SPSC - BACSU - GREMLIN Contacts

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SPSC - Spore coat polysaccharide biosynthesis protein SpsC

UniProt:	P39623	Sequences: MVQKRNHFLPYSLPLIGKEEIQEVTETLESGWLSKGPKVQQFEKEFAAFVGAKHAVAVNSCTAALFLALKAKGIGPGDEVITSPLTFSSTANTIIHTGATPVFADIDENTLNIDPVKLEAAVTPRTKAVVPVHFGGQSCDMDAILAVAQNHGLFVLEDAAHAVYTTYKQRMIGSIGDATAFSFYATKNLATGEGGMLTTDDEELADKIRVLSLHGMSKAAWNRYSSNGSWYYEVESPGYKMNMFDLQAALGLHQLKRLDDMQKRREEIAGRYQTAFQQIPGLITPFVHDDGRHAWHLYVLQVDEKKAGVTRSEMITALKDEYNIGTSVHFIPVHIHPYYQKQFGYKEADFPNAMNYYKRTLSLPLYPSMSDDDVDDVIEAVRDIVKGAD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	389 (351)
Sequences:	10860 (8145)
Seq/√Len:	434.8

ECOLI - ARNB RFFA
BACSU - SPSC NTDA EPSN

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
273_Q	298_Y	3.633	1.00
45_E	252_L	3.050	1.00
119_E	150_N	2.913	1.00
275_A	378_I	2.805	1.00
145_L	149_Q	2.665	1.00
140_D	143_A	2.630	1.00
26_E	38_K	2.617	1.00
355_N	359_R	2.597	1.00
21_I	25_T	2.596	1.00
301_Q	359_R	2.486	1.00
271_R	374_V	2.462	1.00
49_F	259_D	2.442	1.00
142_D	168_K	2.431	1.00
322_Y	380_A	2.421	1.00
166_T	171_M	2.421	1.00
145_L	155_V	2.367	1.00
271_R	375_D	2.276	1.00
117_K	120_A	2.261	1.00
317_A	384_I	2.209	1.00
138_S	172_I	2.150	1.00
118_L	144_I	2.128	1.00
53_K	200_D	2.124	1.00
54_H	202_E	2.101	1.00
41_Q	45_E	2.070	1.00
45_E	256_K	2.061	1.00
264_R	267_E	2.045	1.00
322_Y	383_D	2.037	1.00
370_S	373_D	2.031	1.00
116_V	143_A	2.026	1.00
166_T	292_R	2.008	1.00
21_I	29_E	1.991	1.00
376_D	380_A	1.951	1.00
18_K	22_Q	1.903	1.00
154_F	177_D	1.902	1.00
114_D	117_K	1.899	1.00
19_E	256_K	1.897	1.00
335_I	354_M	1.889	1.00
117_K	121_A	1.870	1.00
72_K	154_F	1.865	1.00
104_A	121_A	1.823	1.00
197_L	208_I	1.815	1.00
244_F	247_Q	1.793	1.00
146_A	150_N	1.775	1.00
275_A	375_D	1.766	1.00
46_F	196_M	1.766	1.00
68_A	178_A	1.762	1.00
53_K	202_E	1.757	1.00
271_R	371_D	1.740	1.00
64_A	180_A	1.736	1.00
25_T	29_E	1.736	1.00
202_E	206_D	1.733	1.00
181_F	198_T	1.730	1.00
271_R	275_A	1.724	1.00
199_T	205_A	1.721	1.00
107_D	110_T	1.720	1.00
38_K	252_L	1.713	1.00
183_F	196_M	1.713	1.00
207_K	236_S	1.679	1.00
129_V	148_A	1.641	1.00
47_A	55_A	1.639	1.00
79_E	126_T	1.629	1.00
314_M	384_I	1.601	1.00
59_N	63_A	1.597	1.00
