UNG - BACSU - GREMLIN Contacts

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UNG - Uracil-DNA glycosylase

UniProt:	P39615	Sequences: MKQLLQDSWWNQLKEEFEKPYYQELREMLKREYAEQTIYPDSRDIFNALHYTSYDDVKVVILGQDPYHGPGQAQGLSFSVKPGVKQPPSLKNIFLELQQDIGCSIPNHGSLVSWAKQGVLLLNTVLTVRRGQANSHKGKGWERLTDRIIDVLSERERPVIFILWGRHAQMKKERIDTSKHFIIESTHPSPFSARNGFFGSRPFSRANAYLEKMGEAPIDWCIKDL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	225 (217)
Sequences:	3428 (2151)
Seq/√Len:	146.0

ECOLI - UNG
BACSU - UNG

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
172_K	184_E	3.459	1.00
28_M	139_K	3.127	1.00
162_I	206_A	3.086	1.00
211_E	217_P	2.932	1.00
152_L	159_V	2.869	1.00
129_R	132_Q	2.856	1.00
36_Q	129_R	2.712	1.00
169_Q	184_E	2.672	1.00
49_L	148_I	2.607	1.00
100_D	204_S	2.507	1.00
41_D	44_D	2.500	1.00
124_T	167_H	2.411	1.00
51_Y	116_K	2.381	1.00
181_F	209_Y	2.374	1.00
166_R	169_Q	2.256	1.00
44_D	81_K	2.255	1.00
147_R	150_D	2.220	1.00
16_E	21_Y	2.159	1.00
53_S	56_D	2.120	1.00
8_S	55_D	2.060	1.00
166_R	170_M	2.042	1.00
39_Y	70_P	2.031	1.00
185_S	200_S	2.027	1.00
74_Q	81_K	1.931	1.00
176_D	179_K	1.905	1.00
82_P	108_H	1.899	1.00
32_E	129_R	1.868	1.00
16_E	19_K	1.865	1.00
98_Q	105_I	1.783	1.00
201_R	204_S	1.774	1.00
112_V	116_K	1.754	1.00
209_Y	213_M	1.738	1.00
100_D	201_R	1.736	1.00
45_I	127_T	1.730	1.00
208_A	212_K	1.696	1.00
161_F	180_H	1.668	1.00
150_D	174_R	1.633	1.00
99_Q	201_R	1.628	1.00
82_P	110_S	1.612	1.00
69_G	131_G	1.593	1.00
146_D	171_K	1.580	1.00
32_E	36_Q	1.576	1.00
37_T	130_R	1.570	1.00
134_N	167_H	1.550	1.00
33_Y	45_I	1.537	1.00
44_D	47_N	1.532	1.00
47_N	51_Y	1.530	1.00
181_F	213_M	1.521	1.00
86_Q	94_F	1.514	1.00
158_P	213_M	1.512	1.00
183_I	202_P	1.493	1.00
12_Q	151_V	1.482	1.00
25_L	139_K	1.479	1.00
74_Q	79_S	1.477	1.00
98_Q	104_S	1.473	1.00
96_E	199_G	1.471	1.00
160_I	206_A	1.462	1.00
139_K	142_E	1.450	1.00
162_I	202_P	1.448	1.00
147_R	151_V	1.433	1.00
74_Q	110_S	1.427	1.00
57_V	152_L	1.424	1.00
153_S	176_D	1.403	1.00
58_K	216_A	1.360	1.00
93_I	203_F	1.355	1.00
160_I	209_Y	1.352	1.00
47_N	50_H	1.331	1.00
53_S	57_V	1.313	1.00
33_Y	42_S	1.313	1.00
68_H	133_A	1.295	1.00
191_F	195_N	1.288	1.00
177_T	184_E	1.288	1.00
30_K	42_S	1.283	1.00
70_P	130_R	1.278	1.00
158_P	209_Y	1.255	1.00
125_V	134_N	1.249	1.00
208_A	211_E	1.244	1.00
125_V	142_E	1.238	1.00
150_D	154_E	1.223	1.00
157_R	215_E	1.195	1.00
108_H	113_S	1.185	1.00
101_I	204_S	1.178	1.00
193_A	198_F	1.178	1.00
68_H	88_P	1.172	1.00
29_L	33_Y	1.160	1.00
134_N	137_K	1.153	1.00
26_R	29_L	1.139	0.99
137_K	167_H	1.137	0.99
69_G	72_Q	1.127	0.99
205_R	208_A	1.125	0.99
113_S	219_D	1.121	0.99
186_T	195_N	1.120	0.99
47_N	74_Q	1.117	0.99
138_G	142_E	1.108	0.99
8_S	54_Y	1.107	0.99
31_R	35_E	1.095	0.99
103_C	221_C	1.094	0.99
103_C	106_P	1.085	0.99
68_H	72_Q	1.083	0.99
