GREMLIN Database
EFEN - Probable deferrochelatase/peroxidase EfeN
UniProt: P39597 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 416 (379)
Sequences: 1520 (1009)
Seq/√Len: 51.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
407_E411_Q6.3181.00
337_I375_M5.4351.00
88_D91_D4.7421.00
83_D216_R4.7171.00
325_S328_S4.1741.00
310_K314_D3.7371.00
141_F409_I3.5821.00
82_L206_L3.5781.00
67_A107_T3.5731.00
209_A213_C3.4851.00
62_Y104_Q3.4501.00
143_F400_P3.3071.00
300_R303_S2.8461.00
271_T364_F2.7051.00
273_M362_I2.6981.00
59_V67_A2.6031.00
80_A215_V2.5081.00
92_I147_F2.4841.00
84_V147_F2.4821.00
167_A369_D2.3871.00
84_V92_I2.3651.00
143_F410_A2.3421.00
236_F280_M2.3171.00
281_F284_V2.2911.00
311_K314_D2.2291.00
27_V30_G2.2041.00
65_H269_G2.1821.00
267_M398_A2.1681.00
184_G397_Y2.1571.00
136_N193_D2.1571.00
155_R158_L2.1121.00
407_E412_R2.1011.00
316_V327_V2.0871.00
59_V136_N2.0831.00
96_F414_L2.0781.00
277_K392_I2.0621.00
308_G314_D2.0551.00
77_V360_L2.0381.00
191_C342_F2.0101.00
281_F390_Q1.9951.00
376_L379_L1.9711.00
31_A35_G1.9581.00
192_A198_A1.9501.00
64_K269_G1.9110.99
84_V156_F1.9080.99
17_L25_A1.8740.99
100_T409_I1.8580.99
295_D322_P1.8210.99
337_I363_S1.7940.99
125_D200_H1.7880.99
259_I267_M1.7850.99
400_P409_I1.7750.99
307_F321_I1.7650.99
69_I399_C1.7640.99
69_I271_T1.7550.99
265_D268_T1.7510.99
29_I32_S1.7490.99
275_F360_L1.7430.99
33_G36_G1.7390.99
79_F362_I1.7390.99
165_H367_N1.7340.99
81_A184_G1.7220.99
288_S292_D1.6440.98
24_G32_S1.6290.98
89_K93_I1.6270.98
82_L188_I1.6190.98
373_I396_L1.6070.98
35_G38_A1.5990.98
169_L172_M1.5990.98
275_F362_I1.5740.98
28_A33_G1.5690.98
403_C409_I1.5660.98
34_L38_A1.5570.98
190_V198_A1.5470.97
314_D318_L1.5460.97
172_M376_L1.5370.97
27_V34_L1.5240.97
28_A31_A1.5220.97
20_G23_A1.5070.97
273_M364_F1.5060.97
25_A36_G1.5060.97
33_G37_L1.4930.97
187_C273_M1.4860.97
32_S36_G1.4580.96
29_I33_G1.4380.96
303_S311_K1.4270.96
408_Y411_Q1.4180.96
100_T403_C1.4180.96
176_N390_Q1.4100.96
190_V202_L1.4070.96
219_N277_K1.4030.95
235_L280_M1.3980.95
274_A363_S1.3950.95
74_Q342_F1.3710.95
103_T141_F1.3600.95
93_I414_L1.3480.94
322_P384_A1.3270.94
101_S104_Q1.3270.94
143_F409_I1.3160.94
53_K56_E1.3110.93
34_L37_L1.3090.93
330_A379_L1.3090.93
104_Q406_G1.3090.93
96_F143_F1.3050.93
178_D181_Q1.2980.93
32_S35_G1.2960.93
48_S52_E1.2860.93
26_A29_I1.2820.93
