GREMLIN Database
CIDA - Holin-like protein CidA
UniProt: P39591 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 128 (112)
Sequences: 1803 (1374)
Seq/√Len: 129.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_F45_L4.5811.00
106_S110_L2.7481.00
109_T112_Q2.7471.00
44_T48_F2.5961.00
108_G112_Q2.4611.00
105_V109_T2.4301.00
40_V44_T2.3811.00
25_T37_I2.1391.00
16_I20_L2.1241.00
98_I102_V1.9761.00
21_I34_G1.9701.00
91_S95_V1.8791.00
85_M92_I1.8701.00
37_I41_I1.8381.00
88_F91_S1.8251.00
17_F41_I1.8171.00
20_L45_L1.7891.00
79_I82_G1.7561.00
22_N26_A1.7241.00
10_Q59_G1.7101.00
9_I55_W1.7061.00
18_A22_N1.7041.00
35_S70_F1.6771.00
18_A35_S1.6401.00
110_L113_L1.5801.00
23_W27_L1.5381.00
52_K55_W1.5351.00
109_T113_L1.5161.00
24_V27_L1.4371.00
33_P74_S1.4211.00
39_I75_A1.3921.00
78_V81_Y1.3761.00
41_I45_L1.3601.00
57_E61_A1.3591.00
53_L56_I1.3381.00
113_L117_R1.2951.00
83_D86_S1.2801.00
49_N52_K1.2741.00
53_L57_E1.2221.00
81_Y84_I1.2120.99
94_L98_I1.1730.99
24_V41_I1.1710.99
17_F21_I1.1310.99
114_I117_R1.1220.99
111_T115_A1.1190.99
25_T29_H1.1010.99
39_I111_T1.0780.99
40_V62_W1.0740.99
25_T34_G1.0700.99
83_D87_K1.0690.99
82_G86_S1.0470.98
96_V103_V1.0420.98
84_I88_F1.0290.98
21_I37_I1.0240.98
113_L116_K0.9970.98
11_I59_G0.9890.98
68_L72_I0.9770.98
14_L59_G0.9740.98
103_V107_T0.9710.98
45_L51_I0.9490.97
65_G74_S0.9430.97
45_L50_I0.9410.97
36_I68_L0.9360.97
24_V37_I0.9340.97
79_I97_I0.9320.97
9_I12_A0.9280.97
42_L51_I0.9260.97
10_Q17_F0.9200.97
107_T111_T0.9170.97
25_T28_L0.9110.96
24_V29_H0.9000.96
101_F105_V0.8870.96
22_N34_G0.8840.96
21_I77_G0.8770.96
23_W26_A0.8720.95
50_I53_L0.8660.95
51_I56_I0.8460.95
13_L16_I0.8370.94
24_V57_E0.8300.94
34_G37_I0.8280.94
39_I56_I0.8240.94
15_F77_G0.8230.94
100_T103_V0.8150.93
11_I21_I0.8120.93
36_I64_L0.7900.92
88_F92_I0.7900.92
15_F107_T0.7890.92
57_E77_G0.7830.92
20_L41_I0.7830.92
43_F47_H0.7660.91
51_I55_W0.7630.91
45_L48_F0.7560.91
10_Q62_W0.7540.90
25_T30_I0.7490.90
18_A33_P0.7390.90
76_V79_I0.7340.89
71_F74_S0.7330.89
64_L67_L0.7260.89
11_I99_S0.7260.89
80_E83_D0.7160.88
40_V43_F0.7110.88
68_L75_A0.7100.88
7_T58_L0.7080.87
35_S104_M0.7080.87
32_I38_G0.6970.87
96_V100_T0.6930.86
44_T110_L0.6900.86
111_T114_I0.6870.86
63_L68_L0.6810.85
31_N36_I0.6750.85
54_E63_L0.6740.85
28_L37_I0.6690.84
24_V28_L0.6640.84
75_A78_V0.6630.84
108_G117_R0.6550.83
56_I64_L0.6550.83
53_L60_A0.6480.82
14_L55_W0.6470.82
66_E69_L0.6390.82
42_L56_I0.6380.81
29_H40_V0.6330.81
9_I54_E0.6240.80
75_A82_G0.6220.80
67_L103_V0.6220.80
95_V104_M0.6200.80
110_L117_R0.6190.79
75_A81_Y0.6170.79
57_E103_V0.6110.79
100_T104_M0.6100.78
51_I67_L0.6090.78
69_L72_I0.6050.78
9_I13_L0.6050.78
87_K98_I0.5950.77
112_Q117_R0.5930.77
8_V118_K0.5930.77
68_L99_S0.5870.76
15_F21_I0.5870.76
26_A85_M0.5700.74
32_I77_G0.5650.73
69_L84_I0.5650.73
103_V111_T0.5610.73
53_L88_F0.5600.72
36_I76_V0.5600.72
60_A101_F0.5570.72
14_L99_S0.5520.71
27_L97_I0.5510.71
19_R101_F0.5510.71
67_L71_F0.5460.70
9_I59_G0.5460.70
19_R22_N0.5370.69
88_F98_I0.5340.69
55_W59_G0.5280.68
62_W67_L0.5280.68
54_E113_L0.5280.68
50_I54_E0.5270.68
45_L49_N0.5270.68
35_S43_F0.5260.68
35_S96_V0.5190.67
35_S64_L0.5180.67
47_H50_I0.5170.66
49_N53_L0.5110.65
23_W97_I0.5110.65
52_K98_I0.5100.65
41_I112_Q0.5070.65
84_I92_I0.5050.65
13_L17_F0.5030.64
11_I15_F0.5010.64
110_L114_I0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kv5A 1 0.2578 56.2 0.902 Contact Map
3w9iA 3 0.9375 53.8 0.904 Contact Map
4dx5A 3 0.9922 49.3 0.906 Contact Map
4cz8A 2 0.9531 46.3 0.908 Contact Map
4czbA 2 0.9609 46.3 0.908 Contact Map
3ne5A 3 0.9219 37.4 0.913 Contact Map
4k0jA 3 0.8828 33.1 0.915 Contact Map
4mt1A 3 0.8984 32.5 0.916 Contact Map
2m20A 2 0.3203 29.2 0.917 Contact Map
2kncA 1 0.3984 27.7 0.918 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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