EFEM - BACSU - GREMLIN Contacts

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EFEM - Probable iron uptake system component EfeM

UniProt:	P39596	Sequences: MNFTKIAVSAGCILALCAGCGANDTSSTKEKASSEKSGVTKEITASVNKMETIISKLNDSVEKGDQKEIEKKGKELNSYWLSFENDIRSDYPFEYTEIEKHLQPIYTEAQKDKPDAGKIKTESESLKASLEDLTEAKKSGKKASDQLAKAADEYKGYVKEQSDQLVKATEAFTGAVKSGDIEKSKTLYAKARVYYERIEPIAESLGDLDPKIDARENDVEEGDKWTGFHKLEKAIWKDQDISGEKATADQLLKDVKELDGSIQSLKLTPEQIVAGAMELLNEAGISKITGEEERYSRIDLVDLMANVEGSEAVYQTVKSALVKDHSDLTEKLDTEFSEFEVLMAKYKTNDQSYTSYDKLSEKQIRELSTKLTTLSETMSKIANVL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	385 (362)
Sequences:	575 (388)
Seq/√Len:	20.4

ECOLI - EFEO
BACSU - EFEM

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
173_T	252_L	5.752	1.00
318_K	333_D	5.638	1.00
188_Y	293_E	5.496	1.00
183_K	187_L	4.696	1.00
180_D	183_K	4.161	1.00
250_Q	254_D	4.074	1.00
217_N	294_R	3.947	1.00
342_L	370_K	3.499	1.00
212_I	255_V	3.452	1.00
177_K	249_D	3.451	1.00
234_A	244_E	3.351	1.00
170_E	174_G	3.333	1.00
359_L	364_I	3.284	1.00
304_M	353_Y	3.276	1.00
175_A	187_L	3.243	1.00
360_S	363_Q	3.108	0.99
340_E	344_A	3.022	0.99
219_V	223_D	2.942	0.99
165_L	255_V	2.828	0.99
170_E	256_K	2.770	0.99
181_I	185_K	2.644	0.98
228_F	255_V	2.639	0.98
354_T	358_K	2.619	0.98
175_A	180_D	2.474	0.97
211_K	250_Q	2.427	0.97
211_K	257_E	2.363	0.96
176_V	181_I	2.266	0.95
217_N	295_Y	2.201	0.95
220_E	223_D	2.168	0.94
170_E	252_L	2.142	0.94
93_F	102_L	2.115	0.93
147_L	269_P	2.084	0.93
195_Y	228_F	2.084	0.93
182_E	185_K	1.997	0.91
214_A	225_W	1.993	0.91
193_V	305_A	1.983	0.91
311_E	340_E	1.979	0.91
185_K	239_Q	1.978	0.91
149_K	153_E	1.925	0.90
60_S	130_L	1.912	0.89
80_W	93_F	1.904	0.89
161_Q	194_Y	1.860	0.88
195_Y	258_L	1.856	0.88
226_T	254_D	1.853	0.88
19_G	68_E	1.841	0.87
233_K	238_D	1.838	0.87
209_D	215_R	1.829	0.87
219_V	225_W	1.813	0.86
325_H	380_K	1.764	0.85
170_E	173_T	1.759	0.85
230_K	247_T	1.755	0.85
168_A	194_Y	1.728	0.84
209_D	282_E	1.727	0.84
369_T	372_T	1.724	0.84
169_T	255_V	1.724	0.84
16_L	19_G	1.697	0.83
80_W	102_L	1.675	0.82
154_Y	309_G	1.672	0.82
81_L	108_E	1.651	0.81
216_E	233_K	1.646	0.80
111_K	117_G	1.638	0.80
197_R	308_E	1.633	0.80
240_D	243_G	1.627	0.80
177_K	245_K	1.622	0.79
12_C	15_A	1.611	0.79
347_K	353_Y	1.609	0.79
174_G	178_S	1.605	0.79
