GREMLIN Database
GERQ - Spore coat protein GerQ
UniProt: P39620 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 181 (150)
Sequences: 115 (108)
Seq/√Len: 8.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
120_S125_S4.7500.99
115_M153_L4.6120.99
96_E177_S3.9850.98
178_Y181_R3.8920.98
134_A150_R3.5470.96
140_I154_L3.3890.95
113_I142_I3.3250.94
120_S124_G2.7770.86
115_M154_L2.6370.83
120_S123_W2.5670.81
140_I158_L2.3050.73
132_I152_L2.3020.73
115_M158_L2.1890.69
158_L161_I2.0750.65
119_N125_S1.9710.61
153_L158_L1.9050.58
76_P167_I1.8150.54
114_Y119_N1.7890.53
119_N123_W1.7290.50
107_R154_L1.6720.48
143_S148_G1.6650.48
122_E129_R1.6630.47
156_I167_I1.6350.46
119_N124_G1.6280.46
90_G166_E1.6100.45
107_R167_I1.5900.44
49_M127_I1.5040.41
84_P161_I1.4940.40
52_G58_G1.4910.40
116_T159_D1.4280.38
113_I117_F1.4080.37
87_S131_V1.3890.36
123_W126_K1.3870.36
121_K142_I1.3820.36
140_I153_L1.3620.35
170_T173_Y1.3470.34
61_G70_G1.3460.34
127_I164_D1.3330.34
143_S150_R1.3260.34
144_D149_T1.3140.33
90_G107_R1.2950.32
121_K151_Y1.2910.32
129_R164_D1.2420.30
165_E168_A1.2230.30
112_T150_R1.1910.29
63_G88_V1.1860.28
131_V166_E1.1810.28
126_K150_R1.1780.28
146_K166_E1.1720.28
96_E155_T1.1460.27
96_E149_T1.1430.27
154_L158_L1.1370.27
145_P148_G1.1360.27
118_E124_G1.1010.26
126_K143_S1.0970.25
88_V94_V1.0870.25
33_G36_S1.0860.25
99_I117_F1.0580.24
157_Y166_E1.0550.24
129_R176_A1.0530.24
115_M140_I1.0500.24
42_G88_V1.0490.24
35_G176_A1.0420.24
73_F77_S1.0340.23
121_K170_T1.0270.23
150_R166_E1.0250.23
115_M172_P1.0230.23
111_A172_P1.0190.23
48_P62_F0.9960.22
49_M60_Q0.9910.22
32_Q129_R0.9900.22
113_I157_Y0.9790.22
113_I146_K0.9640.21
99_I155_T0.9600.21
87_S168_A0.9510.21
140_I161_I0.9450.21
110_T131_V0.9420.21
72_G78_G0.9340.20
55_G64_F0.9280.20
140_I164_D0.9220.20
156_I166_E0.9180.20
94_V167_I0.9150.20
40_T80_T0.9080.20
69_Q80_T0.9080.20
41_M57_Q0.8970.19
117_F128_F0.8950.19
156_I171_Y0.8890.19
122_E128_F0.8880.19
140_I149_T0.8770.19
112_T147_S0.8770.19
93_P99_I0.8720.19
88_V141_I0.8720.19
89_P154_L0.8700.19
111_A114_Y0.8700.19
126_K134_A0.8680.19
69_Q122_E0.8630.19
107_R173_Y0.8420.18
114_Y164_D0.8350.18
40_T48_P0.8270.18
34_Q37_Q0.8240.18
96_E179_S0.8220.17
114_Y160_Y0.8150.17
50_Q168_A0.8110.17
122_E127_I0.8040.17
86_Q89_P0.8020.17
118_E159_D0.8020.17
62_F65_P0.8000.17
50_Q66_G0.8000.17
83_G127_I0.7990.17
96_E156_I0.7930.17
98_Y121_K0.7920.17
119_N122_E0.7910.17
85_G176_A0.7880.17
142_I146_K0.7660.16
69_Q78_G0.7650.16
116_T125_S0.7640.16
110_T168_A0.7610.16
67_Q79_P0.7610.16
111_A149_T0.7600.16
