GREMLIN Database
YWAC - GTP pyrophosphokinase YwaC
UniProt: P39583 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 210 (180)
Sequences: 5167 (3159)
Seq/√Len: 235.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_F100_D3.6781.00
96_S160_I3.2071.00
14_V17_D2.7951.00
67_N71_R2.7081.00
56_K163_D2.6751.00
94_I160_I2.5511.00
54_H160_I2.5151.00
100_D103_N2.5111.00
115_R139_E2.4721.00
40_S44_N2.4691.00
46_I49_H2.3261.00
53_E96_S2.2171.00
20_N24_V2.1921.00
95_C104_V2.1571.00
109_K119_V2.1071.00
29_L59_V2.1001.00
17_D20_N2.0961.00
189_K193_E2.0511.00
43_Y108_L2.0351.00
46_I111_H1.9721.00
138_I155_I1.9341.00
102_Y124_Q1.7901.00
105_V109_K1.7861.00
19_K22_L1.7831.00
187_E201_K1.7801.00
139_E150_Y1.7781.00
133_S158_R1.7771.00
33_D37_S1.7241.00
96_S100_D1.7191.00
22_L62_F1.7091.00
39_I153_A1.6961.00
29_L33_D1.6771.00
34_T38_I1.6731.00
99_S103_N1.6541.00
86_H152_K1.5991.00
105_V134_L1.5801.00
74_C85_I1.5631.00
74_C84_H1.5581.00
38_I149_E1.5521.00
160_I164_F1.5511.00
109_K136_L1.5301.00
28_A31_A1.5281.00
108_L155_I1.4901.00
105_V119_V1.4431.00
65_I85_I1.4341.00
75_E83_E1.4301.00
23_L27_F1.4101.00
187_E190_E1.3701.00
21_E62_F1.3681.00
163_D167_S1.3671.00
105_V136_L1.3651.00
190_E197_Y1.3281.00
25_Y62_F1.3101.00
45_L49_H1.2861.00
24_V76_I1.2851.00
44_N48_G1.2821.00
102_Y106_N1.2761.00
41_Q45_L1.2671.00
66_V70_M1.2581.00
64_S175_K1.2581.00
173_Y185_T1.2551.00
104_V107_V1.2401.00
138_I153_A1.2381.00
27_F151_V1.2361.00
37_S40_S1.2301.00
41_Q44_N1.2231.00
106_N109_K1.2081.00
182_K186_D1.1811.00
10_D14_V1.1771.00
132_R165_W1.1751.00
197_Y201_K1.1731.00
47_H104_V1.1611.00
92_R156_Q1.1591.00
63_E67_N1.1501.00
108_L138_I1.1421.00
109_K116_I1.1401.00
161_A164_F1.1381.00
36_F57_S1.1301.00
190_E198_L1.1271.00
19_K23_L1.1261.00
9_D12_K1.1211.00
42_E112_E1.1191.00
118_K137_I1.1121.00
182_K185_T1.1111.00
46_I107_V1.1041.00
22_L26_K1.0881.00
35_K140_M1.0851.00
11_L22_L1.0691.00
60_K156_Q1.0561.00
195_A198_L1.0541.00
58_R90_G1.0491.00
183_Q186_D1.0421.00
190_E201_K1.0351.00
102_Y121_D1.0291.00
119_V136_L1.0281.00
43_Y155_I1.0081.00
92_R158_R0.9921.00
46_I50_N0.9741.00
193_E197_Y0.9701.00
95_C100_D0.9691.00
139_E152_K0.9451.00
15_M19_K0.9371.00
187_E197_Y0.9311.00
60_K68_K0.9271.00
60_K90_G0.9241.00
44_N54_H0.9231.00
185_T192_A0.9191.00
30_D33_D0.9101.00
23_L26_K0.9091.00
190_E194_I0.9061.00
38_I42_E0.9001.00
26_K41_Q0.8960.99
194_I197_Y0.8950.99
115_R119_V0.8940.99
18_W22_L0.8940.99
103_N106_N0.8830.99
189_K192_A0.8800.99
60_K92_R0.8760.99
186_D189_K0.8760.99
130_G165_W0.8740.99
89_A151_V0.8650.99
39_I91_V0.8590.99
102_Y123_I0.8560.99
42_E111_H0.8500.99
184_L199_D0.8450.99
187_E193_E0.8440.99
28_A32_L0.8370.99
32_L59_V0.8350.99
89_A153_A0.8320.99
122_Y127_K0.8280.99
35_K89_A0.8280.99
129_N162_M0.8270.99
10_D17_D0.8230.99
21_E24_V0.8170.99
64_S133_S0.8170.99
194_I198_L0.8140.99
120_K137_I0.8110.99
59_V62_F0.8100.99
68_K156_Q0.8070.99
60_K154_E0.8070.99
69_L76_I0.8070.99
68_K154_E0.7980.99
173_Y192_A0.7910.99
