GREMLIN Database
YWDF - Uncharacterized glycosyltransferase YwdF
UniProt: P39614 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 268 (219)
Sequences: 36250 (31256)
Seq/√Len: 2112.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
157_R161_D3.3531.00
12_R87_D3.2771.00
13_I43_V2.6581.00
98_K193_C2.5881.00
177_D181_R2.4941.00
72_A76_E2.4391.00
4_S79_G2.4091.00
9_T44_V2.3201.00
92_T197_I2.2691.00
81_C103_I2.2481.00
75_K165_Y2.2151.00
37_N59_N2.1871.00
27_T97_E2.1851.00
32_E56_A2.1621.00
36_V73_G2.0901.00
18_E199_A2.0851.00
64_S68_A2.0711.00
45_P48_A2.0301.00
7_I33_I2.0121.00
17_C21_E2.0091.00
6_V73_G1.9951.00
91_F95_H1.9141.00
11_N41_E1.9031.00
3_I100_A1.8771.00
70_R86_D1.8601.00
45_P59_N1.8431.00
102_E191_V1.8371.00
68_A168_A1.8341.00
4_S32_E1.8201.00
99_M154_M1.8201.00
83_M154_M1.8081.00
18_E90_F1.8081.00
58_I76_E1.8061.00
102_E189_K1.7681.00
60_L72_A1.7431.00
28_L100_A1.7431.00
95_H99_M1.7271.00
17_C50_Y1.7031.00
7_I19_L1.6911.00
66_H70_R1.6821.00
94_G98_K1.6751.00
13_I46_V1.6661.00
90_F197_I1.6561.00
37_N40_G1.6411.00
35_I47_K1.6321.00
83_M95_H1.6101.00
56_A76_E1.6091.00
67_V174_W1.5911.00
45_P57_V1.5831.00
72_A75_K1.5831.00
17_C49_L1.5571.00
21_E25_R1.5501.00
85_C91_F1.5391.00
17_C46_V1.5341.00
81_C154_M1.5321.00
58_I72_A1.5261.00
103_I154_M1.5091.00
9_T35_I1.5011.00
83_M96_I1.4871.00
10_Y63_N1.4781.00
21_E50_Y1.4651.00
167_D177_D1.4581.00
32_E79_G1.4521.00
98_K101_K1.4451.00
28_L31_Y1.4161.00
48_A59_N1.4151.00
9_T12_R1.4031.00
97_E101_K1.3881.00
162_E185_D1.3861.00
3_I96_I1.3821.00
158_F162_E1.3481.00
61_E64_S1.3431.00
70_R84_L1.3371.00
22_S91_F1.3301.00
153_S179_Y1.3211.00
4_S77_A1.3151.00
82_I157_R1.3141.00
80_D156_R1.3011.00
74_V160_H1.2811.00
106_A189_K1.2671.00
66_H174_W1.2621.00
61_E72_A1.2551.00
11_N40_G1.2551.00
12_R15_A1.2521.00
46_V50_Y1.2501.00
90_F199_A1.2461.00
20_L33_I1.2361.00
159_L182_A1.2281.00
107_D187_R1.2271.00
38_D63_N1.2251.00
77_A157_R1.2231.00
74_V84_L1.2021.00
9_T87_D1.1771.00
36_V69_A1.1661.00
19_L85_C1.1651.00
83_M91_F1.1561.00
100_A104_E1.1391.00
32_E78_S1.1281.00
158_F161_D1.1241.00
37_N45_P1.1181.00
94_G97_E1.1091.00
102_E105_T1.0901.00
101_K105_T1.0901.00
3_I154_M1.0841.00
4_S34_I1.0811.00
116_V197_I1.0781.00
25_R93_P1.0701.00
106_A109_V1.0611.00
8_V69_A1.0571.00
110_H188_V1.0551.00
201_S204_G1.0391.00
