GREMLIN Database
ALDH2 - Probable aldehyde dehydrogenase YwdH
UniProt: P39616 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 456 (422)
Sequences: 35374 (20773)
Seq/√Len: 1011.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
254_E346_R5.3471.00
198_E202_K4.0151.00
254_E344_T3.3301.00
226_Q263_E3.3031.00
257_K344_T3.0361.00
325_R328_S3.0191.00
221_K253_H2.8781.00
308_Q317_A2.8331.00
288_E292_Q2.7331.00
261_T342_L2.6521.00
230_K267_A2.6281.00
38_R72_S2.5991.00
300_D329_P2.5881.00
149_I152_K2.5791.00
12_K182_D2.5111.00
221_K255_D2.4931.00
40_H43_D2.4751.00
298_L316_I2.4351.00
368_T374_E2.3391.00
33_L154_I2.2551.00
42_A60_Y2.2381.00
155_S160_T2.1931.00
41_E65_G2.1651.00
103_E426_K2.1391.00
348_I373_I2.1291.00
295_L299_N2.1001.00
285_I294_L2.0701.00
265_K269_R2.0171.00
142_Y287_S2.0051.00
359_P407_E1.9941.00
217_C232_I1.9931.00
174_T178_Q1.9931.00
321_L330_V1.9701.00
29_I158_F1.9491.00
102_P420_N1.9411.00
376_A380_N1.9401.00
178_Q199_A1.9391.00
295_L309_S1.9371.00
295_L316_I1.9191.00
43_D149_I1.9141.00
222_D373_I1.8911.00
259_K263_E1.8821.00
348_I376_A1.8791.00
251_F354_K1.8711.00
251_F351_V1.8631.00
102_P423_T1.8311.00
382_S406_G1.8251.00
5_P175_A1.8161.00
195_I198_E1.8021.00
36_A153_L1.7931.00
253_H345_Y1.7861.00
194_K407_E1.7751.00
326_D354_K1.7511.00
304_L322_E1.7501.00
331_M343_F1.7381.00
268_I320_I1.7361.00
36_A39_T1.7361.00
151_S165_M1.6901.00
329_P333_E1.6711.00
15_F19_H1.6661.00
232_I260_L1.6581.00
47_A149_I1.6551.00
134_T162_Y1.6481.00
71_I126_I1.6451.00
225_I263_E1.6411.00
257_K261_T1.6361.00
31_R72_S1.6331.00
237_F268_I1.6331.00
250_L340_L1.6311.00
350_E353_E1.6211.00
5_P9_S1.6141.00
258_T344_T1.6111.00
262_E266_R1.5921.00
36_A156_S1.5881.00
22_P25_S1.5781.00
5_P179_Q1.5771.00
35_Q39_T1.5701.00
346_R350_E1.5671.00
56_E60_Y1.5641.00
349_G380_N1.5551.00
296_S329_P1.5411.00
38_R68_L1.5391.00
221_K373_I1.5381.00
35_Q72_S1.5331.00
265_K304_L1.5171.00
257_K322_E1.5171.00
297_F335_I1.5141.00
364_L383_F1.5071.00
263_E266_R1.5041.00
31_R79_R1.4991.00
288_E314_H1.4861.00
8_I179_Q1.4811.00
251_F345_Y1.4791.00
25_S28_N1.4761.00
77_R80_K1.4731.00
229_A263_E1.4661.00
231_R367_F1.4651.00
252_V260_L1.4541.00
32_K35_Q1.4441.00
220_H373_I1.4431.00
42_A46_A1.4371.00
49_Y59_A1.4281.00
46_A50_Q1.4261.00
34_K72_S1.4241.00
232_I250_L1.4191.00
71_I122_L1.4181.00
20_T380_N1.4121.00
41_E60_Y1.4111.00
267_A270_E1.4081.00
110_V135_V1.4051.00
259_K262_E1.4021.00
220_H345_Y1.3921.00
350_E354_K1.3751.00
197_M410_I1.3751.00
101_I379_G1.3621.00
15_F134_T1.3531.00
46_A276_P1.3511.00
183_Y208_T1.3441.00
40_H149_I1.3421.00
141_E170_P1.3421.00
291_Y316_I1.3341.00
151_S163_V1.3191.00