42_G65_P0.7590.16
175_M180_P0.7560.16
160_Y172_P0.7560.16
143_S160_Y0.7520.16
39_Q155_T0.7470.16
66_G177_S0.7460.16
116_T124_G0.7460.16
118_E123_W0.7450.16
111_A151_Y0.7390.16
103_L152_L0.7200.15
32_Q35_G0.7180.15
76_P151_Y0.7160.15
168_A174_S0.7140.15
174_S177_S0.7130.15
119_N157_Y0.7080.15
54_Q62_F0.7060.15
54_Q64_F0.7050.15
33_G38_M0.7040.15
152_L161_I0.7020.15
91_M113_I0.7010.15
111_A157_Y0.7000.15
34_Q41_M0.6990.15
68_Q79_P0.6960.15
42_G48_P0.6950.15
86_Q173_Y0.6940.15
117_F157_Y0.6840.14
98_Y144_D0.6820.14
153_L178_Y0.6770.14
114_Y127_I0.6740.14
99_I105_L0.6720.14
127_I147_S0.6710.14
63_G86_Q0.6680.14
94_V107_R0.6620.14
34_Q38_M0.6600.14
98_Y160_Y0.6580.14
72_G76_P0.6580.14
37_Q165_E0.6530.14
118_E125_S0.6490.14
49_M85_G0.6480.14
133_E155_T0.6410.13
123_W128_F0.6410.13
111_A158_L0.6410.13
114_Y157_Y0.6340.13
53_Q59_Q0.6300.13
123_W127_I0.6280.13
114_Y141_I0.6240.13
33_G37_Q0.6220.13
61_G68_Q0.6140.13
131_V175_M0.6100.13
59_Q67_Q0.6080.13
41_M50_Q0.6080.13
52_G74_Q0.6070.13
43_M64_F0.6070.13
134_A144_D0.6060.13
77_S95_E0.6050.13
152_L158_L0.5930.13
82_S121_K0.5920.12
68_Q78_G0.5890.12
55_G59_Q0.5840.12
74_Q167_I0.5800.12
62_F66_G0.5790.12
99_I181_R0.5790.12
129_R168_A0.5760.12
115_M160_Y0.5760.12
120_S126_K0.5750.12
69_Q77_S0.5750.12
61_G141_I0.5750.12
114_Y144_D0.5740.12
55_G66_G0.5730.12
116_T120_S0.5650.12
134_A143_S0.5640.12
51_Q56_Q0.5630.12
90_G170_T0.5610.12
119_N159_D0.5600.12
41_M73_F0.5590.12
144_D160_Y0.5570.12
89_P98_Y0.5560.12
55_G62_F0.5560.12
36_S41_M0.5530.12
122_E146_K0.5520.12
54_Q57_Q0.5500.12
149_T173_Y0.5480.12
129_R162_T0.5450.12
79_P87_S0.5450.12
44_Q140_I0.5420.12
154_L170_T0.5340.11
40_T63_G0.5310.11
62_F70_G0.5290.11
35_G44_Q0.5290.11
74_Q81_P0.5260.11
43_M48_P0.5240.11
110_T129_R0.5240.11
158_L164_D0.5220.11
35_G38_M0.5220.11
77_S94_V0.5140.11
54_Q73_F0.5140.11
80_T86_Q0.5140.11
77_S177_S0.5110.11
55_G140_I0.5100.11
45_P64_F0.5100.11
110_T179_S0.5080.11
45_P82_S0.5070.11
159_D162_T0.5060.11
98_Y131_V0.5060.11
121_K168_A0.5040.11
142_I162_T0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2z73A 2 0 92.5 0.934 Contact Map
4febA 3 0.1602 83 0.944 Contact Map
4b8cD 1 0.232 14.6 0.966 Contact Map
4m3kA 1 0.4088 9.8 0.969 Contact Map
3kw2A 2 0.4586 6 0.972 Contact Map
2pl3A 1 0.4917 5.8 0.972 Contact Map
1hzoA 1 0.4254 5.2 0.973 Contact Map
4x9cA 3 0.3204 5.2 0.973 Contact Map
2x7xA 2 0.3978 5.2 0.973 Contact Map
1bueA 1 0.3425 5.1 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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