GREMLIN Database
EFEU - Ferrous iron permease EfeU
UniProt: P39595 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 481 (385)
Sequences: 413 (315)
Seq/√Len: 16.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_Q150_E7.1241.00
436_L444_I4.3091.00
270_A347_V3.5180.99
265_A462_L3.2150.99
265_A382_I3.1660.99
273_G374_A3.0900.99
288_F291_G2.9940.98
273_G277_L2.9100.98
278_F347_V2.9100.98
265_A269_A2.9000.98
287_N306_G2.8470.98
431_D449_Y2.7280.97
271_G351_L2.6250.96
444_I451_T2.6180.96
180_S212_I2.5670.95
144_E199_S2.5480.95
448_V452_I2.4630.94
423_Q447_S2.4020.94
137_K206_I2.3990.93
309_L321_K2.3350.92
306_G310_H2.2880.92
264_M338_F2.1580.89
437_P446_P2.1520.89
373_T376_G2.1510.89
267_S350_G2.0850.87
294_T376_G2.0760.87
111_Y114_A2.0640.87
256_I301_M2.0400.86
176_A306_G1.9630.84
272_I459_L1.9540.84
302_L418_G1.9360.83
231_M235_L1.9330.83
329_A437_P1.9130.82
378_I382_I1.9090.82
105_A108_L1.9070.82
338_F404_M1.8820.81
169_V212_I1.8790.81
176_A287_N1.8740.81
448_V455_M1.8640.80
363_K450_S1.8520.80
433_E436_L1.8320.79
363_K394_I1.8100.78
170_V177_Y1.8030.78
148_L393_R1.8010.78
175_E179_T1.7960.78
258_G456_L1.7910.78
173_S176_A1.7840.77
248_R296_V1.7740.77
256_I273_G1.7720.77
265_A393_R1.7670.77
289_L293_V1.7580.76
155_I245_K1.7520.76
132_Y158_L1.7510.76
236_V239_A1.7420.76
267_S271_G1.7150.74
377_L381_V1.7040.74
304_Y311_R1.6960.74
218_S369_L1.6720.73
262_A381_V1.6480.71
447_S450_S1.6390.71
159_V287_N1.6390.71
313_A404_M1.6170.70
198_V211_P1.6040.69
155_I414_F1.5840.68
159_V306_G1.5720.68
274_V283_F1.5680.67
138_D471_K1.5680.67
145_K374_A1.5390.66
124_Q300_V1.5240.65
241_L253_S1.5200.65
272_I428_L1.5180.65
301_M305_V1.5140.65
156_D160_T1.5080.64
354_V407_V1.5020.64
162_W221_D1.4980.64
87_L91_N1.4850.63
216_S379_V1.4850.63
226_P357_F1.4820.63
141_Q447_S1.4450.61
302_L403_S1.4350.60
304_Y358_I1.4330.60
234_L387_M1.4320.60
244_T341_I1.4230.60
217_Y373_T1.4220.60
252_S335_L1.4070.59
312_N317_K1.4060.59
248_R440_S1.3990.58
162_W177_Y1.3990.58
227_V335_L1.3920.58
433_E455_M1.3810.57
273_G452_I1.3710.57
239_A330_L1.3640.56
220_W355_I1.3570.56
307_V358_I1.3530.56
163_L302_L1.3300.54
387_M394_I1.3270.54
287_N310_H1.3260.54
221_D295_G1.3250.54
399_F425_A1.3220.54
264_M312_N1.3210.54
291_G443_G1.3180.54
304_Y418_G1.3180.54
89_F322_I1.2910.52
361_V369_L1.2910.52
163_L418_G1.2890.52
177_Y295_G1.2880.52
238_G384_G1.2850.52
220_W370_I1.2820.52
438_S444_I1.2820.52
196_E452_I1.2780.51
177_Y217_Y1.2720.51
304_Y408_L1.2710.51
