GREMLIN Database
YWBC - Uncharacterized protein YwbC
UniProt: P39586 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 126 (117)
Sequences: 2840 (1429)
Seq/√Len: 132.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_T24_E5.6101.00
87_T91_K4.4541.00
81_D84_A2.9041.00
95_K114_E2.5871.00
15_I44_A2.5481.00
30_L33_R2.4631.00
14_D17_A2.2161.00
23_E29_K2.0841.00
89_A94_A2.0441.00
88_K92_M1.8991.00
40_V63_S1.8341.00
13_R64_S1.8211.00
31_K47_G1.7291.00
114_E120_W1.7031.00
25_V92_M1.6931.00
35_T42_E1.6901.00
29_K49_E1.6791.00
28_M48_F1.6711.00
112_Y122_E1.5231.00
30_L44_A1.5081.00
28_M77_L1.5021.00
67_P70_G1.4861.00
97_I114_E1.4841.00
87_T90_E1.4411.00
19_I46_L1.4241.00
18_S58_L1.4061.00
8_T54_T1.4011.00
31_K55_E1.3931.00
6_D78_L1.3351.00
12_V15_I1.3311.00
84_A88_K1.3181.00
85_E88_K1.3131.00
16_N20_T1.2981.00
35_T62_Y1.2821.00
42_E62_Y1.2421.00
18_S22_Y1.2271.00
74_H122_E1.2161.00
25_V89_A1.2161.00
33_R42_E1.2151.00
36_H41_I1.2091.00
13_R66_L1.2010.99
13_R65_E1.1880.99
17_A20_T1.1870.99
110_Y124_F1.1840.99
26_L113_I1.1740.99
20_T25_V1.1680.99
3_K85_E1.1480.99
33_R44_A1.1370.99
40_V62_Y1.1280.99
24_E92_M1.1240.99
17_A117_D1.1220.99
48_F77_L1.0990.99
97_I120_W1.0810.99
86_Y90_E1.0670.99
68_A71_K1.0670.99
18_S117_D1.0600.99
86_Y111_F1.0570.99
64_S71_K1.0540.99
13_R17_A1.0470.99
77_L121_I1.0430.99
89_A123_F1.0120.98
83_A87_T1.0100.98
6_D124_F0.9920.98
7_H76_A0.9900.98
20_T23_E0.9880.98
114_E118_G0.9800.98
15_I60_Q0.9730.98
7_H57_E0.9600.98
37_T62_Y0.9530.97
26_L123_F0.9520.97
75_I121_I0.9500.97
89_A111_F0.9480.97
36_H39_G0.9350.97
22_Y115_G0.9270.97
8_T75_I0.9260.97
49_E52_P0.9090.97
48_F52_P0.8990.96
74_H112_Y0.8980.96
42_E60_Q0.8960.96
9_G59_I0.8810.96
37_T40_V0.8800.96
19_I23_E0.8730.96
4_R53_E0.8710.96
4_R78_L0.8590.95
44_A60_Q0.8540.95
39_G106_N0.8530.95
39_G62_Y0.8420.95
11_M119_E0.8100.93
56_I75_I0.8030.93
109_R125_Q0.8020.93
43_L59_I0.7970.93
41_I104_L0.7960.93
41_I61_G0.7920.93
111_F123_F0.7840.92
72_V75_I0.7780.92
32_D55_E0.7670.92
30_L42_E0.7660.91
9_G61_G0.7660.91
84_A87_T0.7600.91
105_P109_R0.7580.91
50_D55_E0.7480.90
36_H40_V0.7410.90
10_I22_Y0.7350.90
12_V20_T0.7340.90
41_I59_I0.7210.89
16_N33_R0.7200.89
34_I43_L0.7120.88
6_D55_E0.7100.88
7_H74_H0.7080.88
9_G73_H0.7040.88
11_M61_G0.7010.87
4_R50_D0.6990.87
5_I75_I0.6900.87
79_T85_E0.6900.87
35_T60_Q0.6850.86
24_E88_K0.6850.86
47_G55_E0.6820.86
14_D60_Q0.6810.86
88_K91_K0.6800.86
86_Y95_K0.6740.85
20_T92_M0.6740.85
88_K95_K0.6730.85
115_G119_E0.6730.85
23_E46_L0.6720.85
5_I10_I0.6690.85
10_I75_I0.6530.83
43_L57_E0.6390.82
104_L107_G0.6370.82
45_F57_E0.6330.82
25_V94_A0.6280.81
98_D111_F0.6240.81
29_K50_D0.6230.81
96_F114_E0.6220.80
18_S115_G0.6120.79
18_S116_P0.6060.79
4_R7_H0.6030.78
83_A109_R0.6020.78
46_L56_I0.5960.78
11_M72_V0.5920.77
41_I106_N0.5900.77
76_A112_Y0.5890.77
4_R55_E0.5880.77
70_G73_H0.5810.76
94_A113_I0.5750.75
33_R62_Y0.5720.75
69_E118_G0.5650.74
57_E61_G0.5650.74
61_G67_P0.5600.73
78_L82_I0.5590.73
76_A122_E0.5540.72
19_I30_L0.5540.72
107_G112_Y0.5540.72
105_P125_Q0.5520.72
26_L77_L0.5480.71
21_F113_I0.5440.71
34_I39_G0.5440.71
25_V113_I0.5320.69
82_I109_R0.5310.69
78_L124_F0.5300.69
67_P71_K0.5290.69
90_E93_N0.5280.69
61_G72_V0.5270.69
69_E72_V0.5270.69
59_I67_P0.5210.68
5_I48_F0.5180.67
50_D53_E0.5170.67
35_T40_V0.5170.67
68_A118_G0.5170.67
31_K53_E0.5170.67
64_S67_P0.5130.66
90_E98_D0.5110.66
97_I105_P0.5070.66
82_I106_N0.5050.65
90_E95_K0.5020.65
36_H43_L0.5020.65
6_D54_T0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ss4A 4 0.9762 99.9 0.398 Contact Map
3hdpA 2 0.9603 99.8 0.408 Contact Map
1f9zA 2 0.9762 99.8 0.411 Contact Map
3w0tA 2 0.9841 99.8 0.411 Contact Map
4mtsA 2 0.9762 99.8 0.416 Contact Map
2c21A 2 0.9444 99.8 0.421 Contact Map
1jc4A 2 1 99.8 0.424 Contact Map
3rmuA 4 0.9683 99.8 0.426 Contact Map
3l7tA 2 0.9524 99.8 0.431 Contact Map
3gm5A 2 0.9524 99.8 0.433 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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