178_A	204_L	1.595	1.00
44_K	48_A	1.594	1.00
56_V	205_A	1.566	1.00
79_E	100_T	1.563	1.00
374_V	378_I	1.558	1.00
191_T	251_G	1.553	1.00
148_A	155_V	1.550	1.00
317_A	322_Y	1.549	1.00
318_L	326_T	1.546	1.00
86_T	333_V	1.523	1.00
278_Q	382_R	1.514	1.00
74_I	99_A	1.497	1.00
49_F	171_M	1.494	1.00
41_Q	252_L	1.493	1.00
205_A	209_R	1.489	1.00
78_D	127_K	1.487	1.00
108_E	352_N	1.478	1.00
177_D	201_D	1.477	1.00
170_R	174_S	1.474	1.00
266_E	292_R	1.466	1.00
162_A	172_I	1.464	1.00
79_E	123_T	1.462	1.00
55_A	196_M	1.451	1.00
122_V	147_V	1.419	1.00
46_F	163_V	1.410	1.00
275_A	382_R	1.398	1.00
201_D	204_L	1.389	1.00
283_I	301_Q	1.387	1.00
149_Q	177_D	1.379	1.00
143_A	146_A	1.376	1.00
142_D	167_Y	1.360	1.00
111_L	356_Y	1.355	1.00
270_G	274_T	1.338	1.00
82_T	94_I	1.338	1.00
79_E	125_R	1.337	1.00
315_I	326_T	1.335	1.00
84_P	353_A	1.330	1.00
264_R	268_I	1.326	1.00
38_K	41_Q	1.323	1.00
20_E	253_H	1.322	1.00
133_H	141_M	1.322	1.00
109_N	286_F	1.314	1.00
263_K	267_E	1.303	1.00
123_T	126_T	1.302	1.00
104_A	117_K	1.290	1.00
137_Q	288_H	1.284	1.00
108_E	355_N	1.283	1.00
45_E	48_A	1.282	1.00
50_V	198_T	1.276	1.00
276_F	381_V	1.271	1.00
314_M	361_L	1.264	1.00
253_H	256_K	1.258	1.00
68_A	156_L	1.258	1.00
264_R	371_D	1.248	1.00
324_I	380_A	1.243	1.00
217_S	235_E	1.243	1.00
168_K	290_D	1.237	1.00
111_L	301_Q	1.231	1.00
75_G	78_D	1.230	1.00
42_F	251_G	1.230	1.00
145_L	175_I	1.229	1.00
106_I	356_Y	1.226	1.00
22_Q	25_T	1.226	1.00
81_I	104_A	1.215	1.00
19_E	257_R	1.213	1.00
23_E	253_H	1.211	1.00
314_M	381_V	1.207	1.00
144_I	155_V	1.196	1.00
302_V	314_M	1.193	1.00
315_I	361_L	1.192	1.00
210_V	236_S	1.181	1.00
66_F	96_H	1.181	1.00
72_K	178_A	1.177	1.00
22_Q	26_E	1.177	1.00
19_E	22_Q	1.173	1.00
72_K	156_L	1.172	1.00
279_I	382_R	1.169	1.00
375_D	379_E	1.165	1.00
271_R	378_I	1.161	1.00
67_L	208_I	1.147	1.00
352_N	355_N	1.146	1.00
118_L	147_V	1.145	1.00
66_F	241_M	1.138	1.00
131_P	155_V	1.138	1.00
40_Q	44_K	1.132	1.00
67_L	211_L	1.125	1.00
84_P	334_H	1.123	1.00
113_I	118_L	1.122	1.00
334_H	354_M	1.122	1.00
267_E	371_D	1.115	1.00
299_V	360_T	1.114	1.00
133_H	176_G	1.112	1.00
313_E	317_A	1.110	1.00
54_H	205_A	1.104	1.00
283_I	303_D	1.103	1.00
119_E	143_A	1.100	1.00
268_I	374_V	1.099	1.00