430_S447_S1.2670.51
286_N336_L1.2640.51
159_V163_L1.2630.51
138_D374_A1.2600.50
203_D265_A1.2540.50
167_G177_Y1.2510.50
223_A458_L1.2490.50
322_I363_K1.2470.50
287_N291_G1.2450.49
199_S382_I1.2400.49
131_A271_G1.2390.49
251_R265_A1.2310.49
202_I322_I1.2200.48
367_T378_I1.2190.48
158_L163_L1.2170.48
244_T256_I1.2150.48
306_G461_L1.2140.48
271_G274_V1.2000.47
257_W260_A1.1980.47
110_T115_V1.1960.47
132_Y403_S1.1960.47
414_F418_G1.1910.46
236_V425_A1.1860.46
137_K199_S1.1840.46
257_W384_G1.1730.45
220_W223_A1.1710.45
136_L202_I1.1520.44
207_Q458_L1.1510.44
150_E153_S1.1500.44
172_Q339_A1.1490.44
382_I471_K1.1470.44
100_Q107_H1.1410.43
184_L310_H1.1410.43
354_V376_G1.1390.43
321_K399_F1.1380.43
354_V360_L1.1360.43
117_L386_L1.1310.43
100_Q290_L1.1250.43
303_L461_L1.1240.43
367_T444_I1.1210.42
322_I457_I1.1020.41
184_L403_S1.1010.41
226_P292_G1.1000.41
299_A415_L1.0970.41
289_L427_I1.0960.41
425_A428_L1.0960.41
149_D324_I1.0950.41
155_I463_I1.0930.41
238_G387_M1.0850.40
223_A379_V1.0840.40
359_G364_L1.0800.40
433_E451_T1.0740.40
187_M198_V1.0710.40
152_S192_G1.0700.39
341_I384_G1.0690.39
345_A354_V1.0690.39
180_S231_M1.0680.39
256_I361_V1.0680.39
104_L165_V1.0680.39
441_V460_F1.0670.39
132_Y170_V1.0670.39
208_L290_L1.0660.39
427_I462_L1.0650.39
288_F351_L1.0650.39
173_S212_I1.0640.39
371_G459_L1.0580.39
155_I345_A1.0510.38
250_T320_E1.0510.38
174_K236_V1.0460.38
159_V288_F1.0450.38
339_A342_A1.0440.38
294_T311_R1.0350.38
434_S446_P1.0280.37
176_A212_I1.0260.37
292_G342_A1.0250.37
394_I438_S1.0160.37
179_T198_V1.0160.37
268_L340_L1.0130.36
124_Q428_L1.0120.36
147_Q265_A1.0110.36
334_S406_V1.0080.36
139_T187_M1.0060.36
169_V351_L1.0030.36
106_S141_Q0.9950.35
205_M409_Y0.9940.35
134_Q459_L0.9910.35
219_W346_V0.9870.35
129_L363_K0.9860.35
367_T374_A0.9850.35
341_I355_I0.9810.35
224_L301_M0.9810.35
417_T443_G0.9800.35
185_A407_V0.9770.34
218_S364_L0.9750.34
209_L402_L0.9740.34
252_S369_L0.9700.34
260_A267_S0.9700.34
370_I378_I0.9680.34
113_Q160_T0.9680.34
204_E466_V0.9660.34
139_T227_V0.9620.34
403_S418_G0.9610.34
242_T246_K0.9570.33
163_L263_G0.9540.33
224_L338_F0.9520.33
318_W321_K0.9510.33
134_Q382_I0.9500.33
223_A375_A0.9500.33
378_I436_L0.9430.33
288_F443_G0.9430.33
310_H384_G0.9410.33
271_G350_G0.9400.33
111_Y347_V0.9350.32
255_W410_M0.9350.32
419_V467_S0.9350.32
321_K393_R0.9320.32
149_D434_S0.9270.32
312_N357_F0.9250.32
411_C450_S0.9240.32
345_A376_G0.9240.32
404_M418_G0.9230.32
130_T203_D0.9180.31
144_E385_V0.9150.31
