1.072	0.96
224_A	227_R	1.069	0.96
126_F	142_V	1.068	0.96
309_T	326_L	1.068	0.96
319_S	322_N	1.064	0.96
47_D	265_R	1.060	0.96
360_V	363_D	1.058	0.96
196_V	289_K	1.049	0.95
312_I	353_I	1.042	0.95
179_M	232_L	1.039	0.95
353_I	363_D	1.035	0.95
308_T	318_F	1.030	0.95
160_D	163_E	1.018	0.95
16_P	47_D	1.015	0.94
91_I	95_L	1.013	0.94
240_D	243_L	1.011	0.94
37_L	237_F	1.010	0.94
158_I	203_A	0.994	0.94
197_I	209_I	0.992	0.94
98_C	105_F	0.992	0.94
115_A	126_F	0.989	0.94
106_L	125_A	0.981	0.93
17_V	226_V	0.979	0.93
56_A	78_F	0.978	0.93
48_A	104_I	0.976	0.93
82_Q	85_E	0.973	0.93
40_A	257_L	0.973	0.93
296_G	299_R	0.972	0.93
93_P	96_D	0.967	0.93
43_E	254_P	0.964	0.93
187_A	192_S	0.960	0.93
160_D	303_Y	0.954	0.92
178_I	207_A	0.951	0.92
312_I	318_F	0.948	0.92
122_S	147_R	0.942	0.92
150_I	232_L	0.937	0.92
116_D	145_L	0.937	0.92
33_Q	36_A	0.937	0.92
88_A	120_S	0.935	0.92
201_A	231_K	0.932	0.92
184_K	188_P	0.925	0.91
35_F	39_D	0.919	0.91
137_P	340_F	0.917	0.91
61_Q	309_T	0.916	0.91
157_E	291_T	0.915	0.91
48_A	125_A	0.914	0.91
115_A	138_L	0.909	0.90
16_P	265_R	0.906	0.90
91_I	117_L	0.902	0.90
93_P	97_Y	0.901	0.90
307_F	326_L	0.900	0.90
199_M	289_K	0.887	0.89
144_R	171_E	0.887	0.89
273_Q	288_Y	0.885	0.89
188_P	191_Y	0.885	0.89
211_F	221_A	0.882	0.89
165_W	178_I	0.881	0.89
308_T	322_N	0.878	0.89
40_A	44_A	0.878	0.89
193_N	272_K	0.877	0.89
92_L	120_S	0.877	0.89
228_L	271_L	0.871	0.88
195_S	198_P	0.869	0.88
237_F	254_P	0.865	0.88
305_G	329_G	0.863	0.88
31_L	93_P	0.862	0.88
48_A	106_L	0.861	0.88
155_G	303_Y	0.860	0.88
91_I	121_T	0.858	0.88
40_A	237_F	0.858	0.88
23_A	51_F	0.857	0.88
222_P	235_K	0.854	0.88
112_E	320_E	0.851	0.87
339_F	361_W	0.848	0.87
309_T	324_A	0.846	0.87
354_P	357_T	0.836	0.86
96_D	99_R	0.834	0.86
169_R	176_I	0.834	0.86
224_A	270_E	0.833	0.86
219_T	222_P	0.832	0.86
252_L	257_L	0.831	0.86
71_A	75_V	0.831	0.86
39_D	100_E	0.830	0.86
219_T	260_M	0.829	0.86
140_K	167_T	0.828	0.86
151_F	168_I	0.827	0.86
320_E	340_F	0.826	0.86
41_A	103_V	0.826	0.86
65_G	68_K	0.826	0.86
308_T	349_A	0.824	0.86
32_D	35_F	0.823	0.86
76_S	79_S	0.822	0.85
28_D	33_Q	0.819	0.85
17_V	265_R	0.816	0.85
196_V	200_L	0.814	0.85
297_E	300_N	0.812	0.85
161_V	200_L	0.812	0.85
37_L	238_T	0.810	0.85
240_D	253_N	0.807	0.84
20_I	150_I	0.804	0.84
168_I	171_E	0.804	0.84
201_A	208_V	0.799	0.84
167_T	171_E	0.798	0.84
252_L	260_M	0.794	0.83
30_K	33_Q	0.789	0.83
31_L	90_W	0.781	0.82
56_A	82_Q	0.778	0.82
330_Q	358_G	0.776	0.82
109_V	118_L	0.774	0.82
71_A	249_S	0.768	0.81
94_L	98_C	0.767	0.81
139_L	164_A	0.765	0.81
350_V	362_D	0.765	0.81
322_N	340_F	0.763	0.81
163_E	167_T	0.758	0.80
88_A	117_L	0.756	0.80
233_I	264_I	0.753	0.80
136_L	140_K	0.748	0.80
39_D	43_E	0.743	0.79
136_L	163_E	0.743	0.79
58_R	88_A	0.743	0.79
65_G	69_T	0.741	0.79
238_T	245_G	0.738	0.79