119_E	151_H	1.094	1.00
66_F	239_Y	1.088	1.00
37_P	41_Q	1.087	1.00
284_T	298_Y	1.086	1.00
334_H	350_F	1.083	1.00
70_K	97_T	1.077	1.00
107_D	114_D	1.066	1.00
23_E	256_K	1.065	1.00
76_P	98_G	1.065	1.00
115_P	147_V	1.063	1.00
304_E	313_E	1.057	1.00
66_F	70_K	1.051	1.00
20_E	250_L	1.046	1.00
35_K	212_S	1.045	1.00
58_V	67_L	1.038	1.00
45_E	255_L	1.036	1.00
57_A	243_M	1.034	1.00
23_E	38_K	1.032	1.00
17_G	21_I	1.022	1.00
75_G	99_A	1.020	1.00
380_A	383_D	1.016	1.00
141_M	175_I	1.014	1.00
119_E	123_T	1.012	1.00
163_V	258_L	1.011	1.00
23_E	26_E	1.007	1.00
257_R	260_D	1.006	1.00
128_A	154_F	1.003	1.00
69_L	130_V	1.000	1.00
268_I	365_L	0.992	1.00
310_T	313_E	0.987	1.00
71_A	208_I	0.985	1.00
148_A	153_L	0.981	1.00
81_I	118_L	0.979	1.00
17_G	257_R	0.978	1.00
104_A	113_I	0.978	1.00
233_E	337_P	0.974	1.00
84_P	350_F	0.971	1.00
303_D	359_R	0.970	1.00
69_L	94_I	0.970	1.00
268_I	369_M	0.968	1.00
379_E	383_D	0.968	1.00
273_Q	284_T	0.968	1.00
54_H	199_T	0.965	1.00
312_S	316_T	0.964	1.00
17_G	20_E	0.963	1.00
111_L	285_P	0.963	1.00
91_A	333_V	0.960	1.00
243_M	248_A	0.959	1.00
145_L	177_D	0.956	1.00
273_Q	287_V	0.956	1.00
235_E	337_P	0.951	1.00
263_K	266_E	0.944	1.00
61_C	64_A	0.943	1.00
188_N	296_H	0.940	1.00
52_A	200_D	0.940	1.00
269_A	295_W	0.939	1.00
92_N	214_H	0.935	1.00
95_I	339_Y	0.933	1.00
119_E	147_V	0.929	1.00
59_N	241_M	0.928	1.00
371_D	375_D	0.927	1.00
266_E	287_V	0.926	1.00
91_A	103_F	0.924	1.00
371_D	374_V	0.924	1.00
68_A	180_A	0.922	1.00
199_T	204_L	0.922	1.00
73_G	207_K	0.921	1.00
315_I	319_K	0.921	1.00
52_A	174_S	0.919	1.00
147_V	151_H	0.915	1.00
313_E	384_I	0.913	1.00
55_A	198_T	0.906	1.00
44_K	47_A	0.905	1.00
299_V	362_S	0.904	1.00
317_A	380_A	0.902	1.00
79_E	102_V	0.901	1.00
39_V	248_A	0.893	1.00
74_I	80_V	0.890	1.00
137_Q	291_G	0.889	1.00
116_V	119_E	0.888	1.00
159_A	172_I	0.887	1.00
63_A	241_M	0.885	1.00
348_A	354_M	0.885	1.00
128_A	156_L	0.880	1.00
270_G	273_Q	0.879	1.00
56_V	209_R	0.874	1.00
46_F	181_F	0.873	1.00
332_P	353_A	0.872	1.00
355_N	358_K	0.872	1.00
322_Y	376_D	0.870	1.00
82_T	91_A	0.863	1.00
372_D	375_D	0.857	1.00
165_T	294_A	0.855	1.00
233_E	331_I	0.851	1.00
369_M	377_V	0.850	1.00
262_Q	294_A	0.847	1.00
272_Y	377_V	0.846	1.00
