GREMLIN Database
EFEM - Probable iron uptake system component EfeM
UniProt: P39596 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 385 (362)
Sequences: 575 (388)
Seq/√Len: 20.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
173_T252_L5.7521.00
318_K333_D5.6381.00
188_Y293_E5.4961.00
183_K187_L4.6961.00
180_D183_K4.1611.00
250_Q254_D4.0741.00
217_N294_R3.9471.00
342_L370_K3.4991.00
212_I255_V3.4521.00
177_K249_D3.4511.00
234_A244_E3.3511.00
170_E174_G3.3331.00
359_L364_I3.2841.00
304_M353_Y3.2761.00
175_A187_L3.2431.00
360_S363_Q3.1080.99
340_E344_A3.0220.99
219_V223_D2.9420.99
165_L255_V2.8280.99
170_E256_K2.7700.99
181_I185_K2.6440.98
228_F255_V2.6390.98
354_T358_K2.6190.98
175_A180_D2.4740.97
211_K250_Q2.4270.97
211_K257_E2.3630.96
176_V181_I2.2660.95
217_N295_Y2.2010.95
220_E223_D2.1680.94
170_E252_L2.1420.94
93_F102_L2.1150.93
147_L269_P2.0840.93
195_Y228_F2.0840.93
182_E185_K1.9970.91
214_A225_W1.9930.91
193_V305_A1.9830.91
311_E340_E1.9790.91
185_K239_Q1.9780.91
149_K153_E1.9250.90
60_S130_L1.9120.89
80_W93_F1.9040.89
161_Q194_Y1.8600.88
195_Y258_L1.8560.88
226_T254_D1.8530.88
19_G68_E1.8410.87
233_K238_D1.8380.87
209_D215_R1.8290.87
219_V225_W1.8130.86
325_H380_K1.7640.85
170_E173_T1.7590.85
230_K247_T1.7550.85
168_A194_Y1.7280.84
209_D282_E1.7270.84
369_T372_T1.7240.84
169_T255_V1.7240.84
16_L19_G1.6970.83
80_W102_L1.6750.82
154_Y309_G1.6720.82
81_L108_E1.6510.81
216_E233_K1.6460.80
111_K117_G1.6380.80
197_R308_E1.6330.80
240_D243_G1.6270.80
177_K245_K1.6220.79
12_C15_A1.6110.79
347_K353_Y1.6090.79
174_G178_S1.6050.79
195_Y286_S1.5910.78
80_W104_P1.5730.77
62_E110_Q1.5470.76
363_Q366_E1.5440.76
312_A316_T1.5380.76
157_Y197_R1.5370.76
195_Y261_S1.4990.74
277_M281_N1.4780.73
225_W233_K1.4720.72
215_R292_E1.4550.71
166_V259_D1.4380.71
15_A19_G1.4240.70
42_E53_I1.4180.69
304_M308_E1.3860.68
347_K350_D1.3740.67
47_V74_K1.3730.67
78_S98_I1.3720.67
250_Q257_E1.3590.66
335_E338_E1.3580.66
80_W119_I1.3360.65
344_A347_K1.3320.64
80_W118_K1.3320.64
73_G123_S1.3280.64
195_Y332_L1.3270.64
60_S65_D1.3160.63
274_A377_T1.3080.63
262_I272_I1.3080.63
213_D299_D1.2970.62
321_L381_I1.2890.62
298_I350_D1.2840.62
176_V244_E1.2760.61
112_D129_S1.2650.60
92_P98_I1.2540.60
212_I228_F1.2430.59
283_A303_L1.2370.59
78_S92_P1.2370.59
171_A187_L1.2360.59
50_M63_K1.2320.58
365_R372_T1.2280.58
211_K254_D1.2270.58
231_L247_T1.2250.58
156_G160_E1.2220.58
178_S183_K1.2160.57
8_V19_G1.2090.57
63_K117_G1.2080.57
240_D245_K1.2070.57
257_E261_S1.2020.56
219_V294_R1.2000.56
307_V339_F1.1900.56
71_K117_G1.1730.54
192_R302_D1.1650.54
296_S306_N1.1650.54
315_Q347_K1.1580.53
47_V75_E1.1540.53
242_S245_K1.1530.53
195_Y212_I1.1520.53
287_K292_E1.1520.53
332_L371_L1.1500.53
19_G260_G1.1460.53
321_L329_T1.1390.52
209_D213_D1.1390.52
188_Y321_L1.1360.52
339_F374_L1.1300.52
241_I245_K1.1260.51
173_T177_K1.1250.51