195_Y	286_S	1.591	0.78
80_W	104_P	1.573	0.77
62_E	110_Q	1.547	0.76
363_Q	366_E	1.544	0.76
312_A	316_T	1.538	0.76
157_Y	197_R	1.537	0.76
195_Y	261_S	1.499	0.74
277_M	281_N	1.478	0.73
225_W	233_K	1.472	0.72
215_R	292_E	1.455	0.71
166_V	259_D	1.438	0.71
15_A	19_G	1.424	0.70
42_E	53_I	1.418	0.69
304_M	308_E	1.386	0.68
347_K	350_D	1.374	0.67
47_V	74_K	1.373	0.67
78_S	98_I	1.372	0.67
250_Q	257_E	1.359	0.66
335_E	338_E	1.358	0.66
80_W	119_I	1.336	0.65
344_A	347_K	1.332	0.64
80_W	118_K	1.332	0.64
73_G	123_S	1.328	0.64
195_Y	332_L	1.327	0.64
60_S	65_D	1.316	0.63
274_A	377_T	1.308	0.63
262_I	272_I	1.308	0.63
213_D	299_D	1.297	0.62
321_L	381_I	1.289	0.62
298_I	350_D	1.284	0.62
176_V	244_E	1.276	0.61
112_D	129_S	1.265	0.60
92_P	98_I	1.254	0.60
212_I	228_F	1.243	0.59
283_A	303_L	1.237	0.59
78_S	92_P	1.237	0.59
171_A	187_L	1.236	0.59
50_M	63_K	1.232	0.58
365_R	372_T	1.228	0.58
211_K	254_D	1.227	0.58
231_L	247_T	1.225	0.58
156_G	160_E	1.222	0.58
178_S	183_K	1.216	0.57
8_V	19_G	1.209	0.57
63_K	117_G	1.208	0.57
240_D	245_K	1.207	0.57
257_E	261_S	1.202	0.56
219_V	294_R	1.200	0.56
307_V	339_F	1.190	0.56
71_K	117_G	1.173	0.54
192_R	302_D	1.165	0.54
296_S	306_N	1.165	0.54
315_Q	347_K	1.158	0.53
47_V	75_E	1.154	0.53
242_S	245_K	1.153	0.53
195_Y	212_I	1.152	0.53
287_K	292_E	1.152	0.53
332_L	371_L	1.150	0.53
19_G	260_G	1.146	0.53
321_L	329_T	1.139	0.52
209_D	213_D	1.139	0.52
188_Y	321_L	1.136	0.52
339_F	374_L	1.130	0.52
241_I	245_K	1.126	0.51
173_T	177_K	1.125	0.51
279_L	287_K	1.124	0.51
63_K	111_K	1.119	0.51
199_E	279_L	1.119	0.51
269_P	317_V	1.118	0.51
307_V	340_E	1.109	0.50
52_T	73_G	1.106	0.50
82_S	85_N	1.102	0.50
334_T	338_E	1.097	0.49
60_S	81_L	1.094	0.49
91_Y	102_L	1.070	0.48
71_K	111_K	1.069	0.48
206_G	382_A	1.067	0.48
188_Y	301_V	1.057	0.47
283_A	377_T	1.055	0.47
196_E	287_K	1.051	0.46
165_L	228_F	1.050	0.46
177_K	252_L	1.050	0.46
68_E	101_H	1.047	0.46
196_E	306_N	1.046	0.46
282_E	287_K	1.046	0.46
318_K	359_L	1.046	0.46
355_S	358_K	1.045	0.46
283_A	307_V	1.040	0.46
338_E	370_K	1.036	0.46
93_F	104_P	1.032	0.45
186_T	347_K	1.026	0.45
353_Y	356_Y	1.024	0.45
80_W	125_S	1.017	0.44
44_T	72_K	1.013	0.44
292_E	299_D	1.008	0.44
134_T	212_I	1.007	0.44
62_E	137_K	1.003	0.43
217_N	225_W	1.003	0.43
63_K	78_S	0.998	0.43
