NFRA1 - BACSU - GREMLIN Contacts

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NFRA1 - FMN reductase (NADPH)

UniProt:	P39605	Sequences: MNNTIETILNHRSIRSFTDQLLTAEEIDTLVKSAQAASTSSYVQAYSIIGVSDPEKKRELSVLAGNQPYVEKNGHFFVFCADLYRHQQLAEEKGEHISELLENTEMFMVSLIDAALAAQNMSIAAESMGLGICYIGGIRNELDKVTEVLQTPDHVLPLFGLAVGHPANLSGKKPRLPKQAVYHENTYNVNTDDFRHTMNTYDKTISDYYRERTNGKREETWSDQILNFMKQKPRTYLNDYVKEKGFNKN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	249 (238)
Sequences:	1508 (1111)
Seq/√Len:	72.0

ECOLI - NFSA NFNB RUTE YDJA
BACSU - NFRA1 NFRA2 YODC MHQN YDGI YFHC YFKO
HALSA - Q9HQZ4
SULSO - Q97VQ3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
52_S	185_N	4.187	1.00
122_S	132_I	3.488	1.00
80_C	155_V	3.410	1.00
60_L	145_V	3.355	1.00
8_I	123_I	3.232	1.00
23_T	26_E	3.167	1.00
56_K	185_N	3.013	1.00
58_R	71_E	2.935	1.00
81_A	110_S	2.918	1.00
150_Q	186_T	2.861	1.00
141_E	144_K	2.617	1.00
20_Q	165_H	2.615	1.00
238_N	242_K	2.586	1.00
78_V	149_L	2.477	1.00
38_S	132_I	2.452	1.00
30_L	121_M	2.317	1.00
143_D	243_E	2.276	1.00
122_S	161_L	2.236	1.00
50_G	75_H	2.236	1.00
3_N	6_E	2.215	1.00
50_G	182_Y	2.125	1.00
26_E	165_H	2.098	1.00
54_P	58_R	2.091	1.00
138_I	145_V	2.085	1.00
17_F	162_A	2.045	1.00
79_F	121_M	2.034	1.00
198_M	222_S	2.006	1.00
52_S	184_E	2.006	1.00
202_D	222_S	2.004	1.00
24_A	52_S	1.997	1.00
130_L	165_H	1.996	1.00
18_T	167_A	1.983	1.00
14_I	170_S	1.950	1.00
56_K	186_T	1.948	1.00
118_A	134_Y	1.910	1.00
28_D	178_K	1.856	1.00
146_T	244_K	1.828	1.00
144_K	147_E	1.809	1.00
34_A	121_M	1.757	1.00
146_T	240_Y	1.742	1.00
29_T	128_M	1.734	1.00
77_F	121_M	1.705	1.00
59_E	62_V	1.695	1.00
55_E	58_R	1.692	1.00
48_I	77_F	1.680	1.00
133_C	162_A	1.665	1.00
9_L	29_T	1.653	1.00
63_L	141_E	1.644	1.00
16_S	167_A	1.640	0.99
22_L	74_G	1.640	0.99
26_E	30_L	1.630	0.99
53_D	56_K	1.594	0.99
37_A	116_L	1.586	0.99
31_V	182_Y	1.570	0.99
62_V	66_N	1.566	0.99
63_L	144_K	1.563	0.99
84_Y	189_V	1.549	0.99
18_T	165_H	1.547	0.99
48_I	79_F	1.532	0.99
135_I	162_A	1.528	0.99
143_D	147_E	1.524	0.99
108_M	111_L	1.510	0.99
203_K	207_D	1.478	0.99
76_F	160_G	1.427	0.99
59_E	144_K	1.385	0.98
26_E	128_M	1.377	0.98
28_D	32_K	1.374	0.98
76_F	135_I	1.361	0.98
32_K	35_Q	1.358	0.98
140_N	234_R	1.325	0.98
59_E	148_V	1.319	0.98
24_A	28_D	1.302	0.97
61_S	71_E	1.281	0.97
