GREMLIN Database
YWBA - Putative permease IIC component YwbA
UniProt: P39584 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 444 (414)
Sequences: 2130 (1550)
Seq/√Len: 76.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_F107_G4.8001.00
375_V406_M4.2761.00
304_T336_N4.2301.00
365_A413_I3.8181.00
306_A414_T3.7531.00
376_A400_K2.9391.00
276_A284_P2.9281.00
249_S352_I2.9081.00
401_V405_V2.8931.00
308_V339_I2.8671.00
91_I153_M2.8601.00
362_T414_T2.7921.00
361_L417_I2.7471.00
315_S426_D2.7261.00
84_A152_A2.4791.00
272_A285_S2.4211.00
362_T410_N2.4151.00
365_A406_M2.3991.00
427_H431_R2.3451.00
412_L416_A2.3241.00
207_I218_V2.2991.00
358_A361_L2.2601.00
99_Y164_R2.2511.00
202_L206_L2.2371.00
88_A110_S2.1901.00
166_I195_I2.1851.00
358_A417_I2.1781.00
24_H95_L2.1761.00
96_A106_A2.1631.00
397_T403_G2.1071.00
366_T370_M2.0761.00
234_L364_T2.0751.00
361_L413_I2.0571.00
314_R419_Y2.0201.00
23_R99_Y2.0171.00
310_T415_C2.0131.00
429_K432_E2.0051.00
252_I257_I2.0041.00
99_Y161_E1.9891.00
409_V413_I1.9881.00
376_A402_S1.9481.00
431_R435_A1.9381.00
277_F283_L1.9181.00
394_Y404_A1.9171.00
242_F360_L1.9081.00
309_L411_L1.8751.00
406_M410_N1.8671.00
238_L360_L1.8651.00
369_G374_L1.8601.00
351_L425_W1.8571.00
24_H161_E1.8521.00
368_I372_T1.8361.00
232_G285_S1.8321.00
317_S426_D1.8231.00
92_A106_A1.8081.00
366_T410_N1.8071.00
393_G407_Q1.7901.00
430_W434_S1.7901.00
315_S422_F1.7631.00
345_I351_L1.7351.00
369_G406_M1.7331.00
304_T331_A1.7021.00
310_T422_F1.6971.00
9_E14_P1.6951.00
393_G403_G1.6751.00
161_E164_R1.6681.00
275_L279_A1.6651.00
276_A283_L1.6641.00
374_L402_S1.6591.00
390_L404_A1.6581.00
369_G375_V1.6541.00
306_A415_C1.6521.00
102_D185_K1.6421.00
234_L238_L1.6241.00
358_A414_T1.6231.00
264_P268_G1.6111.00
60_M68_W1.6021.00
23_R98_S1.6011.00
246_L250_C1.5951.00
164_R168_Q1.5930.99
238_L364_T1.5810.99
366_T406_M1.5730.99
156_A160_T1.5660.99
44_V48_L1.5660.99
425_W429_K1.5600.99
117_A155_I1.5590.99
303_A362_T1.5550.99
92_A107_G1.5490.99
416_A419_Y1.5460.99
255_A301_S1.5450.99
402_S405_V1.5320.99
248_W254_G1.5270.99
242_F246_L1.5250.99
7_V11_K1.5170.99
392_S407_Q1.5100.99
306_A411_L1.5090.99
93_Y104_L1.5030.99
320_M425_W1.4970.99
165_Y169_K1.4940.99
310_T419_Y1.4770.99
374_L406_M1.4750.99
89_F111_I1.4500.99
92_A110_S1.4490.99
176_P179_V1.4440.99
113_A200_V1.4330.99
319_Q429_K1.4170.99
95_L161_E1.4060.99
28_L157_L1.4040.99
214_S217_N1.4010.99
364_T368_I1.3890.99
408_L412_L1.3880.99
305_L411_L1.3850.99
271_D275_L1.3720.98
113_A196_I1.3580.98
352_I356_I1.3530.98
166_I171_I1.3500.98
321_K325_R1.3500.98
22_Q161_E1.3460.98
390_L408_L1.3460.98
