GREMLIN Database
YWCA - Uncharacterized symporter YwcA
UniProt: P39599 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 513 (463)
Sequences: 11642 (7359)
Seq/√Len: 342.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
433_T479_G5.9071.00
363_T366_E4.2661.00
260_D263_T3.8801.00
422_F480_A3.8171.00
358_R366_E3.6431.00
18_I22_F3.5081.00
194_I198_S3.4071.00
163_T379_S3.2921.00
433_T475_L3.2671.00
429_W483_G3.2471.00
481_W485_V3.2351.00
353_Y362_A3.0831.00
479_G483_G3.0671.00
196_V288_G3.0591.00
206_T209_E3.0461.00
423_N487_S2.9351.00
437_S475_L2.9341.00
430_G480_A2.9151.00
369_K373_W2.8581.00
483_G487_S2.7971.00
365_K369_K2.7781.00
150_D153_A2.7741.00
425_S487_S2.7601.00
108_A117_R2.7531.00
415_F480_A2.6681.00
159_G383_I2.5531.00
426_G484_T2.5331.00
373_W377_A2.3821.00
259_K263_T2.3291.00
171_M257_T2.3191.00
289_A308_A2.2791.00
97_N261_A2.2781.00
31_S38_G2.2751.00
40_L175_S2.2311.00
11_A15_L2.1681.00
206_T210_Q2.1291.00
362_A366_E2.1071.00
419_W422_F2.0821.00
423_N426_G2.0791.00
429_W479_G2.0661.00
425_S429_W2.0331.00
209_E213_T2.0171.00
64_G306_N2.0161.00
106_M416_T2.0111.00
358_R361_E1.9941.00
354_S367_Q1.9701.00
32_E37_G1.9581.00
380_V384_L1.9541.00
156_L160_V1.9311.00
412_L427_A1.9301.00
436_I440_V1.9271.00
263_T266_T1.9171.00
188_G328_I1.9001.00
350_H354_S1.8991.00
190_L194_I1.8971.00
14_G18_I1.8791.00
262_K266_T1.8611.00
111_F422_F1.8511.00
56_A138_G1.8441.00
311_L315_A1.8271.00
421_R485_V1.8111.00
100_K109_A1.8051.00
293_V315_A1.8021.00
423_N484_T1.7981.00
426_G483_G1.7931.00
415_F477_F1.7921.00
353_Y370_A1.7851.00
112_K115_K1.7791.00
35_T38_G1.7671.00
12_I16_T1.7631.00
44_Q179_I1.7541.00
369_K372_R1.7351.00
262_K265_R1.7331.00
209_E212_K1.7321.00
478_L482_L1.7311.00
162_M337_V1.7281.00
366_E369_K1.7261.00
419_W485_V1.7131.00
205_N209_E1.7091.00
19_I180_I1.7071.00
210_Q213_T1.6981.00
218_G221_F1.6801.00
220_D223_N1.6671.00
426_G430_G1.6631.00
358_R362_A1.6511.00
169_G173_A1.6381.00
348_F352_I1.6341.00
42_G263_T1.6311.00
152_T387_I1.6171.00
429_W433_T1.6131.00
323_A327_A1.6031.00
474_P478_L1.5961.00
221_F224_P1.5751.00
6_F10_L1.5721.00
353_Y366_E1.5641.00
419_W481_W1.5601.00
348_F374_A1.5491.00
115_K428_L1.5471.00
341_V379_S1.5391.00
353_Y358_R1.5271.00
47_L179_I1.5171.00
433_T437_S1.5061.00
421_R488_S1.5031.00
160_V164_I1.5021.00
141_A304_A1.4851.00
219_A224_P1.4811.00
344_A378_V1.4311.00
112_K424_A1.4151.00
140_G155_V1.4001.00