53_D	185_N	1.273	0.97
26_E	130_L	1.268	0.97
179_Q	197_T	1.267	0.97
38_S	122_S	1.251	0.97
208_Y	212_R	1.250	0.97
132_I	163_V	1.213	0.96
27_I	77_F	1.211	0.96
46_Y	117_A	1.207	0.96
22_L	25_E	1.207	0.96
207_D	210_R	1.200	0.96
56_K	59_E	1.199	0.96
153_D	244_K	1.191	0.96
77_F	163_V	1.186	0.95
56_K	148_V	1.174	0.95
105_E	139_R	1.149	0.95
27_I	31_V	1.147	0.95
35_Q	181_V	1.141	0.94
219_E	224_Q	1.138	0.94
87_Q	154_H	1.137	0.94
88_Q	91_E	1.136	0.94
93_K	202_D	1.135	0.94
6_E	10_N	1.123	0.94
76_F	162_A	1.123	0.94
202_D	220_T	1.105	0.93
125_A	132_I	1.104	0.93
118_A	159_F	1.092	0.93
122_S	134_Y	1.080	0.93
113_D	136_G	1.077	0.93
84_Y	88_Q	1.069	0.92
206_S	220_T	1.068	0.92
107_F	110_S	1.065	0.92
65_G	137_G	1.060	0.92
30_L	125_A	1.052	0.92
69_Y	168_N	1.050	0.92
11_H	120_N	1.049	0.92
49_I	80_C	1.033	0.91
239_D	243_E	1.032	0.91
32_K	178_K	1.029	0.91
55_E	59_E	1.027	0.91
36_A	172_K	1.024	0.91
180_A	197_T	1.023	0.90
188_N	191_T	1.023	0.90
23_T	165_H	1.017	0.90
48_I	182_Y	1.008	0.90
29_T	33_S	1.002	0.90
54_P	186_T	0.999	0.89
5_I	124_A	0.991	0.89
217_R	224_Q	0.974	0.88
236_Y	239_D	0.974	0.88
92_E	199_N	0.973	0.88
207_D	211_E	0.972	0.88
4_T	123_I	0.971	0.88
117_A	121_M	0.964	0.88
24_A	184_E	0.960	0.87
107_F	241_V	0.959	0.87
64_A	137_G	0.954	0.87
69_Y	135_I	0.949	0.87
132_I	161_L	0.945	0.87
48_I	117_A	0.942	0.86
87_Q	91_E	0.938	0.86
47_S	183_H	0.936	0.86
9_L	32_K	0.915	0.85
108_M	112_I	0.912	0.85
50_G	184_E	0.901	0.84
40_S	105_E	0.891	0.83
12_R	170_S	0.890	0.83
112_I	159_F	0.887	0.83
142_L	240_Y	0.887	0.83
9_L	33_S	0.885	0.83
11_H	126_E	0.884	0.83
54_P	57_K	0.878	0.82
81_A	158_L	0.877	0.82
61_S	64_A	0.870	0.82
68_P	72_K	0.868	0.82
31_V	50_G	0.864	0.81
220_T	223_D	0.858	0.81
68_P	71_E	0.856	0.81
28_D	179_Q	0.849	0.80
151_T	187_Y	0.846	0.80
8_I	33_S	0.845	0.80
78_V	138_I	0.845	0.80
4_T	7_T	0.845	0.80
8_I	124_A	0.843	0.80
115_A	159_F	0.843	0.80
196_H	199_N	0.838	0.79
11_H	132_I	0.837	0.79
16_S	168_N	0.834	0.79
73_N	162_A	0.831	0.79
4_T	127_S	0.827	0.78
46_Y	181_V	0.825	0.78
232_K	235_T	0.822	0.78
171_G	213_T	0.820	0.78
14_I	168_N	0.807	0.77
119_Q	134_Y	0.805	0.76
236_Y	240_Y	0.805	0.76
111_L	156_L	0.801	0.76
38_S	134_Y	0.800	0.76
22_L	26_E	0.797	0.76
16_S	72_K	0.795	0.76
63_L	148_V	0.794	0.75
5_I	127_S	0.792	0.75
134_Y	159_F	0.788	0.75
5_I	29_T	0.787	0.75