257_W346_V0.9150.31
197_K378_I0.9140.31
300_V374_A0.9120.31
359_G413_K0.9100.31
439_V442_L0.9100.31
159_V188_K0.9090.31
142_F147_Q0.9050.31
277_L386_L0.9040.31
233_A292_G0.9010.31
148_L194_H0.9000.31
287_N326_K0.8980.30
154_A231_M0.8980.30
240_L424_L0.8970.30
217_Y376_G0.8960.30
91_N110_T0.8920.30
97_L355_I0.8900.30
291_G351_L0.8880.30
103_E107_H0.8880.30
270_A285_E0.8840.30
158_L263_G0.8820.30
254_T381_V0.8790.29
345_A447_S0.8780.29
398_P414_F0.8780.29
301_M341_I0.8770.29
455_M458_L0.8770.29
158_L188_K0.8760.29
100_Q105_A0.8760.29
256_I376_G0.8740.29
205_M236_V0.8740.29
312_N406_V0.8720.29
129_L212_I0.8720.29
303_L460_F0.8700.29
207_Q261_S0.8660.29
347_V359_G0.8660.29
162_W420_H0.8650.29
239_A394_I0.8640.29
99_T269_A0.8610.29
370_I374_A0.8560.28
253_S283_F0.8550.28
338_F449_Y0.8540.28
321_K410_M0.8530.28
322_I393_R0.8520.28
159_V291_G0.8520.28
296_V458_L0.8490.28
437_P445_Y0.8450.28
163_L291_G0.8400.28
354_V373_T0.8400.28
96_K460_F0.8360.27
174_K415_L0.8360.27
307_V406_V0.8330.27
142_F150_E0.8280.27
150_E261_S0.8250.27
237_I264_M0.8230.27
252_S410_M0.8160.27
426_G442_L0.8160.27
256_I432_A0.8150.27
118_K267_S0.8150.27
124_Q146_K0.8130.26
345_A373_T0.8120.26
145_K200_K0.8110.26
367_T393_R0.8110.26
222_A420_H0.8100.26
278_F393_R0.8090.26
297_L444_I0.8090.26
286_N301_M0.8080.26
150_E452_I0.8080.26
266_V341_I0.8060.26
129_L165_V0.8060.26
279_S337_S0.8040.26
95_R459_L0.8040.26
247_A444_I0.8010.26
138_D154_A0.8010.26
200_K204_E0.8000.26
427_I436_L0.7990.26
136_L284_G0.7990.26
160_T353_T0.7980.26
132_Y169_V0.7980.26
305_V415_L0.7980.26
170_V236_V0.7960.26
332_K441_V0.7950.26
342_A347_V0.7950.26
297_L319_R0.7890.25
350_G414_F0.7890.25
398_P401_L0.7880.25
234_L237_I0.7880.25
216_S240_L0.7870.25
95_R367_T0.7850.25
358_I407_V0.7850.25
296_V379_V0.7820.25
226_P410_M0.7820.25
222_A369_L0.7820.25
132_Y184_L0.7780.25
269_A382_I0.7770.25
96_K145_K0.7760.25
300_V382_I0.7760.25
407_V415_L0.7750.25
137_K459_L0.7740.25
158_L271_G0.7730.25
106_S452_I0.7720.25
261_S325_Q0.7720.25
258_G300_V0.7720.25
147_Q374_A0.7680.24
136_L231_M0.7670.24
318_W380_L0.7660.24
257_W267_S0.7620.24
93_D96_K0.7610.24
325_Q383_V0.7590.24
89_F344_L0.7590.24
207_Q374_A0.7590.24
315_M319_R0.7550.24
177_Y221_D0.7550.24
335_L339_A0.7550.24
219_W241_L0.7540.24
177_Y310_H0.7520.24
144_E428_L0.7510.24
178_T405_A0.7510.24
100_Q104_L0.7510.24
136_L423_Q0.7490.24
287_N307_V0.7490.24
163_L413_K0.7480.24
459_L463_I0.7480.24
383_V436_L0.7470.24
226_P244_T0.7460.23
