GREMLIN Database
YWDJ - Putative purine permease YwdJ
UniProt: P39618 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 440 (391)
Sequences: 4272 (2177)
Seq/√Len: 110.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
171_A194_G5.1421.00
167_V198_L5.0321.00
101_L286_G4.7341.00
147_I165_A4.1341.00
134_L412_G4.0831.00
172_A191_A3.6821.00
214_L329_F3.6031.00
45_F325_S3.5631.00
197_V201_A3.5161.00
106_C237_I3.3911.00
208_I211_P3.1701.00
175_M190_L3.1351.00
94_R227_L3.0061.00
382_T415_A3.0031.00
95_G227_L2.9371.00
164_L199_F2.9131.00
207_P210_M2.8001.00
48_G322_I2.7631.00
98_G228_F2.6871.00
164_L204_A2.6831.00
167_V194_G2.6621.00
379_S416_A2.6481.00
371_R424_L2.6131.00
221_F287_L2.5831.00
169_I348_V2.5161.00
50_A281_S2.3591.00
7_A316_L2.3581.00
251_M274_A2.3481.00
212_D329_F2.3431.00
101_L283_L2.3421.00
11_T320_L2.3231.00
164_L202_A2.2881.00
167_V171_A2.2301.00
4_V320_L2.2111.00
102_V233_I2.1791.00
193_F197_V2.1351.00
60_R268_K2.1351.00
171_A175_M2.1041.00
255_D266_D2.1011.00
46_V288_T2.0951.00
52_V318_S2.0541.00
256_I363_S2.0471.00
122_L421_Q2.0211.00
163_G167_V2.0051.00
197_V200_A2.0011.00
108_F283_L1.9831.00
52_V315_M1.9661.00
171_A198_L1.9561.00
25_V75_Y1.9541.00
108_F276_F1.9461.00
55_C315_M1.9421.00
209_E336_S1.9401.00
308_M313_P1.9401.00
111_S276_F1.9261.00
160_L204_A1.9221.00
210_M333_T1.9031.00
212_D332_N1.8941.00
172_A345_V1.8901.00
45_F322_I1.8661.00
105_V109_L1.8591.00
92_T95_G1.8421.00
196_W336_S1.7881.00
418_A422_F1.7701.00
319_I323_V1.7661.00
3_L316_L1.7641.00
264_Q267_G1.7641.00
100_L286_G1.7621.00
104_A283_L1.7571.00
137_M354_G1.7531.00
159_G163_G1.7411.00
108_F279_S1.7221.00
124_T420_D1.7201.00
174_I178_S1.7181.00
110_L244_I1.7081.00
146_G339_S1.6901.00
105_V283_L1.6521.00
175_M179_N1.6401.00
75_Y96_L1.6221.00
11_T317_G1.6071.00
267_G270_H1.5971.00
198_L202_A1.5971.00
264_Q270_H1.5941.00
26_A31_L1.5941.00
201_A204_A1.5841.00
47_L64_N1.5361.00
196_W205_A1.5151.00
379_S415_A1.5121.00
163_G166_L1.4941.00
270_H273_H1.4931.00
99_A103_S1.4801.00
76_T79_A1.4771.00
126_V376_I1.4711.00
182_F186_Y1.4591.00
183_F190_L1.4551.00
169_I378_I1.4491.00
91_D229_N1.4381.00
195_G341_V1.4281.00
179_N183_F1.4261.00
220_L287_L1.4251.00
229_N232_L1.4241.00
57_K280_F1.4161.00
108_F280_F1.4141.00
375_I419_A1.4111.00
166_L170_A1.3981.00
95_G229_N1.3961.00
52_V55_C1.3861.00
150_I157_V1.3701.00
220_L289_G1.3691.00
160_L202_A1.3661.00
382_T411_L1.3541.00
14_I18_A1.3531.00
10_W299_A1.3311.00
72_W76_T1.3281.00
