GREMLIN Database
YWBE - Uncharacterized protein YwbE
UniProt: P39588 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 65 (62)
Sequences: 410 (227)
Seq/√Len: 28.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_D50_R3.8781.00
16_D30_R3.6371.00
22_D27_K3.4361.00
14_Q30_R2.8181.00
19_L55_R2.7951.00
9_I33_V2.4480.99
18_V60_Q2.0480.97
28_L60_Q2.0080.97
16_D61_Q1.8240.94
11_K35_D1.6640.91
45_H60_Q1.6280.90
21_A27_K1.5980.89
16_D63_V1.5910.89
17_I55_R1.2690.75
44_P56_I1.2660.75
5_E42_F1.2250.72
16_D28_L1.1980.70
45_H56_I1.1650.68
14_Q32_T1.1590.68
25_T60_Q1.1570.68
19_L22_D1.1180.65
4_Q44_P1.0600.61
9_I36_I1.0580.61
39_K44_P1.0320.59
10_S13_L1.0320.59
2_N8_S1.0290.58
42_F45_H1.0230.58
40_S44_P1.0000.56
7_N10_S0.9980.56
9_I13_L0.9930.56
40_S45_H0.9790.55
14_Q63_V0.9780.54
39_K60_Q0.9690.54
11_K50_R0.9600.53
6_R36_I0.9000.48
25_T61_Q0.8970.48
18_V45_H0.8860.47
50_R56_I0.8860.47
28_L61_Q0.8780.47
7_N41_N0.8600.45
2_N5_E0.8530.45
5_E8_S0.8200.42
21_A55_R0.8120.42
32_T52_E0.7820.39
3_G24_K0.7820.39
50_R54_G0.7630.38
5_E10_S0.7570.38
36_I39_K0.7560.37
18_V28_L0.7490.37
34_K50_R0.7350.36
11_K52_E0.7320.36
17_I49_V0.7250.35
16_D62_I0.7240.35
4_Q45_H0.7190.35
5_E41_N0.7090.34
30_R61_Q0.6920.33
10_S56_I0.6910.33
39_K45_H0.6880.33
34_K53_D0.6830.32
10_S18_V0.6750.32
4_Q62_I0.6680.31
25_T63_V0.6660.31
39_K52_E0.6620.31
13_L62_I0.6520.30
17_I35_D0.6220.28
10_S41_N0.6180.28
11_K36_I0.6040.27
27_K32_T0.6040.27
32_T53_D0.5990.27
3_G36_I0.5890.26
17_I24_K0.5850.26
60_Q63_V0.5840.26
14_Q34_K0.5820.26
7_N42_F0.5710.25
3_G62_I0.5680.25
2_N27_K0.5630.25
32_T63_V0.5610.25
35_D52_E0.5580.24
8_S61_Q0.5560.24
49_V54_G0.5540.24
9_I42_F0.5510.24
13_L32_T0.5460.24
21_A32_T0.5400.23
7_N13_L0.5370.23
51_L54_G0.5340.23
17_I50_R0.5330.23
4_Q32_T0.5280.23
13_L63_V0.5270.23
42_F63_V0.5210.22
15_V29_T0.5150.22
11_K42_F0.5060.22
14_Q53_D0.5010.21
17_I51_L0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hikA 1 0.9077 22.3 0.903 Contact Map
4ql5A 4 0.5231 15.5 0.91 Contact Map
3dlmA 1 0.8308 13.3 0.913 Contact Map
4lduA 2 1 12.3 0.914 Contact Map
3sqrA 1 0.8154 10.2 0.917 Contact Map
1aozA 3 0.8154 10 0.917 Contact Map
2q9oA 2 0.8 9.6 0.918 Contact Map
3i4oA 1 0.5231 8.6 0.92 Contact Map
3gdcA 3 0.8 8 0.921 Contact Map
1x6vB 2 0.9231 7.8 0.921 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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