101_I123_I0.7810.99
48_G53_E0.7790.99
192_A195_A0.7760.99
58_R175_K0.7680.98
96_S171_K0.7680.98
40_S91_V0.7630.98
104_V157_I0.7540.98
60_K87_D0.7460.98
93_I157_I0.7450.98
114_L124_Q0.7430.98
58_R174_Y0.7420.98
42_E46_I0.7420.98
64_S166_A0.7410.98
21_E65_I0.7400.98
90_G156_Q0.7380.98
68_K174_Y0.7370.98
37_S41_Q0.7240.98
123_I127_K0.7170.98
58_R154_E0.7170.98
161_A165_W0.7080.97
75_E84_H0.7030.97
30_D37_S0.6990.97
68_K90_G0.6990.97
194_I201_K0.6980.97
102_Y109_K0.6950.97
121_D126_P0.6860.97
184_L188_L0.6860.97
68_K92_R0.6840.97
21_E69_L0.6830.97
35_K141_P0.6810.97
181_P184_L0.6800.97
102_Y122_Y0.6800.97
122_Y132_R0.6790.97
113_D125_T0.6770.97
16_E19_K0.6740.96
187_E192_A0.6690.96
106_N110_Q0.6680.96
122_Y126_P0.6670.96
73_G149_E0.6640.96
50_N107_V0.6630.96
184_L187_E0.6620.96
193_E200_E0.6620.96
171_K175_K0.6600.96
93_I104_V0.6570.96
89_A137_I0.6560.96
60_K174_Y0.6540.96
25_Y65_I0.6490.96
113_D139_E0.6480.96
24_V28_A0.6440.95
90_G174_Y0.6420.95
36_F59_V0.6400.95
29_L62_F0.6400.95
38_I41_Q0.6400.95
11_L19_K0.6350.95
131_Y135_H0.6340.95
137_I152_K0.6320.95
87_D156_Q0.6320.95
190_E196_H0.6220.95
14_V19_K0.6220.95
26_K30_D0.6200.94
92_R154_E0.6200.94
40_S57_S0.6150.94
63_E66_V0.6100.94
106_N124_Q0.6020.94
92_R174_Y0.6000.93
191_A197_Y0.5950.93
40_S55_T0.5940.93
141_P149_E0.5940.93
171_K174_Y0.5900.93
35_K39_I0.5890.93
102_Y134_L0.5880.93
86_H118_K0.5870.93
154_E174_Y0.5830.92
71_R74_C0.5830.92
98_I110_Q0.5810.92
39_I152_K0.5780.92
87_D90_G0.5780.92
169_E172_I0.5740.92
87_D92_R0.5740.92
103_N107_V0.5720.92
102_Y105_V0.5710.92
101_I157_I0.5650.91
69_L74_C0.5650.91
105_V157_I0.5640.91
43_Y47_H0.5630.91
27_F31_A0.5610.91
36_F91_V0.5610.91
191_A195_A0.5570.91
10_D62_F0.5560.91
123_I129_N0.5560.91
165_W188_L0.5540.90
98_I132_R0.5480.90
36_F89_A0.5470.90
188_L192_A0.5460.90
56_K167_S0.5450.90
68_K175_K0.5450.90
187_E194_I0.5450.90
67_N70_M0.5410.89
188_L199_D0.5400.89
168_L172_I0.5390.89
121_D129_N0.5340.89
98_I159_T0.5330.89
136_L157_I0.5310.88
191_A194_I0.5290.88
65_I88_I0.5290.88
197_Y200_E0.5290.88
117_V152_K0.5260.88
32_L153_A0.5240.88
11_L18_W0.5230.88
180_V184_L0.5230.88
101_I105_V0.5230.88
193_E199_D0.5230.88
30_D34_T0.5220.88
35_K151_V0.5180.87
20_N70_M0.5180.87
53_E176_L0.5170.87
20_N23_L0.5170.87
53_E100_D0.5160.87
27_F149_E0.5130.87
72_K76_I0.5100.86
56_K94_I0.5080.86
101_I134_L0.5060.86
123_I162_M0.5060.86
180_V183_Q0.5030.86
107_V110_Q0.5020.86
68_K87_D0.5000.85
90_G154_E0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vj7A 1 0.7857 100 0.189 Contact Map
3l9dA 1 0.9048 100 0.223 Contact Map
2be3A 2 0.9286 100 0.238 Contact Map
2dgkA 3 0.6238 12.1 0.951 Contact Map
3j3wN 1 0.5524 11.1 0.952 Contact Map
3d7aA 2 0.5286 11 0.952 Contact Map
4otnA 2 0.3667 10.9 0.953 Contact Map
1fg7A 2 0.519 7.5 0.956 Contact Map
3k66A 1 0.381 7.4 0.956 Contact Map
3f9tA 2 0.4905 7.2 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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