GREMLIN Database
YWCJ - Uncharacterized transporter YwcJ
UniProt: P39608 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 256 (243)
Sequences: 2226 (1534)
Seq/√Len: 98.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
157_F239_T7.0071.00
157_F235_L4.4451.00
156_L233_V3.7751.00
31_S114_G3.7731.00
181_G185_F3.5891.00
94_A101_W3.4381.00
112_Y234_T3.2891.00
28_V114_G3.0981.00
235_L239_T3.0711.00
32_I121_L3.0241.00
39_G122_F2.9131.00
153_A232_P2.8281.00
222_T225_G2.5691.00
44_A193_C2.4481.00
124_I128_A2.2761.00
69_G188_M2.2601.00
16_K93_T2.2411.00
28_V110_S2.2051.00
83_F87_T2.1541.00
221_V225_G2.1411.00
165_W244_M2.0701.00
161_M239_T2.0131.00
94_A104_T2.0121.00
104_T108_W1.9271.00
21_A103_D1.8781.00
24_K110_S1.8061.00
32_I117_I1.8061.00
152_P155_E1.8041.00
179_G182_A1.7851.00
105_L109_M1.7741.00
221_V224_M1.7481.00
86_N107_L1.7331.00
83_F238_L1.7201.00
78_G249_Y1.7181.00
94_A99_I1.7041.00
73_L184_L1.6971.00
151_P159_R1.6951.00
27_Y110_S1.6731.00
28_V117_I1.6701.00
143_H146_E1.6621.00
177_L182_A1.6461.00
112_Y202_S1.6111.00
123_A214_L1.6101.00
108_W238_L1.6031.00
125_L158_F1.5881.00
116_L206_M1.5761.00
36_I165_W1.5471.00
78_G172_F1.5181.00
173_I186_T1.5051.00
209_F225_G1.5031.00
202_S234_T1.4921.00
74_M169_L1.4901.00
45_A64_A1.4861.00
87_T108_W1.4581.00
16_K19_I1.4521.00
124_I214_L1.4291.00
93_T99_I1.4031.00
154_S158_F1.3990.99
244_M248_M1.3870.99
14_L98_K1.3620.99
113_A117_I1.3370.99
125_L162_L1.3340.99
8_K176_S1.3240.99
44_A192_F1.3200.99
28_V32_I1.2920.99
40_F165_W1.2890.99
109_M113_A1.2810.99
231_I235_L1.2790.99
176_S180_E1.2770.99
36_I39_G1.2670.99
65_A196_I1.2660.99
102_R106_Y1.2590.99
101_W105_L1.2480.99
70_A193_C1.2400.99
146_E150_E1.2380.99
49_G140_F1.2350.99
147_H150_E1.2330.99
62_P192_F1.2280.99
30_R252_L1.2100.99
205_N229_N1.2090.99
151_P156_L1.2070.99
56_D59_F1.2060.98
155_E159_R1.1970.98
42_I208_T1.1910.98
33_L248_M1.1910.98
123_A211_I1.1900.98
160_G232_P1.1880.98
213_L222_T1.1860.98
177_L180_E1.1850.98
243_V247_W1.1840.98
234_T238_L1.1810.98
44_A196_I1.1620.98
66_V188_M1.1440.98
140_F143_H1.1320.98
100_S103_D1.1290.98
209_F213_L1.1190.98
12_Y175_M1.1120.97
80_G249_Y1.1100.97
66_V192_F1.1020.97
238_L242_I1.0940.97
92_Y246_G1.0840.97
203_I206_M1.0790.97
245_M249_Y1.0790.97
211_I215_I1.0760.97
77_Y180_E1.0720.97
153_A235_L1.0690.97
27_Y106_Y1.0690.97
46_S144_L1.0670.97
75_I160_G1.0580.97
120_I214_L1.0580.97
75_I80_G1.0560.97
30_R81_D1.0540.96
49_G64_A1.0510.96
95_L247_W1.0300.96
112_Y230_L1.0290.96
17_Q98_K1.0240.96
96_R250_Y1.0200.96
14_L18_N1.0190.96
163_C203_I1.0160.96
52_F59_F1.0140.96
43_T197_S1.0140.96
23_S26_R1.0130.96
