GREMLIN Database
UNG - Uracil-DNA glycosylase
UniProt: P39615 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 225 (217)
Sequences: 3428 (2151)
Seq/√Len: 146.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
172_K184_E3.4591.00
28_M139_K3.1271.00
162_I206_A3.0861.00
211_E217_P2.9321.00
152_L159_V2.8691.00
129_R132_Q2.8561.00
36_Q129_R2.7121.00
169_Q184_E2.6721.00
49_L148_I2.6071.00
100_D204_S2.5071.00
41_D44_D2.5001.00
124_T167_H2.4111.00
51_Y116_K2.3811.00
181_F209_Y2.3741.00
166_R169_Q2.2561.00
44_D81_K2.2551.00
147_R150_D2.2201.00
16_E21_Y2.1591.00
53_S56_D2.1201.00
8_S55_D2.0601.00
166_R170_M2.0421.00
39_Y70_P2.0311.00
185_S200_S2.0271.00
74_Q81_K1.9311.00
176_D179_K1.9051.00
82_P108_H1.8991.00
32_E129_R1.8681.00
16_E19_K1.8651.00
98_Q105_I1.7831.00
201_R204_S1.7741.00
112_V116_K1.7541.00
209_Y213_M1.7381.00
100_D201_R1.7361.00
45_I127_T1.7301.00
208_A212_K1.6961.00
161_F180_H1.6681.00
150_D174_R1.6331.00
99_Q201_R1.6281.00
82_P110_S1.6121.00
69_G131_G1.5931.00
146_D171_K1.5801.00
32_E36_Q1.5761.00
37_T130_R1.5701.00
134_N167_H1.5501.00
33_Y45_I1.5371.00
44_D47_N1.5321.00
47_N51_Y1.5301.00
181_F213_M1.5211.00
86_Q94_F1.5141.00
158_P213_M1.5121.00
183_I202_P1.4931.00
12_Q151_V1.4821.00
25_L139_K1.4791.00
74_Q79_S1.4771.00
98_Q104_S1.4731.00
96_E199_G1.4711.00
160_I206_A1.4621.00
139_K142_E1.4501.00
162_I202_P1.4481.00
147_R151_V1.4331.00
74_Q110_S1.4271.00
57_V152_L1.4241.00
153_S176_D1.4031.00
58_K216_A1.3601.00
93_I203_F1.3551.00
160_I209_Y1.3521.00
47_N50_H1.3311.00
53_S57_V1.3131.00
33_Y42_S1.3131.00
68_H133_A1.2951.00
191_F195_N1.2881.00
177_T184_E1.2881.00
30_K42_S1.2831.00
70_P130_R1.2781.00
158_P209_Y1.2551.00
125_V134_N1.2491.00
208_A211_E1.2441.00
125_V142_E1.2381.00
150_D154_E1.2231.00
157_R215_E1.1951.00
108_H113_S1.1851.00
101_I204_S1.1781.00
193_A198_F1.1781.00
68_H88_P1.1721.00
29_L33_Y1.1601.00
134_N137_K1.1531.00
26_R29_L1.1390.99
137_K167_H1.1370.99
69_G72_Q1.1270.99
205_R208_A1.1250.99
113_S219_D1.1210.99
186_T195_N1.1200.99
47_N74_Q1.1170.99
138_G142_E1.1080.99
8_S54_Y1.1070.99
31_R35_E1.0950.99
103_C221_C1.0940.99
103_C106_P1.0850.99
68_H72_Q1.0830.99
51_Y112_V1.0830.99
172_K182_I1.0530.99
99_Q198_F1.0490.99
86_Q109_G1.0470.99
28_M32_E1.0450.99
12_Q54_Y1.0430.99
191_F194_R1.0410.99
128_V135_S1.0330.99
183_I206_A1.0310.99
31_R34_A1.0280.99