304_M	344_A	0.997	0.43
71_K	113_K	0.995	0.43
63_K	92_P	0.993	0.43
247_T	254_D	0.991	0.43
273_V	382_A	0.990	0.43
301_V	355_S	0.990	0.43
60_S	69_I	0.990	0.43
183_K	186_T	0.986	0.42
166_V	183_K	0.978	0.42
14_L	18_A	0.977	0.42
63_K	67_K	0.970	0.41
304_M	340_E	0.969	0.41
289_T	296_S	0.968	0.41
46_S	49_K	0.967	0.41
113_K	117_G	0.965	0.41
345_K	366_E	0.958	0.41
300_L	306_N	0.957	0.40
293_E	364_I	0.955	0.40
360_S	364_I	0.950	0.40
9_S	18_A	0.947	0.40
237_K	295_Y	0.934	0.39
217_N	231_L	0.932	0.39
98_I	117_G	0.930	0.39
207_D	261_S	0.929	0.39
225_W	294_R	0.927	0.39
331_K	335_E	0.927	0.39
171_A	183_K	0.925	0.38
300_L	309_G	0.922	0.38
149_K	152_D	0.921	0.38
342_L	366_E	0.915	0.38
102_L	294_R	0.914	0.38
63_K	113_K	0.911	0.38
214_A	217_N	0.909	0.37
308_E	340_E	0.907	0.37
209_D	306_N	0.906	0.37
71_K	94_E	0.905	0.37
229_H	296_S	0.902	0.37
293_E	298_I	0.902	0.37
63_K	98_I	0.901	0.37
297_R	357_D	0.898	0.37
40_T	68_E	0.897	0.37
147_L	320_A	0.895	0.37
337_S	341_V	0.892	0.36
96_T	104_P	0.889	0.36
92_P	117_G	0.885	0.36
310_S	371_L	0.878	0.36
279_L	292_E	0.875	0.35
192_R	299_D	0.874	0.35
77_N	119_I	0.869	0.35
282_E	306_N	0.867	0.35
37_S	40_T	0.863	0.35
78_S	111_K	0.860	0.35
67_K	78_S	0.857	0.34
214_A	321_L	0.857	0.34
63_K	71_K	0.854	0.34
146_Q	323_K	0.852	0.34
236_W	293_E	0.851	0.34
157_Y	215_R	0.849	0.34
78_S	117_G	0.849	0.34
348_T	358_K	0.847	0.34
172_F	187_L	0.845	0.34
311_E	337_S	0.844	0.34
291_E	306_N	0.842	0.33
164_Q	168_A	0.842	0.33
102_L	318_K	0.841	0.33
50_M	117_G	0.841	0.33
346_Y	354_T	0.840	0.33
280_L	331_K	0.836	0.33
203_E	279_L	0.830	0.33
231_L	249_D	0.827	0.33
95_Y	99_E	0.823	0.32
226_T	250_Q	0.822	0.32
192_R	306_N	0.822	0.32
67_K	117_G	0.821	0.32
50_M	92_P	0.816	0.32
92_P	111_K	0.807	0.31
312_A	315_Q	0.806	0.31
280_L	339_F	0.797	0.31
142_K	149_K	0.797	0.31
225_W	230_K	0.796	0.31
354_T	359_L	0.793	0.31
287_K	302_D	0.791	0.31
209_D	292_E	0.791	0.31
303_L	356_Y	0.791	0.31
163_D	256_K	0.789	0.30
178_S	185_K	0.789	0.30
288_I	313_V	0.786	0.30
17_C	231_L	0.781	0.30
166_V	170_E	0.781	0.30
225_W	318_K	0.778	0.30
9_S	19_G	0.778	0.30
17_C	183_K	0.777	0.30
283_A	378_M	0.776	0.30
115_D	130_L	0.776	0.30
127_K	195_Y	0.775	0.30
92_P	99_E	0.775	0.30
46_S	72_K	0.773	0.30
199_E	287_K	0.770	0.29
155_K	265_L	0.769	0.29
339_F	371_L	0.768	0.29
11_G	16_L	0.766	0.29
