GREMLIN Database
THIM - Hydroxyethylthiazole kinase
UniProt: P39593 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 272 (253)
Sequences: 1883 (1471)
Seq/√Len: 92.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
119_A208_C3.6861.00
181_Y215_L2.9741.00
78_I110_D2.6401.00
54_D102_P2.5981.00
190_L229_A2.5831.00
256_T259_D2.5451.00
74_V107_S2.4841.00
41_A206_A2.4411.00
63_V205_G2.3781.00
28_V32_T2.3691.00
121_R201_T2.3651.00
28_V195_G2.3611.00
213_N216_F2.3511.00
185_N226_G2.3461.00
83_S87_H2.3401.00
241_P253_S2.3321.00
44_V55_M2.3031.00
119_A204_V2.2951.00
168_T222_I2.2841.00
35_G252_L2.2541.00
111_I117_L2.2161.00
35_G199_L2.2111.00
39_L203_V2.2001.00
185_N227_V2.1561.00
81_G115_V2.1121.00
187_H233_A2.0401.00
193_V196_A1.9951.00
118_A214_P1.9821.00
26_N29_T1.9631.00
22_S36_L1.9581.00
234_Q263_W1.9251.00
42_S142_D1.9111.00
50_E71_K1.8471.00
231_L251_K1.8341.00
207_F224_S1.8241.00
247_E250_N1.8221.00
22_S202_S1.8081.00
36_L202_S1.7551.00
185_N230_Q1.7491.00
102_P106_E1.7261.00
227_V263_W1.7231.00
166_A218_A1.7121.00
154_A167_I1.7021.00
125_A138_I1.6721.00
154_A175_A1.6361.00
176_D179_H1.6361.00
110_D114_E1.6361.00
158_A176_D1.6111.00
20_V209_A1.6061.00
63_V201_T1.5721.00
32_T202_S1.5471.00
171_V184_H1.5471.00
173_V182_T1.5411.00
181_Y219_I1.5381.00
36_L206_A1.5311.00
55_M101_T1.5301.00
47_Y73_S1.5181.00
83_S86_E1.5111.00
122_G127_I1.5001.00
66_I108_A1.4881.00
29_T47_Y1.4861.00
251_K254_T1.4811.00
31_F245_Q1.4501.00
183_L219_I1.4440.99
203_V225_Y1.4080.99
49_K75_E1.4000.99
119_A218_A1.3980.99
23_I62_L1.3830.99
243_S246_I1.3820.99
158_A175_A1.3760.99
31_F199_L1.3660.99
47_Y70_S1.3480.99
235_Q247_E1.3450.99
171_V182_T1.3330.99
9_C207_F1.3300.99
12_A16_H1.3270.99
108_A130_T1.3120.99
158_A177_T1.3110.99
93_L108_A1.3070.99
127_I165_I1.3020.99
22_S63_V1.2760.99
155_Q180_V1.2530.99
17_S192_K1.2480.99
44_V97_G1.2390.98
66_I93_L1.2360.98
231_L259_D1.2300.98
60_G209_A1.2290.98
227_V230_Q1.2210.98
156_Q160_K1.2070.98
174_I183_L1.1990.98
11_T257_E1.1990.98
11_T15_R1.1980.98
56_A87_H1.1940.98
166_A222_I1.1940.98
166_A204_V1.1900.98
179_H213_N1.1870.98
225_Y248_L1.1530.98
64_L81_G1.1410.97
91_V115_V1.1410.97
242_G249_L1.1400.97
151_I155_Q1.1380.97
13_V210_V1.1360.97
69_L107_S1.1270.97
85_N116_R1.1260.97
37_L194_T1.1220.97
85_N117_L1.1170.97
82_K114_E1.1130.97
26_N47_Y1.1080.97
204_V221_A1.1030.97
20_V61_A1.0890.96
236_T247_E1.0880.96
210_V217_A1.0860.96
211_E217_A1.0820.96
106_E110_D1.0760.96
16_H60_G1.0730.96
48_A103_F1.0700.96
29_T73_S1.0590.96
61_A205_G1.0520.96
53_A83_S1.0510.96
170_E188_K1.0490.96
91_V117_L1.0480.96
85_N115_V1.0400.95
56_A83_S1.0300.95
54_D57_K1.0180.95
70_S73_S1.0180.95
121_R191_T1.0170.95
74_V103_F1.0130.95