60_L69_A1.0361.00
33_I55_I1.0311.00
156_R159_L1.0311.00
22_S90_F1.0301.00
98_K191_V1.0271.00
60_L64_S1.0141.00
107_D156_R1.0021.00
70_R174_W0.9961.00
23_I85_C0.9921.00
160_H178_F0.9831.00
74_V82_I0.9771.00
21_E24_S0.9751.00
114_E197_I0.9691.00
66_H205_D0.9661.00
109_V112_D0.9661.00
27_T94_G0.9611.00
47_K57_V0.9571.00
68_A72_A0.9531.00
99_M111_S0.9521.00
56_A78_S0.9501.00
46_V49_L0.9341.00
81_C100_A0.9341.00
95_H195_S0.9181.00
24_S50_Y0.9151.00
99_M103_I0.9151.00
61_E68_A0.8981.00
66_H150_P0.8931.00
38_D69_A0.8921.00
117_S121_K0.8901.00
20_L50_Y0.8891.00
43_V46_V0.8841.00
98_K102_E0.8811.00
24_S55_I0.8801.00
66_H86_D0.8741.00
5_I83_M0.8691.00
67_V71_N0.8681.00
151_S196_V0.8621.00
15_A199_A0.8541.00
163_I185_D0.8521.00
5_I23_I0.8451.00
150_P166_F0.8451.00
19_L22_S0.8391.00
38_D65_G0.8381.00
9_T47_K0.8381.00
31_Y96_I0.8341.00
37_N60_L0.8281.00
23_I33_I0.8281.00
9_T16_L0.8221.00
106_A111_S0.8131.00
57_V60_L0.8071.00
36_V72_A0.8021.00
27_T93_P0.7951.00
155_Y179_Y0.7951.00
163_I182_A0.7941.00
159_L186_Y0.7921.00
150_P153_S0.7921.00
84_L166_F0.7861.00
218_Y221_R0.7861.00
12_R201_S0.7821.00
20_L35_I0.7811.00
38_D64_S0.7751.00
66_H69_A0.7701.00
159_L163_I0.7671.00
74_V77_A0.7631.00
5_I96_I0.7621.00
71_N165_Y0.7621.00
64_S69_A0.7601.00
214_K218_Y0.7601.00
92_T95_H0.7591.00
7_I23_I0.7531.00
23_I91_F0.7511.00
178_F182_A0.7431.00
18_E21_E0.7371.00
165_Y178_F0.7361.00
34_I73_G0.7331.00
28_L96_I0.7331.00
216_K220_D0.7281.00
28_L97_E0.7271.00
69_A72_A0.7251.00
24_S53_L0.7191.00
213_A217_Q0.7181.00
159_L162_E0.7181.00
217_Q221_R0.7171.00
13_I17_C0.7131.00
141_D144_V0.7131.00
92_T195_S0.7111.00
48_A57_V0.7081.00
103_I111_S0.7061.00
108_F189_K0.6921.00
34_I56_A0.6881.00
8_V87_D0.6881.00
114_E194_A0.6861.00
113_A152_G0.6851.00
71_N168_A0.6851.00
112_D190_R0.6851.00
24_S54_P0.6831.00
80_D158_F0.6831.00
16_L87_D0.6831.00
204_G207_Q0.6811.00
20_L24_S0.6801.00
109_V113_A0.6781.00
122_N125_R0.6781.00
100_A154_M0.6771.00
64_S72_A0.6741.00
155_Y178_F0.6711.00
77_A82_I0.6701.00
118_F122_N0.6691.00
83_M152_G0.6691.00
160_H165_Y0.6671.00
101_K104_E0.6661.00
15_A201_S0.6641.00
5_I31_Y0.6621.00
95_H152_G0.6611.00
34_I76_E0.6601.00
89_D198_Y0.6571.00
8_V38_D0.6561.00
19_L23_I0.6561.00
16_L46_V0.6551.00
71_N166_F0.6541.00
103_I156_R0.6501.00
110_H113_A0.6491.00
91_F96_I0.6481.00