429_P439_V0.7450.23
274_V351_L0.7440.23
413_K424_L0.7360.23
322_I369_L0.7350.23
212_I287_N0.7340.23
222_A226_P0.7330.23
219_W305_V0.7320.23
252_S260_A0.7300.23
209_L394_I0.7300.23
263_G319_R0.7290.23
319_R355_I0.7290.23
295_G421_S0.7290.23
282_V389_K0.7270.23
263_G369_L0.7260.23
211_P451_T0.7250.23
293_V462_L0.7240.23
249_V252_S0.7230.23
174_K265_A0.7220.23
294_T414_F0.7220.23
182_E286_N0.7220.23
225_I410_M0.7210.22
263_G267_S0.7190.22
312_N408_L0.7160.22
130_T474_T0.7140.22
163_L170_V0.7130.22
137_K428_L0.7120.22
140_K144_E0.7120.22
209_L333_R0.7110.22
163_L351_L0.7110.22
371_G393_R0.7050.22
149_D261_S0.7040.22
391_G399_F0.7010.22
419_V437_P0.7010.22
263_G364_L0.7000.22
309_L344_L0.7000.22
191_I363_K0.6970.22
231_M388_I0.6970.22
163_L287_N0.6950.21
164_A383_V0.6950.21
170_V287_N0.6930.21
153_S207_Q0.6920.21
163_L403_S0.6910.21
193_S197_K0.6890.21
382_I466_V0.6870.21
255_W336_L0.6860.21
134_Q197_K0.6840.21
342_A458_L0.6810.21
380_L399_F0.6770.21
162_W315_M0.6760.21
104_L114_A0.6750.21
141_Q175_E0.6740.21
158_L260_A0.6730.21
395_P399_F0.6720.21
258_G262_A0.6710.21
141_Q377_L0.6710.21
130_T277_L0.6690.20
258_G387_M0.6690.20
165_V180_S0.6680.20
285_E433_E0.6650.20
293_V358_I0.6650.20
147_Q455_M0.6640.20
379_V467_S0.6610.20
161_S260_A0.6610.20
139_T370_I0.6610.20
148_L265_A0.6590.20
160_T163_L0.6580.20
382_I472_H0.6570.20
360_L453_P0.6570.20
227_V410_M0.6560.20
289_L425_A0.6550.20
335_L357_F0.6540.20
97_L360_L0.6540.20
290_L359_G0.6540.20
243_M399_F0.6530.20
289_L342_A0.6520.20
245_K392_M0.6500.20
404_M408_L0.6480.20
202_I320_E0.6460.20
337_S342_A0.6430.19
348_R356_F0.6430.19
166_E356_F0.6430.19
166_E228_R0.6430.19
166_E348_R0.6430.19
228_R348_R0.6430.19
228_R356_F0.6430.19
345_A461_L0.6420.19
310_H423_Q0.6410.19
157_N347_V0.6410.19
311_R317_K0.6370.19
277_L427_I0.6340.19
267_S351_L0.6340.19
287_N351_L0.6330.19
238_G242_T0.6300.19
129_L169_V0.6290.19
252_S406_V0.6270.19
158_L389_K0.6270.19
129_L132_Y0.6270.19
379_V449_Y0.6260.19
259_G423_Q0.6220.19
369_L373_T0.6210.19
287_N357_F0.6210.19
215_S383_V0.6200.19
463_I467_S0.6200.19
244_T422_L0.6190.19
303_L316_D0.6190.19
217_Y221_D0.6190.19
248_R273_G0.6180.19
163_L288_F0.6170.19
131_A135_S0.6170.19
312_N353_T0.6140.18
275_T290_L0.6130.18
155_I295_G0.6120.18
264_M394_I0.6120.18
162_W223_A0.6110.18
134_Q196_E0.6100.18
313_A460_F0.6100.18
429_P467_S0.6100.18
144_E474_T0.6080.18
274_V299_A0.6070.18
240_L304_Y0.6060.18
306_G407_V0.6050.18
385_V405_A0.6030.18
