YWCJ - BACSU - GREMLIN Contacts

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YWCJ - Uncharacterized transporter YwcJ

UniProt:	P39608	Sequences: METQALQKVEQYALKKQNIFASSKIRYVLRSILASIFIGFGITAASKTGSYFFMADSPFAFPAAAVTFGAAILMIAYGGGDLFTGNTFYFTYTALRKKISWRDTLYLWMSSYAGNLIGAILFAILISATGLFEEPSVHSFLIHLAEHKMEPPASELFFRGMLCNWLVCLAFFIPMSLKGEGAKLFTMMLFVFCFFISGFEHSIANMCTFAISLLIEHPDTVTLMGAVRNLIPVTLGNLTAGIVMMGWMYYTLNPDQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	256 (243)
Sequences:	2226 (1534)
Seq/√Len:	98.4

ECOLI - FOCA NIRC FOCB YFDC
BACSU - YWCJ YRHG

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
157_F	239_T	7.007	1.00
157_F	235_L	4.445	1.00
156_L	233_V	3.775	1.00
31_S	114_G	3.773	1.00
181_G	185_F	3.589	1.00
94_A	101_W	3.438	1.00
112_Y	234_T	3.289	1.00
28_V	114_G	3.098	1.00
235_L	239_T	3.071	1.00
32_I	121_L	3.024	1.00
39_G	122_F	2.913	1.00
153_A	232_P	2.828	1.00
222_T	225_G	2.569	1.00
44_A	193_C	2.448	1.00
124_I	128_A	2.276	1.00
69_G	188_M	2.260	1.00
16_K	93_T	2.241	1.00
28_V	110_S	2.205	1.00
83_F	87_T	2.154	1.00
221_V	225_G	2.141	1.00
165_W	244_M	2.070	1.00
161_M	239_T	2.013	1.00
94_A	104_T	2.012	1.00
104_T	108_W	1.927	1.00
21_A	103_D	1.878	1.00
24_K	110_S	1.806	1.00
32_I	117_I	1.806	1.00
152_P	155_E	1.804	1.00
179_G	182_A	1.785	1.00
105_L	109_M	1.774	1.00
221_V	224_M	1.748	1.00
86_N	107_L	1.733	1.00
83_F	238_L	1.720	1.00
78_G	249_Y	1.718	1.00
94_A	99_I	1.704	1.00
73_L	184_L	1.697	1.00
151_P	159_R	1.695	1.00
27_Y	110_S	1.673	1.00
28_V	117_I	1.670	1.00
143_H	146_E	1.662	1.00
177_L	182_A	1.646	1.00
112_Y	202_S	1.611	1.00
123_A	214_L	1.610	1.00
108_W	238_L	1.603	1.00
125_L	158_F	1.588	1.00
116_L	206_M	1.576	1.00
36_I	165_W	1.547	1.00
78_G	172_F	1.518	1.00
173_I	186_T	1.505	1.00
209_F	225_G	1.503	1.00
202_S	234_T	1.492	1.00
74_M	169_L	1.490	1.00
45_A	64_A	1.486	1.00
87_T	108_W	1.458	1.00
16_K	19_I	1.452	1.00
124_I	214_L	1.429	1.00
93_T	99_I	1.403	1.00
154_S	158_F	1.399	0.99
244_M	248_M	1.387	0.99
14_L	98_K	1.362	0.99
113_A	117_I	1.337	0.99
125_L	162_L	1.334	0.99
8_K	176_S	1.324	0.99
44_A	192_F	1.320	0.99
28_V	32_I	1.292	0.99
40_F	165_W	1.289	0.99
109_M	113_A	1.281	0.99
231_I	235_L	1.279	0.99
176_S	180_E	1.277	0.99
36_I	39_G	1.267	0.99
65_A	196_I	1.266	0.99
102_R	106_Y	1.259	0.99
101_W	105_L	1.248	0.99
70_A	193_C	1.240	0.99
146_E	150_E	1.238	0.99
49_G	140_F	1.235	0.99