368_P396_L1.2800.93
15_D18_K1.2760.93
181_Q277_K1.2730.92
367_N370_N1.2720.92
297_F325_S1.2700.92
305_A314_D1.2590.92
365_Q371_Q1.2540.92
157_G160_S1.2510.92
20_G28_A1.2380.91
366_K371_Q1.2310.91
234_N280_M1.2280.91
277_K344_Y1.2060.90
318_L327_V1.2020.90
102_L208_Q1.2000.90
288_S296_T1.1900.90
77_V342_F1.1860.89
80_A202_L1.1810.89
11_I35_G1.1770.89
330_A375_M1.1770.89
385_L389_T1.1720.89
146_G155_R1.1700.89
71_T191_C1.1700.89
183_G397_Y1.1630.89
29_I35_G1.1630.89
89_K92_I1.1620.88
174_N391_T1.1560.88
15_D24_G1.1550.88
15_D35_G1.1440.88
219_N346_E1.1350.87
401_G412_R1.1260.87
26_A37_L1.1150.86
158_L161_K1.1140.86
297_F341_A1.1120.86
30_G34_L1.1110.86
30_G37_L1.1110.86
168_A183_G1.1100.86
145_P162_K1.1020.86
68_G74_Q1.1020.86
323_S328_S1.1020.86
75_T225_G1.1020.86
19_W25_A1.0950.85
49_K52_E1.0940.85
182_G397_Y1.0920.85
274_A368_P1.0870.85
62_Y405_K1.0850.85
93_I97_R1.0840.85
21_A29_I1.0690.84
103_T409_I1.0690.84
52_E55_E1.0580.83
77_V187_C1.0580.83
386_N389_T1.0570.83
95_L186_I1.0570.83
262_G265_D1.0510.83
346_E356_D1.0500.83
236_F325_S1.0480.83
155_R159_K1.0410.82
66_Q69_I1.0380.82
48_S58_I1.0360.82
78_Y198_A1.0310.82
95_L99_W1.0220.81
294_E301_K1.0210.81
208_Q212_T1.0150.81
74_Q191_C1.0030.80
50_K53_K1.0010.80
149_E162_K0.9980.79
24_G28_A0.9950.79
187_C364_F0.9910.79
232_P239_K0.9900.79
252_L255_S0.9880.79
98_N208_Q0.9880.79
99_W209_A0.9830.78
18_K28_A0.9790.78
93_I408_Y0.9780.78
279_K356_D0.9760.78
28_A38_A0.9750.78
148_F162_K0.9740.78
324_N384_A0.9730.78
63_G402_G0.9730.78
246_S250_D0.9730.78
337_I365_Q0.9680.77
317_K320_Q0.9660.77
406_G411_Q0.9650.77
344_Y356_D0.9650.77
181_Q392_I0.9630.77
238_F297_F0.9610.77
157_G161_K0.9580.77
162_K166_L0.9550.76
245_Q252_L0.9550.76
92_I156_F0.9540.76
401_G407_E0.9520.76
78_Y218_V0.9500.76
335_K375_M0.9480.76
71_T189_Q0.9470.76
48_S51_D0.9450.76
35_G404_K0.9450.76
96_F400_P0.9360.75
337_I371_Q0.9340.75
19_W35_G0.9280.74
53_K57_Q0.9280.74
26_A31_A0.9280.74
368_P391_T0.9240.74
33_G52_E0.9160.73
79_F187_C0.9130.73
165_H272_Y0.9110.73
266_W270_G0.9070.73
71_T74_Q0.9060.73
74_Q193_D0.9050.72
174_N380_S0.9050.72
12_H15_D0.9030.72
22_M26_A0.8990.72
15_D20_G0.8980.72
288_S386_N0.8970.72
141_F213_C0.8960.72
19_W26_A0.8950.72
294_E300_R0.8950.72
165_H369_D0.8930.71
15_D19_W0.8930.71
177_L393_G0.8900.71
369_D377_K0.8880.71
24_G31_A0.8820.70
404_K407_E0.8810.70
