GREMLIN Database
YWCH - Uncharacterized protein YwcH
UniProt: P39606 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 333 (290)
Sequences: 16568 (10677)
Seq/√Len: 627.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
232_E291_Q5.4361.00
30_Q66_K3.4021.00
71_R103_D2.8251.00
232_E288_T2.8061.00
132_P182_E2.8011.00
295_R298_A2.6511.00
31_A34_D2.5591.00
33_E69_R2.5561.00
178_L208_R2.5481.00
64_A98_T2.5441.00
203_R207_R2.5161.00
232_E236_E2.5041.00
231_T234_K2.4901.00
229_A234_K2.4181.00
60_I72_V2.3931.00
288_T291_Q2.3731.00
136_K183_S2.3191.00
177_A204_Q2.2611.00
202_V220_A2.1971.00
202_V206_K2.1781.00
26_V30_Q2.1621.00
207_R211_P2.1541.00
29_A63_I2.1501.00
23_Q99_P2.1441.00
209_F218_P2.1171.00
30_Q34_D2.1101.00
204_Q208_R2.0901.00
199_E203_R2.0341.00
298_A302_A2.0181.00
199_E302_A2.0161.00
143_H164_A2.0121.00
40_F70_I1.9741.00
233_E237_E1.9561.00
26_V66_K1.9491.00
91_F102_I1.9051.00
95_E100_G1.8951.00
27_A30_Q1.8781.00
285_I292_V1.8641.00
41_W73_G1.8601.00
55_S90_N1.8281.00
64_A72_V1.8201.00
181_A208_R1.8201.00
240_A244_F1.8011.00
139_T164_A1.7771.00
29_A40_F1.7611.00
114_P118_W1.7571.00
31_A35_L1.7371.00
204_Q207_R1.6981.00
91_F104_L1.6821.00
208_R211_P1.6491.00
63_I72_V1.6111.00
171_G187_Y1.6061.00
200_G203_R1.5861.00
290_E294_E1.5821.00
136_K140_M1.5801.00
178_L211_P1.5651.00
291_Q294_E1.5641.00
139_T183_S1.5501.00
275_R278_A1.5361.00
293_K297_L1.5281.00
17_N20_T1.5261.00
178_L182_E1.4921.00
26_V62_H1.4781.00
34_D68_K1.4731.00
33_E67_T1.4711.00
123_G126_R1.4711.00
228_C292_V1.4601.00
29_A67_T1.4441.00
222_V305_T1.4391.00
62_H65_A1.4011.00
234_K238_L1.3891.00
140_M145_L1.3841.00
42_V60_I1.3691.00
140_M144_D1.3661.00
62_H97_L1.3661.00
297_L300_S1.3651.00
132_P183_S1.3641.00
139_T167_V1.3631.00
228_C289_K1.3621.00
152_F155_L1.3551.00
291_Q295_R1.3491.00
23_Q27_A1.3171.00
20_T24_Q1.3161.00
55_S58_V1.3131.00
82_Y90_N1.3011.00
157_A160_H1.2961.00
168_W221_A1.2941.00
147_D150_H1.2881.00
272_Y275_R1.2851.00
229_A235_A1.2801.00
27_A31_A1.2791.00
174_G204_Q1.2741.00
219_R306_E1.2731.00
209_F214_L1.2621.00
294_E298_A1.2561.00
132_P136_K1.2411.00
33_E68_K1.2391.00
230_D234_K1.2361.00
181_A212_S1.2291.00
234_K237_E1.2291.00
60_I74_S1.2251.00
29_A70_I1.2221.00
237_E240_A1.2191.00
139_T185_A1.2161.00
178_L204_Q1.2141.00
73_G103_D1.1991.00
227_L238_L1.1951.00
95_E162_S1.1931.00
94_L102_I1.1911.00
168_W186_G1.1911.00
87_V134_Q1.1861.00
118_W121_N1.1751.00
178_L212_S1.1741.00
30_Q68_K1.1531.00
239_G243_D1.1361.00
104_L138_L1.1321.00
126_R129_D1.1281.00
54_S93_V1.1281.00
135_I183_S1.1251.00
57_E90_N1.1231.00
58_V61_S1.1221.00
182_E212_S1.1221.00
208_R212_S1.1191.00
194_N197_G1.1151.00
42_V63_I1.1011.00
62_H66_K1.0991.00
138_L142_L1.0951.00
195_G298_A1.0951.00
24_Q27_A1.0941.00
175_E178_L1.0931.00
285_I295_R1.0921.00
276_R279_D1.0871.00
86_K90_N1.0871.00
237_E241_V1.0851.00
114_P117_S1.0851.00
116_A119_A1.0831.00
106_L135_I1.0751.00
226_V310_V1.0641.00
236_E240_A1.0631.00
199_E303_Y1.0621.00
272_Y277_I1.0591.00
287_G292_V1.0561.00
200_G204_Q1.0401.00
24_Q317_F1.0391.00
129_D175_E1.0381.00
27_A317_F1.0351.00
130_Q133_Q1.0281.00
