GREMLIN Database
YWBG - Uncharacterized protein YwbG
UniProt: P39590 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 225 (219)
Sequences: 1920 (1343)
Seq/√Len: 90.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
131_I211_A5.5861.00
132_A150_V4.9871.00
134_N137_E4.1471.00
136_S146_T3.7261.00
124_P136_S3.2071.00
161_G180_L3.0841.00
180_L192_A3.0801.00
11_T54_Y3.0121.00
173_E196_S2.8581.00
157_G184_A2.7531.00
14_V39_V2.6631.00
189_T203_S2.4981.00
127_V135_V2.4151.00
166_R176_R2.3381.00
191_K194_E2.3351.00
109_A114_L2.2511.00
161_G165_I2.0861.00
109_A119_I2.0811.00
14_V36_T1.9331.00
18_A35_V1.9131.00
120_D139_I1.8901.00
196_S199_S1.8771.00
20_K24_R1.8751.00
165_I180_L1.8571.00
176_R199_S1.8461.00
35_V39_V1.8431.00
55_N62_T1.7771.00
96_V100_I1.7701.00
18_A36_T1.7671.00
121_S141_G1.7501.00
121_S142_M1.7221.00
98_S210_A1.7051.00
81_P85_K1.6961.00
42_G46_L1.6681.00
14_V40_L1.6631.00
14_V43_L1.6531.00
42_G45_L1.6261.00
17_G21_V1.5961.00
86_Y89_E1.5711.00
178_V182_T1.5601.00
205_V211_A1.5461.00
106_A123_V1.5461.00
109_A122_L1.5341.00
126_S153_T1.5341.00
14_V18_A1.5261.00
7_S49_V1.5041.00
107_L111_W1.5041.00
105_T153_T1.5031.00
116_T120_D1.4831.00
128_T131_I1.4741.00
163_M167_Y1.4601.00
95_A213_M1.4360.99
55_N58_G1.4340.99
55_N59_G1.4180.99
43_L47_V1.4100.99
127_V131_I1.3820.99
130_P134_N1.3810.99
38_A42_G1.3500.99
178_V206_S1.3470.99
87_A91_I1.3220.99
98_S102_I1.3190.99
17_G39_V1.3190.99
124_P146_T1.3110.99
178_V202_I1.2970.99
56_L59_G1.2950.99
20_K25_F1.2940.99
13_L17_G1.2910.99
69_T74_I1.2680.99
135_V214_T1.2530.98
107_L110_K1.2520.98
80_F84_K1.2310.98
44_L51_Y1.2220.98
184_A203_S1.2220.98
86_Y202_I1.2210.98
125_R153_T1.2210.98
17_G20_K1.2110.98
22_Y30_T1.2050.98
133_M147_A1.2010.98
103_I107_L1.1960.98
102_I218_A1.1890.98
10_L40_L1.1860.98
129_T151_I1.1760.98
151_I155_L1.1670.98
115_G118_L1.1620.97
143_P147_A1.1580.97
145_V149_F1.1560.97
66_Q130_P1.1510.97
173_E199_S1.1490.97
22_Y27_R1.1340.97
75_P204_S1.1060.97
165_I170_I1.0990.96
216_C220_F1.0870.96
41_V45_L1.0860.96
102_I123_V1.0830.96
69_T153_T1.0740.96
153_T184_A1.0630.96
81_P84_K1.0630.96
192_A196_S1.0530.95
65_L186_G1.0520.95
192_A200_G1.0310.95
118_L121_S1.0170.95
20_K23_Q1.0120.94
78_K197_S1.0020.94
204_S208_I0.9920.94
25_F30_T0.9740.93
97_G182_T0.9700.93
7_S57_G0.9690.93
158_T187_A0.9670.93
133_M136_S0.9650.93
133_M143_P0.9610.93