202_D	212_R	0.786	0.75
34_A	117_A	0.783	0.74
33_S	123_I	0.780	0.74
121_M	161_L	0.773	0.73
57_K	162_A	0.772	0.73
138_I	157_P	0.772	0.73
83_L	110_S	0.770	0.73
56_K	150_Q	0.767	0.73
79_F	114_A	0.766	0.73
210_R	218_E	0.765	0.73
25_E	28_D	0.764	0.73
26_E	121_M	0.762	0.72
151_T	155_V	0.761	0.72
21_L	74_G	0.756	0.72
167_A	170_S	0.755	0.72
6_E	9_L	0.754	0.72
43_V	106_M	0.747	0.71
213_T	216_K	0.744	0.71
75_H	182_Y	0.743	0.71
22_L	163_V	0.742	0.70
84_Y	155_V	0.739	0.70
52_S	75_H	0.736	0.70
75_H	163_V	0.736	0.70
22_L	28_D	0.734	0.70
86_H	225_I	0.732	0.69
239_D	242_K	0.729	0.69
58_R	61_S	0.722	0.68
87_Q	153_D	0.704	0.66
112_I	115_A	0.701	0.66
203_K	211_E	0.698	0.66
131_G	166_P	0.698	0.66
38_S	161_L	0.692	0.65
5_I	33_S	0.692	0.65
180_A	198_M	0.689	0.65
125_A	163_V	0.684	0.64
124_A	127_S	0.684	0.64
31_V	178_K	0.682	0.64
156_L	240_Y	0.678	0.63
105_E	234_R	0.676	0.63
17_F	69_Y	0.675	0.63
91_E	94_G	0.675	0.63
5_I	128_M	0.672	0.63
45_A	109_V	0.671	0.63
67_Q	70_V	0.671	0.63
200_T	203_K	0.663	0.62
77_F	161_L	0.660	0.61
112_I	134_Y	0.659	0.61
76_F	137_G	0.650	0.60
146_T	153_D	0.650	0.60
93_K	223_D	0.649	0.60
42_Y	205_I	0.649	0.60
200_T	204_T	0.646	0.60
46_Y	115_A	0.644	0.59
51_V	60_L	0.642	0.59
139_R	221_W	0.641	0.59
38_S	159_F	0.640	0.59
217_R	222_S	0.637	0.59
51_V	149_L	0.636	0.59
74_G	130_L	0.635	0.58
7_T	10_N	0.633	0.58
216_K	219_E	0.628	0.58
115_A	221_W	0.627	0.57
57_K	75_H	0.625	0.57
40_S	140_N	0.623	0.57
111_L	158_L	0.622	0.57
110_S	156_L	0.620	0.57
178_K	182_Y	0.619	0.56
209_Y	224_Q	0.618	0.56
142_L	157_P	0.618	0.56
6_E	32_K	0.618	0.56
57_K	73_N	0.617	0.56
173_K	209_Y	0.616	0.56
205_I	209_Y	0.614	0.56
229_M	233_P	0.614	0.56
11_H	38_S	0.611	0.56
210_R	227_N	0.610	0.55
50_G	77_F	0.609	0.55
150_Q	179_Q	0.606	0.55
223_D	227_N	0.600	0.54
153_D	245_G	0.597	0.54
108_M	237_L	0.596	0.54
19_D	72_K	0.596	0.54
170_S	173_K	0.595	0.54
183_H	188_N	0.591	0.53
48_I	121_M	0.591	0.53
130_L	163_V	0.590	0.53
206_S	218_E	0.589	0.53
120_N	123_I	0.589	0.53
69_Y	133_C	0.587	0.53
64_A	70_V	0.585	0.52
88_Q	189_V	0.585	0.52
70_V	85_R	0.584	0.52
12_R	169_L	0.581	0.52
51_V	78_V	0.581	0.52
115_A	119_Q	0.576	0.51
40_S	136_G	0.576	0.51
94_G	97_I	0.573	0.51
33_S	124_A	0.573	0.51
50_G	57_K	0.570	0.50
235_T	239_D	0.570	0.50
197_T	200_T	0.570	0.50
86_H	142_L	0.564	0.50
