GREMLIN Database
PDXK - Pyridoxine kinase
UniProt: P39610 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 271 (251)
Sequences: 6245 (4413)
Seq/√Len: 278.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_K134_L3.2981.00
24_L34_G2.8931.00
90_E130_Q2.7761.00
151_M166_K2.7551.00
156_T159_D2.7431.00
55_F58_D2.6941.00
52_H68_T2.6311.00
30_K225_E2.6211.00
176_V218_F2.5681.00
231_E234_E2.5631.00
225_E230_A2.5001.00
67_A95_T2.3921.00
83_L92_A2.2421.00
145_A177_I2.2401.00
80_T106_I2.1271.00
41_I61_T2.0941.00
117_E121_P2.0911.00
199_E233_K2.0761.00
32_V224_A2.0651.00
63_R94_K2.0511.00
125_Q129_E2.0091.00
161_I198_A2.0001.00
154_L163_A1.9861.00
27_F224_A1.9641.00
41_I57_I1.9631.00
225_E228_K1.9591.00
6_A32_V1.9571.00
187_K202_E1.9081.00
27_F34_G1.9071.00
53_Q64_A1.9011.00
8_T36_T1.8911.00
62_I88_I1.8731.00
12_S21_Q1.8521.00
112_C116_N1.8131.00
27_F32_V1.8111.00
97_K130_Q1.7731.00
56_P84_P1.7681.00
157_V200_V1.7201.00
222_V236_I1.7091.00
174_Y232_V1.6981.00
63_R91_L1.6961.00
146_S153_E1.6911.00
230_A238_A1.6881.00
95_T98_E1.6331.00
240_K244_T1.6071.00
67_A71_D1.6041.00
66_L95_T1.5821.00
225_E238_A1.5611.00
188_A240_K1.5491.00
6_A27_F1.5431.00
96_I104_V1.5231.00
8_T27_F1.5161.00
59_T91_L1.5081.00
63_R95_T1.5081.00
21_Q36_T1.5021.00
244_T248_K1.4991.00
189_V200_V1.4861.00
155_K159_D1.4781.00
5_K76_D1.4661.00
106_I135_A1.4641.00
164_A177_I1.4521.00
37_A66_L1.4471.00
245_A248_K1.4361.00
89_I127_L1.4321.00
80_T104_V1.4281.00
204_E248_K1.4171.00
138_I167_I1.4041.00
86_V122_E1.3981.00
56_P85_T1.3901.00
168_H193_Y1.3701.00
119_L123_H1.3681.00
20_I38_L1.3651.00
103_N136_T1.3631.00
161_I200_V1.3531.00
149_S167_I1.3451.00
5_K35_M1.3341.00
55_F61_T1.3171.00
201_L237_Y1.3131.00
164_A193_Y1.3111.00
146_S154_L1.2521.00
136_T173_Q1.2491.00
193_Y198_A1.2461.00
12_S42_V1.2451.00
174_Y194_D1.2451.00
199_E237_Y1.2431.00
57_I61_T1.2271.00
203_S240_K1.2201.00
151_M162_E1.2161.00
191_V200_V1.2001.00
117_E124_A1.1881.00
5_K73_I1.1861.00
126_A130_Q1.1801.00
60_D64_A1.1771.00
105_V223_T1.1671.00
230_A234_E1.1621.00
5_K74_G1.1611.00
70_T75_V1.1571.00
52_H71_D1.1571.00
59_T87_D1.1561.00
203_S244_T1.1521.00
166_K169_A1.1301.00
70_T98_E1.1251.00
26_T217_T1.1211.00
85_T88_I1.1181.00
89_I126_A1.1131.00
93_A130_Q1.1041.00
6_A227_A1.0961.00
83_L89_I1.0921.00
37_A62_I1.0921.00
137_V232_V1.0861.00
226_L232_V1.0851.00
67_A98_E1.0791.00
128_R148_L1.0761.00
165_K169_A1.0741.00
94_K130_Q1.0711.00
132_A138_I1.0641.00
30_K221_A1.0621.00
146_S163_A1.0601.00
160_M191_V1.0581.00
189_V202_E1.0551.00
233_K237_Y1.0531.00
91_L94_K1.0501.00
128_R170_L1.0471.00
12_S38_L1.0371.00
26_T221_A1.0301.00
61_T64_A1.0281.00
43_A64_A1.0241.00