295_W370_M1.3460.98
31_G90_G1.3320.98
158_F199_L1.3310.98
24_H157_L1.3250.98
88_A152_A1.3180.98
389_P411_L1.2990.98
95_L99_Y1.2940.98
365_A369_G1.2890.98
241_E363_I1.2870.98
317_S433_E1.2860.98
296_I363_I1.2770.98
6_R10_E1.2760.98
56_Y60_M1.2750.98
431_R434_S1.2750.98
88_A156_A1.2700.97
350_L424_I1.2700.97
289_T293_Q1.2610.97
171_I195_I1.2600.97
172_V188_V1.2590.97
31_G94_R1.2580.97
367_Y371_S1.2540.97
221_D225_T1.2490.97
340_I355_F1.2490.97
288_T379_A1.2460.97
311_M343_M1.2380.97
87_A149_L1.2360.97
320_M429_K1.2330.97
276_A281_E1.2310.97
76_V81_D1.2270.97
38_L86_I1.2250.97
310_T324_G1.2240.97
317_S430_W1.2240.97
68_W72_L1.2230.97
210_T213_Q1.2220.97
277_F380_G1.2180.97
365_A410_N1.2040.96
54_P58_D1.1970.96
331_A336_N1.1960.96
112_A197_V1.1920.96
276_A280_G1.1880.96
142_T147_K1.1860.96
34_L90_G1.1800.96
400_K403_G1.1790.96
45_F75_P1.1740.96
269_A285_S1.1590.96
309_L415_C1.1580.96
118_T216_H1.1570.96
318_K322_Q1.1530.96
35_T90_G1.1450.95
299_G305_L1.1410.95
42_G79_S1.1400.95
283_L380_G1.1400.95
276_A282_A1.1390.95
50_S73_G1.1380.95
88_A92_A1.1330.95
276_A279_A1.1310.95
175_M179_V1.1290.95
162_I196_I1.1250.95
88_A107_G1.1230.95
7_V14_P1.1180.95
274_R278_Q1.1130.95
275_L278_Q1.1120.95
387_M395_L1.1070.94
323_L327_G1.1070.94
75_P201_W1.1060.94
322_Q325_R1.1020.94
101_V164_R1.1010.94
151_V216_H1.0710.93
109_I193_G1.0690.93
23_R161_E1.0660.93
308_V324_G1.0610.93
8_M424_I1.0600.93
423_R426_D1.0590.93
271_D274_R1.0510.93
40_I190_L1.0500.93
152_A156_A1.0430.92
299_G302_G1.0410.92
389_P407_Q1.0370.92
158_F200_V1.0360.92
85_M115_L1.0330.92
235_G239_I1.0320.92
310_T313_V1.0310.92
390_L407_Q1.0240.92
160_T164_R1.0210.92
31_G156_A1.0200.92
357_I361_L1.0150.91
8_M14_P1.0150.91
77_N81_D1.0110.91
101_V167_I1.0040.91
95_L160_T1.0040.91
336_N340_I1.0030.91
97_E103_A1.0000.91
358_A362_T0.9970.91
94_R97_E0.9960.91
175_M178_G0.9920.90
312_L328_I0.9910.90
302_G336_N0.9890.90
298_V303_A0.9880.90
240_A262_M0.9870.90
32_I87_A0.9850.90
355_F418_Y0.9840.90
324_G422_F0.9790.90
310_T314_R0.9750.90
410_N414_T0.9740.90
300_G304_T0.9730.90
158_F162_I0.9670.89
428_Q431_R0.9650.89
368_I371_S0.9640.89
295_W397_T0.9610.89
263_A289_T0.9580.89
303_A306_A0.9570.89
314_R415_C0.9550.89
155_I200_V0.9550.89
390_L393_G0.9520.88
272_A276_A0.9520.88
24_H99_Y0.9490.88
260_G264_P0.9480.88
93_Y103_A0.9450.88
241_E296_I0.9420.88
217_N221_D0.9400.88
27_A98_S0.9380.88
49_T73_G0.9380.88
235_G238_L0.9350.88
6_R11_K0.9340.88
426_D433_E0.9330.87
365_A409_V0.9330.87
306_A309_L0.9310.87
191_I195_I0.9300.87
31_G91_I0.9290.87
308_V311_M0.9250.87
313_V426_D0.9220.87
412_L415_C0.9180.87
