GREMLIN Database
SPSC - Spore coat polysaccharide biosynthesis protein SpsC
UniProt: P39623 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 389 (351)
Sequences: 10860 (8145)
Seq/√Len: 434.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
273_Q298_Y3.6331.00
45_E252_L3.0501.00
119_E150_N2.9131.00
275_A378_I2.8051.00
145_L149_Q2.6651.00
140_D143_A2.6301.00
26_E38_K2.6171.00
355_N359_R2.5971.00
21_I25_T2.5961.00
301_Q359_R2.4861.00
271_R374_V2.4621.00
49_F259_D2.4421.00
142_D168_K2.4311.00
322_Y380_A2.4211.00
166_T171_M2.4211.00
145_L155_V2.3671.00
271_R375_D2.2761.00
117_K120_A2.2611.00
317_A384_I2.2091.00
138_S172_I2.1501.00
118_L144_I2.1281.00
53_K200_D2.1241.00
54_H202_E2.1011.00
41_Q45_E2.0701.00
45_E256_K2.0611.00
264_R267_E2.0451.00
322_Y383_D2.0371.00
370_S373_D2.0311.00
116_V143_A2.0261.00
166_T292_R2.0081.00
21_I29_E1.9911.00
376_D380_A1.9511.00
18_K22_Q1.9031.00
154_F177_D1.9021.00
114_D117_K1.8991.00
19_E256_K1.8971.00
335_I354_M1.8891.00
117_K121_A1.8701.00
72_K154_F1.8651.00
104_A121_A1.8231.00
197_L208_I1.8151.00
244_F247_Q1.7931.00
146_A150_N1.7751.00
275_A375_D1.7661.00
46_F196_M1.7661.00
68_A178_A1.7621.00
53_K202_E1.7571.00
271_R371_D1.7401.00
64_A180_A1.7361.00
25_T29_E1.7361.00
202_E206_D1.7331.00
181_F198_T1.7301.00
271_R275_A1.7241.00
199_T205_A1.7211.00
107_D110_T1.7201.00
38_K252_L1.7131.00
183_F196_M1.7131.00
207_K236_S1.6791.00
129_V148_A1.6411.00
47_A55_A1.6391.00
79_E126_T1.6291.00
314_M384_I1.6011.00
59_N63_A1.5971.00
178_A204_L1.5951.00
44_K48_A1.5941.00
56_V205_A1.5661.00
79_E100_T1.5631.00
374_V378_I1.5581.00
191_T251_G1.5531.00
148_A155_V1.5501.00
317_A322_Y1.5491.00
318_L326_T1.5461.00
86_T333_V1.5231.00
278_Q382_R1.5141.00
74_I99_A1.4971.00
49_F171_M1.4941.00
41_Q252_L1.4931.00
205_A209_R1.4891.00
78_D127_K1.4871.00
108_E352_N1.4781.00
177_D201_D1.4771.00
170_R174_S1.4741.00
266_E292_R1.4661.00
162_A172_I1.4641.00
79_E123_T1.4621.00
55_A196_M1.4511.00
122_V147_V1.4191.00
46_F163_V1.4101.00
275_A382_R1.3981.00
201_D204_L1.3891.00
283_I301_Q1.3871.00
149_Q177_D1.3791.00
143_A146_A1.3761.00
142_D167_Y1.3601.00
111_L356_Y1.3551.00
270_G274_T1.3381.00
82_T94_I1.3381.00
79_E125_R1.3371.00
315_I326_T1.3351.00
84_P353_A1.3301.00
264_R268_I1.3261.00
38_K41_Q1.3231.00
20_E253_H1.3221.00
133_H141_M1.3221.00
109_N286_F1.3141.00
263_K267_E1.3031.00
123_T126_T1.3021.00
104_A117_K1.2901.00
137_Q288_H1.2841.00
108_E355_N1.2831.00
45_E48_A1.2821.00
50_V198_T1.2761.00
276_F381_V1.2711.00
314_M361_L1.2641.00
253_H256_K1.2581.00
68_A156_L1.2581.00
264_R371_D1.2481.00
324_I380_A1.2431.00
217_S235_E1.2431.00
168_K290_D1.2371.00
111_L301_Q1.2311.00
75_G78_D1.2301.00
42_F251_G1.2301.00
145_L175_I1.2291.00
106_I356_Y1.2261.00
22_Q25_T1.2261.00
81_I104_A1.2151.00
19_E257_R1.2131.00