279_L	282_E	0.763	0.29
365_R	369_T	0.762	0.29
52_T	115_D	0.760	0.29
45_A	80_W	0.759	0.29
104_P	119_I	0.758	0.29
377_T	382_A	0.754	0.29
12_C	68_E	0.751	0.28
50_M	111_K	0.751	0.28
147_L	317_V	0.748	0.28
196_E	296_S	0.748	0.28
78_S	95_Y	0.747	0.28
215_R	294_R	0.746	0.28
310_S	378_M	0.746	0.28
333_D	359_L	0.741	0.28
65_D	108_E	0.741	0.28
214_A	218_D	0.741	0.28
228_F	310_S	0.734	0.27
219_V	226_T	0.732	0.27
282_E	291_E	0.729	0.27
68_E	103_Q	0.727	0.27
185_K	323_K	0.724	0.27
219_V	222_G	0.724	0.27
185_K	236_W	0.723	0.27
112_D	334_T	0.723	0.27
342_L	376_E	0.722	0.27
49_K	170_E	0.721	0.27
19_G	214_A	0.721	0.27
14_L	21_G	0.720	0.27
282_E	302_D	0.718	0.27
92_P	95_Y	0.716	0.27
318_K	329_T	0.714	0.26
16_L	24_D	0.714	0.26
177_K	365_R	0.714	0.26
16_L	361_E	0.713	0.26
94_E	117_G	0.713	0.26
199_E	282_E	0.712	0.26
127_K	277_M	0.712	0.26
50_M	53_I	0.710	0.26
282_E	292_E	0.709	0.26
168_A	308_E	0.708	0.26
333_D	337_S	0.707	0.26
55_S	128_A	0.707	0.26
73_G	298_I	0.705	0.26
234_A	240_D	0.705	0.26
18_A	34_S	0.703	0.26
71_K	98_I	0.702	0.26
279_L	306_N	0.701	0.26
183_K	318_K	0.700	0.26
91_Y	106_Y	0.700	0.26
215_R	291_E	0.699	0.26
293_E	296_S	0.698	0.26
287_K	306_N	0.697	0.26
192_R	291_E	0.697	0.26
334_T	362_K	0.695	0.25
98_I	111_K	0.691	0.25
275_G	287_K	0.690	0.25
69_I	126_L	0.690	0.25
296_S	302_D	0.689	0.25
246_A	326_S	0.688	0.25
212_I	231_L	0.687	0.25
272_I	319_S	0.686	0.25
361_E	365_R	0.686	0.25
240_D	244_E	0.684	0.25
78_S	94_E	0.683	0.25
80_W	86_D	0.683	0.25
214_A	224_K	0.683	0.25
302_D	306_N	0.682	0.25
177_K	231_L	0.682	0.25
67_K	92_P	0.682	0.25
8_V	13_I	0.675	0.25
135_E	171_A	0.671	0.24
52_T	83_F	0.671	0.24
277_M	317_V	0.670	0.24
275_G	302_D	0.670	0.24
114_P	129_S	0.668	0.24
196_E	302_D	0.668	0.24
50_M	78_S	0.665	0.24
67_K	98_I	0.665	0.24
202_A	292_E	0.664	0.24
36_K	48_N	0.664	0.24
11_G	174_G	0.662	0.24
76_L	120_K	0.659	0.24
287_K	299_D	0.658	0.24
181_I	241_I	0.658	0.24
346_Y	359_L	0.657	0.24
314_Y	381_I	0.657	0.24
238_D	273_V	0.656	0.24
213_D	282_E	0.655	0.24
163_D	167_K	0.655	0.24
48_N	297_R	0.652	0.23
71_K	78_S	0.651	0.23
43_I	182_E	0.650	0.23
271_Q	360_S	0.648	0.23
191_A	267_L	0.648	0.23
245_K	249_D	0.647	0.23
118_K	123_S	0.647	0.23
168_A	191_A	0.646	0.23
108_E	117_G	0.645	0.23
174_G	252_L	0.645	0.23
94_E	111_K	0.641	0.23