109_I196_I0.9170.87
313_V419_Y0.9170.87
314_R422_F0.9130.86
135_V138_G0.9120.86
106_A163_Y0.9090.86
85_M144_L0.9060.86
89_F104_L0.9050.86
369_G373_G0.9030.86
82_I86_I0.9020.86
311_M422_F0.8980.85
31_G157_L0.8970.85
312_L324_G0.8970.85
50_S386_T0.8960.85
274_R380_G0.8940.85
339_I345_I0.8940.85
240_A258_I0.8930.85
204_R208_E0.8930.85
340_I345_I0.8930.85
36_M39_I0.8920.85
306_A310_T0.8900.85
232_G269_A0.8880.85
139_I144_L0.8870.85
230_L239_I0.8860.85
270_M290_Q0.8820.84
8_M79_S0.8780.84
49_T72_L0.8740.84
405_V409_V0.8730.84
206_L209_M0.8710.84
59_F63_V0.8710.84
375_V402_S0.8660.83
307_L418_Y0.8650.83
311_M324_G0.8630.83
114_F152_A0.8630.83
277_F280_G0.8610.83
84_A88_A0.8570.83
87_A91_I0.8520.82
58_D62_S0.8510.82
311_M331_A0.8490.82
312_L325_R0.8460.82
299_G303_A0.8460.82
426_D430_W0.8430.82
248_W253_H0.8420.81
46_L80_F0.8370.81
331_A339_I0.8370.81
30_D182_A0.8370.81
162_I199_L0.8330.81
369_G372_T0.8310.81
401_V404_A0.8280.80
35_T87_A0.8240.80
277_F284_P0.8230.80
337_E341_F0.8220.80
180_P226_P0.8160.79
103_A107_G0.8160.79
173_F176_P0.8150.79
237_S363_I0.8150.79
10_E14_P0.8140.79
30_D98_S0.8130.79
122_V138_G0.8080.79
97_E100_G0.8070.79
269_A272_A0.8040.78
173_F179_V0.8040.78
19_I25_L0.8040.78
159_S196_I0.8030.78
334_N385_W0.8020.78
422_F426_D0.8010.78
307_L422_F0.8000.78
113_A159_S0.7980.78
369_G409_V0.7960.78
245_M301_S0.7960.78
161_E165_Y0.7950.78
162_I195_I0.7910.77
154_L219_V0.7900.77
53_I56_Y0.7900.77
78_A115_L0.7890.77
350_L428_Q0.7860.77
253_H337_E0.7850.77
383_V396_A0.7840.77
419_Y422_F0.7820.76
306_A416_A0.7820.76
115_L144_L0.7790.76
184_S188_V0.7770.76
180_P338_P0.7760.76
295_W366_T0.7740.76
406_M409_V0.7720.76
291_F366_T0.7720.76
375_V403_G0.7710.75
404_A407_Q0.7710.75
424_I428_Q0.7690.75
85_M111_I0.7690.75
155_I159_S0.7670.75
114_F144_L0.7670.75
409_V412_L0.7650.75
299_G336_N0.7620.75
205_L209_M0.7580.74
311_M320_M0.7570.74
286_I370_M0.7570.74
300_G336_N0.7550.74
101_V168_Q0.7540.74
411_L415_C0.7530.74
175_M187_F0.7510.74
298_V305_L0.7510.74
51_L56_Y0.7500.73
358_A413_I0.7480.73
143_L217_N0.7460.73
199_L202_L0.7450.73
245_M297_N0.7450.73
17_G21_G0.7440.73
238_L242_F0.7410.73
58_D61_A0.7370.72
375_V400_K0.7360.72
327_G339_I0.7360.72
313_V324_G0.7350.72
410_N413_I0.7310.72
46_L76_V0.7290.71
49_T75_P0.7280.71
371_S376_A0.7270.71
286_I291_F0.7250.71
308_V331_A0.7250.71
8_M12_I0.7230.71
302_G355_F0.7220.71
270_M382_A0.7220.71
25_L347_M0.7220.71
159_S200_V0.7200.70
302_G418_Y0.7200.70
394_Y398_G0.7190.70
14_P17_G0.7190.70
430_W433_E0.7150.70
413_I417_I0.7140.70
315_S320_M0.7120.70
9_E13_M0.7120.70
234_L368_I0.7120.70
21_G108_A0.7120.70