23_E253_H1.2111.00
314_M381_V1.2071.00
144_I155_V1.1961.00
302_V314_M1.1931.00
315_I361_L1.1921.00
210_V236_S1.1811.00
66_F96_H1.1811.00
72_K178_A1.1771.00
22_Q26_E1.1771.00
19_E22_Q1.1731.00
72_K156_L1.1721.00
279_I382_R1.1691.00
375_D379_E1.1651.00
271_R378_I1.1611.00
67_L208_I1.1471.00
352_N355_N1.1461.00
118_L147_V1.1451.00
66_F241_M1.1381.00
131_P155_V1.1381.00
40_Q44_K1.1321.00
67_L211_L1.1251.00
84_P334_H1.1231.00
113_I118_L1.1221.00
334_H354_M1.1221.00
267_E371_D1.1151.00
299_V360_T1.1141.00
133_H176_G1.1121.00
313_E317_A1.1101.00
54_H205_A1.1041.00
283_I303_D1.1031.00
119_E143_A1.1001.00
268_I374_V1.0991.00
119_E151_H1.0941.00
66_F239_Y1.0881.00
37_P41_Q1.0871.00
284_T298_Y1.0861.00
334_H350_F1.0831.00
70_K97_T1.0771.00
107_D114_D1.0661.00
23_E256_K1.0651.00
76_P98_G1.0651.00
115_P147_V1.0631.00
304_E313_E1.0571.00
66_F70_K1.0511.00
20_E250_L1.0461.00
35_K212_S1.0451.00
58_V67_L1.0381.00
45_E255_L1.0361.00
57_A243_M1.0341.00
23_E38_K1.0321.00
17_G21_I1.0221.00
75_G99_A1.0201.00
380_A383_D1.0161.00
141_M175_I1.0141.00
119_E123_T1.0121.00
163_V258_L1.0111.00
23_E26_E1.0071.00
257_R260_D1.0061.00
128_A154_F1.0031.00
69_L130_V1.0001.00
268_I365_L0.9921.00
310_T313_E0.9871.00
71_A208_I0.9851.00
148_A153_L0.9811.00
81_I118_L0.9791.00
17_G257_R0.9781.00
104_A113_I0.9781.00
233_E337_P0.9741.00
84_P350_F0.9711.00
303_D359_R0.9701.00
69_L94_I0.9701.00
268_I369_M0.9681.00
379_E383_D0.9681.00
273_Q284_T0.9681.00
54_H199_T0.9651.00
312_S316_T0.9641.00
17_G20_E0.9631.00
111_L285_P0.9631.00
91_A333_V0.9601.00
243_M248_A0.9591.00
145_L177_D0.9561.00
273_Q287_V0.9561.00
235_E337_P0.9511.00
263_K266_E0.9441.00
61_C64_A0.9431.00
188_N296_H0.9401.00
52_A200_D0.9401.00
269_A295_W0.9391.00
92_N214_H0.9351.00
95_I339_Y0.9331.00
119_E147_V0.9291.00
59_N241_M0.9281.00
371_D375_D0.9271.00
266_E287_V0.9261.00
91_A103_F0.9241.00
371_D374_V0.9241.00
68_A180_A0.9221.00
199_T204_L0.9221.00
73_G207_K0.9211.00
315_I319_K0.9211.00
52_A174_S0.9191.00
147_V151_H0.9151.00
313_E384_I0.9131.00
55_A198_T0.9061.00
44_K47_A0.9051.00
299_V362_S0.9041.00
317_A380_A0.9021.00
79_E102_V0.9011.00
39_V248_A0.8931.00
74_I80_V0.8901.00
137_Q291_G0.8891.00
116_V119_E0.8881.00
159_A172_I0.8871.00
63_A241_M0.8851.00
348_A354_M0.8851.00
128_A156_L0.8801.00
270_G273_Q0.8791.00
56_V209_R0.8741.00
46_F181_F0.8731.00
332_P353_A0.8721.00
355_N358_K0.8721.00
322_Y376_D0.8701.00
82_T91_A0.8631.00
372_D375_D0.8571.00
165_T294_A0.8551.00
233_E331_I0.8511.00
369_M377_V0.8501.00
262_Q294_A0.8471.00
272_Y377_V0.8461.00
264_R368_S0.8441.00
37_P40_Q0.8431.00
313_E316_T0.8421.00
266_E270_G0.8421.00
74_I128_A0.8401.00
139_C144_I0.8391.00
260_D263_K0.8391.00
43_E57_A0.8351.00
271_R274_T0.8341.00
281_G303_D0.8341.00
41_Q44_K0.8311.00
131_P144_I0.8301.00