147_H	150_E	1.233	0.99
62_P	192_F	1.228	0.99
30_R	252_L	1.210	0.99
205_N	229_N	1.209	0.99
151_P	156_L	1.207	0.99
56_D	59_F	1.206	0.98
155_E	159_R	1.197	0.98
42_I	208_T	1.191	0.98
33_L	248_M	1.191	0.98
123_A	211_I	1.190	0.98
160_G	232_P	1.188	0.98
213_L	222_T	1.186	0.98
177_L	180_E	1.185	0.98
243_V	247_W	1.184	0.98
234_T	238_L	1.181	0.98
44_A	196_I	1.162	0.98
66_V	188_M	1.144	0.98
140_F	143_H	1.132	0.98
100_S	103_D	1.129	0.98
209_F	213_L	1.119	0.98
12_Y	175_M	1.112	0.97
80_G	249_Y	1.110	0.97
66_V	192_F	1.102	0.97
238_L	242_I	1.094	0.97
92_Y	246_G	1.084	0.97
203_I	206_M	1.079	0.97
245_M	249_Y	1.079	0.97
211_I	215_I	1.076	0.97
77_Y	180_E	1.072	0.97
153_A	235_L	1.069	0.97
27_Y	106_Y	1.069	0.97
46_S	144_L	1.067	0.97
75_I	160_G	1.058	0.97
120_I	214_L	1.058	0.97
75_I	80_G	1.056	0.97
30_R	81_D	1.054	0.96
49_G	64_A	1.051	0.96
95_L	247_W	1.030	0.96
112_Y	230_L	1.029	0.96
17_Q	98_K	1.024	0.96
96_R	250_Y	1.020	0.96
14_L	18_N	1.019	0.96
163_C	203_I	1.016	0.96
52_F	59_F	1.014	0.96
43_T	197_S	1.014	0.96
23_S	26_R	1.013	0.96
48_T	63_A	1.005	0.95
73_L	189_L	1.001	0.95
40_F	166_L	0.994	0.95
165_W	245_M	0.990	0.95
76_A	187_M	0.982	0.95
40_F	122_F	0.975	0.95
46_S	141_L	0.956	0.94
33_L	37_F	0.953	0.94
160_G	234_T	0.950	0.94
205_N	233_V	0.948	0.94
227_V	231_I	0.947	0.94
228_R	232_P	0.942	0.93
24_K	28_V	0.937	0.93
7_Q	10_E	0.924	0.93
20_F	99_I	0.923	0.93
153_A	157_F	0.920	0.93
37_F	80_G	0.916	0.92
95_L	250_Y	0.915	0.92
113_A	227_V	0.911	0.92
10_E	14_L	0.909	0.92
141_L	211_I	0.907	0.92
17_Q	21_A	0.906	0.92
164_N	167_V	0.895	0.92
107_L	111_S	0.895	0.92
156_L	160_G	0.888	0.91
71_A	195_F	0.888	0.91
148_K	204_A	0.887	0.91
25_I	251_T	0.880	0.91
116_L	120_I	0.878	0.91
159_R	200_E	0.872	0.91
78_G	169_L	0.863	0.90
116_L	227_V	0.863	0.90
166_L	187_M	0.850	0.89
48_T	67_T	0.844	0.89
14_L	17_Q	0.839	0.89
46_S	207_C	0.836	0.89
83_F	234_T	0.836	0.89
81_D	86_N	0.835	0.89
83_F	203_I	0.832	0.88
69_G	73_L	0.828	0.88
148_K	205_N	0.828	0.88
111_S	172_F	0.821	0.88
103_D	106_Y	0.820	0.88
37_F	249_Y	0.820	0.88
167_V	194_F	0.815	0.87
89_Y	93_T	0.814	0.87
59_F	63_A	0.812	0.87
148_K	194_F	0.804	0.87
83_F	112_Y	0.803	0.87
135_P	139_S	0.802	0.86
120_I	210_A	0.801	0.86
101_W	104_T	0.800	0.86
78_G	173_I	0.798	0.86
24_K	109_M	0.796	0.86
243_V	248_M	0.795	0.86
139_S	142_I	0.795	0.86
27_Y	111_S	0.792	0.86
73_L	187_M	0.790	0.86