105_D351_D1.3821.00
215_T218_G1.3741.00
105_D350_H1.3731.00
219_A222_L1.3701.00
10_L14_G1.3631.00
216_P219_A1.3561.00
45_N258_V1.3471.00
359_K362_A1.3461.00
123_N435_L1.3411.00
368_M372_R1.3371.00
155_V383_I1.3331.00
153_A157_I1.3281.00
475_L479_G1.3271.00
108_A113_E1.3161.00
29_T32_E1.3151.00
218_G222_L1.3031.00
162_M334_L1.3021.00
91_V414_V1.3001.00
153_A156_L1.2971.00
159_G379_S1.2921.00
5_A320_F1.2921.00
348_F353_Y1.2901.00
362_A367_Q1.2661.00
34_Y371_A1.2651.00
7_L11_A1.2611.00
366_E370_A1.2601.00
15_L19_I1.2571.00
421_R489_D1.2551.00
216_P220_D1.2531.00
357_I362_A1.2491.00
178_Q254_R1.2381.00
203_S206_T1.2221.00
200_F207_M1.2191.00
46_G270_S1.2171.00
152_T156_L1.2161.00
16_T180_I1.2071.00
122_L126_A1.2071.00
397_L401_A1.2041.00
238_N241_L1.2021.00
110_R416_T1.1941.00
149_L154_A1.1921.00
144_K151_Y1.1861.00
119_V428_L1.1841.00
311_L314_K1.1771.00
199_K292_F1.1731.00
156_L383_I1.1711.00
106_M110_R1.1671.00
424_A428_L1.1651.00
219_A223_N1.1631.00
156_L387_I1.1591.00
177_V338_T1.1571.00
437_S479_G1.1571.00
102_T346_S1.1571.00
374_A377_A1.1561.00
118_G356_I1.1561.00
304_A307_M1.1531.00
422_F484_T1.1521.00
302_D305_G1.1441.00
237_L240_A1.1421.00
195_I199_K1.1411.00
136_L159_G1.1361.00
210_Q291_A1.1351.00
349_A370_A1.1341.00
220_D224_P1.1341.00
370_A374_A1.1271.00
423_N488_S1.1271.00
412_L431_S1.1261.00
349_A371_A1.1241.00
139_A158_V1.1231.00
116_I428_L1.1191.00
117_R351_D1.1161.00
425_S486_L1.1161.00
425_S483_G1.1151.00
132_M382_S1.1141.00
310_P313_A1.1131.00
36_A40_L1.1111.00
423_N483_G1.1081.00
474_P477_F1.1061.00
52_D339_G1.1031.00
183_V187_A1.1011.00
66_I73_G1.0991.00
120_A431_S1.0951.00
17_L20_T1.0931.00
440_V444_M1.0901.00
187_A191_V1.0851.00
208_F212_K1.0811.00
477_F481_W1.0791.00
15_L18_I1.0731.00
122_L352_I1.0731.00
399_A403_A1.0711.00
36_A171_M1.0651.00
384_L388_F1.0601.00
48_A339_G1.0601.00
204_L208_F1.0551.00
234_T241_L1.0541.00
108_A355_Q1.0521.00
15_L180_I1.0441.00
353_Y357_I1.0431.00
74_F78_I1.0431.00
18_I21_Y1.0421.00
398_V402_F1.0421.00
232_L236_S1.0411.00
364_E367_Q1.0381.00
42_G46_G1.0351.00
165_Y338_T1.0351.00
205_N208_F1.0261.00
234_T238_N1.0261.00
479_G482_L1.0231.00
234_T237_L1.0231.00
50_A274_I1.0221.00
17_L21_Y1.0191.00
471_I474_P1.0181.00
191_V195_I1.0151.00
216_P221_F1.0081.00
231_P236_S1.0071.00
178_Q338_T1.0041.00
191_V321_L1.0021.00
207_M211_M0.9961.00
86_V90_I0.9951.00
31_S99_G0.9951.00
233_E237_L0.9931.00
415_F422_F0.9931.00