24_E27_E1.0270.99
125_V167_H1.0210.99
20_P24_E1.0150.99
125_V137_K1.0110.99
94_F106_P1.0090.99
172_K175_I1.0060.99
133_A191_F1.0030.99
166_R194_R1.0030.99
6_Q10_W0.9950.99
86_Q91_K0.9940.99
26_R30_K0.9860.98
60_V161_F0.9850.98
194_R198_F0.9680.98
104_S221_C0.9600.98
172_K177_T0.9520.98
186_T196_G0.9440.98
88_P190_P0.9400.98
27_E30_K0.9320.98
6_Q50_H0.9210.98
39_Y130_R0.9170.98
39_Y69_G0.9150.98
27_E31_R0.9150.98
14_K18_E0.9130.98
177_T182_I0.9120.98
52_T57_V0.9100.97
72_Q131_G0.9070.97
54_Y156_E0.9050.97
54_Y152_L0.8960.97
194_R197_F0.8920.97
158_P215_E0.8920.97
26_R42_S0.8900.97
54_Y151_V0.8860.97
88_P194_R0.8790.97
5_L17_F0.8770.97
160_I181_F0.8710.97
183_I200_S0.8670.97
186_T194_R0.8650.97
129_R135_S0.8640.97
95_L99_Q0.8620.96
151_V154_E0.8600.96
153_S174_R0.8500.96
21_Y143_R0.8470.96
49_L120_L0.8460.96
162_I183_I0.8450.96
8_S53_S0.8250.96
10_W50_H0.8250.96
97_L103_C0.8210.95
151_V155_R0.8140.95
23_Q27_E0.8140.95
86_Q108_H0.8070.95
36_Q132_Q0.8040.95
11_N14_K0.7980.95
19_K143_R0.7940.94
170_M173_E0.7930.94
185_S202_P0.7920.94
80_V109_G0.7890.94
201_R205_R0.7840.94
22_Y26_R0.7780.94
88_P91_K0.7770.94
99_Q199_G0.7750.94
29_L38_I0.7720.94
72_Q88_P0.7720.94
18_E23_Q0.7720.94
156_E159_V0.7710.94
183_I205_R0.7670.93
57_V120_L0.7660.93
62_L171_K0.7560.93
95_L194_R0.7490.93
32_E139_K0.7480.93
166_R186_T0.7450.92
37_T70_P0.7430.92
156_E215_E0.7410.92
58_K215_E0.7370.92
30_K34_A0.7360.92
54_Y155_R0.7330.92
70_P131_G0.7260.91
94_F108_H0.7260.91
6_Q54_Y0.7230.91
144_L148_I0.7210.91
155_R159_V0.7150.91
117_Q218_I0.7140.91
94_F109_G0.7130.91
162_I185_S0.7110.91
69_G88_P0.7060.90
28_M142_E0.7020.90
44_D51_Y0.7000.90
98_Q103_C0.6980.90
198_F201_R0.6930.89
7_D10_W0.6930.89
117_Q219_D0.6930.89
155_R158_P0.6880.89
24_E143_R0.6820.89
186_T197_F0.6800.88
186_T198_F0.6790.88
25_L142_E0.6790.88
85_K91_K0.6780.88
44_D50_H0.6780.88
105_I108_H0.6780.88
153_S179_K0.6760.88
21_Y144_L0.6750.88
146_D149_I0.6740.88
69_G133_A0.6730.88
92_N192_S0.6720.88
15_E19_K0.6650.87
124_T134_N0.6640.87
166_R191_F0.6630.87
173_E191_F0.6630.87
91_K95_L0.6620.87
16_E147_R0.6600.87
74_Q112_V0.6580.87
153_S175_I0.6560.87
146_D150_D0.6540.86
60_V159_V0.6530.86
12_Q155_R0.6460.86
47_N112_V0.6460.86
10_W14_K0.6440.86
193_A196_G0.6430.86
146_D174_R0.6420.85
186_T191_F0.6390.85
16_E144_L0.6380.85
97_L202_P0.6360.85
106_P109_G0.6360.85