264_R	368_S	0.844	1.00
37_P	40_Q	0.843	1.00
313_E	316_T	0.842	1.00
266_E	270_G	0.842	1.00
74_I	128_A	0.840	1.00
139_C	144_I	0.839	1.00
260_D	263_K	0.839	1.00
43_E	57_A	0.835	1.00
271_R	274_T	0.834	1.00
281_G	303_D	0.834	1.00
41_Q	44_K	0.831	1.00
131_P	144_I	0.830	1.00
304_E	310_T	0.824	1.00
50_V	171_M	0.822	1.00
38_K	245_D	0.822	1.00
47_A	50_V	0.821	1.00
146_A	149_Q	0.818	1.00
260_D	264_R	0.818	1.00
316_T	319_K	0.814	1.00
376_D	379_E	0.813	1.00
17_G	29_E	0.810	1.00
190_A	194_G	0.810	1.00
94_I	101_P	0.807	1.00
131_P	139_C	0.804	1.00
171_M	174_S	0.798	1.00
133_H	157_E	0.795	1.00
83_S	94_I	0.793	1.00
314_M	318_L	0.790	1.00
107_D	115_P	0.789	1.00
141_M	145_L	0.787	1.00
24_V	246_L	0.786	1.00
18_K	29_E	0.779	1.00
49_F	164_Y	0.779	1.00
273_Q	295_W	0.778	1.00
58_V	197_L	0.778	1.00
67_L	212_S	0.778	1.00
210_V	235_E	0.778	1.00
259_D	263_K	0.777	1.00
170_R	175_I	0.777	1.00
267_E	270_G	0.777	1.00
142_D	146_A	0.775	1.00
311_R	328_V	0.774	1.00
94_I	99_A	0.771	1.00
78_D	99_A	0.770	1.00
350_F	353_A	0.770	1.00
329_H	362_S	0.767	1.00
81_I	121_A	0.766	1.00
172_I	179_T	0.762	1.00
164_Y	262_Q	0.757	1.00
69_L	156_L	0.756	1.00
95_I	101_P	0.755	1.00
267_E	271_R	0.753	1.00
203_E	206_D	0.750	1.00
75_G	127_K	0.749	1.00
206_D	217_S	0.748	1.00
175_I	179_T	0.747	1.00
27_T	249_A	0.746	1.00
18_K	21_I	0.746	1.00
80_V	94_I	0.745	1.00
26_E	30_S	0.744	1.00
56_V	208_I	0.744	1.00
24_V	250_L	0.740	1.00
373_D	376_D	0.739	1.00
375_D	378_I	0.733	1.00
90_T	93_T	0.733	1.00
24_V	28_L	0.732	1.00
275_A	278_Q	0.731	1.00
269_A	298_Y	0.730	1.00
332_P	335_I	0.730	1.00
92_N	339_Y	0.728	1.00
46_F	255_L	0.727	1.00
148_A	151_H	0.727	1.00
70_K	96_H	0.726	1.00
347_E	358_K	0.723	1.00
107_D	140_D	0.723	1.00
68_A	197_L	0.721	1.00
115_P	139_C	0.721	1.00
178_A	197_L	0.721	1.00
352_N	356_Y	0.719	1.00
275_A	379_E	0.717	1.00
378_I	382_R	0.716	1.00
129_V	153_L	0.712	1.00
71_A	178_A	0.711	1.00
188_N	262_Q	0.710	1.00
274_T	277_Q	0.709	1.00
166_T	169_Q	0.709	1.00
39_V	57_A	0.706	1.00
93_T	97_T	0.706	1.00
66_F	97_T	0.705	1.00
74_I	127_K	0.705	1.00
171_M	259_D	0.704	1.00
52_A	198_T	0.703	1.00
167_Y	291_G	0.702	1.00
176_G	179_T	0.702	1.00
192_G	246_L	0.700	1.00
118_L	129_V	0.698	1.00
218_K	233_E	0.698	1.00