226_G229_A1.0130.95
225_Y229_A1.0080.95
190_L196_A1.0080.95
60_G89_V1.0070.95
208_C214_P1.0070.95
200_L221_A1.0020.94
157_A161_L0.9850.94
214_P218_A0.9800.94
258_Q262_E0.9740.94
157_A165_I0.9720.93
164_V218_A0.9660.93
159_Q178_S0.9650.93
34_N37_L0.9590.93
78_I115_V0.9550.93
235_Q251_K0.9510.93
203_V248_L0.9500.93
120_I130_T0.9460.93
46_A51_E0.9460.93
49_K79_I0.9460.93
243_S247_E0.9430.92
200_L222_I0.9350.92
30_N194_T0.9330.92
112_I117_L0.9330.92
10_L260_V0.9310.92
21_H46_A0.9310.92
46_A55_M0.9230.92
9_C211_E0.9190.91
20_V205_G0.9160.91
10_L207_F0.9150.91
117_L120_I0.9060.91
224_S255_V0.9040.91
243_S250_N0.8970.90
125_A128_A0.8950.90
244_F248_L0.8940.90
174_I222_I0.8910.90
175_A180_V0.8900.90
49_K72_E0.8860.90
239_K247_E0.8830.90
196_A229_A0.8820.90
133_V156_Q0.8760.89
191_T229_A0.8740.89
199_L248_L0.8740.89
26_N73_S0.8720.89
235_Q239_K0.8710.89
245_Q249_L0.8640.89
183_L226_G0.8610.88
179_H215_L0.8600.88
44_V101_T0.8550.88
93_L111_I0.8440.87
189_L253_S0.8410.87
12_A15_R0.8400.87
66_I69_L0.8400.87
81_G85_N0.8370.87
98_A108_A0.8350.87
81_G91_V0.8320.87
120_I163_T0.8320.87
78_I82_K0.8320.87
152_R156_Q0.8270.86
240_G254_T0.8270.86
196_A248_L0.8270.86
131_V157_A0.8260.86
9_C220_A0.8240.86
78_I81_G0.8160.86
93_L117_L0.8140.86
204_V218_A0.8120.85
151_I182_T0.8110.85
176_D215_L0.8080.85
124_A143_A0.8070.85
187_H191_T0.8020.85
69_L74_V0.8000.85
50_E103_F0.7940.84
192_K253_S0.7900.84
53_A79_I0.7880.84
29_T32_T0.7840.83
103_F107_S0.7840.83
116_R162_N0.7820.83
173_V180_V0.7790.83
27_V68_T0.7790.83
201_T204_V0.7770.83
187_H226_G0.7760.83
75_E79_I0.7760.83
128_A150_I0.7760.83
57_K83_S0.7760.83
259_D262_E0.7760.83
81_G111_I0.7730.82
26_N70_S0.7710.82
191_T196_A0.7670.82
52_V56_A0.7630.82
188_K191_T0.7630.82
57_K87_H0.7620.82
203_V252_L0.7620.82
64_L91_V0.7610.81
236_T239_K0.7600.81
242_G246_I0.7510.81
56_A89_V0.7510.81
143_A147_G0.7500.81
13_V220_A0.7500.81
32_T63_V0.7470.80
30_N34_N0.7470.80
85_N91_V0.7460.80
259_D263_W0.7400.80
155_Q159_Q0.7350.79
228_A252_L0.7350.79
189_L241_P0.7340.79
21_H76_A0.7320.79
59_A89_V0.7300.79
200_L225_Y0.7300.79
211_E216_F0.7270.78
231_L263_W0.7270.78
33_A45_M0.7260.78
223_S227_V0.7230.78
38_A242_G0.7220.78
105_T108_A0.7220.78
92_I205_G0.7220.78
55_M97_G0.7210.78
46_A76_A0.7200.78
56_A62_L0.7190.78
119_A164_V0.7160.77
30_N245_Q0.7130.77
13_V206_A0.7100.77
137_L144_G0.7060.76
215_L219_I0.7030.76
183_L223_S0.7000.76
32_T199_L0.6990.76
154_A173_V0.6990.76
32_T195_G0.6980.76
35_G203_V0.6930.75
32_T36_L0.6910.75
251_K259_D0.6900.75
44_V59_A0.6860.74
175_A215_L0.6830.74
46_A73_S0.6820.74
62_L91_V0.6810.74
199_L249_L0.6740.73
151_I173_V0.6680.72
193_V232_A0.6670.72
118_A163_T0.6650.72
78_I114_E0.6620.72
130_T161_L0.6610.72