215_R	299_D	0.641	0.23
199_E	302_D	0.641	0.23
214_A	219_V	0.638	0.23
237_K	288_I	0.638	0.23
109_A	138_K	0.637	0.23
22_A	182_E	0.635	0.23
8_V	11_G	0.633	0.23
216_E	294_R	0.630	0.22
116_A	127_K	0.630	0.22
17_C	35_E	0.630	0.22
178_S	187_L	0.630	0.22
218_D	286_S	0.629	0.22
50_M	113_K	0.629	0.22
192_R	287_K	0.629	0.22
323_K	334_T	0.629	0.22
211_K	261_S	0.628	0.22
209_D	296_S	0.628	0.22
16_L	243_G	0.624	0.22
275_G	279_L	0.624	0.22
173_T	248_A	0.623	0.22
71_K	92_P	0.620	0.22
125_S	281_N	0.620	0.22
298_I	301_V	0.619	0.22
196_E	209_D	0.618	0.22
10_A	36_K	0.618	0.22
81_L	122_E	0.617	0.22
317_V	320_A	0.617	0.22
346_Y	363_Q	0.615	0.22
120_K	281_N	0.613	0.22
158_V	169_T	0.612	0.22
291_E	299_D	0.609	0.21
296_S	300_L	0.608	0.21
322_V	330_E	0.607	0.21
9_S	182_E	0.606	0.21
151_A	155_K	0.603	0.21
173_T	249_D	0.603	0.21
230_K	241_I	0.602	0.21
228_F	321_L	0.602	0.21
85_N	88_R	0.601	0.21
37_S	257_E	0.599	0.21
212_I	258_L	0.598	0.21
19_G	44_T	0.598	0.21
217_N	308_E	0.598	0.21
283_A	371_L	0.596	0.21
322_V	378_M	0.596	0.21
67_K	111_K	0.593	0.21
46_S	349_N	0.593	0.21
202_A	284_G	0.593	0.21
192_R	275_G	0.592	0.21
165_L	321_L	0.591	0.21
138_K	253_K	0.589	0.21
293_E	301_V	0.588	0.21
81_L	119_I	0.587	0.20
199_E	202_A	0.585	0.20
199_E	213_D	0.585	0.20
37_S	66_Q	0.585	0.20
164_Q	194_Y	0.584	0.20
215_R	282_E	0.584	0.20
17_C	20_C	0.583	0.20
137_K	260_G	0.583	0.20
176_V	234_A	0.582	0.20
77_N	80_W	0.582	0.20
131_E	137_K	0.582	0.20
40_T	307_V	0.582	0.20
96_T	123_S	0.581	0.20
209_D	309_G	0.579	0.20
192_R	356_Y	0.578	0.20
50_M	71_K	0.578	0.20
49_K	323_K	0.577	0.20
19_G	331_K	0.576	0.20
47_V	185_K	0.576	0.20
242_S	362_K	0.575	0.20
313_V	332_L	0.573	0.20
106_Y	217_N	0.571	0.20
66_Q	273_V	0.571	0.20
16_L	174_G	0.570	0.20
293_E	310_S	0.570	0.20
370_K	376_E	0.568	0.20
155_K	266_K	0.568	0.20
134_T	255_V	0.568	0.20
214_A	278_E	0.567	0.20
271_Q	321_L	0.567	0.20
292_E	356_Y	0.567	0.20
100_K	151_A	0.565	0.20
233_K	237_K	0.564	0.20
280_L	370_K	0.563	0.19
192_R	300_L	0.563	0.19
226_T	230_K	0.563	0.19
166_V	256_K	0.563	0.19
345_K	367_L	0.562	0.19
371_L	378_M	0.561	0.19
50_M	67_K	0.560	0.19
275_G	282_E	0.560	0.19
192_R	199_E	0.560	0.19
67_K	258_L	0.560	0.19
97_E	101_H	0.559	0.19
73_G	116_A	0.558	0.19
138_K	378_M	0.557	0.19
110_Q	134_T	0.557	0.19
186_T	334_T	0.557	0.19