345_Y354_K1.3101.00
121_A137_L1.2981.00
21_R25_S1.2951.00
174_T199_A1.2911.00
299_N303_P1.2881.00
3_S6_S1.2841.00
352_I377_V1.2801.00
154_I163_V1.2791.00
258_T262_E1.2751.00
347_N350_E1.2721.00
220_H377_V1.2721.00
44_L149_I1.2671.00
266_R269_R1.2661.00
294_L337_G1.2641.00
161_D164_A1.2601.00
261_T265_K1.2541.00
34_K38_R1.2501.00
4_I172_V1.2491.00
291_Y295_L1.2461.00
292_Q296_S1.2371.00
253_H256_I1.2331.00
273_G280_P1.2231.00
178_Q202_K1.2201.00
33_L153_L1.2191.00
291_Y309_S1.2181.00
417_D420_N1.2141.00
253_H347_N1.2131.00
264_M340_L1.2111.00
288_E291_Y1.2111.00
271_F282_Y1.2101.00
174_T195_I1.2081.00
49_Y275_Q1.2071.00
32_K36_A1.1961.00
10_K164_A1.1871.00
327_D332_Q1.1861.00
296_S300_D1.1791.00
102_P425_K1.1771.00
218_I351_V1.1761.00
33_L71_I1.1741.00
99_I375_R1.1741.00
364_L386_G1.1721.00
332_Q357_S1.1691.00
260_L264_M1.1651.00
378_L428_V1.1631.00
374_E388_V1.1591.00
125_L163_V1.1571.00
326_D357_S1.1571.00
192_V195_I1.1551.00
416_F420_N1.1541.00
46_A56_E1.1501.00
175_A179_Q1.1491.00
256_I259_K1.1471.00
21_R29_I1.1471.00
33_L158_F1.1461.00
110_V185_F1.1431.00
109_L176_L1.1411.00
269_R305_T1.1361.00
266_R270_E1.1321.00
40_H153_L1.1301.00
8_I181_F1.1281.00
261_T322_E1.1251.00
217_C247_P1.1211.00
9_S13_A1.1191.00
214_K248_D1.1151.00
263_E267_A1.1151.00
403_G412_S1.1061.00
332_Q359_P1.1061.00
218_I377_V1.1031.00
224_D369_T1.1021.00
105_Y183_Y1.0981.00
269_R317_A1.0961.00
31_R76_K1.0951.00
297_F300_D1.0931.00
349_G376_A1.0911.00
148_A167_E1.0881.00
195_I199_A1.0871.00
116_Y243_T1.0861.00
348_I377_V1.0861.00
291_Y314_H1.0841.00
306_G319_T1.0771.00
294_L339_I1.0741.00
191_A195_I1.0731.00
417_D425_K1.0711.00
197_M207_V1.0701.00
352_I380_N1.0651.00
412_S424_H1.0611.00
148_A165_M1.0571.00
14_Y134_T1.0561.00
299_N302_I1.0531.00
84_P417_D1.0501.00
194_K204_L1.0491.00
125_L135_V1.0491.00
218_I355_V1.0491.00
44_L153_L1.0481.00
370_N373_I1.0441.00
109_L181_F1.0421.00
101_I428_V1.0411.00
84_P416_F1.0361.00
216_P364_L1.0341.00
16_A353_E1.0291.00
258_T261_T1.0201.00
197_M201_A1.0161.00
27_L79_R1.0141.00
324_V328_S1.0111.00
224_D227_L1.0101.00
107_T181_F1.0071.00
274_P277_E1.0071.00
349_G353_E1.0001.00
345_Y351_V0.9931.00
16_A20_T0.9931.00
265_K305_T0.9881.00
16_A382_S0.9791.00
105_Y206_P0.9721.00
182_D382_S0.9671.00
45_I60_Y0.9671.00
67_V122_L0.9651.00
54_K63_E0.9651.00
405_V424_H0.9531.00
297_F329_P0.9521.00
235_G247_P0.9521.00
226_Q259_K0.9521.00
236_K248_D0.9491.00
78_L130_A0.9491.00
220_H348_I0.9481.00
103_E379_G0.9421.00
98_S400_L0.9421.00
12_K16_A0.9401.00
107_T134_T0.9361.00
43_D46_A0.9361.00
229_A264_M0.9341.00
353_E357_S0.9331.00
261_T304_L0.9321.00
306_G317_A0.9271.00
206_P424_H0.9231.00