78_Y232_L1.3140.99
170_A174_I1.3120.99
101_L226_P1.3120.99
198_L201_A1.3090.99
49_I322_I1.3000.99
52_V322_I1.2970.99
329_F332_N1.2970.99
222_P289_G1.2870.99
402_I406_S1.2870.99
303_I309_P1.2720.99
221_F226_P1.2700.99
51_A64_N1.2640.99
200_A207_P1.2600.99
190_L194_G1.2520.99
91_D232_L1.2490.99
56_L315_M1.2400.99
186_Y190_L1.2270.99
254_V303_I1.2150.99
45_F288_T1.2090.99
179_N184_K1.2090.99
228_F233_I1.2060.99
96_L99_A1.2030.99
194_G198_L1.2030.99
414_L418_A1.1980.99
250_S297_S1.1980.99
378_I415_A1.1900.99
55_C314_F1.1850.99
230_S233_I1.1840.99
34_S41_Q1.1800.99
107_F111_S1.1740.99
148_L156_G1.1660.99
63_I254_V1.1560.99
163_G202_A1.1510.99
216_Q328_P1.1400.99
134_L383_G1.1390.98
79_A96_L1.1360.98
111_S114_K1.1280.98
155_D158_D1.1180.98
68_A243_L1.1150.98
327_I331_M1.1030.98
380_L384_V1.1010.98
144_I385_G1.0990.98
221_F224_G1.0910.98
126_V130_V1.0870.98
94_R97_Q1.0830.98
246_N294_V1.0800.98
99_A107_F1.0780.98
66_S296_I1.0660.98
401_F404_L1.0590.98
70_L243_L1.0590.98
49_I53_I1.0580.98
104_A282_H1.0500.97
104_A279_S1.0500.97
323_V327_I1.0370.97
65_E295_P1.0340.97
250_S300_A1.0280.97
160_L163_G1.0270.97
174_I422_F1.0240.97
149_G157_V1.0220.97
251_M278_A1.0150.97
285_S293_P1.0110.97
78_Y236_S1.0100.97
13_F302_F1.0080.97
247_M251_M1.0070.97
107_F243_L1.0070.97
399_P402_I1.0060.97
101_L287_L0.9970.97
74_V239_I0.9910.96
103_S240_T0.9870.96
33_H40_I0.9860.96
64_N317_G0.9820.96
49_I284_L0.9820.96
312_K315_M0.9740.96
359_A363_S0.9740.96
133_L380_L0.9720.96
199_F203_G0.9710.96
401_F405_L0.9660.96
81_L91_D0.9610.96
258_M265_P0.9570.96
21_V69_G0.9480.95
52_V319_I0.9430.95
258_M309_P0.9400.95
217_L326_V0.9400.95
91_D95_G0.9370.95
111_S272_R0.9290.95
160_L164_L0.9270.95
374_S378_I0.9260.95
284_L288_T0.9210.95
98_G102_V0.9200.95
200_A205_A0.9170.94
54_Q58_G0.9160.94
180_I184_K0.9130.94
247_M274_A0.9110.94
10_W13_F0.9040.94
140_S381_L0.8990.94
167_V202_A0.8960.94
354_G380_L0.8940.94
77_I80_G0.8930.94
161_V340_P0.8900.93
158_D161_V0.8840.93
95_G98_G0.8820.93
54_Q61_L0.8810.93
63_I295_P0.8780.93
164_L198_L0.8780.93
189_L193_F0.8750.93
170_A173_F0.8720.93
77_I81_L0.8690.93
171_A191_A0.8660.93
364_Y372_V0.8640.92
214_L327_I0.8620.92
231_G235_T0.8620.92
94_R98_G0.8610.92
371_R375_I0.8610.92
315_M318_S0.8500.92
390_P405_L0.8500.92
169_I173_F0.8480.92
206_K209_E0.8460.92
23_V40_I0.8450.92
64_N314_F0.8420.91
199_F204_A0.8420.91
10_W14_I0.8410.91
4_V316_L0.8400.91
99_A104_A0.8400.91
92_T99_A0.8400.91
138_Q409_L0.8380.91