237_Y241_E1.0211.00
161_I165_K1.0211.00
162_E166_K1.0201.00
30_K224_A1.0171.00
234_E237_Y1.0151.00
78_M101_L1.0151.00
43_A61_T1.0091.00
149_S166_K1.0081.00
53_Q61_T1.0051.00
93_A134_L1.0041.00
26_T30_K0.9951.00
32_V228_K0.9911.00
105_V226_L0.9861.00
48_N72_G0.9831.00
64_A68_T0.9831.00
90_E126_A0.9731.00
9_I92_A0.9681.00
35_M75_V0.9661.00
86_V90_E0.9611.00
168_H175_V0.9571.00
168_H195_G0.9561.00
111_V147_Q0.9561.00
137_V222_V0.9551.00
77_A223_T0.9541.00
86_V126_A0.9521.00
70_T101_L0.9491.00
137_V176_V0.9461.00
201_L236_I0.9461.00
117_E147_Q0.9461.00
4_H76_D0.9451.00
45_D48_N0.9441.00
157_V161_I0.9391.00
162_E165_K0.9371.00
222_V239_A0.9321.00
192_L201_L0.9271.00
40_V82_M0.9271.00
187_K204_E0.9191.00
35_M73_I0.9151.00
197_T233_K0.9131.00
168_H172_A0.9121.00
157_V191_V0.9081.00
128_R150_G0.9031.00
87_D90_E0.9031.00
84_P88_I0.9021.00
174_Y192_L0.9011.00
210_Y252_P0.8991.00
159_D162_E0.8991.00
211_T247_I0.8991.00
89_I119_L0.8911.00
5_K75_V0.8901.00
70_T95_T0.8861.00
245_A249_E0.8851.00
192_L236_I0.8821.00
201_L240_K0.8801.00
165_K198_A0.8801.00
12_S36_T0.8781.00
136_T174_Y0.8761.00
191_V198_A0.8741.00
124_A128_R0.8721.00
217_T242_F0.8711.00
138_I175_V0.8711.00
206_I244_T0.8711.00
190_D240_K0.8701.00
176_V192_L0.8691.00
15_S42_V0.8611.00
49_S255_Q0.8561.00
206_I247_I0.8541.00
124_A147_Q0.8531.00
157_V189_V0.8481.00
96_I101_L0.8431.00
136_T232_V0.8371.00
188_A205_M0.8361.00
30_K228_K0.8361.00
94_K98_E0.8331.00
64_A67_A0.8321.00
68_T71_D0.8321.00
221_A242_F0.8301.00
48_N254_N0.8170.99
137_V174_Y0.8160.99
14_S42_V0.8050.99
80_T83_L0.7950.99
208_T258_G0.7920.99
52_H64_A0.7900.99
14_S36_T0.7850.99
166_K170_L0.7850.99
226_L229_G0.7820.99
32_V227_A0.7810.99
59_T63_R0.7800.99
63_R67_A0.7790.99
113_K257_V0.7780.99
17_G212_H0.7580.99
125_Q128_R0.7570.99
11_G39_T0.7550.99
14_S43_A0.7500.99
241_E245_A0.7450.99
226_L235_A0.7420.99
177_I191_V0.7400.99
210_Y258_G0.7380.99
27_F223_T0.7330.99
142_L146_S0.7310.99
151_M159_D0.7240.99
158_D161_I0.7220.99
100_Q103_N0.7210.99
6_A224_A0.7200.99
15_S73_I0.7170.99
27_F220_A0.7170.99
79_K220_A0.7150.99
93_A131_L0.7110.99
7_L35_M0.7030.98
234_E238_A0.7000.98
168_H174_Y0.7000.98
154_L160_M0.6980.98
192_L232_V0.6950.98
143_F181_G0.6950.98
70_T99_K0.6950.98
22_A217_T0.6900.98
141_N144_E0.6870.98
21_Q24_L0.6830.98
35_M69_I0.6830.98
137_V236_I0.6820.98
10_A23_D0.6810.98
90_E129_E0.6800.98
93_A97_K0.6740.98
8_T219_S0.6710.98
230_A235_A0.6660.98
194_D197_T0.6650.98
135_A138_I0.6620.98
40_V56_P0.6600.98
243_I247_I0.6590.98
228_K238_A0.6580.98
78_M96_I0.6570.98
170_L173_Q0.6560.98
12_S41_I0.6550.98
168_H173_Q0.6530.97
6_A223_T0.6530.97
208_T211_T0.6530.97
