GREMLIN Database
YWCB - Uncharacterized protein YwcB
UniProt: P39600 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 102 (94)
Sequences: 682 (411)
Seq/√Len: 42.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_S92_A3.1581.00
54_A63_L3.0781.00
20_K24_A3.0371.00
14_S96_D2.5991.00
74_I78_V2.5761.00
63_L67_A2.4241.00
23_R27_V2.2801.00
70_A74_I2.1420.99
22_K26_I2.0740.99
9_I97_L2.0290.99
17_A89_Y2.0180.99
89_Y92_A1.9740.99
91_S95_E1.9680.99
54_A60_W1.9530.99
32_F71_M1.9010.99
74_I77_T1.8780.99
82_R86_F1.8290.98
36_F68_Q1.5460.95
76_S80_S1.5420.95
31_I35_V1.4890.94
35_V39_S1.4270.93
58_V63_L1.3930.92
5_D46_Y1.3770.91
43_L64_F1.3560.91
36_F67_A1.3460.90
44_T61_A1.3410.90
45_S71_M1.3380.90
49_F60_W1.3340.90
55_I58_V1.3330.90
53_P59_S1.3310.90
92_A96_D1.3060.89
73_W90_V1.2750.88
61_A76_S1.2670.88
5_D8_Q1.2600.87
9_I96_D1.2480.87
17_A21_Q1.1850.84
39_S90_V1.1850.84
80_S93_L1.1060.79
22_K82_R1.1040.79
13_P17_A1.0930.79
33_F75_L1.0860.78
8_Q13_P1.0290.74
30_A33_F1.0270.74
68_Q72_T1.0220.74
40_L60_W1.0000.72
40_L76_S0.9980.72
9_I13_P0.9880.71
54_A58_V0.9860.71
36_F40_L0.9830.71
29_S34_F0.9810.71
10_A16_Q0.9660.69
19_L65_A0.9590.69
21_Q24_A0.9290.66
26_I82_R0.9260.66
67_A71_M0.8980.64
47_F50_L0.8980.64
32_F74_I0.8930.63
26_I87_D0.8890.63
43_L47_F0.8820.62
42_V46_Y0.8690.61
22_K45_S0.8620.60
36_F72_T0.8600.60
44_T80_S0.8600.60
31_I34_F0.8590.60
33_F87_D0.8560.60
12_T28_P0.8440.59
85_H88_K0.8410.59
33_F50_L0.8320.58
39_S64_F0.8240.57
27_V31_I0.8100.56
53_P57_A0.8100.56
7_K11_A0.8090.56
5_D97_L0.8090.56
13_P92_A0.8000.55
50_L62_W0.7950.54
29_S78_V0.7900.54
17_A55_I0.7830.53
22_K38_F0.7810.53
35_V38_F0.7810.53
33_F37_Y0.7430.49
21_Q89_Y0.7360.49
61_A80_S0.7160.47
29_S56_G0.7120.46
12_T23_R0.7100.46
29_S75_L0.7030.46
77_T80_S0.6970.45
26_I61_A0.6930.45
67_A70_A0.6910.44
61_A68_Q0.6870.44
60_W64_F0.6810.44
34_F80_S0.6750.43
6_Y95_E0.6650.42
11_A38_F0.6640.42
78_V81_R0.6600.42
18_F89_Y0.6560.41
24_A95_E0.6490.41
28_P31_I0.6480.41
28_P76_S0.6470.40
62_W76_S0.6470.40
19_L23_R0.6360.39
81_R84_A0.6240.38
26_I37_Y0.6160.38
72_T75_L0.6120.37
45_S76_S0.6110.37
18_F88_K0.6050.37
21_Q94_K0.6040.37
61_A84_A0.6040.37
35_V96_D0.6010.36
84_A96_D0.6000.36
82_R85_H0.5900.35
91_S94_K0.5880.35
49_F63_L0.5850.35
53_P90_V0.5800.35
52_A59_S0.5690.34
24_A78_V0.5660.33
81_R85_H0.5630.33
44_T76_S0.5620.33
87_D91_S0.5620.33
12_T93_L0.5610.33
30_A55_I0.5590.33
40_L68_Q0.5580.33
6_Y9_I0.5510.32
5_D55_I0.5450.32
38_F42_V0.5430.31
72_T76_S0.5410.31
7_K46_Y0.5370.31
57_A90_V0.5320.31
14_S88_K0.5290.30
19_L59_S0.5270.30
32_F36_F0.5270.30
33_F90_V0.5230.30
35_V92_A0.5210.30
20_K96_D0.5170.29
77_T81_R0.5160.29
65_A88_K0.5120.29
77_T85_H0.5080.29
25_F78_V0.5080.29
12_T81_R0.5070.29
48_T55_I0.5060.28
55_I93_L0.5020.28
19_L27_V0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4x9eA 4 0.7647 39.1 0.919 Contact Map
2pgsA 4 0.6667 35.6 0.92 Contact Map
3bg2A 4 0.7255 28.4 0.924 Contact Map
4hkrA 3 0.8627 11.9 0.936 Contact Map
3wvfA 1 0.951 8.5 0.94 Contact Map
3rlfF 1 0.7451 8.5 0.94 Contact Map
3d31C 2 0.7745 7.3 0.942 Contact Map
4jrbA 1 0.3922 6.6 0.943 Contact Map
4eogA 2 0.6373 5.9 0.945 Contact Map
4m32A 6 0.4902 5.5 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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