17_A298_G0.8370.91
133_L358_F0.8360.91
213_R216_Q0.8300.91
196_W207_P0.8290.91
123_F413_T0.8290.91
48_G318_S0.8270.91
72_W241_I0.8260.91
92_T103_S0.8250.91
117_D272_R0.8230.91
348_V374_S0.8220.90
210_M336_S0.8220.90
355_G373_R0.8210.90
241_I253_V0.8200.90
132_L250_S0.8130.90
100_L107_F0.8120.90
196_W337_L0.8100.90
6_G10_W0.8090.90
17_A350_F0.8090.90
248_L271_E0.8080.90
68_A294_V0.8070.90
105_V108_F0.8050.90
70_L349_V0.8050.90
103_S111_S0.8020.89
146_G350_F0.8000.89
103_S107_F0.7990.89
8_L320_L0.7990.89
101_L228_F0.7970.89
55_C311_K0.7970.89
96_L100_L0.7950.89
247_M278_A0.7930.89
97_Q101_L0.7860.88
149_G155_D0.7830.88
43_T291_I0.7830.88
101_L105_V0.7780.88
355_G376_I0.7720.88
243_L294_V0.7720.88
315_M319_I0.7710.87
330_F333_T0.7710.87
324_I330_F0.7680.87
95_G99_A0.7680.87
46_V290_A0.7680.87
247_M294_V0.7650.87
23_V342_G0.7650.87
11_T324_I0.7640.87
122_L417_I0.7600.87
21_V67_P0.7560.86
42_S45_F0.7560.86
63_I251_M0.7560.86
143_I168_V0.7560.86
63_I302_F0.7540.86
197_V323_V0.7520.86
382_T386_I0.7490.86
300_A303_I0.7470.86
164_L340_P0.7430.85
46_V284_L0.7420.85
148_L162_F0.7400.85
130_V379_S0.7390.85
4_V8_L0.7380.85
18_A47_L0.7380.85
175_M191_A0.7370.85
57_K277_A0.7370.85
241_I245_V0.7360.85
269_H273_H0.7300.84
230_S234_I0.7290.84
175_M183_F0.7290.84
375_I379_S0.7280.84
378_I419_A0.7260.84
280_F284_L0.7260.84
237_I240_T0.7250.84
166_L202_A0.7230.84
67_P71_W0.7220.84
188_I302_F0.7190.84
156_G159_G0.7190.84
177_N355_G0.7180.83
217_L325_S0.7160.83
126_V372_V0.7160.83
145_K148_L0.7150.83
14_I299_A0.7130.83
175_M194_G0.7110.83
111_S279_S0.7110.83
361_F364_Y0.7100.83
92_T100_L0.7090.83
146_G342_G0.7080.83
282_H293_P0.7080.83
20_V146_G0.7070.83
386_I411_L0.7070.83
192_L345_V0.7050.82
104_A111_S0.7030.82
383_G412_G0.7010.82
207_P336_S0.7000.82
92_T96_L0.7000.82
62_P314_F0.7000.82
367_E372_V0.6990.82
93_L97_Q0.6980.82
97_Q103_S0.6940.81
306_T320_L0.6930.81
223_F226_P0.6920.81
191_A194_G0.6880.81
53_I57_K0.6850.81
100_L104_A0.6810.80
202_A330_F0.6780.80
132_L135_L0.6780.80
43_T47_L0.6770.80
133_L361_F0.6760.80
42_S46_V0.6740.79
199_F202_A0.6740.79
91_D227_L0.6730.79
7_A317_G0.6720.79
46_V285_S0.6720.79
351_S355_G0.6700.79
162_F166_L0.6700.79
259_K309_P0.6700.79
97_Q100_L0.6700.79
190_L193_F0.6690.79
143_I165_A0.6670.79
14_I64_N0.6660.79
377_G381_L0.6660.79
183_F187_S0.6660.79
107_F279_S0.6650.79
23_V26_A0.6640.78
43_T67_P0.6640.78
94_R224_G0.6610.78
214_L218_P0.6580.78
257_A304_E0.6570.78
107_F240_T0.6560.78