13_V16_T0.9911.00
224_P227_K0.9791.00
27_T32_E0.9751.00
430_G476_G0.9751.00
313_A325_V0.9741.00
68_L305_G0.9651.00
149_L157_I0.9641.00
92_A95_L0.9641.00
167_V376_V0.9611.00
7_L10_L0.9601.00
430_G434_G0.9561.00
399_A402_F0.9551.00
136_L155_V0.9541.00
133_I385_L0.9531.00
198_S204_L0.9531.00
162_M338_T0.9521.00
236_S239_L0.9491.00
94_P97_N0.9481.00
353_Y359_K0.9481.00
65_M69_Y0.9471.00
469_G473_I0.9461.00
165_Y334_L0.9461.00
408_A476_G0.9461.00
288_G292_F0.9441.00
237_L241_L0.9441.00
181_K338_T0.9391.00
222_L226_N0.9381.00
400_L442_V0.9381.00
12_I334_L0.9371.00
345_A349_A0.9361.00
119_V431_S0.9351.00
348_F378_V0.9261.00
116_I427_A0.9241.00
258_V264_A0.9211.00
377_A381_L0.9201.00
362_A370_A0.9201.00
9_F13_V0.9191.00
48_A51_G0.9171.00
228_Y231_P0.9161.00
123_N431_S0.9151.00
447_S450_D0.9131.00
42_G266_T0.9111.00
416_T427_A0.9081.00
475_L478_L0.9071.00
22_F26_R0.9061.00
178_Q339_G0.9061.00
371_A375_S0.9011.00
422_F426_G0.8971.00
41_T263_T0.8941.00
434_G438_A0.8931.00
217_L220_D0.8931.00
125_I348_F0.8911.00
193_S281_M0.8901.00
412_L476_G0.8861.00
207_M288_G0.8841.00
48_A175_S0.8841.00
482_L485_V0.8831.00
415_F481_W0.8811.00
411_P477_F0.8811.00
9_F330_F0.8791.00
144_K148_G0.8781.00
210_Q214_A0.8781.00
107_I116_I0.8731.00
56_A333_I0.8711.00
207_M210_Q0.8711.00
16_T20_T0.8711.00
421_R490_K0.8691.00
313_A322_F0.8681.00
221_F225_G0.8661.00
478_L481_W0.8631.00
353_Y356_I0.8631.00
81_L276_G0.8631.00
289_A312_L0.8591.00
34_Y346_S0.8591.00
93_E265_R0.8561.00
111_F416_T0.8531.00
177_V181_K0.8521.00
440_V443_S0.8501.00
107_I120_A0.8491.00
342_L345_A0.8481.00
380_V383_I0.8461.00
52_D178_Q0.8451.00
115_K424_A0.8421.00
44_Q175_S0.8361.00
24_A168_F0.8361.00
285_L312_L0.8301.00
104_A120_A0.8191.00
307_M311_L0.8161.00
225_G228_Y0.8151.00
151_Y155_V0.8151.00
8_L320_F0.8151.00
432_L436_I0.8131.00
20_T24_A0.8131.00
155_V386_A0.8131.00
269_V273_W0.8131.00
428_L432_L0.8111.00
47_L182_A0.8051.00
468_P472_S0.8041.00
477_F480_A0.8021.00
176_W179_I0.8001.00
335_A338_T0.7991.00
174_T177_V0.7981.00
191_V194_I0.7981.00
111_F480_A0.7961.00
192_I309_A0.7941.00
12_I331_A0.7931.00
22_F25_K0.7911.00
223_N228_Y0.7911.00
36_A257_T0.7891.00
231_P237_L0.7881.00
192_I196_V0.7871.00
30_T34_Y0.7861.00
476_G480_A0.7851.00
27_T368_M0.7841.00
423_N489_D0.7841.00
51_G254_R0.7841.00
419_W423_N0.7821.00
81_L272_T0.7821.00
112_K491_T0.7811.00
207_M291_A0.7811.00
92_A264_A0.7791.00
79_G83_A0.7781.00