304_E310_T0.8241.00
50_V171_M0.8221.00
38_K245_D0.8221.00
47_A50_V0.8211.00
146_A149_Q0.8181.00
260_D264_R0.8181.00
316_T319_K0.8141.00
376_D379_E0.8131.00
17_G29_E0.8101.00
190_A194_G0.8101.00
94_I101_P0.8071.00
131_P139_C0.8041.00
171_M174_S0.7981.00
133_H157_E0.7951.00
83_S94_I0.7931.00
314_M318_L0.7901.00
107_D115_P0.7891.00
141_M145_L0.7871.00
24_V246_L0.7861.00
18_K29_E0.7791.00
49_F164_Y0.7791.00
273_Q295_W0.7781.00
58_V197_L0.7781.00
67_L212_S0.7781.00
210_V235_E0.7781.00
259_D263_K0.7771.00
170_R175_I0.7771.00
267_E270_G0.7771.00
142_D146_A0.7751.00
311_R328_V0.7741.00
94_I99_A0.7711.00
78_D99_A0.7701.00
350_F353_A0.7701.00
329_H362_S0.7671.00
81_I121_A0.7661.00
172_I179_T0.7621.00
164_Y262_Q0.7571.00
69_L156_L0.7561.00
95_I101_P0.7551.00
267_E271_R0.7531.00
203_E206_D0.7501.00
75_G127_K0.7491.00
206_D217_S0.7481.00
175_I179_T0.7471.00
27_T249_A0.7461.00
18_K21_I0.7461.00
80_V94_I0.7451.00
26_E30_S0.7441.00
56_V208_I0.7441.00
24_V250_L0.7401.00
373_D376_D0.7391.00
375_D378_I0.7331.00
90_T93_T0.7331.00
24_V28_L0.7321.00
275_A278_Q0.7311.00
269_A298_Y0.7301.00
332_P335_I0.7301.00
92_N339_Y0.7281.00
46_F255_L0.7271.00
148_A151_H0.7271.00
70_K96_H0.7261.00
347_E358_K0.7231.00
107_D140_D0.7231.00
68_A197_L0.7211.00
115_P139_C0.7211.00
178_A197_L0.7211.00
352_N356_Y0.7191.00
275_A379_E0.7171.00
378_I382_R0.7161.00
129_V153_L0.7121.00
71_A178_A0.7111.00
188_N262_Q0.7101.00
274_T277_Q0.7091.00
166_T169_Q0.7091.00
39_V57_A0.7061.00
93_T97_T0.7061.00
66_F97_T0.7051.00
74_I127_K0.7051.00
171_M259_D0.7041.00
52_A198_T0.7031.00
167_Y291_G0.7021.00
176_G179_T0.7021.00
192_G246_L0.7001.00
118_L129_V0.6981.00
218_K233_E0.6981.00
69_L74_I0.6981.00
39_V243_M0.6971.00
157_E176_G0.6961.00
174_S200_D0.6961.00
87_F232_Y0.6951.00
115_P144_I0.6951.00
96_H239_Y0.6921.00
15_L368_S0.6921.00
288_H291_G0.6911.00
81_I126_T0.6901.00
122_V153_L0.6861.00
50_V174_S0.6841.00
354_M358_K0.6841.00
145_L176_G0.6841.00
80_V128_A0.6831.00
46_F55_A0.6831.00
85_L329_H0.6791.00
276_F382_R0.6791.00
61_C180_A0.6741.00
83_S132_V0.6711.00
332_P357_Y0.6711.00
157_E179_T0.6691.00
20_E257_R0.6671.00
194_G243_M0.6671.00
50_V55_A0.6651.00
58_V64_A0.6581.00
269_A273_Q0.6581.00
273_Q286_F0.6581.00
268_I272_Y0.6561.00
19_E253_H0.6550.99
266_E295_W0.6500.99
237_P338_Y0.6490.99
165_T172_I0.6480.99
319_K326_T0.6470.99
131_P141_M0.6460.99
268_I271_R0.6460.99
23_E249_A0.6450.99
366_Y369_M0.6450.99
95_I338_Y0.6440.99
19_E23_E0.6440.99
282_L300_L0.6430.99
335_I348_A0.6420.99
207_K211_L0.6410.99
137_Q287_V0.6400.99
95_I237_P0.6350.99
86_T90_T0.6350.99
346_K349_D0.6330.99
64_A197_L0.6330.99
262_Q266_E0.6330.99
93_T130_V0.6330.99
179_T198_T0.6300.99
134_F161_H0.6290.99
257_R261_M0.6290.99
94_I130_V0.6290.99
70_K239_Y0.6280.99
269_A365_L0.6270.99
70_K211_L0.6250.99