34_K75_M0.9201.00
351_V354_K0.9191.00
189_S192_V0.9191.00
19_H382_S0.9171.00
292_Q295_L0.9171.00
343_F354_K0.9131.00
52_L143_T0.9111.00
257_K342_L0.9111.00
50_Q276_P0.9101.00
219_V260_L0.9081.00
326_D343_F0.9071.00
31_R75_M0.9051.00
105_Y133_N0.9031.00
227_L231_R0.9031.00
27_L75_M0.9021.00
108_V183_Y0.9001.00
225_I229_A0.8981.00
228_A232_I0.8961.00
233_V267_A0.8951.00
345_Y350_E0.8941.00
23_L27_L0.8921.00
103_E405_V0.8921.00
217_C367_F0.8901.00
366_L377_V0.8901.00
301_G321_L0.8891.00
229_A267_A0.8881.00
229_A260_L0.8851.00
257_K323_Q0.8801.00
40_H152_K0.8801.00
294_L335_I0.8801.00
105_Y424_H0.8781.00
364_L381_L0.8771.00
158_F163_V0.8761.00
400_L427_S0.8751.00
99_I430_K0.8741.00
27_L31_R0.8721.00
10_K161_D0.8711.00
37_V67_V0.8671.00
184_I196_V0.8661.00
220_H368_T0.8651.00
109_L173_S0.8641.00
194_K198_E0.8641.00
168_G172_V0.8631.00
152_K155_S0.8611.00
4_I109_L0.8581.00
28_N32_K0.8571.00
197_M200_A0.8551.00
215_S248_D0.8551.00
298_L339_I0.8501.00
229_A233_V0.8471.00
124_P413_Y0.8451.00
14_Y162_Y0.8451.00
36_A40_H0.8451.00
228_A260_L0.8441.00
32_K156_S0.8401.00
30_L130_A0.8401.00
142_Y289_R0.8351.00
67_V118_L0.8351.00
375_R379_G0.8341.00
322_E344_T0.8321.00
233_V264_M0.8301.00
184_I200_A0.8301.00
9_S12_K0.8291.00
20_T379_G0.8281.00
352_I356_Q0.8281.00
127_G418_S0.8281.00
177_L196_V0.8241.00
197_M204_L0.8191.00
298_L321_L0.8171.00
193_G211_L0.8151.00
37_V68_L0.8131.00
6_S10_K0.8121.00
121_A125_L0.8101.00
137_L147_S0.8081.00
49_Y56_E0.8061.00
271_F281_Q0.8051.00
109_L184_I0.8041.00
296_S299_N0.8041.00
170_P174_T0.8031.00
302_I321_L0.8021.00
13_A16_A0.8011.00
303_P323_Q0.8001.00
264_M320_I0.7971.00
294_L316_I0.7961.00
193_G209_L0.7921.00
50_Q145_A0.7911.00
262_E265_K0.7881.00
383_F386_G0.7881.00
216_P355_V0.7881.00
371_K374_E0.7861.00
128_A135_V0.7861.00
24_E79_R0.7851.00
139_P167_E0.7821.00
173_S177_L0.7801.00
52_L286_V0.7791.00
148_A152_K0.7781.00
131_A423_T0.7771.00
45_I56_E0.7761.00
321_L324_V0.7761.00
110_V124_P0.7751.00
11_H164_A0.7741.00
45_I49_Y0.7721.00
122_L150_L0.7711.00
57_Q281_Q0.7671.00
177_L184_I0.7661.00
31_R35_Q0.7651.00
177_L199_A0.7631.00
252_V256_I0.7621.00
371_K430_K0.7611.00
13_A17_A0.7611.00
133_N423_T0.7601.00
60_Y278_R0.7571.00
18_G162_Y0.7571.00
253_H348_I0.7531.00
220_H253_H0.7511.00
16_A19_H0.7501.00
168_G173_S0.7491.00
158_F162_Y0.7481.00
136_V164_A0.7461.00
29_I156_S0.7451.00
186_F192_V0.7451.00
297_F333_E0.7441.00
200_A207_V0.7441.00
48_L51_D0.7421.00
6_S9_S0.7421.00
225_I256_I0.7401.00
151_S155_S0.7391.00
226_Q267_A0.7371.00
265_K268_I0.7361.00
268_I271_F0.7361.00
141_E293_R0.7351.00
190_V407_E0.7341.00
44_L118_L0.7321.00
4_I175_A0.7321.00