101_S105_M0.8790.70
89_K414_L0.8790.70
61_F103_T0.8770.70
231_T313_T0.8760.70
282_L357_A0.8750.70
15_D36_G0.8740.70
27_V31_A0.8730.70
81_A397_Y0.8720.70
32_S38_A0.8720.70
243_G316_V0.8690.69
11_I19_W0.8680.69
169_L376_L0.8670.69
227_K313_T0.8670.69
329_L379_L0.8650.69
31_A36_G0.8590.68
11_I15_D0.8540.68
12_H17_L0.8530.68
23_A27_V0.8500.68
236_F281_F0.8500.68
20_G24_G0.8480.67
149_E159_K0.8470.67
89_K100_T0.8450.67
249_D253_M0.8400.67
73_H223_L0.8400.67
271_T399_C0.8390.67
236_F327_V0.8350.66
231_T242_T0.8340.66
18_K24_G0.8320.66
123_P290_L0.8310.66
90_S93_I0.8300.66
309_Q314_D0.8300.66
20_G29_I0.8260.65
30_G36_G0.8260.65
25_A53_K0.8250.65
144_G148_F0.8230.65
371_Q375_M0.8230.65
315_P318_L0.8210.65
158_L166_L0.8170.65
28_A35_G0.8160.64
19_W23_A0.8160.64
174_N389_T0.8150.64
332_S375_M0.8130.64
104_Q108_S0.8090.64
163_P166_L0.8060.63
26_A34_L0.8050.63
31_A34_L0.8050.63
20_G35_G0.8040.63
30_G33_G0.8030.63
62_Y403_C0.8030.63
283_E353_G0.8020.63
15_D34_L0.7980.63
65_H258_W0.7960.63
30_G38_A0.7940.62
182_G393_G0.7940.62
28_A50_K0.7910.62
159_K162_K0.7910.62
365_Q389_T0.7910.62
253_M257_V0.7910.62
56_E412_R0.7890.62
177_L182_G0.7890.62
12_H52_E0.7860.62
18_K32_S0.7800.61
297_F389_T0.7800.61
322_P325_S0.7800.61
27_V33_G0.7780.61
335_K371_Q0.7770.61
341_A359_L0.7720.60
266_W398_A0.7710.60
85_T214_E0.7710.60
227_K230_E0.7710.60
64_K404_K0.7700.60
239_K283_E0.7670.60
32_S37_L0.7660.60
25_A31_A0.7640.59
37_L48_S0.7620.59
70_T373_I0.7600.59
52_E56_E0.7600.59
61_F403_C0.7540.58
127_G388_Y0.7520.58
54_E57_Q0.7510.58
35_G57_Q0.7510.58
22_M27_V0.7490.58
13_R16_I0.7460.58
238_F301_K0.7460.58
226_G248_K0.7380.57
34_L412_R0.7380.57
293_Q301_K0.7380.57
329_L381_A0.7330.56
26_A32_S0.7300.56
100_T107_T0.7300.56
394_S398_A0.7280.56
143_F147_F0.7220.55
30_G35_G0.7200.55
349_D352_T0.7200.55
68_G189_Q0.7200.55
18_K48_S0.7200.55
126_T204_N0.7190.55
301_K371_Q0.7170.55
283_E355_M0.7160.54
105_M112_M0.7140.54
17_L21_A0.7140.54
249_D315_P0.7130.54
15_D21_A0.7110.54
181_Q356_D0.7110.54
162_K370_N0.7110.54
15_D38_A0.7100.54
36_G54_E0.7090.54
33_G414_L0.7050.53
383_D386_N0.7040.53
18_K37_L0.7030.53
113_S124_Q0.7030.53
18_K22_M0.7000.53
94_T98_N0.7000.53
76_Y220_K0.7000.53
87_K91_D0.6990.53
138_T191_C0.6990.53
203_R286_D0.6980.53
57_Q136_N0.6960.52
277_K395_A0.6960.52
22_M55_E0.6960.52
234_N361_F0.6950.52
181_Q393_G0.6870.51