69_L	74_I	0.698	1.00
39_V	243_M	0.697	1.00
157_E	176_G	0.696	1.00
174_S	200_D	0.696	1.00
87_F	232_Y	0.695	1.00
115_P	144_I	0.695	1.00
96_H	239_Y	0.692	1.00
15_L	368_S	0.692	1.00
288_H	291_G	0.691	1.00
81_I	126_T	0.690	1.00
122_V	153_L	0.686	1.00
50_V	174_S	0.684	1.00
354_M	358_K	0.684	1.00
145_L	176_G	0.684	1.00
80_V	128_A	0.683	1.00
46_F	55_A	0.683	1.00
85_L	329_H	0.679	1.00
276_F	382_R	0.679	1.00
61_C	180_A	0.674	1.00
83_S	132_V	0.671	1.00
332_P	357_Y	0.671	1.00
157_E	179_T	0.669	1.00
20_E	257_R	0.667	1.00
194_G	243_M	0.667	1.00
50_V	55_A	0.665	1.00
58_V	64_A	0.658	1.00
269_A	273_Q	0.658	1.00
273_Q	286_F	0.658	1.00
268_I	272_Y	0.656	1.00
19_E	253_H	0.655	0.99
266_E	295_W	0.650	0.99
237_P	338_Y	0.649	0.99
165_T	172_I	0.648	0.99
319_K	326_T	0.647	0.99
131_P	141_M	0.646	0.99
268_I	271_R	0.646	0.99
23_E	249_A	0.645	0.99
366_Y	369_M	0.645	0.99
95_I	338_Y	0.644	0.99
19_E	23_E	0.644	0.99
282_L	300_L	0.643	0.99
335_I	348_A	0.642	0.99
207_K	211_L	0.641	0.99
137_Q	287_V	0.640	0.99
95_I	237_P	0.635	0.99
86_T	90_T	0.635	0.99
346_K	349_D	0.633	0.99
64_A	197_L	0.633	0.99
262_Q	266_E	0.633	0.99
93_T	130_V	0.633	0.99
179_T	198_T	0.630	0.99
134_F	161_H	0.629	0.99
257_R	261_M	0.629	0.99
94_I	130_V	0.629	0.99
70_K	239_Y	0.628	0.99
269_A	365_L	0.627	0.99
70_K	211_L	0.625	0.99
337_P	340_Q	0.625	0.99
141_M	155_V	0.623	0.99
301_Q	360_T	0.621	0.99
133_H	172_I	0.621	0.99
27_T	38_K	0.619	0.99
178_A	199_T	0.618	0.99
301_Q	355_N	0.618	0.99
13_L	368_S	0.617	0.99
167_Y	175_I	0.617	0.99
159_A	179_T	0.615	0.99
16_I	20_E	0.615	0.99
15_L	257_R	0.614	0.99
21_I	28_L	0.611	0.99
143_A	167_Y	0.608	0.99
105_D	352_N	0.607	0.99
30_S	37_P	0.606	0.99
90_T	130_V	0.604	0.99
273_Q	277_Q	0.603	0.99
206_D	210_V	0.602	0.99
138_S	165_T	0.601	0.99
52_A	179_T	0.601	0.99
259_D	292_R	0.600	0.99
47_A	54_H	0.600	0.99
69_L	97_T	0.599	0.99
80_V	130_V	0.596	0.99
84_P	103_F	0.596	0.99
349_D	354_M	0.596	0.99
85_L	360_T	0.595	0.99
60_S	63_A	0.594	0.99
304_E	359_R	0.594	0.99
26_E	41_Q	0.592	0.99
73_G	99_A	0.587	0.99
317_A	383_D	0.587	0.99
243_M	247_Q	0.585	0.99
75_G	97_T	0.585	0.99
106_I	353_A	0.582	0.99
214_H	242_N	0.582	0.99
344_G	348_A	0.581	0.99
167_Y	170_R	0.581	0.99
27_T	30_S	0.580	0.99
80_V	99_A	0.580	0.99