54_K58_E0.7291.00
56_E276_P0.7281.00
277_E280_P0.7261.00
347_N353_E0.7241.00
121_A147_S0.7241.00
170_P195_I0.7211.00
307_G319_T0.7211.00
194_K202_K0.7211.00
118_L146_V0.7191.00
2_N5_P0.7171.00
137_L163_V0.7161.00
142_Y286_V0.7131.00
47_A145_A0.7131.00
17_A21_R0.7121.00
316_I319_T0.7111.00
348_I352_I0.7091.00
307_G317_A0.7081.00
289_R293_R0.7071.00
38_R65_G0.7061.00
250_L260_L0.7041.00
154_I158_F0.7031.00
388_V430_K0.7031.00
251_F331_M0.7021.00
23_L78_L0.7021.00
222_D368_T0.7001.00
354_K357_S0.6981.00
274_P280_P0.6971.00
198_E201_A0.6971.00
38_R41_E0.6961.00
251_F326_D0.6951.00
49_Y276_P0.6941.00
36_A157_V0.6931.00
290_H293_R0.6921.00
287_S290_H0.6921.00
326_D331_M0.6911.00
149_I153_L0.6901.00
2_N6_S0.6891.00
12_K15_F0.6871.00
18_G29_I0.6861.00
134_T164_A0.6861.00
175_A178_Q0.6841.00
105_Y182_D0.6831.00
42_A56_E0.6831.00
11_H134_T0.6831.00
98_S427_S0.6821.00
19_H380_N0.6801.00
141_E195_I0.6771.00
268_I305_T0.6751.00
112_A121_A0.6721.00
4_I8_I0.6721.00
369_T372_E0.6711.00
43_D152_K0.6711.00
324_V331_M0.6711.00
264_M342_L0.6711.00
240_A282_Y0.6701.00
289_R292_Q0.6701.00
64_I68_L0.6691.00
48_L63_E0.6681.00
171_D174_T0.6661.00
232_I264_M0.6651.00
99_I428_V0.6621.00
121_A150_L0.6611.00
206_P421_T0.6601.00
54_K116_Y0.6591.00
97_K375_R0.6581.00
177_L203_Q0.6581.00
19_H103_E0.6561.00
378_L388_V0.6541.00
17_A20_T0.6541.00
208_T421_T0.6541.00
10_K160_T0.6531.00
265_K320_I0.6531.00
124_P185_F0.6531.00
374_E378_L0.6521.00
335_I339_I0.6511.00
285_I290_H0.6491.00
29_I157_V0.6461.00
324_V330_V0.6461.00
34_K68_L0.6451.00
35_Q38_R0.6441.00
272_Y282_Y0.6421.00
219_V228_A0.6411.00
48_L59_A0.6391.00
375_R430_K0.6361.00
368_T373_I0.6351.00
288_E309_S0.6341.00
19_H104_P0.6341.00
98_S429_V0.6321.00
382_S405_V0.6321.00
16_A380_N0.6311.00
371_K375_R0.6301.00
295_L298_L0.6291.00
90_P93_H0.6291.00
420_N425_K0.6291.00
37_V118_L0.6281.00
125_L137_L0.6281.00
101_I426_K0.6271.00
199_A202_K0.6271.00
233_V271_F0.6231.00
352_I381_L0.6231.00
25_S29_I0.6221.00
7_I166_A0.6211.00
420_N423_T0.6201.00
18_G129_I0.6191.00
352_I376_A0.6181.00
366_L374_E0.6181.00
225_I259_K0.6171.00
41_E45_I0.6151.00
305_T320_I0.6141.00
169_G173_S0.6131.00
141_E191_A0.6131.00
46_A49_Y0.6121.00
386_G426_K0.6121.00
217_C250_L0.6111.00
14_Y17_A0.6111.00
252_V342_L0.6101.00
23_L130_A0.6091.00
293_R296_S0.6091.00
217_C365_Y0.6031.00
33_L36_A0.6021.00
37_V71_I0.6021.00
64_I118_L0.6021.00
183_Y421_T0.6021.00
197_M209_L0.6011.00
222_D370_N0.6011.00
37_V150_L0.6001.00
48_L146_V0.5991.00
222_D369_T0.5991.00
372_E376_A0.5991.00
272_Y281_Q0.5971.00
235_G391_T0.5941.00
243_T246_A0.5931.00
227_L230_K0.5921.00
81_W423_T0.5921.00
323_Q344_T0.5921.00