167_V	191_V	0.789	0.86
225_G	232_P	0.784	0.85
50_S	140_F	0.783	0.85
123_A	210_A	0.782	0.85
165_W	169_L	0.776	0.85
153_A	228_R	0.772	0.84
76_A	171_F	0.770	0.84
133_E	155_E	0.765	0.84
139_S	143_H	0.764	0.84
194_F	205_N	0.762	0.84
130_G	155_E	0.759	0.83
157_F	160_G	0.758	0.83
230_L	234_T	0.757	0.83
112_Y	116_L	0.757	0.83
77_Y	176_S	0.755	0.83
94_A	105_L	0.753	0.83
172_F	249_Y	0.752	0.83
51_Y	65_A	0.751	0.83
122_F	165_W	0.750	0.83
249_Y	253_N	0.744	0.82
164_N	194_F	0.744	0.82
11_Q	175_M	0.743	0.82
11_Q	15_K	0.739	0.82
224_M	228_R	0.733	0.81
194_F	204_A	0.732	0.81
170_A	194_F	0.731	0.81
225_G	228_R	0.730	0.81
37_F	74_M	0.729	0.81
131_L	159_R	0.729	0.81
202_S	233_V	0.721	0.80
29_L	248_M	0.717	0.80
166_L	190_F	0.717	0.80
52_F	58_P	0.712	0.79
163_C	233_V	0.710	0.79
221_V	227_V	0.705	0.79
202_S	230_L	0.704	0.78
88_F	184_L	0.702	0.78
120_I	123_A	0.699	0.78
148_K	164_N	0.698	0.78
39_G	207_C	0.695	0.78
173_I	190_F	0.690	0.77
209_F	226_A	0.689	0.77
45_A	49_G	0.684	0.76
84_T	163_C	0.682	0.76
51_Y	58_P	0.682	0.76
153_A	156_L	0.681	0.76
109_M	231_I	0.677	0.76
145_A	209_F	0.676	0.76
27_Y	107_L	0.675	0.75
112_Y	203_I	0.671	0.75
90_F	93_T	0.670	0.75
46_S	208_T	0.668	0.75
30_R	172_F	0.667	0.75
127_S	214_L	0.665	0.74
116_L	226_A	0.664	0.74
221_V	232_P	0.662	0.74
184_L	189_L	0.662	0.74
129_T	158_F	0.661	0.74
74_M	166_L	0.660	0.74
200_E	205_N	0.659	0.74
172_F	245_M	0.657	0.74
210_A	214_L	0.649	0.73
9_V	13_A	0.647	0.72
38_I	71_A	0.646	0.72
10_E	98_K	0.646	0.72
28_V	113_A	0.637	0.71
128_A	158_F	0.635	0.71
85_G	147_H	0.634	0.71
232_P	235_L	0.634	0.71
135_P	138_H	0.632	0.71
121_L	124_I	0.631	0.71
13_A	96_R	0.628	0.70
42_I	207_C	0.624	0.70
15_K	18_N	0.623	0.70
34_A	85_G	0.620	0.69
241_G	246_G	0.620	0.69
138_H	142_I	0.620	0.69
213_L	216_E	0.617	0.69
229_N	233_V	0.616	0.69
50_S	136_S	0.613	0.68
31_S	34_A	0.612	0.68
52_F	55_A	0.612	0.68
149_M	213_L	0.612	0.68
19_I	31_S	0.609	0.68
52_F	60_A	0.608	0.68
144_L	208_T	0.608	0.68
29_L	252_L	0.607	0.68
242_I	246_G	0.604	0.67
31_S	110_S	0.603	0.67
164_N	229_N	0.598	0.66
194_F	200_E	0.598	0.66
207_C	210_A	0.596	0.66
91_T	95_L	0.595	0.66
16_K	90_F	0.592	0.66
9_V	253_N	0.592	0.66
66_V	187_M	0.592	0.66
30_R	80_G	0.592	0.66
223_L	227_V	0.588	0.65
187_M	191_V	0.584	0.65
43_T	132_F	0.584	0.65
87_T	241_G	0.583	0.64
77_Y	177_L	0.582	0.64
17_Q	99_I	0.581	0.64