65_E247_M0.6560.78
16_A22_P0.6530.77
18_A43_T0.6500.77
76_T80_G0.6500.77
254_V300_A0.6490.77
131_Y169_I0.6490.77
150_I156_G0.6480.77
98_G226_P0.6470.77
73_G77_I0.6470.77
10_W302_F0.6470.77
246_N278_A0.6420.76
193_F333_T0.6410.76
148_L157_V0.6410.76
177_N353_M0.6400.76
149_G156_G0.6380.76
381_L384_V0.6380.76
175_M187_S0.6380.76
70_L135_L0.6370.76
172_A348_V0.6370.76
266_D270_H0.6370.76
376_I380_L0.6360.75
53_I277_A0.6360.75
118_R122_L0.6360.75
79_A93_L0.6350.75
73_G76_T0.6350.75
362_D366_K0.6350.75
362_D367_E0.6340.75
194_G197_V0.6340.75
383_G408_G0.6320.75
167_V201_A0.6310.75
304_E359_A0.6300.75
254_V295_P0.6300.75
283_L287_L0.6290.75
332_N336_S0.6280.74
215_F327_I0.6280.74
95_G232_L0.6280.74
18_A321_V0.6230.74
192_L245_V0.6230.74
179_N182_F0.6220.74
124_T301_G0.6220.74
70_L294_V0.6220.74
25_V192_L0.6220.74
176_T305_T0.6210.74
18_A21_V0.6210.74
243_L246_N0.6190.73
249_A383_G0.6180.73
172_A358_F0.6170.73
225_T287_L0.6150.73
68_A71_W0.6130.73
8_L148_L0.6120.73
176_T374_S0.6120.73
412_G416_A0.6110.72
375_I424_L0.6110.72
47_L63_I0.6100.72
31_L291_I0.6080.72
200_A203_G0.6080.72
74_V408_G0.6060.72
387_M390_P0.6060.72
146_G346_N0.6050.72
185_Q424_L0.6030.71
320_L324_I0.5990.71
171_A174_I0.5970.71
92_T102_V0.5970.71
142_P146_G0.5970.71
7_A132_L0.5970.71
417_I421_Q0.5950.70
123_F181_M0.5940.70
46_V281_S0.5920.70
332_N335_A0.5910.70
105_V225_T0.5910.70
14_I359_A0.5890.70
140_S377_G0.5880.70
106_C110_L0.5860.69
212_D328_P0.5860.69
408_G412_G0.5860.69
75_Y79_A0.5850.69
135_L296_I0.5840.69
253_V356_L0.5840.69
351_S373_R0.5830.69
20_V23_V0.5830.69
200_A422_F0.5820.69
210_M329_F0.5820.69
203_G341_V0.5820.69
118_R123_F0.5810.69
99_A102_V0.5810.69
59_H270_H0.5810.69
45_F326_V0.5810.69
218_P348_V0.5800.69
52_V56_L0.5790.68
65_E282_H0.5790.68
362_D365_E0.5790.68
48_G52_V0.5790.68
107_F244_I0.5780.68
147_I347_F0.5780.68
240_T282_H0.5760.68
99_A111_S0.5740.68
366_K376_I0.5730.68
49_I288_T0.5720.67
163_G198_L0.5710.67
140_S384_V0.5700.67
61_L274_A0.5690.67
116_I248_L0.5680.67
117_D121_K0.5670.67
298_G350_F0.5670.67
181_M184_K0.5670.67
250_S295_P0.5640.66
99_A232_L0.5640.66
32_D222_P0.5640.66
342_G345_V0.5630.66
278_A294_V0.5630.66
112_V116_I0.5620.66
174_I179_N0.5620.66
311_K315_M0.5610.66
138_Q408_G0.5600.66
248_L252_K0.5600.66
100_L103_S0.5590.66
196_W200_A0.5580.66
126_V375_I0.5580.66
22_P26_A0.5570.65
236_S340_P0.5570.65
67_P294_V0.5560.65
217_L220_L0.5560.65
6_G297_S0.5540.65
140_S347_F0.5530.65
158_D163_G0.5530.65