397_T400_K0.7120.70
206_L210_T0.7060.69
314_R321_K0.7060.69
390_L411_L0.7050.69
15_V19_I0.7050.69
151_V155_I0.7020.68
114_F118_T0.7010.68
74_Y204_R0.6960.68
262_M266_W0.6960.68
22_Q99_Y0.6940.68
86_I112_A0.6900.67
69_A73_G0.6890.67
305_L331_A0.6890.67
23_R27_A0.6880.67
267_Y271_D0.6880.67
171_I191_I0.6870.67
167_I172_V0.6840.66
357_I417_I0.6840.66
186_S190_L0.6820.66
432_E435_A0.6790.66
295_W375_V0.6790.66
25_L29_R0.6770.66
111_I144_L0.6770.66
362_T366_T0.6770.66
30_D94_R0.6740.65
393_G404_A0.6730.65
96_A160_T0.6670.64
305_L332_L0.6650.64
226_P338_P0.6650.64
320_M351_L0.6640.64
106_A160_T0.6640.64
56_Y59_F0.6630.64
359_P418_Y0.6630.64
269_A288_T0.6620.64
11_K14_P0.6600.64
170_N174_K0.6580.63
188_V191_I0.6560.63
32_I47_I0.6560.63
6_R9_E0.6540.63
340_I346_V0.6540.63
91_I157_L0.6530.63
180_P187_F0.6490.62
92_A96_A0.6480.62
320_M324_G0.6480.62
248_W347_M0.6470.62
193_G197_V0.6460.62
27_A31_G0.6450.62
309_L353_V0.6450.62
308_V422_F0.6440.62
82_I85_M0.6430.62
287_F367_Y0.6420.62
46_L49_T0.6420.62
5_T352_I0.6420.62
328_I332_L0.6420.62
27_A95_L0.6410.61
19_I364_T0.6390.61
317_S320_M0.6390.61
374_L409_V0.6360.61
31_G87_A0.6360.61
281_E284_P0.6350.61
415_C419_Y0.6350.61
311_M339_I0.6340.61
357_I360_L0.6330.60
223_L247_L0.6300.60
245_M355_F0.6300.60
230_L331_A0.6290.60
324_G327_G0.6280.60
237_S292_F0.6280.60
300_G418_Y0.6270.60
50_S53_I0.6260.60
244_Q297_N0.6250.59
319_Q426_D0.6240.59
10_E242_F0.6230.59
180_P183_V0.6220.59
286_I367_Y0.6210.59
236_G250_C0.6210.59
177_D181_P0.6210.59
253_H256_S0.6200.59
25_L266_W0.6200.59
33_I364_T0.6180.59
323_L339_I0.6180.59
22_Q95_L0.6160.58
156_A159_S0.6150.58
194_F198_L0.6150.58
185_K188_V0.6130.58
303_A414_T0.6130.58
106_A159_S0.6130.58
167_I170_N0.6120.58
290_Q379_A0.6110.58
238_L363_I0.6100.58
360_L364_T0.6100.58
376_A403_G0.6100.58
178_G329_G0.6100.58
8_M11_K0.6090.58
236_G249_S0.6080.57
301_S355_F0.6050.57
228_S268_G0.6050.57
376_A404_A0.6040.57
176_P180_P0.5980.56
354_P421_F0.5980.56
89_F92_A0.5970.56
210_T218_V0.5970.56
424_I427_H0.5970.56
225_T229_I0.5950.56
253_H341_F0.5940.56
317_S324_G0.5920.55
26_S29_R0.5910.55
71_K201_W0.5910.55
419_Y423_R0.5870.55
114_F145_G0.5870.55
40_I384_P0.5860.55
423_R430_W0.5860.55
183_V384_P0.5850.55
222_L405_V0.5850.55
308_V328_I0.5850.55
413_I416_A0.5820.54
404_A408_L0.5810.54
361_L365_A0.5800.54
313_V415_C0.5760.53
241_E292_F0.5730.53
345_I355_F0.5680.52
248_W337_E0.5680.52
56_Y63_V0.5670.52
114_F162_I0.5670.52
166_I170_N0.5670.52
180_P264_P0.5660.52
270_M288_T0.5650.52
76_V80_F0.5640.52
29_R102_D0.5640.52
90_G94_R0.5620.52
423_R427_H0.5610.51
16_A22_Q0.5610.51