61_C	160_A	0.578	0.99
60_S	240_K	0.575	0.99
174_S	179_T	0.574	0.99
90_T	132_V	0.574	0.99
345_Y	348_A	0.573	0.99
314_M	317_A	0.572	0.99
287_V	293_H	0.568	0.99
133_H	139_C	0.568	0.99
143_A	147_V	0.568	0.99
87_F	216_M	0.567	0.99
192_G	247_Q	0.567	0.99
106_I	352_N	0.567	0.99
68_A	72_K	0.566	0.99
135_G	299_V	0.566	0.99
210_V	217_S	0.564	0.98
137_Q	293_H	0.560	0.98
138_S	167_Y	0.559	0.98
258_L	262_Q	0.558	0.98
157_E	173_G	0.556	0.98
259_D	262_Q	0.556	0.98
300_L	361_L	0.553	0.98
177_D	200_D	0.552	0.98
272_Y	374_V	0.552	0.98
127_K	154_F	0.551	0.98
275_A	374_V	0.550	0.98
91_A	339_Y	0.548	0.98
178_A	208_I	0.548	0.98
66_F	93_T	0.546	0.98
109_N	283_I	0.546	0.98
164_Y	258_L	0.546	0.98
35_K	245_D	0.546	0.98
138_S	291_G	0.546	0.98
122_V	151_H	0.545	0.98
335_I	358_K	0.545	0.98
135_G	329_H	0.545	0.98
312_S	315_I	0.545	0.98
297_L	362_S	0.545	0.98
160_A	187_K	0.544	0.98
162_A	165_T	0.541	0.98
74_I	78_D	0.541	0.98
301_Q	356_Y	0.540	0.98
23_E	27_T	0.539	0.98
115_P	143_A	0.538	0.98
115_P	140_D	0.536	0.98
183_F	251_G	0.536	0.98
77_G	100_T	0.536	0.98
300_L	381_V	0.535	0.98
287_V	295_W	0.534	0.98
114_D	143_A	0.533	0.98
30_S	38_K	0.531	0.98
142_D	170_R	0.529	0.98
54_H	209_R	0.528	0.98
184_Y	193_E	0.527	0.98
47_A	52_A	0.527	0.98
122_V	126_T	0.527	0.98
21_I	24_V	0.527	0.98
39_V	245_D	0.523	0.98
82_T	90_T	0.522	0.98
351_P	354_M	0.521	0.97
85_L	134_F	0.520	0.97
281_G	382_R	0.519	0.97
56_V	199_T	0.519	0.97
57_A	196_M	0.514	0.97
72_K	204_L	0.514	0.97
113_I	131_P	0.513	0.97
113_I	144_I	0.512	0.97
300_L	363_L	0.511	0.97
253_H	257_R	0.509	0.97
25_T	28_L	0.505	0.97
88_S	216_M	0.503	0.97
20_E	24_V	0.502	0.97
130_V	156_L	0.501	0.97
188_N	294_A	0.501	0.97
65_L	93_T	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4zwvA	2	0.9332	100	0.412	Contact Map
4lc3A	2	0.9614	100	0.455	Contact Map
2fnuA	2	0.9537	100	0.457	Contact Map
3frkA	2	0.9332	100	0.458	Contact Map
1o69A	2	0.9049	100	0.463	Contact Map
2c81A	2	0.964	100	0.468	Contact Map
3bb8A	2	0.9846	100	0.472	Contact Map
3b8xA	2	0.9563	100	0.472	Contact Map
3nytA	2	0.9049	100	0.488	Contact Map
1b9hA	2	0.9512	100	0.491	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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