59_V117_Q0.6340.85
74_Q77_S0.6330.85
126_L145_T0.6320.85
98_Q101_I0.6290.84
152_L156_E0.6280.84
186_T192_S0.6270.84
211_E216_A0.6260.84
204_S208_A0.6200.83
51_Y76_L0.6200.83
162_I200_S0.6190.83
39_Y131_G0.6190.83
69_G130_R0.6170.83
73_A79_S0.6160.83
103_C219_D0.6160.83
15_E151_V0.6160.83
39_Y128_V0.6150.83
39_Y72_Q0.6130.83
192_S196_G0.6130.83
137_K142_E0.6120.83
37_T71_G0.6110.83
86_Q107_N0.6110.83
61_I121_L0.6100.82
56_D116_K0.6040.82
82_P113_S0.6030.82
113_S116_K0.6010.82
94_F105_I0.6010.82
7_D11_N0.5940.81
46_F49_L0.5940.81
81_K110_S0.5920.81
59_V206_A0.5920.81
25_L29_L0.5900.80
39_Y68_H0.5890.80
22_Y144_L0.5880.80
38_I197_F0.5870.80
148_I151_V0.5870.80
24_E139_K0.5860.80
17_F22_Y0.5850.80
128_V133_A0.5840.80
15_E18_E0.5830.80
207_N218_I0.5810.79
169_Q172_K0.5760.79
105_I113_S0.5760.79
104_S108_H0.5720.78
5_L144_L0.5720.78
82_P112_V0.5720.78
97_L113_S0.5700.78
207_N210_L0.5700.78
33_Y38_I0.5680.78
153_S180_H0.5680.78
149_I175_I0.5680.78
114_W121_L0.5610.77
83_G86_Q0.5580.77
167_H170_M0.5560.76
117_Q221_C0.5560.76
83_G109_G0.5540.76
12_Q147_R0.5530.76
162_I198_F0.5490.75
6_Q12_Q0.5490.75
51_Y115_A0.5460.75
44_D74_Q0.5460.75
38_I130_R0.5450.75
21_Y25_L0.5450.75
13_L49_L0.5440.75
52_T115_A0.5430.75
6_Q11_N0.5400.74
186_T193_A0.5390.74
113_S117_Q0.5350.74
49_L159_V0.5300.73
48_A122_L0.5290.73
30_K33_Y0.5290.73
149_I171_K0.5280.73
77_S124_T0.5240.72
80_V87_P0.5240.72
23_Q26_R0.5230.72
120_L148_I0.5210.72
167_H191_F0.5190.71
98_Q102_G0.5190.71
48_A52_T0.5180.71
8_S57_V0.5170.71
5_L49_L0.5150.71
6_Q53_S0.5130.70
122_L126_L0.5130.70
206_A218_I0.5100.70
108_H221_C0.5100.70
101_I104_S0.5100.70
158_P181_F0.5070.70
192_S195_N0.5060.69
153_S177_T0.5060.69
120_L152_L0.5060.69
162_I209_Y0.5060.69
60_V149_I0.5060.69
97_L101_I0.5050.69
206_A215_E0.5040.69
59_V160_I0.5020.69
77_S121_L0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zoqA 1 0.9911 100 -0.002 Contact Map
3tr7A 1 0.9689 100 0.006 Contact Map
3uf7A 1 0.9822 100 0.009 Contact Map
2booA 1 0.9956 100 0.014 Contact Map
3fciA 1 0.9867 100 0.015 Contact Map
3cxmA 1 1 100 0.018 Contact Map
3wdfA 1 0.96 100 0.02 Contact Map
2j8xA 1 0.9822 100 0.027 Contact Map
1udgA 1 0.9778 100 0.031 Contact Map
4wpkA 1 0.9778 100 0.062 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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