279_L287_K1.1240.51
63_K111_K1.1190.51
199_E279_L1.1190.51
269_P317_V1.1180.51
307_V340_E1.1090.50
52_T73_G1.1060.50
82_S85_N1.1020.50
334_T338_E1.0970.49
60_S81_L1.0940.49
91_Y102_L1.0700.48
71_K111_K1.0690.48
206_G382_A1.0670.48
188_Y301_V1.0570.47
283_A377_T1.0550.47
196_E287_K1.0510.46
165_L228_F1.0500.46
177_K252_L1.0500.46
68_E101_H1.0470.46
196_E306_N1.0460.46
282_E287_K1.0460.46
318_K359_L1.0460.46
355_S358_K1.0450.46
283_A307_V1.0400.46
338_E370_K1.0360.46
93_F104_P1.0320.45
186_T347_K1.0260.45
353_Y356_Y1.0240.45
80_W125_S1.0170.44
44_T72_K1.0130.44
292_E299_D1.0080.44
134_T212_I1.0070.44
62_E137_K1.0030.43
217_N225_W1.0030.43
63_K78_S0.9980.43
304_M344_A0.9970.43
71_K113_K0.9950.43
63_K92_P0.9930.43
247_T254_D0.9910.43
273_V382_A0.9900.43
301_V355_S0.9900.43
60_S69_I0.9900.43
183_K186_T0.9860.42
166_V183_K0.9780.42
14_L18_A0.9770.42
63_K67_K0.9700.41
304_M340_E0.9690.41
289_T296_S0.9680.41
46_S49_K0.9670.41
113_K117_G0.9650.41
345_K366_E0.9580.41
300_L306_N0.9570.40
293_E364_I0.9550.40
360_S364_I0.9500.40
9_S18_A0.9470.40
237_K295_Y0.9340.39
217_N231_L0.9320.39
98_I117_G0.9300.39
207_D261_S0.9290.39
225_W294_R0.9270.39
331_K335_E0.9270.39
171_A183_K0.9250.38
300_L309_G0.9220.38
149_K152_D0.9210.38
342_L366_E0.9150.38
102_L294_R0.9140.38
63_K113_K0.9110.38
214_A217_N0.9090.37
308_E340_E0.9070.37
209_D306_N0.9060.37
71_K94_E0.9050.37
229_H296_S0.9020.37
293_E298_I0.9020.37
63_K98_I0.9010.37
297_R357_D0.8980.37
40_T68_E0.8970.37
147_L320_A0.8950.37
337_S341_V0.8920.36
96_T104_P0.8890.36
92_P117_G0.8850.36
310_S371_L0.8780.36
279_L292_E0.8750.35
192_R299_D0.8740.35
77_N119_I0.8690.35
282_E306_N0.8670.35
37_S40_T0.8630.35
78_S111_K0.8600.35
67_K78_S0.8570.34
214_A321_L0.8570.34
63_K71_K0.8540.34
146_Q323_K0.8520.34
236_W293_E0.8510.34
157_Y215_R0.8490.34
78_S117_G0.8490.34
348_T358_K0.8470.34
172_F187_L0.8450.34
311_E337_S0.8440.34
291_E306_N0.8420.33
164_Q168_A0.8420.33
102_L318_K0.8410.33
50_M117_G0.8410.33
346_Y354_T0.8400.33
280_L331_K0.8360.33
203_E279_L0.8300.33
231_L249_D0.8270.33
95_Y99_E0.8230.32
226_T250_Q0.8220.32
192_R306_N0.8220.32
67_K117_G0.8210.32
50_M92_P0.8160.32
92_P111_K0.8070.31
312_A315_Q0.8060.31
280_L339_F0.7970.31
142_K149_K0.7970.31
225_W230_K0.7960.31
354_T359_L0.7930.31
287_K302_D0.7910.31
209_D292_E0.7910.31
303_L356_Y0.7910.31
163_D256_K0.7890.30
178_S185_K0.7890.30
288_I313_V0.7860.30
17_C231_L0.7810.30
166_V170_E0.7810.30
225_W318_K0.7780.30
9_S19_G0.7780.30
17_C183_K0.7770.30
283_A378_M0.7760.30
115_D130_L0.7760.30
127_K195_Y0.7750.30
92_P99_E0.7750.30
46_S72_K0.7730.30
199_E287_K0.7700.29
155_K265_L0.7690.29
339_F371_L0.7680.29
11_G16_L0.7660.29
279_L282_E0.7630.29
365_R369_T0.7620.29
52_T115_D0.7600.29
45_A80_W0.7590.29
104_P119_I0.7580.29
377_T382_A0.7540.29
12_C68_E0.7510.28
50_M111_K0.7510.28
147_L317_V0.7480.28
196_E296_S0.7480.28
78_S95_Y0.7470.28