12_S20_I0.6510.97
79_K219_S0.6500.97
165_K193_Y0.6500.97
78_M104_V0.6500.97
80_T96_I0.6500.97
132_A172_A0.6460.97
145_A167_I0.6460.97
95_T99_K0.6450.97
112_C118_V0.6410.97
39_T88_I0.6380.97
168_H171_G0.6380.97
29_E242_F0.6350.97
80_T219_S0.6340.97
73_I76_D0.6330.97
13_D19_G0.6320.97
168_H194_D0.6310.97
26_T242_F0.6280.97
82_M118_V0.6270.97
91_L95_T0.6260.97
145_A163_A0.6240.97
194_D199_E0.6220.97
84_P120_Y0.6210.97
94_K97_K0.6200.97
85_T120_Y0.6200.97
231_E235_A0.6170.96
127_L132_A0.6160.96
25_K33_Y0.6160.96
240_K243_I0.6090.96
5_K253_L0.6070.96
58_D61_T0.6060.96
110_M119_L0.6030.96
93_A106_I0.6010.96
173_Q195_G0.6000.96
59_T62_I0.5980.96
217_T246_A0.5950.96
148_L167_I0.5950.96
154_L159_D0.5920.96
89_I123_H0.5910.95
62_I91_L0.5890.95
176_V236_I0.5850.95
106_I131_L0.5830.95
23_D79_K0.5820.95
74_G102_K0.5810.95
115_A118_V0.5800.95
30_K238_A0.5780.95
45_D52_H0.5770.95
238_A241_E0.5770.95
143_F146_S0.5750.95
44_M212_H0.5710.95
157_V202_E0.5690.94
71_D99_K0.5690.94
158_D162_E0.5680.94
107_D140_P0.5670.94
168_H196_E0.5670.94
15_S33_Y0.5660.94
242_F246_A0.5650.94
229_G235_A0.5650.94
20_I36_T0.5640.94
49_S52_H0.5630.94
9_I66_L0.5600.94
90_E94_K0.5590.94
8_T34_G0.5570.94
104_V134_L0.5570.94
67_A99_K0.5550.94
164_A175_V0.5540.94
18_A212_H0.5530.94
7_L37_A0.5520.94
151_M163_A0.5510.93
77_A227_A0.5480.93
137_V239_A0.5460.93
189_V193_Y0.5440.93
160_M183_L0.5430.93
62_I66_L0.5430.93
142_L154_L0.5420.93
165_K168_H0.5410.93
48_N256_Y0.5390.93
89_I131_L0.5390.93
70_T78_M0.5390.93
67_A70_T0.5380.93
130_Q134_L0.5370.93
155_K184_K0.5360.93
107_D141_N0.5350.92
77_A219_S0.5330.92
161_I193_Y0.5320.92
105_V137_V0.5290.92
201_L233_K0.5280.92
45_D49_S0.5270.92
111_V116_N0.5260.92
140_P144_E0.5220.92
111_V117_E0.5220.92
5_K33_Y0.5220.92
193_Y196_E0.5180.91
106_I127_L0.5170.91
204_E244_T0.5170.91
53_Q60_D0.5170.91
25_K28_Q0.5170.91
65_Q69_I0.5150.91
13_D23_D0.5150.91
45_D68_T0.5140.91
194_D198_A0.5130.91
236_I239_A0.5120.91
142_L160_M0.5110.91
37_A69_I0.5110.91
113_K214_A0.5090.90
66_L69_I0.5090.90
239_A243_I0.5090.90
40_V84_P0.5060.90
130_Q133_P0.5060.90
38_L41_I0.5040.90
78_M102_K0.5010.90
181_G205_M0.5010.90
146_S151_M0.5000.90
11_G18_A0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i5bA 2 1 100 0.313 Contact Map
3rm5A 2 0.9557 100 0.333 Contact Map
1ub0A 2 0.9077 100 0.388 Contact Map
3h74A 2 0.9705 100 0.389 Contact Map
4yl5A 2 0.8339 100 0.393 Contact Map
2yxtA 3 0.9815 100 0.398 Contact Map
1jxhA 2 0.9041 100 0.399 Contact Map
3pzsA 2 0.9852 100 0.399 Contact Map
2ddmA 2 0.9557 100 0.4 Contact Map
3mbhA 5 0.9779 100 0.411 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0095 seconds.