195_I198_S0.7741.00
42_G270_S0.7731.00
398_V401_A0.7701.00
141_A144_K0.7681.00
223_N227_K0.7681.00
48_A254_R0.7661.00
140_G151_Y0.7651.00
110_R419_W0.7631.00
48_A52_D0.7621.00
349_A367_Q0.7611.00
181_K331_A0.7611.00
354_S359_K0.7591.00
165_Y335_A0.7581.00
197_F203_S0.7561.00
66_I287_F0.7551.00
17_L164_I0.7541.00
317_G321_L0.7521.00
20_T23_A0.7521.00
165_Y181_K0.7501.00
118_G122_L0.7491.00
435_L439_L0.7451.00
483_G486_L0.7451.00
437_S441_L0.7441.00
55_S131_Y0.7441.00
71_F287_F0.7441.00
373_W376_V0.7441.00
21_Y168_F0.7441.00
113_E424_A0.7431.00
85_L89_Y0.7421.00
5_A322_F0.7410.99
40_L45_N0.7400.99
419_W484_T0.7390.99
487_S490_K0.7380.99
235_L241_L0.7370.99
444_M448_V0.7320.99
200_F203_S0.7310.99
105_D109_A0.7290.99
25_K28_K0.7290.99
196_V199_K0.7270.99
214_A290_A0.7260.99
472_S476_G0.7260.99
295_F302_D0.7250.99
425_S488_S0.7230.99
186_M190_L0.7210.99
434_G476_G0.7190.99
488_S491_T0.7190.99
89_Y269_V0.7190.99
67_A295_F0.7180.99
165_Y173_A0.7180.99
199_K316_L0.7180.99
139_A333_I0.7170.99
181_K334_L0.7160.99
125_I344_A0.7160.99
312_L316_L0.7160.99
197_F284_F0.7150.99
437_S440_V0.7150.99
131_Y249_P0.7140.99
217_L221_F0.7140.99
221_F226_N0.7120.99
189_T282_T0.7080.99
21_Y24_A0.7070.99
486_L489_D0.7060.99
375_S379_S0.7060.99
174_T339_G0.7060.99
348_F370_A0.7030.99
422_F427_A0.7030.99
470_I474_P0.7010.99
201_G206_T0.6990.99
429_W432_L0.6980.99
135_Q336_V0.6960.99
67_A302_D0.6960.99
302_D311_L0.6960.99
5_A8_L0.6950.99
273_W277_V0.6950.99
22_F176_W0.6920.99
320_F324_F0.6900.99
307_M310_P0.6900.99
434_G437_S0.6900.99
171_M175_S0.6890.99
217_L222_L0.6870.99
441_L471_I0.6860.99
258_V263_T0.6860.99
419_W426_G0.6830.99
415_F419_W0.6830.99
200_F291_A0.6820.99
84_Y87_V0.6810.99
200_F206_T0.6810.99
482_L486_L0.6790.99
76_Y79_G0.6780.99
384_L387_I0.6780.99
445_S449_W0.6770.99
76_Y80_F0.6770.99
231_P234_T0.6760.99
489_D492_I0.6760.99
96_R261_A0.6750.99
102_T351_D0.6730.99
431_S434_G0.6710.99
8_L323_A0.6680.99
77_S84_Y0.6680.99
93_E97_N0.6670.99
43_V47_L0.6660.99
345_A375_S0.6650.99
16_T23_A0.6650.99
221_F228_Y0.6650.99
383_I387_I0.6640.99
220_D225_G0.6640.99
58_S279_Y0.6620.99
181_K336_V0.6610.99
101_Y105_D0.6610.99
137_V141_A0.6600.99
197_F204_L0.6590.99
426_G429_W0.6590.99
135_Q337_V0.6590.99
272_T276_G0.6580.99
41_T44_Q0.6570.99
154_A158_V0.6570.99
446_P449_W0.6560.99
59_F189_T0.6540.99
290_A294_G0.6540.99
433_T483_G0.6530.99
336_V340_L0.6520.99
340_L343_S0.6520.99