325_S331_M0.5530.65
241_I417_I0.5530.65
185_Q366_K0.5520.65
129_G357_A0.5520.65
102_V228_F0.5510.65
210_M332_N0.5490.64
78_Y91_D0.5490.64
150_I325_S0.5490.64
216_Q400_V0.5490.64
195_G203_G0.5480.64
171_A190_L0.5480.64
161_V164_L0.5480.64
243_L251_M0.5460.64
297_S410_V0.5450.64
176_T187_S0.5450.64
274_A278_A0.5450.64
101_L104_A0.5440.64
160_L198_L0.5440.64
133_L354_G0.5430.64
232_L235_T0.5430.64
164_L192_L0.5430.64
54_Q311_K0.5410.63
209_E288_T0.5410.63
369_S426_R0.5400.63
356_L359_A0.5400.63
192_L342_G0.5400.63
207_P333_T0.5390.63
226_P286_G0.5390.63
247_M295_P0.5370.63
98_G227_L0.5360.63
125_P373_R0.5350.62
50_A277_A0.5350.62
20_V24_A0.5350.62
108_F112_V0.5350.62
6_G14_I0.5340.62
398_H402_I0.5330.62
118_R268_K0.5330.62
75_Y100_L0.5320.62
78_Y99_A0.5320.62
170_A399_P0.5320.62
62_P258_M0.5310.62
121_K421_Q0.5310.62
145_K156_G0.5300.62
24_A76_T0.5290.62
265_P269_H0.5280.61
297_S356_L0.5280.61
201_A205_A0.5280.61
94_R225_T0.5270.61
112_V276_F0.5270.61
101_L225_T0.5260.61
79_A92_T0.5250.61
282_H285_S0.5250.61
400_V403_S0.5250.61
250_S356_L0.5240.61
280_F315_M0.5240.61
95_G100_L0.5230.61
217_L241_I0.5220.61
75_Y236_S0.5220.61
130_V416_A0.5220.61
299_A302_F0.5210.60
172_A175_M0.5210.60
244_I293_P0.5210.60
78_Y235_T0.5210.60
62_P99_A0.5200.60
378_I384_V0.5190.60
42_S289_G0.5190.60
235_T404_L0.5180.60
371_R425_W0.5180.60
127_V420_D0.5160.60
100_L111_S0.5150.59
106_C162_F0.5150.59
138_Q407_N0.5150.59
136_V143_I0.5140.59
308_M342_G0.5140.59
21_V43_T0.5140.59
130_V336_S0.5140.59
355_G358_F0.5140.59
252_K307_K0.5110.59
255_D259_K0.5110.59
298_G352_A0.5110.59
25_V32_D0.5110.59
358_F369_S0.5090.59
125_P308_M0.5080.58
151_G155_D0.5080.58
221_F225_T0.5070.58
47_L239_I0.5070.58
278_A377_G0.5060.58
283_L286_G0.5050.58
67_P135_L0.5050.58
267_G272_R0.5050.58
126_V201_A0.5040.58
194_G201_A0.5040.58
51_A294_V0.5030.58
128_T328_P0.5010.57
67_P143_I0.5010.57
397_L402_I0.5000.57
375_I385_G0.5000.57
60_R76_T0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qe7A 2 0.8841 100 0.426 Contact Map
4ikvA 1 0.8886 75.4 0.962 Contact Map
2gfpA 2 0.4273 71.3 0.963 Contact Map
1pw4A 1 0.475 69.5 0.964 Contact Map
3o7qA 1 0.4523 65.5 0.965 Contact Map
2cfqA 1 0.8818 63.8 0.965 Contact Map
3wdoA 1 0.4386 51.3 0.968 Contact Map
4j05A 3 0.8659 41 0.969 Contact Map
4tphA 2 0.8409 37.1 0.97 Contact Map
2nwlA 3 0.5091 34.7 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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