98_S214_T0.9580.93
65_L130_P0.9550.92
185_H188_G0.9540.92
193_F201_T0.9510.92
106_A119_I0.9480.92
102_I217_A0.9480.92
53_S58_G0.9480.92
19_K23_Q0.9450.92
77_Y80_F0.9400.92
88_V91_I0.9330.92
87_A151_I0.9320.92
182_T210_A0.9220.91
21_V35_V0.9160.91
189_T200_G0.9110.91
94_V210_A0.8930.90
146_T150_V0.8920.90
31_S35_V0.8870.89
174_I202_I0.8820.89
155_L187_A0.8800.89
186_G204_S0.8770.89
157_G203_S0.8750.89
147_A150_V0.8740.89
123_V222_L0.8710.89
121_S146_T0.8640.88
16_L20_K0.8630.88
154_A157_G0.8600.88
76_L219_P0.8480.87
33_L187_A0.8450.87
30_T35_V0.8450.87
31_S34_L0.8410.87
90_I178_V0.8390.87
45_L48_N0.8370.87
153_T156_L0.8340.86
118_L142_M0.8340.86
193_F200_G0.8320.86
160_I163_M0.8320.86
176_R195_L0.8260.86
105_T125_R0.8260.86
22_Y25_F0.8240.86
15_Y19_K0.8160.85
110_K119_I0.8130.85
50_P53_S0.8080.85
7_S58_G0.8070.84
57_G124_P0.8060.84
51_Y70_V0.8030.84
134_N138_M0.7990.84
198_V212_I0.7930.83
92_L96_V0.7930.83
30_T161_G0.7910.83
157_G185_H0.7870.83
31_S202_I0.7770.82
94_V182_T0.7770.82
135_V218_A0.7760.82
47_V50_P0.7730.82
182_T204_S0.7710.82
120_D222_L0.7700.82
39_V42_G0.7700.82
121_S136_S0.7680.81
36_T40_L0.7630.81
179_L183_S0.7620.81
71_A147_A0.7610.81
136_S141_G0.7600.81
130_P143_P0.7590.81
196_S202_I0.7580.81
202_I207_M0.7560.80
72_F125_R0.7560.80
23_Q26_P0.7550.80
44_L49_V0.7540.80
81_P96_V0.7530.80
203_S206_S0.7510.80
120_D141_G0.7510.80
139_I218_A0.7510.80
53_S56_L0.7490.80
36_T39_V0.7450.79
93_N202_I0.7420.79
105_T108_I0.7390.79
172_N175_A0.7360.79
122_L149_F0.7290.78
101_A104_S0.7260.78
86_Y174_I0.7240.77
93_N101_A0.7230.77
112_L212_I0.7210.77
160_I164_V0.7180.77
45_L117_G0.7180.77
123_V218_A0.7160.77
185_H189_T0.7160.77
125_R215_L0.7090.76
129_T150_V0.7070.76
102_I207_M0.7060.76
70_V145_V0.7050.76
127_V214_T0.7050.76
10_L43_L0.7050.76
23_Q27_R0.7040.75
128_T211_A0.7010.75
79_Y198_V0.6980.75
6_V47_V0.6940.74
108_I112_L0.6920.74
48_N137_E0.6910.74
82_V174_I0.6710.72
98_S213_M0.6670.71
154_A185_H0.6650.71
74_I101_A0.6640.71
162_P166_R0.6640.71
211_A215_L0.6600.71
51_Y148_V0.6590.71
215_L218_A0.6580.70
55_N60_L0.6570.70
70_V75_P0.6550.70
25_F28_V0.6540.70
34_L159_V0.6510.70
82_V202_I0.6490.69
153_T185_H0.6490.69
86_Y172_N0.6480.69
220_F223_S0.6440.69
99_C103_I0.6420.69
15_Y22_Y0.6390.68
20_K160_I0.6380.68
93_N140_G0.6350.68
61_L64_M0.6340.68
25_F187_A0.6340.68
5_I57_G0.6320.67
82_V198_V0.6320.67