423_N427_A0.6500.99
295_F303_Q0.6490.99
398_V403_A0.6490.99
383_I386_A0.6490.99
393_N396_F0.6480.99
166_V338_T0.6480.99
51_G181_K0.6470.99
163_T376_V0.6460.99
421_R424_A0.6460.99
243_L410_L0.6450.99
59_F325_V0.6440.99
119_V432_L0.6440.99
181_K335_A0.6420.99
141_A145_L0.6420.99
356_I359_K0.6410.99
231_P235_L0.6410.99
67_A308_A0.6410.99
141_A306_N0.6400.99
473_I476_G0.6400.99
357_I361_E0.6390.99
235_L238_N0.6370.98
91_V95_L0.6360.98
163_T167_V0.6360.98
33_F372_R0.6350.98
266_T270_S0.6350.98
30_T33_F0.6320.98
83_A87_V0.6310.98
425_S428_L0.6300.98
201_G204_L0.6290.98
345_A371_A0.6290.98
427_A430_G0.6280.98
43_V179_I0.6270.98
83_A86_V0.6260.98
64_G305_G0.6260.98
241_L245_T0.6250.98
111_F415_F0.6220.98
277_V281_M0.6210.98
395_A399_A0.6210.98
55_S59_F0.6200.98
44_Q176_W0.6200.98
294_G302_D0.6190.98
481_W484_T0.6180.98
234_T239_L0.6170.98
367_Q371_A0.6170.98
236_S240_A0.6160.98
422_F430_G0.6160.98
236_S470_I0.6160.98
222_L225_G0.6160.98
104_A124_T0.6160.98
407_S411_P0.6150.98
208_F211_M0.6140.98
16_T21_Y0.6130.98
90_I93_E0.6120.98
32_E172_I0.6120.98
45_N48_A0.6100.98
354_S364_E0.6090.98
83_A242_V0.6080.98
285_L309_A0.6070.98
283_V287_F0.6060.98
334_L338_T0.6030.98
232_L239_L0.6010.98
442_V447_S0.6010.98
11_A18_I0.6000.98
345_A374_A0.5990.98
40_L257_T0.5980.98
79_G88_L0.5960.98
112_K116_I0.5960.98
172_I176_W0.5960.98
90_I94_P0.5950.98
132_M337_V0.5930.98
131_Y340_L0.5930.98
143_I147_L0.5920.98
211_M287_F0.5910.98
124_T347_A0.5910.98
318_G321_L0.5900.98
33_F375_S0.5900.98
293_V311_L0.5890.97
199_K204_L0.5890.97
144_K150_D0.5870.97
302_D307_M0.5860.97
189_T281_M0.5850.97
244_G249_P0.5850.97
136_L173_A0.5840.97
485_V488_S0.5840.97
107_I412_L0.5840.97
410_L414_V0.5820.97
430_G433_T0.5810.97
143_I154_A0.5810.97
250_H253_I0.5810.97
255_F268_V0.5790.97
427_A434_G0.5780.97
13_V17_L0.5780.97
93_E261_A0.5780.97
245_T249_P0.5770.97
190_L193_S0.5770.97
187_A190_L0.5770.97
50_A278_F0.5760.97
118_G121_A0.5760.97
65_M73_G0.5750.97
156_L380_V0.5740.97
156_L159_G0.5730.97
193_S284_F0.5730.97
349_A353_Y0.5730.97
53_Y402_F0.5730.97
116_I424_A0.5720.97
134_A401_A0.5710.97
376_V380_V0.5710.97
305_G308_A0.5690.97
48_A178_Q0.5690.97
290_A308_A0.5690.97
421_R484_T0.5680.97
23_A27_T0.5680.97
31_S364_E0.5680.97
88_L92_A0.5670.97
26_R172_I0.5660.97
23_A176_W0.5660.97
421_R425_S0.5660.97
129_T381_L0.5650.97
381_L384_L0.5630.97
59_F64_G0.5620.97
319_D322_F0.5610.97
13_V20_T0.5600.97