215_R294_R0.7460.28
310_S378_M0.7460.28
333_D359_L0.7410.28
65_D108_E0.7410.28
214_A218_D0.7410.28
228_F310_S0.7340.27
219_V226_T0.7320.27
282_E291_E0.7290.27
68_E103_Q0.7270.27
185_K323_K0.7240.27
219_V222_G0.7240.27
185_K236_W0.7230.27
112_D334_T0.7230.27
342_L376_E0.7220.27
49_K170_E0.7210.27
19_G214_A0.7210.27
14_L21_G0.7200.27
282_E302_D0.7180.27
92_P95_Y0.7160.27
318_K329_T0.7140.26
16_L24_D0.7140.26
177_K365_R0.7140.26
16_L361_E0.7130.26
94_E117_G0.7130.26
199_E282_E0.7120.26
127_K277_M0.7120.26
50_M53_I0.7100.26
282_E292_E0.7090.26
168_A308_E0.7080.26
333_D337_S0.7070.26
55_S128_A0.7070.26
73_G298_I0.7050.26
234_A240_D0.7050.26
18_A34_S0.7030.26
71_K98_I0.7020.26
279_L306_N0.7010.26
183_K318_K0.7000.26
91_Y106_Y0.7000.26
215_R291_E0.6990.26
293_E296_S0.6980.26
287_K306_N0.6970.26
192_R291_E0.6970.26
334_T362_K0.6950.25
98_I111_K0.6910.25
275_G287_K0.6900.25
69_I126_L0.6900.25
296_S302_D0.6890.25
246_A326_S0.6880.25
212_I231_L0.6870.25
272_I319_S0.6860.25
361_E365_R0.6860.25
240_D244_E0.6840.25
78_S94_E0.6830.25
80_W86_D0.6830.25
214_A224_K0.6830.25
302_D306_N0.6820.25
177_K231_L0.6820.25
67_K92_P0.6820.25
8_V13_I0.6750.25
135_E171_A0.6710.24
52_T83_F0.6710.24
277_M317_V0.6700.24
275_G302_D0.6700.24
114_P129_S0.6680.24
196_E302_D0.6680.24
50_M78_S0.6650.24
67_K98_I0.6650.24
202_A292_E0.6640.24
36_K48_N0.6640.24
11_G174_G0.6620.24
76_L120_K0.6590.24
287_K299_D0.6580.24
181_I241_I0.6580.24
346_Y359_L0.6570.24
314_Y381_I0.6570.24
238_D273_V0.6560.24
213_D282_E0.6550.24
163_D167_K0.6550.24
48_N297_R0.6520.23
71_K78_S0.6510.23
43_I182_E0.6500.23
271_Q360_S0.6480.23
191_A267_L0.6480.23
245_K249_D0.6470.23
118_K123_S0.6470.23
168_A191_A0.6460.23
108_E117_G0.6450.23
174_G252_L0.6450.23
94_E111_K0.6410.23
215_R299_D0.6410.23
199_E302_D0.6410.23
214_A219_V0.6380.23
237_K288_I0.6380.23
109_A138_K0.6370.23
22_A182_E0.6350.23
8_V11_G0.6330.23
216_E294_R0.6300.22
116_A127_K0.6300.22
17_C35_E0.6300.22
178_S187_L0.6300.22
218_D286_S0.6290.22
50_M113_K0.6290.22
192_R287_K0.6290.22
323_K334_T0.6290.22
211_K261_S0.6280.22
209_D296_S0.6280.22
16_L243_G0.6240.22
275_G279_L0.6240.22
173_T248_A0.6230.22
71_K92_P0.6200.22
125_S281_N0.6200.22
298_I301_V0.6190.22
196_E209_D0.6180.22
10_A36_K0.6180.22
81_L122_E0.6170.22
317_V320_A0.6170.22
346_Y363_Q0.6150.22
120_K281_N0.6130.22
158_V169_T0.6120.22
291_E299_D0.6090.21
296_S300_L0.6080.21
322_V330_E0.6070.21
9_S182_E0.6060.21
151_A155_K0.6030.21
173_T249_D0.6030.21
230_K241_I0.6020.21
228_F321_L0.6020.21
85_N88_R0.6010.21
37_S257_E0.5990.21
212_I258_L0.5980.21
19_G44_T0.5980.21
217_N308_E0.5980.21
283_A371_L0.5960.21
322_V378_M0.5960.21
67_K111_K0.5930.21
46_S349_N0.5930.21
202_A284_G0.5930.21
192_R275_G0.5920.21
165_L321_L0.5910.21
138_K253_K0.5890.21
293_E301_V0.5880.21
81_L119_I0.5870.20
199_E202_A0.5850.20
199_E213_D0.5850.20
37_S66_Q0.5850.20
164_Q194_Y0.5840.20