156_L160_I0.6310.67
73_A127_V0.6290.67
162_P191_K0.6270.67
184_A188_G0.6250.67
83_L201_T0.6200.66
96_V107_L0.6110.65
157_G189_T0.6110.65
104_S108_I0.6100.65
69_T214_T0.6090.65
95_A209_L0.6090.65
193_F204_S0.6090.65
30_T90_I0.6050.64
15_Y172_N0.6040.64
12_V16_L0.6020.64
186_G189_T0.6020.64
22_Y130_P0.6020.64
31_S37_P0.6000.63
129_T133_M0.5990.63
165_I179_L0.5980.63
98_S183_S0.5970.63
162_P211_A0.5970.63
94_V206_S0.5960.63
135_V222_L0.5950.63
79_Y133_M0.5930.62
207_M211_A0.5930.62
11_T186_G0.5910.62
138_M208_I0.5890.62
103_I106_A0.5890.62
186_G194_E0.5820.61
99_C167_Y0.5820.61
174_I206_S0.5820.61
128_T162_P0.5820.61
27_R30_T0.5810.61
39_V43_L0.5790.61
191_K197_S0.5780.61
187_A190_S0.5770.60
66_Q125_R0.5740.60
135_V215_L0.5720.60
191_K195_L0.5720.60
101_A179_L0.5710.60
74_I205_V0.5700.59
99_C108_I0.5690.59
83_L202_I0.5660.59
131_I135_V0.5640.59
184_A217_A0.5630.59
191_K203_S0.5610.58
37_P129_T0.5590.58
20_K26_P0.5590.58
47_V52_E0.5570.58
165_I169_R0.5550.57
7_S93_N0.5540.57
60_L122_L0.5540.57
122_L190_S0.5530.57
100_I104_S0.5530.57
17_G25_F0.5530.57
10_L13_L0.5520.57
165_I219_P0.5510.57
203_S210_A0.5500.57
91_I164_V0.5480.56
60_L99_C0.5480.56
72_F189_T0.5460.56
107_L117_G0.5440.56
39_V140_G0.5420.56
19_K125_R0.5410.56
206_S215_L0.5380.55
195_L199_S0.5380.55
83_L92_L0.5380.55
17_G43_L0.5370.55
21_V30_T0.5360.55
5_I16_L0.5340.55
109_A145_V0.5330.54
26_P115_G0.5320.54
72_F193_F0.5320.54
48_N166_R0.5320.54
129_T146_T0.5300.54
110_K116_T0.5280.54
37_P64_M0.5250.53
48_N52_E0.5240.53
8_L61_L0.5230.53
65_L75_P0.5210.53
177_G189_T0.5200.53
176_R209_L0.5200.53
72_F89_E0.5190.53
94_V121_S0.5150.52
108_I114_L0.5120.52
158_T190_S0.5080.51
95_A217_A0.5060.51
22_Y34_L0.5060.51
36_T206_S0.5060.51
13_L48_N0.5040.50
101_A130_P0.5030.50
76_L109_A0.5030.50
89_E208_I0.5020.50
201_T205_V0.5020.50
129_T208_I0.5010.50
10_L155_L0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zuxA 1 0.7422 95.1 0.912 Contact Map
4n7wA 2 0.72 94.1 0.917 Contact Map
4czbA 2 0.9733 55.3 0.946 Contact Map
4cz8A 2 0.9111 42.9 0.95 Contact Map
4bwzA 2 0.84 39 0.951 Contact Map
2a65A 2 0.3822 25.2 0.956 Contact Map
2zy9A 2 0.7911 14.2 0.96 Contact Map
3nd0A 2 0.9067 10.9 0.962 Contact Map
2ju0B 1 0.2311 8.6 0.964 Contact Map
4z7fA 2 0.3911 7.1 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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