321_L324_F0.5600.97
437_S472_S0.5600.97
439_L443_S0.5590.97
466_S470_I0.5580.97
118_G352_I0.5570.96
12_I20_T0.5570.96
12_I181_K0.5560.96
127_I404_V0.5560.96
292_F312_L0.5560.96
51_G182_A0.5550.96
211_M214_A0.5540.96
111_F427_A0.5540.96
153_A160_V0.5540.96
215_T221_F0.5540.96
266_T269_V0.5540.96
372_R375_S0.5530.96
103_M413_I0.5530.96
46_G50_A0.5530.96
212_K216_P0.5530.96
81_L85_L0.5510.96
261_A265_R0.5490.96
30_T364_E0.5480.96
174_T254_R0.5480.96
350_H367_Q0.5470.96
387_I390_Q0.5460.96
145_L307_M0.5460.96
84_Y88_L0.5450.96
16_T24_A0.5440.96
92_A261_A0.5430.96
175_S178_Q0.5430.96
117_R355_Q0.5430.96
134_A398_V0.5430.96
167_V369_K0.5430.96
81_L84_Y0.5410.96
53_Y80_F0.5410.96
65_M68_L0.5390.96
132_M378_V0.5390.96
192_I325_V0.5380.96
206_T291_A0.5380.96
204_L207_M0.5380.96
233_E236_S0.5370.96
101_Y350_H0.5360.96
197_F201_G0.5350.96
394_V397_L0.5350.96
140_G154_A0.5340.96
314_K322_F0.5340.96
21_Y25_K0.5340.96
259_K262_K0.5340.96
159_G386_A0.5340.96
129_T385_L0.5330.96
349_A374_A0.5330.96
197_F207_M0.5310.95
50_A182_A0.5290.95
130_F401_A0.5290.95
62_I66_I0.5290.95
184_L327_A0.5280.95
75_F79_G0.5280.95
246_A249_P0.5280.95
246_A250_H0.5270.95
19_I23_A0.5260.95
5_A323_A0.5260.95
113_E355_Q0.5260.95
222_L227_K0.5250.95
292_F316_L0.5250.95
155_V158_V0.5240.95
429_W482_L0.5230.95
467_N471_I0.5230.95
315_A319_D0.5220.95
317_G325_V0.5200.95
340_L409_N0.5200.95
57_A402_F0.5200.95
137_V151_Y0.5190.95
232_L237_L0.5190.95
178_Q335_A0.5180.95
113_E117_R0.5160.95
136_L382_S0.5160.95
279_Y282_T0.5160.95
191_V324_F0.5150.95
223_N226_N0.5140.95
476_G479_G0.5130.95
61_G131_Y0.5130.95
361_E366_E0.5120.94
26_R39_G0.5120.94
174_T342_L0.5110.94
254_R339_G0.5100.94
23_A26_R0.5100.94
30_T367_Q0.5090.94
8_L327_A0.5070.94
115_K119_V0.5070.94
41_T45_N0.5050.94
51_G177_V0.5030.94
89_Y93_E0.5020.94
127_I405_A0.5020.94
150_D154_A0.5020.94
145_L310_P0.5010.94
94_P417_V0.5010.94
50_A54_M0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xq2A 2 0.9162 100 0.236 Contact Map
3dh4A 3 0.8752 100 0.277 Contact Map
3l1lA 2 0.7934 99.4 0.852 Contact Map
3giaA 1 0.8246 99.3 0.858 Contact Map
4djkA 2 0.8031 99 0.875 Contact Map
4wgvA 2 0.7135 98.7 0.889 Contact Map
2jlnA 1 0.7992 98.7 0.89 Contact Map
4c7rA 3 0.8402 97.7 0.916 Contact Map
2wswA 3 0.768 96.2 0.932 Contact Map
2a65A 2 0.8226 94.5 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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