58_V94_L1.0201.00
197_G200_G1.0171.00
137_E140_M1.0111.00
272_Y276_R1.0071.00
229_A238_L1.0071.00
136_K149_K1.0011.00
139_T143_H1.0001.00
115_I118_W0.9991.00
116_A121_N0.9941.00
19_E23_Q0.9931.00
132_P179_L0.9861.00
233_E236_E0.9831.00
258_V261_Y0.9801.00
126_R130_Q0.9781.00
219_R307_E0.9781.00
133_Q137_E0.9741.00
39_R73_G0.9691.00
180_A187_Y0.9691.00
76_G170_L0.9651.00
224_V285_I0.9531.00
179_L183_S0.9521.00
273_E278_A0.9431.00
57_E77_V0.9321.00
130_Q134_Q0.9291.00
273_E277_I0.9271.00
239_G286_V0.9211.00
157_A161_I0.9211.00
95_E163_T0.9181.00
146_A154_N0.9181.00
248_A252_G0.9091.00
241_V244_F0.9041.00
23_Q26_V0.9021.00
188_M221_A0.9001.00
161_I164_A0.8961.00
224_V296_L0.8951.00
114_P121_N0.8951.00
27_A34_D0.8941.00
84_A137_E0.8881.00
249_G252_G0.8871.00
152_F157_A0.8851.00
177_A208_R0.8841.00
187_Y205_Y0.8841.00
260_S263_A0.8821.00
61_S65_A0.8751.00
294_E297_L0.8731.00
209_F212_S0.8651.00
134_Q138_L0.8651.00
250_E254_P0.8611.00
22_L97_L0.8611.00
236_E281_R0.8591.00
117_S120_L0.8591.00
297_L302_A0.8561.00
144_D147_D0.8431.00
195_G199_E0.8431.00
231_T235_A0.8421.00
274_Q279_D0.8371.00
203_R304_E0.8341.00
169_L180_A0.8321.00
177_A181_A0.8281.00
79_L134_Q0.8251.00
21_A24_Q0.8191.00
76_G107_G0.8191.00
249_G253_I0.8161.00
115_I121_N0.8161.00
275_R279_D0.8151.00
209_F215_G0.8141.00
169_L176_S0.8141.00
39_R307_E0.8131.00
240_A243_D0.8111.00
206_K220_A0.8091.00
274_Q278_A0.8051.00
95_E164_A0.8021.00
142_L165_P0.7981.00
64_A102_I0.7961.00
65_A98_T0.7931.00
238_L241_V0.7921.00
26_V63_I0.7921.00
60_I64_A0.7871.00
60_I102_I0.7871.00
140_M147_D0.7861.00
78_M109_A0.7861.00
236_E239_G0.7841.00
202_V205_Y0.7751.00
232_E235_A0.7701.00
196_E199_E0.7681.00
205_Y209_F0.7651.00
140_M143_H0.7651.00
209_F217_T0.7641.00
169_L184_G0.7631.00
261_Y264_V0.7631.00
158_A161_I0.7601.00
115_I119_A0.7591.00
132_P175_E0.7531.00
103_D168_W0.7521.00
24_Q28_L0.7511.00
206_K210_K0.7491.00
79_L87_V0.7471.00
146_A149_K0.7461.00
254_P261_Y0.7451.00
60_I94_L0.7451.00
64_A94_L0.7441.00
128_A175_E0.7431.00
136_K182_E0.7431.00
274_Q277_I0.7381.00
205_Y218_P0.7371.00
23_Q65_A0.7301.00
74_S102_I0.7301.00
140_M149_K0.7251.00
249_G254_P0.7241.00
250_E255_L0.7241.00
177_A187_Y0.7241.00
40_F63_I0.7221.00
236_E286_V0.7201.00
156_T160_H0.7181.00
87_V138_L0.7171.00
96_G163_T0.7171.00
153_P157_A0.7151.00
259_P262_E0.7141.00
84_A134_Q0.7131.00
248_A254_P0.7101.00
174_G208_R0.7091.00
117_S121_N0.7081.00
148_D154_N0.7071.00
182_E208_R0.7071.00
22_L62_H0.7041.00
91_F142_L0.7021.00
76_G87_V0.7011.00
137_E152_F0.7001.00
273_E276_R0.6981.00
272_Y279_D0.6931.00
71_R166_D0.6931.00
257_G260_S0.6921.00
221_A307_E0.6911.00
146_A150_H0.6861.00
259_P263_A0.6861.00
41_W75_G0.6851.00
38_K69_R0.6841.00
46_H89_E0.6841.00
83_S86_K0.6811.00
26_V65_A0.6801.00
189_F201_T0.6791.00
152_F160_H0.6781.00
241_V245_T0.6771.00
178_L207_R0.6751.00
154_N157_A0.6751.00
174_G178_L0.6741.00
125_K175_E0.6711.00
141_Y147_D0.6701.00
202_V303_Y0.6701.00
206_K209_F0.6691.00
108_R127_N0.6651.00
137_E149_K0.6651.00
42_V59_L0.6651.00
169_L179_L0.6611.00
171_G176_S0.6611.00
82_Y86_K0.6611.00