32_K157_V0.5881.00
37_V44_L0.5871.00
221_K345_Y0.5861.00
29_I33_L0.5851.00
223_A228_A0.5841.00
34_K71_I0.5841.00
73_F77_R0.5841.00
227_L369_T0.5821.00
44_L64_I0.5821.00
372_E375_R0.5821.00
150_L154_I0.5811.00
245_I395_V0.5791.00
108_V133_N0.5781.00
118_L150_L0.5781.00
12_K107_T0.5761.00
108_V135_V0.5761.00
216_P383_F0.5741.00
331_M354_K0.5731.00
285_I316_I0.5731.00
303_P322_E0.5731.00
119_Q123_S0.5721.00
81_W419_F0.5721.00
191_A289_R0.5711.00
210_E362_L0.5711.00
136_V166_A0.5701.00
11_H136_V0.5681.00
141_E169_G0.5681.00
110_V125_L0.5681.00
109_L136_V0.5671.00
247_P365_Y0.5661.00
190_V194_K0.5651.00
180_P359_P0.5651.00
131_A419_F0.5631.00
351_V355_V0.5621.00
309_S317_A0.5601.00
355_V381_L0.5601.00
254_E257_K0.5581.00
229_A256_I0.5571.00
225_I228_A0.5561.00
65_G68_L0.5561.00
107_T182_D0.5551.00
45_I64_I0.5541.00
250_L342_L0.5531.00
66_I119_Q0.5521.00
7_I164_A0.5501.00
387_C390_D0.5501.00
236_K340_L0.5461.00
11_H107_T0.5461.00
74_V127_G0.5451.00
109_L177_L0.5451.00
207_V410_I0.5441.00
381_L386_G0.5421.00
377_V381_L0.5421.00
169_G172_V0.5411.00
215_S363_A0.5401.00
66_I396_A0.5401.00
41_E68_L0.5381.00
256_I345_Y0.5371.00
363_A387_C0.5351.00
262_E269_R0.5351.00
63_E116_Y0.5351.00
52_L239_N0.5351.00
10_K14_Y0.5351.00
366_L388_V0.5351.00
348_I380_N0.5351.00
111_I196_V0.5341.00
5_P8_I0.5331.00
108_V185_F0.5331.00
382_S424_H0.5321.00
264_M268_I0.5321.00
76_K79_R0.5311.00
12_K179_Q0.5311.00
129_I163_V0.5311.00
115_N336_F0.5301.00
85_K100_I0.5281.00
225_I260_L0.5281.00
330_V335_I0.5271.00
320_I340_L0.5271.00
297_F330_V0.5261.00
252_V257_K0.5241.00
45_I59_A0.5241.00
237_F271_F0.5241.00
9_S179_Q0.5241.00
239_N243_T0.5231.00
8_I175_A0.5211.00
53_H283_G0.5211.00
144_P167_E0.5211.00
129_I158_F0.5201.00
302_I308_Q0.5191.00
326_D353_E0.5181.00
4_I166_A0.5181.00
326_D332_Q0.5171.00
201_A204_L0.5171.00
24_E28_N0.5151.00
273_G277_E0.5141.00
300_D303_P0.5131.00
298_L319_T0.5111.00
261_T320_I0.5101.00
185_F422_F0.5101.00
226_Q266_R0.5091.00
54_K59_A0.5081.00
174_T177_L0.5081.00
103_E382_S0.5051.00
77_R416_F0.5041.00
410_I424_H0.5041.00
15_F162_Y0.5031.00
23_L82_S0.5021.00
219_V223_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3szaA 2 0.9868 100 0.065 Contact Map
4qgkA 2 0.9956 100 0.069 Contact Map
3ek1A 5 0.9364 100 0.085 Contact Map
1a4sA 4 0.9474 100 0.086 Contact Map
4o5hA 4 0.9452 100 0.087 Contact Map
4pxlA 4 0.9474 100 0.088 Contact Map
3u4jA 4 0.9518 100 0.089 Contact Map
4lihA 5 0.9364 100 0.089 Contact Map
1wndA 4 0.9364 100 0.089 Contact Map
4qf6A 4 0.9364 100 0.089 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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