12_H37_L0.6850.51
27_V32_S0.6850.51
37_L53_K0.6840.51
68_G138_T0.6790.51
324_N329_L0.6760.50
215_V348_L0.6750.50
306_P309_Q0.6750.50
21_A26_A0.6740.50
161_K164_K0.6740.50
174_N382_K0.6730.50
204_N208_Q0.6720.50
337_I379_L0.6720.50
385_L391_T0.6710.50
20_G349_D0.6690.50
74_Q77_V0.6690.50
38_A48_S0.6690.50
84_V186_I0.6660.49
236_F385_L0.6660.49
365_Q386_N0.6640.49
12_H26_A0.6630.49
222_F235_L0.6620.49
236_F389_T0.6620.49
169_L383_D0.6610.49
26_A30_G0.6600.49
38_A49_K0.6600.49
384_A387_E0.6570.48
344_Y392_I0.6540.48
279_K392_I0.6530.48
25_A28_A0.6530.48
336_Q371_Q0.6520.48
38_A57_Q0.6510.48
15_D373_I0.6500.48
300_R311_K0.6480.47
106_L109_G0.6480.47
79_F360_L0.6470.47
49_K55_E0.6460.47
158_L401_G0.6450.47
22_M38_A0.6420.47
236_F279_K0.6410.47
93_I411_Q0.6410.47
98_N212_T0.6400.46
26_A33_G0.6400.46
145_P169_L0.6390.46
386_N392_I0.6390.46
13_R17_L0.6380.46
321_I327_V0.6370.46
134_P138_T0.6360.46
316_V321_I0.6330.46
155_R166_L0.6320.46
256_I337_I0.6310.46
90_S405_K0.6300.45
102_L105_M0.6290.45
347_G353_G0.6290.45
245_Q256_I0.6270.45
92_I95_L0.6270.45
389_T393_G0.6260.45
23_A52_E0.6250.45
71_T342_F0.6250.45
231_T239_K0.6240.45
139_V185_D0.6220.45
241_G361_F0.6190.44
231_T312_E0.6180.44
48_S53_K0.6180.44
131_D230_E0.6170.44
29_I38_A0.6170.44
287_R290_L0.6160.44
11_I38_A0.6140.44
296_T384_A0.6130.44
16_I26_A0.6120.44
37_L57_Q0.6090.43
105_M110_K0.6080.43
19_W30_G0.6080.43
19_W37_L0.6060.43
31_A54_E0.6060.43
389_T392_I0.6050.43
164_K263_E0.6040.43
25_A54_E0.6040.43
166_L368_P0.6010.42
181_Q275_F0.5980.42
96_F410_A0.5970.42
259_I398_A0.5970.42
67_A328_S0.5960.42
158_L162_K0.5960.42
15_D303_S0.5950.42
349_D354_Y0.5940.42
172_M175_D0.5930.42
26_A412_R0.5930.42
16_I32_S0.5930.42
22_M51_D0.5920.42
29_I51_D0.5920.42
175_D181_Q0.5910.41
145_P149_E0.5910.41
210_V236_F0.5890.41
31_A37_L0.5880.41
95_L209_A0.5880.41
17_L27_V0.5870.41
29_I36_G0.5830.41
195_E220_K0.5830.41
20_G27_V0.5820.41
36_G51_D0.5820.41
51_D55_E0.5790.40
29_I54_E0.5790.40
49_K53_K0.5780.40
289_S292_D0.5760.40
144_G147_F0.5750.40
12_H25_A0.5740.40
23_A38_A0.5740.40
275_F393_G0.5730.40
287_R388_Y0.5720.40
109_G112_M0.5710.39
31_A50_K0.5710.39
252_L336_Q0.5710.39
24_G70_T0.5700.39
224_S301_K0.5690.39
15_D27_V0.5690.39
15_D37_L0.5680.39
249_D338_L0.5680.39
97_R100_T0.5680.39
189_Q342_F0.5680.39
322_P329_L0.5680.39
18_K25_A0.5670.39
28_A36_G0.5660.39