136_K139_T0.6601.00
109_A116_A0.6581.00
226_V285_I0.6581.00
212_S215_G0.6571.00
108_R131_Y0.6571.00
57_E91_F0.6521.00
209_F216_D0.6511.00
38_K71_R0.6511.00
295_R299_L0.6511.00
44_E82_Y0.6501.00
250_E253_I0.6501.00
152_F158_A0.6501.00
195_G302_A0.6501.00
61_S94_L0.6471.00
220_A305_T0.6471.00
67_T101_R0.6471.00
73_G168_W0.6461.00
206_K306_E0.6411.00
290_E293_K0.6391.00
300_S305_T0.6381.00
26_V29_A0.6361.00
152_F161_I0.6351.00
223_A309_M0.6351.00
32_A70_I0.6301.00
18_A21_A0.6301.00
251_Q254_P0.6291.00
106_L167_V0.6261.00
133_Q136_K0.6231.00
72_V98_T0.6221.00
39_R309_M0.6211.00
114_P119_A0.6201.00
22_L26_V0.6181.00
177_A205_Y0.6171.00
251_Q255_L0.6111.00
175_E179_L0.6091.00
283_R295_R0.6091.00
122_D130_Q0.6091.00
153_P156_T0.6051.00
59_L93_V0.6041.00
61_S98_T0.6021.00
116_A120_L0.6021.00
203_R206_K0.5991.00
79_L106_L0.5981.00
254_P257_G0.5981.00
67_T70_I0.5961.00
95_E98_T0.5951.00
217_T306_E0.5951.00
82_Y87_V0.5951.00
181_A209_F0.5921.00
254_P260_S0.5911.00
198_G201_T0.5891.00
56_P74_S0.5871.00
206_K304_E0.5871.00
115_I120_L0.5851.00
311_V315_H0.5841.00
148_D153_P0.5821.00
33_E70_I0.5811.00
231_T237_E0.5811.00
58_V90_N0.5791.00
248_A251_Q0.5761.00
155_L158_A0.5731.00
182_E211_P0.5721.00
137_E147_D0.5721.00
230_D289_K0.5721.00
85_Y141_Y0.5701.00
228_C288_T0.5701.00
88_A142_L0.5681.00
263_A271_P0.5681.00
201_T204_Q0.5661.00
235_A239_G0.5661.00
296_L310_V0.5651.00
296_L308_I0.5651.00
244_F248_A0.5641.00
27_A318_E0.5621.00
105_G170_L0.5591.00
289_K293_K0.5591.00
23_Q68_K0.5581.00
84_A138_L0.5581.00
62_H98_T0.5581.00
252_G261_Y0.5571.00
20_T23_Q0.5561.00
207_R210_K0.5561.00
75_G188_M0.5551.00
92_R142_L0.5541.00
85_Y155_L0.5501.00
103_D307_E0.5491.00
257_G261_Y0.5481.00
202_V305_T0.5481.00
229_A232_E0.5471.00
257_G262_E0.5440.99
248_A253_I0.5420.99
95_E161_I0.5410.99
60_I98_T0.5410.99
166_D219_R0.5400.99
252_G255_L0.5400.99
206_K216_D0.5380.99
118_W153_P0.5370.99
98_T102_I0.5360.99
95_E165_P0.5360.99
168_W307_E0.5320.99
135_I169_L0.5300.99
156_T161_I0.5300.99
186_G219_R0.5290.99
179_L182_E0.5270.99
106_L138_L0.5260.99
195_G303_Y0.5250.99
206_K217_T0.5230.99
215_G218_P0.5220.99
210_K213_V0.5220.99
172_S191_H0.5210.99
226_V292_V0.5200.99
34_D69_R0.5200.99
292_V295_R0.5160.99
222_V299_L0.5160.99
58_V93_V0.5150.99
135_I139_T0.5140.99
227_L239_G0.5130.99
223_A311_V0.5120.99
58_V62_H0.5110.99
61_S72_V0.5090.99
58_V97_L0.5080.99
25_T28_L0.5080.99
137_E141_Y0.5070.99
94_L98_T0.5050.99
205_Y220_A0.5040.99
299_L303_Y0.5040.99
164_A185_A0.5040.99
224_V308_I0.5030.99
250_E257_G0.5020.99
77_V87_V0.5010.99
196_E200_G0.5000.99
205_Y208_R0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1lucA 1 0.9369 100 0.211 Contact Map
4us5A 3 0.955 100 0.215 Contact Map
2wgkA 2 0.985 100 0.215 Contact Map
1lucB 1 0.9369 100 0.217 Contact Map
2i7gA 2 0.961 100 0.236 Contact Map
1ezwA 3 0.9369 100 0.254 Contact Map
1f07A 3 0.9279 100 0.255 Contact Map
1z69A 4 0.9339 100 0.256 Contact Map
3raoA 2 0.961 100 0.257 Contact Map
1rhcA 2 0.9309 100 0.259 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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