142_M145_F0.6481.00
10_Y38_D0.6471.00
183_A188_V0.6431.00
217_Q220_D0.6431.00
3_I83_M0.6401.00
34_I77_A0.6361.00
173_Y176_W0.6341.00
8_V70_R0.6331.00
74_V165_Y0.6301.00
191_V194_A0.6241.00
135_Y138_D0.6221.00
215_R218_Y0.6211.00
167_D181_R0.6151.00
95_H111_S0.6111.00
145_F148_Y0.6021.00
4_S78_S0.6011.00
48_A60_L0.5971.00
219_L223_S0.5961.00
117_S120_E0.5961.00
81_C156_R0.5941.00
39_A63_N0.5911.00
151_S198_Y0.5901.00
146_S149_V0.5891.00
13_I16_L0.5881.00
24_S52_E0.5871.00
155_Y160_H0.5861.00
111_S195_S0.5861.00
214_K217_Q0.5851.00
85_C89_D0.5831.00
26_Q97_E0.5811.00
13_I42_S0.5811.00
19_L88_D0.5791.00
31_Y54_P0.5761.00
144_V147_T0.5711.00
133_F138_D0.5681.00
27_T31_Y0.5681.00
86_D174_W0.5651.00
98_K195_S0.5651.00
35_I55_I0.5621.00
26_Q91_F0.5591.00
71_N75_K0.5581.00
6_V77_A0.5561.00
194_A197_I0.5551.00
30_P54_P0.5531.00
39_A61_E0.5511.00
7_I20_L0.5481.00
200_F207_Q0.5481.00
215_R219_L0.5471.00
207_Q210_D0.5461.00
99_M102_E0.5431.00
7_I35_I0.5391.00
103_I109_V0.5371.00
106_A113_A0.5371.00
26_Q96_I0.5351.00
49_L52_E0.5341.00
109_V156_R0.5331.00
38_D86_D0.5331.00
48_A51_P0.5311.00
106_A112_D0.5301.00
161_D165_Y0.5301.00
113_A151_S0.5261.00
16_L47_K0.5251.00
117_S123_G0.5251.00
6_V36_V0.5251.00
144_V187_R0.5231.00
99_M152_G0.5231.00
94_G193_C0.5231.00
9_T37_N0.5231.00
39_A60_L0.5231.00
176_W180_L0.5221.00
45_P60_L0.5221.00
24_S33_I0.5211.00
85_C196_V0.5181.00
133_F137_A0.5171.00
31_Y79_G0.5171.00
92_T194_A0.5161.00
106_A110_H0.5141.00
130_R133_F0.5131.00
100_A103_I0.5131.00
213_A218_Y0.5131.00
116_V120_E0.5121.00
115_I151_S0.5121.00
56_A59_N0.5111.00
91_F196_V0.5111.00
3_I28_L0.5101.00
81_C104_E0.5101.00
12_R86_D0.5091.00
8_V66_H0.5091.00
216_K223_S0.5071.00
26_Q94_G0.5061.00
155_Y182_A0.5061.00
167_D170_V0.5061.00
182_A186_Y0.5021.00
47_K50_Y0.5011.00
90_F116_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2d7iA 1 0.9963 100 0.264 Contact Map
1xhbA 1 0.9701 100 0.273 Contact Map
5ajoA 1 0.9925 100 0.281 Contact Map
3l7iA 4 0 100 0.305 Contact Map
3bcvA 2 0.6455 100 0.327 Contact Map
2z86A 2 0.9142 100 0.334 Contact Map
1qg8A 1 0.8134 100 0.342 Contact Map
4fixA 3 0.9851 100 0.389 Contact Map
4p02A 1 0.9366 100 0.425 Contact Map
2nxvA 4 0.8246 100 0.428 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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