215_R282_E0.5840.20
17_C20_C0.5830.20
137_K260_G0.5830.20
176_V234_A0.5820.20
77_N80_W0.5820.20
131_E137_K0.5820.20
40_T307_V0.5820.20
96_T123_S0.5810.20
209_D309_G0.5790.20
192_R356_Y0.5780.20
50_M71_K0.5780.20
49_K323_K0.5770.20
19_G331_K0.5760.20
47_V185_K0.5760.20
242_S362_K0.5750.20
313_V332_L0.5730.20
106_Y217_N0.5710.20
66_Q273_V0.5710.20
16_L174_G0.5700.20
293_E310_S0.5700.20
370_K376_E0.5680.20
155_K266_K0.5680.20
134_T255_V0.5680.20
214_A278_E0.5670.20
271_Q321_L0.5670.20
292_E356_Y0.5670.20
100_K151_A0.5650.20
233_K237_K0.5640.20
280_L370_K0.5630.19
192_R300_L0.5630.19
226_T230_K0.5630.19
166_V256_K0.5630.19
345_K367_L0.5620.19
371_L378_M0.5610.19
50_M67_K0.5600.19
275_G282_E0.5600.19
192_R199_E0.5600.19
67_K258_L0.5600.19
97_E101_H0.5590.19
73_G116_A0.5580.19
138_K378_M0.5570.19
110_Q134_T0.5570.19
186_T334_T0.5570.19
37_S360_S0.5570.19
40_T103_Q0.5560.19
135_E173_T0.5550.19
55_S179_G0.5540.19
196_E229_H0.5530.19
310_S314_Y0.5520.19
216_E343_M0.5510.19
302_D309_G0.5500.19
109_A193_V0.5500.19
13_I16_L0.5490.19
11_G19_G0.5480.19
284_G375_S0.5480.19
67_K91_Y0.5470.19
39_V315_Q0.5450.19
19_G180_D0.5430.19
174_G246_A0.5430.19
201_I310_S0.5430.19
262_I355_S0.5420.19
36_K70_E0.5410.19
67_K94_E0.5390.19
196_E279_L0.5390.19
176_V319_S0.5380.18
200_P292_E0.5370.18
180_D326_S0.5360.18
202_A279_L0.5360.18
345_K358_K0.5360.18
38_G171_A0.5350.18
108_E111_K0.5350.18
50_M98_I0.5350.18
42_E170_E0.5350.18
118_K121_T0.5330.18
243_G246_A0.5320.18
52_T123_S0.5310.18
230_K244_E0.5300.18
198_I287_K0.5300.18
330_E334_T0.5300.18
96_T366_E0.5280.18
355_S364_I0.5280.18
292_E306_N0.5270.18
126_L308_E0.5270.18
100_K127_K0.5260.18
279_L302_D0.5250.18
276_A313_V0.5250.18
91_Y104_P0.5250.18
21_G242_S0.5250.18
279_L291_E0.5220.18
162_S198_I0.5210.18
213_D287_K0.5200.18
306_N367_L0.5200.18
112_D221_E0.5170.18
314_Y329_T0.5160.18
98_I113_K0.5160.18
228_F296_S0.5150.18
192_R309_G0.5150.18
88_R108_E0.5150.18
130_L311_E0.5140.18
203_E287_K0.5140.18
165_L381_I0.5140.18
215_R306_N0.5140.18
162_S358_K0.5130.18
342_L345_K0.5100.17
46_S379_S0.5100.17
101_H375_S0.5090.17
346_Y367_L0.5080.17
121_T125_S0.5080.17
189_A198_I0.5080.17
83_F166_V0.5070.17
282_E286_S0.5070.17
82_S381_I0.5060.17
343_M376_E0.5060.17
223_D272_I0.5050.17
38_G56_K0.5050.17
110_Q171_A0.5050.17
92_P113_K0.5040.17
332_L377_T0.5010.17
282_E299_D0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wscA 2 0.6338 100 0.549 Contact Map
4bgoA 1 0.6364 100 0.579 Contact Map
4ecgA 1 0.6468 100 0.708 Contact Map
3pf0A 1 0.6416 100 0.721 Contact Map
3oyvA 1 0.4286 99.9 0.823 Contact Map
3c75A 1 0.2701 98.4 0.923 Contact Map
3ay2A 1 0.2442 97.9 0.932 Contact Map
1cuoA 1 0.2442 97.8 0.933 Contact Map
2aanA 2 0.2364 97.1 0.942 Contact Map
2ccwA 1 0.2442 96.9 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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