129_A	132_E	0.738	0.79
158_I	162_H	0.735	0.78
353_I	359_I	0.734	0.78
306_I	323_I	0.728	0.78
125_A	177_A	0.726	0.78
99_R	103_V	0.724	0.77
160_D	299_R	0.724	0.77
192_S	221_A	0.724	0.77
318_F	359_I	0.724	0.77
164_A	167_T	0.721	0.77
187_A	191_Y	0.721	0.77
125_A	148_P	0.719	0.77
222_P	225_A	0.718	0.77
34_A	94_L	0.716	0.77
183_A	298_I	0.713	0.76
318_F	353_I	0.713	0.76
55_Q	113_G	0.713	0.76
255_D	262_D	0.711	0.76
42_A	97_Y	0.710	0.76
311_P	352_D	0.710	0.76
326_L	355_A	0.709	0.76
42_A	102_Q	0.708	0.76
169_R	207_A	0.708	0.76
109_V	115_A	0.703	0.75
172_G	176_I	0.703	0.75
21_A	41_A	0.703	0.75
41_A	44_A	0.701	0.75
70_A	73_K	0.700	0.75
92_L	121_T	0.699	0.75
182_V	187_A	0.699	0.75
260_M	264_I	0.698	0.75
54_F	81_V	0.696	0.75
158_I	204_F	0.695	0.74
69_T	73_K	0.694	0.74
78_F	82_Q	0.694	0.74
173_N	176_I	0.691	0.74
124_S	148_P	0.689	0.74
124_S	147_R	0.688	0.74
295_E	303_Y	0.684	0.73
53_M	117_L	0.683	0.73
182_V	191_Y	0.683	0.73
309_T	323_I	0.682	0.73
175_Q	208_V	0.682	0.73
95_L	121_T	0.682	0.73
322_N	344_T	0.681	0.73
140_K	144_R	0.681	0.73
155_G	295_E	0.681	0.73
165_W	169_R	0.669	0.72
37_L	248_H	0.667	0.71
181_C	212_S	0.667	0.71
39_D	42_A	0.666	0.71
110_C	302_A	0.665	0.71
180_H	196_V	0.664	0.71
314_K	348_R	0.663	0.71
141_Y	144_R	0.662	0.71
140_K	172_G	0.662	0.71
37_L	46_A	0.661	0.71
19_I	257_L	0.661	0.71
199_M	202_A	0.660	0.71
110_C	132_E	0.660	0.71
184_K	297_E	0.656	0.70
86_M	90_W	0.656	0.70
101_K	104_I	0.653	0.70
131_Y	183_A	0.653	0.70
38_I	97_Y	0.652	0.70
219_T	263_G	0.652	0.70
304_R	326_L	0.652	0.70
262_D	266_K	0.650	0.69
25_I	246_A	0.650	0.69
64_P	76_S	0.649	0.69
126_F	145_L	0.649	0.69
198_P	202_A	0.648	0.69
213_D	327_R	0.647	0.69
359_I	364_I	0.646	0.69
257_L	260_M	0.644	0.69
77_I	80_L	0.643	0.69
323_I	340_F	0.638	0.68
308_T	357_T	0.638	0.68
359_I	363_D	0.638	0.68
15_A	231_K	0.637	0.68
133_I	161_V	0.637	0.68
25_I	77_I	0.636	0.68
110_C	129_A	0.633	0.67
189_P	270_E	0.632	0.67
16_P	268_E	0.631	0.67
38_I	103_V	0.631	0.67
135_H	304_R	0.629	0.67
168_I	176_I	0.628	0.67
54_F	327_R	0.628	0.67
349_A	364_I	0.626	0.67
49_V	98_C	0.626	0.67
54_F	84_M	0.624	0.66
357_T	363_D	0.621	0.66
329_G	358_G	0.621	0.66
255_D	259_E	0.618	0.66
24_G	248_H	0.617	0.65
149_M	164_A	0.616	0.65
49_V	103_V	0.615	0.65
28_D	243_L	0.613	0.65
226_V	268_E	0.613	0.65
81_V	250_F	0.612	0.65
233_I	260_M	0.611	0.65
205_P	209_I	0.611	0.65
90_W	93_P	0.609	0.64
305_G	334_G	0.609	0.64
188_P	294_I	0.609	0.64
149_M	173_N	0.607	0.64
16_P	208_V	0.605	0.64
222_P	252_L	0.605	0.64
291_T	299_R	0.602	0.64
143_A	171_E	0.602	0.64
213_D	235_K	0.602	0.64
324_A	356_D	0.601	0.63
21_A	237_F	0.600	0.63
54_F	111_D	0.599	0.63
148_P	175_Q	0.599	0.63
318_F	364_I	0.598	0.63
54_F	213_D	0.596	0.63
135_H	325_V	0.594	0.63
353_I	357_T	0.593	0.62
220_E	270_E	0.592	0.62