51_Y	112_V	1.083	0.99
172_K	182_I	1.053	0.99
99_Q	198_F	1.049	0.99
86_Q	109_G	1.047	0.99
28_M	32_E	1.045	0.99
12_Q	54_Y	1.043	0.99
191_F	194_R	1.041	0.99
128_V	135_S	1.033	0.99
183_I	206_A	1.031	0.99
31_R	34_A	1.028	0.99
24_E	27_E	1.027	0.99
125_V	167_H	1.021	0.99
20_P	24_E	1.015	0.99
125_V	137_K	1.011	0.99
94_F	106_P	1.009	0.99
172_K	175_I	1.006	0.99
133_A	191_F	1.003	0.99
166_R	194_R	1.003	0.99
6_Q	10_W	0.995	0.99
86_Q	91_K	0.994	0.99
26_R	30_K	0.986	0.98
60_V	161_F	0.985	0.98
194_R	198_F	0.968	0.98
104_S	221_C	0.960	0.98
172_K	177_T	0.952	0.98
186_T	196_G	0.944	0.98
88_P	190_P	0.940	0.98
27_E	30_K	0.932	0.98
6_Q	50_H	0.921	0.98
39_Y	130_R	0.917	0.98
39_Y	69_G	0.915	0.98
27_E	31_R	0.915	0.98
14_K	18_E	0.913	0.98
177_T	182_I	0.912	0.98
52_T	57_V	0.910	0.97
72_Q	131_G	0.907	0.97
54_Y	156_E	0.905	0.97
54_Y	152_L	0.896	0.97
194_R	197_F	0.892	0.97
158_P	215_E	0.892	0.97
26_R	42_S	0.890	0.97
54_Y	151_V	0.886	0.97
88_P	194_R	0.879	0.97
5_L	17_F	0.877	0.97
160_I	181_F	0.871	0.97
183_I	200_S	0.867	0.97
186_T	194_R	0.865	0.97
129_R	135_S	0.864	0.97
95_L	99_Q	0.862	0.96
151_V	154_E	0.860	0.96
153_S	174_R	0.850	0.96
21_Y	143_R	0.847	0.96
49_L	120_L	0.846	0.96
162_I	183_I	0.845	0.96
8_S	53_S	0.825	0.96
10_W	50_H	0.825	0.96
97_L	103_C	0.821	0.95
151_V	155_R	0.814	0.95
23_Q	27_E	0.814	0.95
86_Q	108_H	0.807	0.95
36_Q	132_Q	0.804	0.95
11_N	14_K	0.798	0.95
19_K	143_R	0.794	0.94
170_M	173_E	0.793	0.94
185_S	202_P	0.792	0.94
80_V	109_G	0.789	0.94
201_R	205_R	0.784	0.94
22_Y	26_R	0.778	0.94
88_P	91_K	0.777	0.94
99_Q	199_G	0.775	0.94
29_L	38_I	0.772	0.94
72_Q	88_P	0.772	0.94
18_E	23_Q	0.772	0.94
156_E	159_V	0.771	0.94
183_I	205_R	0.767	0.93
57_V	120_L	0.766	0.93
62_L	171_K	0.756	0.93
95_L	194_R	0.749	0.93
32_E	139_K	0.748	0.93
166_R	186_T	0.745	0.92
37_T	70_P	0.743	0.92
156_E	215_E	0.741	0.92
58_K	215_E	0.737	0.92
30_K	34_A	0.736	0.92
54_Y	155_R	0.733	0.92
70_P	131_G	0.726	0.91
94_F	108_H	0.726	0.91
6_Q	54_Y	0.723	0.91
144_L	148_I	0.721	0.91
155_R	159_V	0.715	0.91
117_Q	218_I	0.714	0.91
94_F	109_G	0.713	0.91
162_I	185_S	0.711	0.91
69_G	88_P	0.706	0.90
28_M	142_E	0.702	0.90
44_D	51_Y	0.700	0.90
98_Q	103_C	0.698	0.90
198_F	201_R	0.693	0.89
7_D	10_W	0.693	0.89
117_Q	219_D	0.693	0.89
155_R	158_P	0.688	0.89
24_E	143_R	0.682	0.89
186_T	197_F	0.680	0.88
186_T	198_F	0.679	0.88
25_L	142_E	0.679	0.88
85_K	91_K	0.678	0.88
44_D	50_H	0.678	0.88
105_I	108_H	0.678	0.88
153_S	179_K	0.676	0.88
21_Y	144_L	0.675	0.88
146_D	149_I	0.674	0.88
69_G	133_A	0.673	0.88
92_N	192_S	0.672	0.88
15_E	19_K	0.665	0.87
124_T	134_N	0.664	0.87
166_R	191_F	0.663	0.87
173_E	191_F	0.663	0.87
91_K	95_L	0.662	0.87
16_E	147_R	0.660	0.87
74_Q	112_V	0.658	0.87
153_S	175_I	0.656	0.87
146_D	150_D	0.654	0.86
60_V	159_V	0.653	0.86
12_Q	155_R	0.646	0.86
47_N	112_V	0.646	0.86