22_S	27_Y	0.580	0.64
164_N	205_N	0.580	0.64
112_Y	206_M	0.579	0.64
10_E	13_A	0.579	0.64
31_S	111_S	0.579	0.64
81_D	111_S	0.579	0.64
91_T	99_I	0.578	0.64
66_V	73_L	0.574	0.63
130_G	133_E	0.574	0.63
40_F	203_I	0.574	0.63
74_M	193_C	0.573	0.63
192_F	196_I	0.573	0.63
163_C	194_F	0.573	0.63
140_F	144_L	0.572	0.63
105_L	239_T	0.571	0.63
138_H	212_S	0.570	0.63
24_K	106_Y	0.569	0.63
71_A	111_S	0.562	0.62
45_A	195_F	0.561	0.62
97_K	101_W	0.559	0.61
172_F	253_N	0.558	0.61
222_T	232_P	0.557	0.61
133_E	136_S	0.556	0.61
68_F	194_F	0.553	0.60
91_T	242_I	0.552	0.60
67_T	192_F	0.549	0.60
157_F	161_M	0.548	0.60
130_G	159_R	0.548	0.60
43_T	126_I	0.548	0.60
223_L	232_P	0.547	0.60
81_D	107_L	0.545	0.59
132_F	141_L	0.545	0.59
149_M	212_S	0.544	0.59
131_L	177_L	0.543	0.59
149_M	225_G	0.542	0.59
127_S	158_F	0.538	0.58
99_I	103_D	0.538	0.58
145_A	212_S	0.537	0.58
67_T	78_G	0.536	0.58
182_A	185_F	0.535	0.58
30_R	75_I	0.535	0.58
69_G	191_V	0.533	0.58
119_A	207_C	0.533	0.58
76_A	174_P	0.532	0.57
154_S	169_L	0.532	0.57
176_S	186_T	0.532	0.57
83_F	108_W	0.531	0.57
7_Q	178_K	0.531	0.57
40_F	89_Y	0.529	0.57
89_Y	99_I	0.528	0.57
52_F	57_S	0.527	0.57
81_D	119_A	0.527	0.57
164_N	191_V	0.526	0.57
19_I	207_C	0.524	0.56
213_L	225_G	0.522	0.56
78_G	176_S	0.520	0.56
72_I	187_M	0.519	0.56
168_C	200_E	0.519	0.56
142_I	212_S	0.519	0.56
174_P	186_T	0.518	0.56
149_M	222_T	0.518	0.56
13_A	16_K	0.516	0.55
143_H	147_H	0.515	0.55
167_V	183_K	0.513	0.55
38_I	42_I	0.511	0.55
20_F	90_F	0.510	0.54
55_A	59_F	0.509	0.54
88_F	168_C	0.509	0.54
126_I	162_L	0.508	0.54
188_M	216_E	0.507	0.54
88_F	245_M	0.507	0.54
141_L	212_S	0.507	0.54
94_A	97_K	0.506	0.54
70_A	74_M	0.506	0.54
88_F	253_N	0.505	0.54
248_M	251_T	0.505	0.54
168_C	246_G	0.503	0.53
63_A	199_F	0.501	0.53
129_T	132_F	0.501	0.53
237_N	240_A	0.500	0.53
117_I	120_I	0.500	0.53

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3klyA	3	0.9297	100	0.055	Contact Map
3kcuA	3	0.9102	100	0.058	Contact Map
3tdsE	3	0.9883	100	0.079	Contact Map
4fc4A	3	0.9648	100	0.105	Contact Map
3llqA	3	0.8633	67.7	0.943	Contact Map
3zojA	3	0.918	53	0.948	Contact Map
3cn5A	3	0.8516	44	0.951	Contact Map
2zz9A	3	0.8203	29.3	0.955	Contact Map
2o9gA	3	0.8555	16.7	0.96	Contact Map
3gd8A	4	0.8164	16.3	0.96	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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