99_T386_L0.6030.18
221_D263_G0.6020.18
104_L413_K0.6000.18
226_P376_G0.5990.18
95_R203_D0.5980.18
185_A307_V0.5970.18
382_I439_V0.5940.18
369_L377_L0.5920.18
272_I324_I0.5920.18
265_A324_I0.5920.18
246_K399_F0.5920.18
324_I409_Y0.5890.18
159_V418_G0.5860.17
162_W167_G0.5860.17
146_K241_L0.5850.17
376_G461_L0.5840.17
246_K405_A0.5810.17
341_I410_M0.5800.17
267_S274_V0.5760.17
286_N360_L0.5760.17
101_L109_E0.5740.17
95_R328_Q0.5740.17
347_V351_L0.5740.17
275_T387_M0.5720.17
172_Q322_I0.5710.17
240_L345_A0.5700.17
225_I353_T0.5700.17
386_L419_V0.5690.17
256_I297_L0.5680.17
269_A273_G0.5660.17
311_R314_S0.5640.17
100_Q458_L0.5640.17
195_P300_V0.5640.17
91_N191_I0.5590.17
303_L411_C0.5580.17
97_L272_I0.5580.17
458_L473_F0.5580.17
190_E195_P0.5570.17
128_S295_G0.5570.17
103_E439_V0.5570.17
311_R392_M0.5560.16
300_V325_Q0.5550.16
162_W413_K0.5550.16
311_R373_T0.5550.16
278_F467_S0.5540.16
428_L436_L0.5530.16
116_V451_T0.5530.16
145_K472_H0.5530.16
168_D415_L0.5520.16
234_L414_F0.5520.16
212_I330_L0.5520.16
170_V407_V0.5510.16
254_T386_L0.5450.16
217_Y263_G0.5430.16
279_S388_I0.5430.16
162_W310_H0.5420.16
423_Q426_G0.5420.16
177_Y236_V0.5400.16
292_G399_F0.5390.16
236_V368_E0.5390.16
409_Y450_S0.5390.16
268_L459_L0.5380.16
180_S288_F0.5380.16
367_T389_K0.5370.16
142_F396_L0.5360.16
261_S382_I0.5320.16
200_K434_S0.5320.16
106_S110_T0.5320.16
388_I418_G0.5290.16
164_A414_F0.5280.16
256_I279_S0.5280.16
450_S453_P0.5280.16
334_S407_V0.5230.15
191_I240_L0.5220.15
144_E382_I0.5220.15
206_I430_S0.5220.15
169_V271_G0.5220.15
107_H273_G0.5210.15
137_K210_E0.5210.15
239_A289_L0.5190.15
226_P380_L0.5180.15
104_L358_I0.5180.15
172_Q411_C0.5170.15
321_K380_L0.5160.15
362_G404_M0.5160.15
309_L409_Y0.5160.15
100_Q338_F0.5150.15
120_T439_V0.5130.15
99_T374_A0.5130.15
93_D462_L0.5130.15
295_G364_L0.5120.15
124_Q175_E0.5080.15
161_S188_K0.5080.15
248_R374_A0.5070.15
270_A355_I0.5040.15
159_V351_L0.5040.15
413_K428_L0.5020.15
93_D107_H0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yviA 1 0.2827 76.8 0.972 Contact Map
4uxvA 1 0.3472 76.4 0.972 Contact Map
4pacA 1 0.3077 76 0.972 Contact Map
2lemA 1 0.4137 74.6 0.972 Contact Map
4jkvA 2 0.6861 73.9 0.972 Contact Map
4g78A 1 0.2765 63.1 0.974 Contact Map
3r2pA 2 0.3638 60.4 0.975 Contact Map
3us6A 1 0.2786 56.1 0.975 Contact Map
3myfA 3 0.2412 55.1 0.975 Contact Map
4bgoA 1 0.4366 52.9 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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