48_T63_A1.0050.95
73_L189_L1.0010.95
40_F166_L0.9940.95
165_W245_M0.9900.95
76_A187_M0.9820.95
40_F122_F0.9750.95
46_S141_L0.9560.94
33_L37_F0.9530.94
160_G234_T0.9500.94
205_N233_V0.9480.94
227_V231_I0.9470.94
228_R232_P0.9420.93
24_K28_V0.9370.93
7_Q10_E0.9240.93
20_F99_I0.9230.93
153_A157_F0.9200.93
37_F80_G0.9160.92
95_L250_Y0.9150.92
113_A227_V0.9110.92
10_E14_L0.9090.92
141_L211_I0.9070.92
17_Q21_A0.9060.92
164_N167_V0.8950.92
107_L111_S0.8950.92
156_L160_G0.8880.91
71_A195_F0.8880.91
148_K204_A0.8870.91
25_I251_T0.8800.91
116_L120_I0.8780.91
159_R200_E0.8720.91
78_G169_L0.8630.90
116_L227_V0.8630.90
166_L187_M0.8500.89
48_T67_T0.8440.89
14_L17_Q0.8390.89
46_S207_C0.8360.89
83_F234_T0.8360.89
81_D86_N0.8350.89
83_F203_I0.8320.88
69_G73_L0.8280.88
148_K205_N0.8280.88
111_S172_F0.8210.88
103_D106_Y0.8200.88
37_F249_Y0.8200.88
167_V194_F0.8150.87
89_Y93_T0.8140.87
59_F63_A0.8120.87
148_K194_F0.8040.87
83_F112_Y0.8030.87
135_P139_S0.8020.86
120_I210_A0.8010.86
101_W104_T0.8000.86
78_G173_I0.7980.86
24_K109_M0.7960.86
243_V248_M0.7950.86
139_S142_I0.7950.86
27_Y111_S0.7920.86
73_L187_M0.7900.86
167_V191_V0.7890.86
225_G232_P0.7840.85
50_S140_F0.7830.85
123_A210_A0.7820.85
165_W169_L0.7760.85
153_A228_R0.7720.84
76_A171_F0.7700.84
133_E155_E0.7650.84
139_S143_H0.7640.84
194_F205_N0.7620.84
130_G155_E0.7590.83
157_F160_G0.7580.83
230_L234_T0.7570.83
112_Y116_L0.7570.83
77_Y176_S0.7550.83
94_A105_L0.7530.83
172_F249_Y0.7520.83
51_Y65_A0.7510.83
122_F165_W0.7500.83
249_Y253_N0.7440.82
164_N194_F0.7440.82
11_Q175_M0.7430.82
11_Q15_K0.7390.82
224_M228_R0.7330.81
194_F204_A0.7320.81
170_A194_F0.7310.81
225_G228_R0.7300.81
37_F74_M0.7290.81
131_L159_R0.7290.81
202_S233_V0.7210.80
29_L248_M0.7170.80
166_L190_F0.7170.80
52_F58_P0.7120.79
163_C233_V0.7100.79
221_V227_V0.7050.79
202_S230_L0.7040.78
88_F184_L0.7020.78
120_I123_A0.6990.78
148_K164_N0.6980.78
39_G207_C0.6950.78
173_I190_F0.6900.77
209_F226_A0.6890.77
45_A49_G0.6840.76
84_T163_C0.6820.76
51_Y58_P0.6820.76
153_A156_L0.6810.76
109_M231_I0.6770.76
145_A209_F0.6760.76
27_Y107_L0.6750.75
112_Y203_I0.6710.75
90_F93_T0.6700.75
46_S208_T0.6680.75
30_R172_F0.6670.75
127_S214_L0.6650.74
116_L226_A0.6640.74
221_V232_P0.6620.74
184_L189_L0.6620.74
129_T158_F0.6610.74
74_M166_L0.6600.74
200_E205_N0.6590.74
172_F245_M0.6570.74
210_A214_L0.6490.73
9_V13_A0.6470.72
38_I71_A0.6460.72
10_E98_K0.6460.72
28_V113_A0.6370.71
128_A158_F0.6350.71
85_G147_H0.6340.71
232_P235_L0.6340.71
135_P138_H0.6320.71
121_L124_I0.6310.71
13_A96_R0.6280.70
42_I207_C0.6240.70
15_K18_N0.6230.70
34_A85_G0.6200.69
241_G246_G0.6200.69