37_S	360_S	0.557	0.19
40_T	103_Q	0.556	0.19
135_E	173_T	0.555	0.19
55_S	179_G	0.554	0.19
196_E	229_H	0.553	0.19
310_S	314_Y	0.552	0.19
216_E	343_M	0.551	0.19
302_D	309_G	0.550	0.19
109_A	193_V	0.550	0.19
13_I	16_L	0.549	0.19
11_G	19_G	0.548	0.19
284_G	375_S	0.548	0.19
67_K	91_Y	0.547	0.19
39_V	315_Q	0.545	0.19
19_G	180_D	0.543	0.19
174_G	246_A	0.543	0.19
201_I	310_S	0.543	0.19
262_I	355_S	0.542	0.19
36_K	70_E	0.541	0.19
67_K	94_E	0.539	0.19
196_E	279_L	0.539	0.19
176_V	319_S	0.538	0.18
200_P	292_E	0.537	0.18
180_D	326_S	0.536	0.18
202_A	279_L	0.536	0.18
345_K	358_K	0.536	0.18
38_G	171_A	0.535	0.18
108_E	111_K	0.535	0.18
50_M	98_I	0.535	0.18
42_E	170_E	0.535	0.18
118_K	121_T	0.533	0.18
243_G	246_A	0.532	0.18
52_T	123_S	0.531	0.18
230_K	244_E	0.530	0.18
198_I	287_K	0.530	0.18
330_E	334_T	0.530	0.18
96_T	366_E	0.528	0.18
355_S	364_I	0.528	0.18
292_E	306_N	0.527	0.18
126_L	308_E	0.527	0.18
100_K	127_K	0.526	0.18
279_L	302_D	0.525	0.18
276_A	313_V	0.525	0.18
91_Y	104_P	0.525	0.18
21_G	242_S	0.525	0.18
279_L	291_E	0.522	0.18
162_S	198_I	0.521	0.18
213_D	287_K	0.520	0.18
306_N	367_L	0.520	0.18
112_D	221_E	0.517	0.18
314_Y	329_T	0.516	0.18
98_I	113_K	0.516	0.18
228_F	296_S	0.515	0.18
192_R	309_G	0.515	0.18
88_R	108_E	0.515	0.18
130_L	311_E	0.514	0.18
203_E	287_K	0.514	0.18
165_L	381_I	0.514	0.18
215_R	306_N	0.514	0.18
162_S	358_K	0.513	0.18
342_L	345_K	0.510	0.17
46_S	379_S	0.510	0.17
101_H	375_S	0.509	0.17
346_Y	367_L	0.508	0.17
121_T	125_S	0.508	0.17
189_A	198_I	0.508	0.17
83_F	166_V	0.507	0.17
282_E	286_S	0.507	0.17
82_S	381_I	0.506	0.17
343_M	376_E	0.506	0.17
223_D	272_I	0.505	0.17
38_G	56_K	0.505	0.17
110_Q	171_A	0.505	0.17
92_P	113_K	0.504	0.17
332_L	377_T	0.501	0.17
282_E	299_D	0.500	0.17

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3wscA	2	0.6338	100	0.549	Contact Map
4bgoA	1	0.6364	100	0.579	Contact Map
4ecgA	1	0.6468	100	0.708	Contact Map
3pf0A	1	0.6416	100	0.721	Contact Map
3oyvA	1	0.4286	99.9	0.823	Contact Map
3c75A	1	0.2701	98.4	0.923	Contact Map
3ay2A	1	0.2442	97.9	0.932	Contact Map
1cuoA	1	0.2442	97.8	0.933	Contact Map
2aanA	2	0.2364	97.1	0.942	Contact Map
2ccwA	1	0.2442	96.9	0.943	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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