316_R423_R0.5600.51
290_Q293_Q0.5600.51
387_M393_G0.5570.51
230_L236_G0.5570.51
351_L418_Y0.5570.51
60_M403_G0.5570.51
308_V312_L0.5550.51
73_G76_V0.5540.51
314_R325_R0.5540.51
249_S349_P0.5530.50
237_S287_F0.5520.50
309_L332_L0.5520.50
116_L197_V0.5510.50
239_I311_M0.5500.50
380_G398_G0.5490.50
336_N355_F0.5480.50
254_G359_P0.5470.50
101_V160_T0.5470.50
219_V225_T0.5460.50
29_R33_I0.5460.50
379_A397_T0.5460.50
254_G355_F0.5460.50
190_L384_P0.5450.49
162_I200_V0.5450.49
22_Q27_A0.5450.49
82_I115_L0.5440.49
174_K177_D0.5440.49
327_G331_A0.5440.49
329_G352_I0.5430.49
117_A200_V0.5420.49
84_A145_G0.5410.49
313_V325_R0.5400.49
304_T327_G0.5390.49
92_A160_T0.5390.49
311_M323_L0.5390.49
183_V186_S0.5380.49
48_L199_L0.5370.48
315_S319_Q0.5360.48
20_A25_L0.5350.48
134_M137_G0.5350.48
100_G281_E0.5330.48
172_V185_K0.5320.48
178_G318_K0.5300.48
57_A61_A0.5290.47
370_M375_V0.5290.47
53_I58_D0.5270.47
215_L218_V0.5270.47
334_N386_T0.5270.47
295_W403_G0.5270.47
228_S236_G0.5270.47
306_A418_Y0.5260.47
25_L314_R0.5250.47
7_V10_E0.5250.47
63_V68_W0.5250.47
163_Y189_A0.5250.47
295_W396_A0.5240.47
10_E357_I0.5240.47
299_G307_L0.5210.46
11_K316_R0.5200.46
256_S263_A0.5200.46
425_W428_Q0.5190.46
72_L201_W0.5190.46
302_G307_L0.5180.46
248_W301_S0.5180.46
54_P57_A0.5180.46
8_M332_L0.5170.46
268_G271_D0.5170.46
218_V223_L0.5170.46
201_W205_L0.5160.46
83_M267_Y0.5160.46
162_I166_I0.5160.46
157_L161_E0.5150.46
57_A60_M0.5150.46
229_I239_I0.5150.46
320_M422_F0.5150.46
92_A378_P0.5150.46
291_F370_M0.5130.45
279_A282_A0.5130.45
201_W204_R0.5130.45
302_G359_P0.5130.45
359_P411_L0.5130.45
234_L286_I0.5130.45
398_G404_A0.5130.45
389_P404_A0.5120.45
143_L216_H0.5110.45
48_L165_Y0.5110.45
21_G26_S0.5100.45
248_W341_F0.5100.45
95_L164_R0.5100.45
355_F359_P0.5090.45
175_M180_P0.5080.45
42_G189_A0.5070.45
23_R40_I0.5070.45
385_W389_P0.5060.45
332_L434_S0.5060.45
158_F353_V0.5050.44
299_G304_T0.5050.44
97_E102_D0.5040.44
18_K21_G0.5040.44
370_M403_G0.5040.44
146_S150_F0.5030.44
43_S80_F0.5030.44
290_Q294_I0.5020.44
70_D85_M0.5010.44
34_L94_R0.5010.44
78_A116_L0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qnqA 2 0.9797 100 0.293 Contact Map
3ne5A 3 0.3536 20.8 0.975 Contact Map
2kncB 1 0.1306 14.4 0.977 Contact Map
3mktA 1 0.3716 13.2 0.977 Contact Map
4lz6A 1 0.3446 13.2 0.977 Contact Map
2kncA 1 0.1171 12.5 0.977 Contact Map
2rddB 1 0.0833 10.2 0.978 Contact Map
4mt1A 3 0.3423 9.6 0.979 Contact Map
3w4tA 1 0.3378 8 0.979 Contact Map
2kluA 1 0.1216 7.3 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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