138_H142_I0.6200.69
213_L216_E0.6170.69
229_N233_V0.6160.69
50_S136_S0.6130.68
31_S34_A0.6120.68
52_F55_A0.6120.68
149_M213_L0.6120.68
19_I31_S0.6090.68
52_F60_A0.6080.68
144_L208_T0.6080.68
29_L252_L0.6070.68
242_I246_G0.6040.67
31_S110_S0.6030.67
164_N229_N0.5980.66
194_F200_E0.5980.66
207_C210_A0.5960.66
91_T95_L0.5950.66
16_K90_F0.5920.66
9_V253_N0.5920.66
66_V187_M0.5920.66
30_R80_G0.5920.66
223_L227_V0.5880.65
187_M191_V0.5840.65
43_T132_F0.5840.65
87_T241_G0.5830.64
77_Y177_L0.5820.64
17_Q99_I0.5810.64
22_S27_Y0.5800.64
164_N205_N0.5800.64
112_Y206_M0.5790.64
10_E13_A0.5790.64
31_S111_S0.5790.64
81_D111_S0.5790.64
91_T99_I0.5780.64
66_V73_L0.5740.63
130_G133_E0.5740.63
40_F203_I0.5740.63
74_M193_C0.5730.63
192_F196_I0.5730.63
163_C194_F0.5730.63
140_F144_L0.5720.63
105_L239_T0.5710.63
138_H212_S0.5700.63
24_K106_Y0.5690.63
71_A111_S0.5620.62
45_A195_F0.5610.62
97_K101_W0.5590.61
172_F253_N0.5580.61
222_T232_P0.5570.61
133_E136_S0.5560.61
68_F194_F0.5530.60
91_T242_I0.5520.60
67_T192_F0.5490.60
157_F161_M0.5480.60
130_G159_R0.5480.60
43_T126_I0.5480.60
223_L232_P0.5470.60
81_D107_L0.5450.59
132_F141_L0.5450.59
149_M212_S0.5440.59
131_L177_L0.5430.59
149_M225_G0.5420.59
127_S158_F0.5380.58
99_I103_D0.5380.58
145_A212_S0.5370.58
67_T78_G0.5360.58
182_A185_F0.5350.58
30_R75_I0.5350.58
69_G191_V0.5330.58
119_A207_C0.5330.58
76_A174_P0.5320.57
154_S169_L0.5320.57
176_S186_T0.5320.57
83_F108_W0.5310.57
7_Q178_K0.5310.57
40_F89_Y0.5290.57
89_Y99_I0.5280.57
52_F57_S0.5270.57
81_D119_A0.5270.57
164_N191_V0.5260.57
19_I207_C0.5240.56
213_L225_G0.5220.56
78_G176_S0.5200.56
72_I187_M0.5190.56
168_C200_E0.5190.56
142_I212_S0.5190.56
174_P186_T0.5180.56
149_M222_T0.5180.56
13_A16_K0.5160.55
143_H147_H0.5150.55
167_V183_K0.5130.55
38_I42_I0.5110.55
20_F90_F0.5100.54
55_A59_F0.5090.54
88_F168_C0.5090.54
126_I162_L0.5080.54
188_M216_E0.5070.54
88_F245_M0.5070.54
141_L212_S0.5070.54
94_A97_K0.5060.54
70_A74_M0.5060.54
88_F253_N0.5050.54
248_M251_T0.5050.54
168_C246_G0.5030.53
63_A199_F0.5010.53
129_T132_F0.5010.53
237_N240_A0.5000.53
117_I120_I0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3klyA 3 0.9297 100 0.055 Contact Map
3kcuA 3 0.9102 100 0.058 Contact Map
3tdsE 3 0.9883 100 0.079 Contact Map
4fc4A 3 0.9648 100 0.105 Contact Map
3llqA 3 0.8633 67.7 0.943 Contact Map
3zojA 3 0.918 53 0.948 Contact Map
3cn5A 3 0.8516 44 0.951 Contact Map
2zz9A 3 0.8203 29.3 0.955 Contact Map
2o9gA 3 0.8555 16.7 0.96 Contact Map
3gd8A 4 0.8164 16.3 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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