28_D	238_T	0.591	0.62
129_A	138_L	0.591	0.62
81_V	84_M	0.589	0.62
44_A	257_L	0.588	0.62
312_I	359_I	0.588	0.62
134_N	303_Y	0.585	0.61
244_P	248_H	0.581	0.61
309_T	321_D	0.578	0.60
317_A	320_E	0.578	0.60
348_R	353_I	0.577	0.60
291_T	296_G	0.576	0.60
305_G	358_G	0.574	0.60
196_V	199_M	0.574	0.60
243_L	248_H	0.570	0.59
37_L	49_V	0.569	0.59
336_H	339_F	0.565	0.59
109_V	142_V	0.564	0.59
226_V	233_I	0.563	0.58
319_S	344_T	0.563	0.58
159_S	199_M	0.561	0.58
136_L	341_E	0.561	0.58
313_Q	349_A	0.560	0.58
205_P	208_V	0.559	0.58
307_F	356_D	0.558	0.58
25_I	81_V	0.557	0.58
343_L	364_I	0.555	0.57
306_I	343_L	0.554	0.57
129_A	135_H	0.554	0.57
350_V	353_I	0.553	0.57
318_F	344_T	0.553	0.57
220_E	267_T	0.552	0.57
184_K	294_I	0.552	0.57
323_I	359_I	0.549	0.57
66_L	297_E	0.547	0.56
261_V	265_R	0.547	0.56
48_A	124_S	0.547	0.56
25_I	54_F	0.545	0.56
21_A	46_A	0.544	0.56
161_V	164_A	0.543	0.56
239_I	243_L	0.543	0.56
84_M	250_F	0.542	0.56
54_F	58_R	0.542	0.56
240_D	255_D	0.541	0.55
194_L	197_I	0.541	0.55
152_S	212_S	0.541	0.55
88_A	113_G	0.540	0.55
33_Q	239_I	0.540	0.55
357_T	360_V	0.538	0.55
144_R	167_T	0.538	0.55
64_P	79_S	0.538	0.55
38_I	49_V	0.537	0.55
98_C	106_L	0.536	0.55
60_Y	80_L	0.536	0.55
223_C	227_R	0.535	0.55
131_Y	302_A	0.535	0.55
31_L	38_I	0.535	0.55
238_T	248_H	0.534	0.54
59_M	325_V	0.533	0.54
133_I	151_F	0.533	0.54
215_S	327_R	0.533	0.54
343_L	349_A	0.533	0.54
41_A	49_V	0.533	0.54
59_M	78_F	0.532	0.54
19_I	264_I	0.531	0.54
54_F	85_E	0.530	0.54
165_W	200_L	0.530	0.54
77_I	302_A	0.529	0.54
18_F	125_A	0.528	0.54
329_G	337_P	0.525	0.53
38_I	101_K	0.524	0.53
123_P	126_F	0.523	0.53
340_F	344_T	0.523	0.53
159_S	202_A	0.522	0.53
352_D	355_A	0.521	0.53
80_L	246_A	0.519	0.52
323_I	344_T	0.517	0.52
156_A	235_K	0.516	0.52
133_I	149_M	0.516	0.52
130_S	153_T	0.515	0.52
259_E	262_D	0.515	0.52
318_F	347_V	0.512	0.51
123_P	147_R	0.511	0.51
184_K	191_Y	0.511	0.51
317_A	346_G	0.510	0.51
189_P	220_E	0.510	0.51
310_A	355_A	0.510	0.51
28_D	239_I	0.510	0.51
169_R	173_N	0.509	0.51
256_E	259_E	0.509	0.51
131_Y	298_I	0.506	0.51
102_Q	311_P	0.506	0.51
63_D	356_D	0.505	0.51
200_L	209_I	0.505	0.51
55_Q	88_A	0.505	0.51
60_Y	77_I	0.503	0.50
55_Q	78_F	0.502	0.50
142_V	168_I	0.502	0.50
112_E	325_V	0.500	0.50
192_S	211_F	0.500	0.50

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1vliA	2	0.9598	100	0.173	Contact Map
2wqpA	2	0.9169	100	0.202	Contact Map
3g8rA	2	0.8874	100	0.245	Contact Map
1vr6A	4	0.6649	100	0.535	Contact Map
1vs1A	4	0.6515	100	0.537	Contact Map
4c1lA	4	0.6515	100	0.546	Contact Map
3nvtA	4	0.6488	100	0.549	Contact Map
3sz8A	4	0.689	100	0.549	Contact Map
1o60A	4	0.6917	100	0.557	Contact Map
2qkfA	4	0.6702	100	0.559	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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