30_L	163_V	0.564	0.50
212_R	215_G	0.562	0.50
73_N	76_F	0.562	0.50
215_G	218_E	0.561	0.49
171_G	211_E	0.561	0.49
31_V	37_A	0.560	0.49
144_K	148_V	0.560	0.49
40_S	109_V	0.559	0.49
34_A	120_N	0.558	0.49
211_E	243_E	0.558	0.49
116_L	119_Q	0.557	0.49
26_E	29_T	0.556	0.49
13_S	135_I	0.556	0.49
27_I	182_Y	0.556	0.49
42_Y	201_Y	0.555	0.49
225_I	229_M	0.552	0.48
54_P	203_K	0.551	0.48
40_S	160_G	0.551	0.48
22_L	29_T	0.550	0.48
10_N	172_K	0.550	0.48
64_A	67_Q	0.550	0.48
32_K	172_K	0.550	0.48
84_Y	188_N	0.549	0.48
46_Y	114_A	0.549	0.48
60_L	138_I	0.549	0.48
22_L	128_M	0.546	0.48
63_L	145_V	0.546	0.48
63_L	137_G	0.542	0.47
150_Q	153_D	0.541	0.47
89_L	92_E	0.541	0.47
57_K	60_L	0.540	0.47
74_G	165_H	0.535	0.46
10_N	169_L	0.534	0.46
150_Q	189_V	0.534	0.46
5_I	9_L	0.534	0.46
142_L	229_M	0.532	0.46
92_E	202_D	0.531	0.46
236_Y	243_E	0.531	0.46
93_K	203_K	0.530	0.46
38_S	126_E	0.530	0.46
81_A	155_V	0.528	0.45
47_S	85_R	0.527	0.45
101_L	111_L	0.527	0.45
207_D	218_E	0.526	0.45
191_T	200_T	0.526	0.45
6_E	81_A	0.524	0.45
204_T	227_N	0.523	0.45
111_L	115_A	0.523	0.45
87_Q	98_S	0.522	0.45
61_S	66_N	0.521	0.44
11_H	123_I	0.520	0.44
4_T	8_I	0.520	0.44
4_T	9_L	0.520	0.44
84_Y	154_H	0.520	0.44
41_S	134_Y	0.520	0.44
43_V	228_F	0.518	0.44
40_S	69_Y	0.518	0.44
221_W	229_M	0.515	0.44
147_E	242_K	0.515	0.44
38_S	173_K	0.513	0.44
225_I	231_Q	0.512	0.43
43_V	229_M	0.510	0.43
36_A	173_K	0.510	0.43
93_K	176_L	0.510	0.43
40_S	173_K	0.509	0.43
82_D	187_Y	0.508	0.43
79_F	118_A	0.508	0.43
218_E	223_D	0.505	0.43
209_Y	212_R	0.504	0.42
77_F	182_Y	0.503	0.42
204_T	207_D	0.503	0.42
8_I	38_S	0.502	0.42
85_R	151_T	0.502	0.42
130_L	166_P	0.501	0.42
99_E	117_A	0.501	0.42
16_S	169_L	0.501	0.42
15_R	136_G	0.500	0.42
199_N	203_K	0.500	0.42
180_A	187_Y	0.500	0.42

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3n2sA	2	0.996	100	0.222	Contact Map
1zchA	2	0.9839	100	0.227	Contact Map
1f5vA	2	0.9639	100	0.239	Contact Map
1bkjA	2	0.9237	100	0.239	Contact Map
3eofA	2	0.9398	100	0.309	Contact Map
3gagA	4	0.739	100	0.466	Contact Map
3bemA	2	0.7349	100	0.467	Contact Map
1noxA	2	0.7349	100	0.47	Contact Map
3gbhA	3	0.7349	100	0.472	Contact Map
3ge6A	2	0.7349	100	0.473	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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