158_L163_P0.5630.39
111_K320_Q0.5620.39
226_G246_S0.5620.39
22_M54_E0.5620.39
142_G399_C0.5610.38
11_I26_A0.5610.38
321_I325_S0.5600.38
18_K300_R0.5600.38
166_L169_L0.5590.38
68_G72_A0.5580.38
280_M341_A0.5560.38
188_I352_T0.5560.38
70_T265_D0.5560.38
194_D197_V0.5550.38
81_A183_G0.5530.38
110_K180_K0.5530.38
23_A29_I0.5510.37
38_A56_E0.5500.37
268_T370_N0.5500.37
21_A371_Q0.5490.37
200_H207_N0.5480.37
65_H270_G0.5480.37
25_A35_G0.5480.37
146_G149_E0.5470.37
14_R17_L0.5470.37
142_G170_P0.5470.37
23_A30_G0.5470.37
243_G327_V0.5460.37
76_Y195_E0.5460.37
18_K303_S0.5450.37
102_L190_V0.5440.37
234_N278_I0.5440.37
33_G58_I0.5430.37
105_M113_S0.5420.37
174_N279_K0.5410.36
238_F293_Q0.5410.36
238_F294_E0.5390.36
156_F159_K0.5380.36
247_T253_M0.5360.36
26_A50_K0.5330.36
51_D57_Q0.5330.36
297_F385_L0.5330.36
51_D303_S0.5320.36
30_G48_S0.5310.36
167_A373_I0.5310.36
31_A53_K0.5300.35
38_A261_S0.5300.35
12_H20_G0.5300.35
49_K57_Q0.5300.35
235_L282_L0.5300.35
17_L28_A0.5300.35
16_I20_G0.5290.35
22_M56_E0.5290.35
318_L325_S0.5280.35
12_H18_K0.5280.35
61_F402_G0.5280.35
282_L398_A0.5270.35
57_Q133_S0.5270.35
68_G233_R0.5270.35
29_I37_L0.5260.35
264_P267_M0.5250.35
64_K405_K0.5240.35
68_G191_C0.5230.35
35_G64_K0.5230.35
145_P395_A0.5230.35
328_S397_Y0.5220.35
165_H368_P0.5210.35
148_F157_G0.5210.35
325_S384_A0.5200.34
214_E350_P0.5200.34
408_Y412_R0.5200.34
22_M261_S0.5190.34
51_D58_I0.5190.34
109_G233_R0.5180.34
246_S253_M0.5170.34
11_I54_E0.5170.34
168_A252_L0.5150.34
230_E245_Q0.5140.34
272_Y368_P0.5130.34
27_V38_A0.5130.34
36_G53_K0.5130.34
15_D33_G0.5120.34
22_M64_K0.5120.34
391_T394_S0.5120.34
330_A376_L0.5110.34
270_G398_A0.5100.34
345_T348_L0.5080.33
34_L52_E0.5070.33
335_K378_A0.5070.33
365_Q385_L0.5050.33
157_G162_K0.5040.33
229_G248_K0.5020.33
27_V35_G0.5000.33
30_G50_K0.5000.33
372_F375_M0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4grcA 2 0.8341 100 0.18 Contact Map
4gt2B 2 0.8486 100 0.206 Contact Map
3o72A 2 0.8534 100 0.257 Contact Map
4gs1A 2 0.8389 100 0.269 Contact Map
4w7kA 1 0.7981 100 0.353 Contact Map
3vxjA 1 0.8005 100 0.354 Contact Map
2gvkA 5 0.7212 100 0.368 Contact Map
4g2cA 2 0.851 100 0.385 Contact Map
2iizA 2 0.7091 100 0.388 Contact Map
4gu7A 2 0.7163 100 0.403 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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