10_W	14_K	0.644	0.86
193_A	196_G	0.643	0.86
146_D	174_R	0.642	0.85
186_T	191_F	0.639	0.85
16_E	144_L	0.638	0.85
97_L	202_P	0.636	0.85
106_P	109_G	0.636	0.85
59_V	117_Q	0.634	0.85
74_Q	77_S	0.633	0.85
126_L	145_T	0.632	0.85
98_Q	101_I	0.629	0.84
152_L	156_E	0.628	0.84
186_T	192_S	0.627	0.84
211_E	216_A	0.626	0.84
204_S	208_A	0.620	0.83
51_Y	76_L	0.620	0.83
162_I	200_S	0.619	0.83
39_Y	131_G	0.619	0.83
69_G	130_R	0.617	0.83
73_A	79_S	0.616	0.83
103_C	219_D	0.616	0.83
15_E	151_V	0.616	0.83
39_Y	128_V	0.615	0.83
39_Y	72_Q	0.613	0.83
192_S	196_G	0.613	0.83
137_K	142_E	0.612	0.83
37_T	71_G	0.611	0.83
86_Q	107_N	0.611	0.83
61_I	121_L	0.610	0.82
56_D	116_K	0.604	0.82
82_P	113_S	0.603	0.82
113_S	116_K	0.601	0.82
94_F	105_I	0.601	0.82
7_D	11_N	0.594	0.81
46_F	49_L	0.594	0.81
81_K	110_S	0.592	0.81
59_V	206_A	0.592	0.81
25_L	29_L	0.590	0.80
39_Y	68_H	0.589	0.80
22_Y	144_L	0.588	0.80
38_I	197_F	0.587	0.80
148_I	151_V	0.587	0.80
24_E	139_K	0.586	0.80
17_F	22_Y	0.585	0.80
128_V	133_A	0.584	0.80
15_E	18_E	0.583	0.80
207_N	218_I	0.581	0.79
169_Q	172_K	0.576	0.79
105_I	113_S	0.576	0.79
104_S	108_H	0.572	0.78
5_L	144_L	0.572	0.78
82_P	112_V	0.572	0.78
97_L	113_S	0.570	0.78
207_N	210_L	0.570	0.78
33_Y	38_I	0.568	0.78
153_S	180_H	0.568	0.78
149_I	175_I	0.568	0.78
114_W	121_L	0.561	0.77
83_G	86_Q	0.558	0.77
167_H	170_M	0.556	0.76
117_Q	221_C	0.556	0.76
83_G	109_G	0.554	0.76
12_Q	147_R	0.553	0.76
162_I	198_F	0.549	0.75
6_Q	12_Q	0.549	0.75
51_Y	115_A	0.546	0.75
44_D	74_Q	0.546	0.75
38_I	130_R	0.545	0.75
21_Y	25_L	0.545	0.75
13_L	49_L	0.544	0.75
52_T	115_A	0.543	0.75
6_Q	11_N	0.540	0.74
186_T	193_A	0.539	0.74
113_S	117_Q	0.535	0.74
49_L	159_V	0.530	0.73
48_A	122_L	0.529	0.73
30_K	33_Y	0.529	0.73
149_I	171_K	0.528	0.73
77_S	124_T	0.524	0.72
80_V	87_P	0.524	0.72
23_Q	26_R	0.523	0.72
120_L	148_I	0.521	0.72
167_H	191_F	0.519	0.71
98_Q	102_G	0.519	0.71
48_A	52_T	0.518	0.71
8_S	57_V	0.517	0.71
5_L	49_L	0.515	0.71
6_Q	53_S	0.513	0.70
122_L	126_L	0.513	0.70
206_A	218_I	0.510	0.70
108_H	221_C	0.510	0.70
101_I	104_S	0.510	0.70
158_P	181_F	0.507	0.70
192_S	195_N	0.506	0.69
153_S	177_T	0.506	0.69
120_L	152_L	0.506	0.69
162_I	209_Y	0.506	0.69
60_V	149_I	0.506	0.69
97_L	101_I	0.505	0.69
206_A	215_E	0.504	0.69
59_V	160_I	0.502	0.69
77_S	121_L	0.500	0.69

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3zoqA	1	0.9911	100	-0.002	Contact Map
3tr7A	1	0.9689	100	0.006	Contact Map
3uf7A	1	0.9822	100	0.009	Contact Map
2booA	1	0.9956	100	0.014	Contact Map
3fciA	1	0.9867	100	0.015	Contact Map
3cxmA	1	1	100	0.018	Contact Map
3wdfA	1	0.96	100	0.02	Contact Map
2j8xA	1	0.9822	100	0.027	Contact Map
1udgA	1	0.9778	100	0.031	Contact Map
4wpkA	1	0.9778	100	0.062	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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