105_T109_R0.6610.72
199_L225_Y0.6590.71
161_L165_I0.6570.71
62_L80_A0.6570.71
55_M59_A0.6560.71
36_L41_A0.6550.71
21_H52_V0.6540.71
84_A89_V0.6500.70
151_I175_A0.6490.70
27_V42_S0.6490.70
218_A221_A0.6490.70
199_L252_L0.6470.70
228_A255_V0.6470.70
105_T129_H0.6430.69
191_T226_G0.6430.69
105_T138_I0.6420.69
27_V95_P0.6380.69
34_N194_T0.6370.69
247_E251_K0.6360.69
111_I115_V0.6320.68
21_H44_V0.6320.68
10_L257_E0.6300.68
227_V260_V0.6270.68
13_V207_F0.6240.67
82_K86_E0.6200.67
175_A178_S0.6170.66
23_I47_Y0.6160.66
22_S200_L0.6140.66
156_Q159_Q0.6140.66
128_A153_L0.6130.66
39_L252_L0.6090.65
20_V71_K0.6060.65
112_I115_V0.6050.65
31_F249_L0.6050.65
52_V83_S0.6040.65
164_V214_P0.6030.65
222_I226_G0.6020.64
28_V199_L0.6000.64
56_A80_A0.5940.63
55_M100_A0.5930.63
187_H190_L0.5910.63
97_G141_V0.5900.63
8_K12_A0.5880.63
106_E109_R0.5880.63
36_L121_R0.5850.62
167_I175_A0.5830.62
19_L140_G0.5810.62
21_H56_A0.5810.62
28_V31_F0.5800.62
22_S201_T0.5800.62
124_A150_I0.5790.61
95_P121_R0.5780.61
231_L234_Q0.5780.61
150_I153_L0.5770.61
49_K76_A0.5720.60
106_E113_R0.5720.60
99_G105_T0.5710.60
23_I80_A0.5710.60
38_A194_T0.5680.60
223_S226_G0.5660.60
62_L84_A0.5630.59
12_A211_E0.5630.59
56_A84_A0.5620.59
228_A260_V0.5620.59
141_V194_T0.5590.59
141_V198_C0.5580.59
24_T141_V0.5570.58
58_I138_I0.5550.58
159_Q215_L0.5540.58
51_E104_R0.5490.57
189_L233_A0.5480.57
120_I161_L0.5470.57
9_C216_F0.5460.57
28_V63_V0.5450.57
49_K71_K0.5440.57
257_E261_Q0.5430.57
78_I111_I0.5420.56
76_A79_I0.5410.56
149_D152_R0.5390.56
72_E75_E0.5390.56
37_L198_C0.5380.56
158_A165_I0.5380.56
128_A136_W0.5380.56
53_A56_A0.5370.56
207_F221_A0.5360.56
24_T37_L0.5340.55
64_L117_L0.5340.55
31_F35_G0.5340.55
22_S43_P0.5290.55
235_Q254_T0.5270.54
29_T70_S0.5270.54
195_G199_L0.5250.54
53_A82_K0.5240.54
21_H55_M0.5230.54
64_L252_L0.5170.53
236_T241_P0.5140.53
166_A174_I0.5130.52
78_I107_S0.5120.52
10_L13_V0.5120.52
125_A144_G0.5110.52
82_K115_V0.5110.52
70_S97_G0.5100.52
24_T198_C0.5100.52
201_T205_G0.5100.52
124_A167_I0.5090.52
134_T137_L0.5090.52
258_Q261_Q0.5080.52
96_V141_V0.5070.52
92_I208_C0.5060.51
46_A97_G0.5060.51
246_I253_S0.5030.51
21_H62_L0.5030.51
38_A198_C0.5010.51
64_L115_V0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ekqA 3 0.9338 100 0.411 Contact Map
3dzvA 3 0.9412 100 0.413 Contact Map
3nl6A 4 0.9265 100 0.538 Contact Map
3hpdA 3 0.9301 100 0.555 Contact Map
3bgkA 3 0.864 99.9 0.728 Contact Map
2r3bA 3 0.864 99.9 0.73 Contact Map
3k5wA 4 0.8051 99.9 0.752 Contact Map
3rpzA 3 0.8493 99.9 0.754 Contact Map
3rssA 4 0.8529 99.9 0.762 Contact Map
2yxtA 3 0.9081 99.8 0.791 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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