337_P340_Q0.6250.99
141_M155_V0.6230.99
301_Q360_T0.6210.99
133_H172_I0.6210.99
27_T38_K0.6190.99
178_A199_T0.6180.99
301_Q355_N0.6180.99
13_L368_S0.6170.99
167_Y175_I0.6170.99
159_A179_T0.6150.99
16_I20_E0.6150.99
15_L257_R0.6140.99
21_I28_L0.6110.99
143_A167_Y0.6080.99
105_D352_N0.6070.99
30_S37_P0.6060.99
90_T130_V0.6040.99
273_Q277_Q0.6030.99
206_D210_V0.6020.99
138_S165_T0.6010.99
52_A179_T0.6010.99
259_D292_R0.6000.99
47_A54_H0.6000.99
69_L97_T0.5990.99
80_V130_V0.5960.99
84_P103_F0.5960.99
349_D354_M0.5960.99
85_L360_T0.5950.99
60_S63_A0.5940.99
304_E359_R0.5940.99
26_E41_Q0.5920.99
73_G99_A0.5870.99
317_A383_D0.5870.99
243_M247_Q0.5850.99
75_G97_T0.5850.99
106_I353_A0.5820.99
214_H242_N0.5820.99
344_G348_A0.5810.99
167_Y170_R0.5810.99
27_T30_S0.5800.99
80_V99_A0.5800.99
61_C160_A0.5780.99
60_S240_K0.5750.99
174_S179_T0.5740.99
90_T132_V0.5740.99
345_Y348_A0.5730.99
314_M317_A0.5720.99
287_V293_H0.5680.99
133_H139_C0.5680.99
143_A147_V0.5680.99
87_F216_M0.5670.99
192_G247_Q0.5670.99
106_I352_N0.5670.99
68_A72_K0.5660.99
135_G299_V0.5660.99
210_V217_S0.5640.98
137_Q293_H0.5600.98
138_S167_Y0.5590.98
258_L262_Q0.5580.98
157_E173_G0.5560.98
259_D262_Q0.5560.98
300_L361_L0.5530.98
177_D200_D0.5520.98
272_Y374_V0.5520.98
127_K154_F0.5510.98
275_A374_V0.5500.98
91_A339_Y0.5480.98
178_A208_I0.5480.98
66_F93_T0.5460.98
109_N283_I0.5460.98
164_Y258_L0.5460.98
35_K245_D0.5460.98
138_S291_G0.5460.98
122_V151_H0.5450.98
335_I358_K0.5450.98
135_G329_H0.5450.98
312_S315_I0.5450.98
297_L362_S0.5450.98
160_A187_K0.5440.98
162_A165_T0.5410.98
74_I78_D0.5410.98
301_Q356_Y0.5400.98
23_E27_T0.5390.98
115_P143_A0.5380.98
115_P140_D0.5360.98
183_F251_G0.5360.98
77_G100_T0.5360.98
300_L381_V0.5350.98
287_V295_W0.5340.98
114_D143_A0.5330.98
30_S38_K0.5310.98
142_D170_R0.5290.98
54_H209_R0.5280.98
184_Y193_E0.5270.98
47_A52_A0.5270.98
122_V126_T0.5270.98
21_I24_V0.5270.98
39_V245_D0.5230.98
82_T90_T0.5220.98
351_P354_M0.5210.97
85_L134_F0.5200.97
281_G382_R0.5190.97
56_V199_T0.5190.97
57_A196_M0.5140.97
72_K204_L0.5140.97
113_I131_P0.5130.97
113_I144_I0.5120.97
300_L363_L0.5110.97
253_H257_R0.5090.97
25_T28_L0.5050.97
88_S216_M0.5030.97
20_E24_V0.5020.97
130_V156_L0.5010.97
188_N294_A0.5010.97
65_L93_T0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4zwvA 2 0.9332 100 0.412 Contact Map
4lc3A 2 0.9614 100 0.455 Contact Map
2fnuA 2 0.9537 100 0.457 Contact Map
3frkA 2 0.9332 100 0.458 Contact Map
1o69A 2 0.9049 100 0.463 Contact Map
2c81A 2 0.964 100 0.468 Contact Map
3bb8A 2 0.9846 100 0.472 Contact Map
3b8xA 2 0.9563 100 0.472 Contact Map
3nytA 2 0.9049 100 0.488 Contact Map
1b9hA 2 0.9512 100 0.491 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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