MENA - BACSU - GREMLIN Contacts

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MENA - 1,4-dihydroxy-2-naphthoate octaprenyltransferase

UniProt:	P39582	Sequences: MNQTNKGEGQTAPQKESMGQILWQLTRPHTLTASFVPVLLGTVLAMFYVKVDLLLFLAMLFSCLWIQIATNLFNEYYDFKRGLDTAESVGIGGAIVRHGMKPKTILQLALASYGIAILLGVYICASSSWWLALIGLVGMAIGYLYTGGPLPIAYTPFGELFSGICMGSVFVLISFFIQTDKINMQSILISIPIAILVGAINLSNNIRDIEEDKKGGRKTLAILMGHKGAVTLLAASFAVAYIWVVGLVITGAASPWLFVVFLSVPKPVQAVKGFVQNEMPMNMIVAMKSTAQTNTFFGFLLSIGLLISYFR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	311 (275)
Sequences:	9277 (6660)
Seq/√Len:	401.6

ECOLI - MENA CYOE UBIA
BACSU - MENA COXX1 COXX2
HALSA - Q9HQN6 LYEL DGGGP COXX
SULSO - COXX Q980Z2 DGGGP

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
79_F	102_P	3.767	1.00
76_Y	102_P	3.723	1.00
69_A	113_Y	3.267	1.00
227_K	231_T	3.125	1.00
18_M	104_T	3.040	1.00
103_K	107_Q	3.005	1.00
76_Y	106_L	2.973	1.00
21_I	99_G	2.835	1.00
101_K	104_T	2.730	1.00
24_Q	99_G	2.311	1.00
210_E	213_K	2.277	1.00
42_T	56_F	2.224	1.00
209_I	213_K	2.220	1.00
86_A	91_I	2.183	1.00
72_L	112_S	2.091	1.00
290_T	294_N	2.083	1.00
279_M	282_N	2.067	1.00
110_L	114_G	2.040	1.00
272_K	276_Q	2.034	1.00
121_V	129_W	2.033	1.00
65_W	115_I	2.026	1.00
58_A	119_L	1.929	1.00
66_I	116_A	1.925	1.00
22_L	104_T	1.917	1.00
31_L	64_L	1.888	1.00
81_R	217_R	1.873	1.00
129_W	133_L	1.863	1.00
269_Q	273_G	1.856	1.00
128_S	131_L	1.840	1.00
289_S	293_T	1.837	1.00
107_Q	111_A	1.815	1.00
224_M	228_G	1.805	1.00
228_G	231_T	1.803	1.00
268_V	272_K	1.796	1.00
77_Y	147_G	1.776	1.00
288_K	292_Q	1.739	1.00
287_M	291_A	1.731	1.00
289_S	292_Q	1.722	1.00
20_Q	24_Q	1.710	1.00
231_T	235_A	1.710	1.00
183_N	186_S	1.673	1.00
213_K	222_I	1.663	1.00
58_A	122_Y	1.654	1.00
39_L	60_L	1.642	1.00
76_Y	105_I	1.633	1.00
264_V	267_P	1.630	1.00
287_M	290_T	1.619	1.00
100_M	105_I	1.598	1.00
121_V	132_A	1.562	1.00
172_L	190_S	1.555	1.00
156_P	223_L	1.547	1.00
72_L	108_L	1.543	1.00
131_L	176_F	1.534	1.00
68_I	112_S	1.525	1.00
241_Y	263_S	1.513	1.00
287_M	294_N	1.511	1.00
153_A	217_R	1.505	1.00
148_G	155_T	1.500	1.00
221_A	229_A	1.492	1.00
289_S	294_N	1.478	1.00
22_L	108_L	1.470	1.00
113_Y	139_M	1.466	1.00
33_A	200_I	1.443	1.00
293_T	297_F	1.440	1.00
65_W	116_A	1.437	1.00
294_N	298_G	1.431	1.00
271_V	275_V	1.426	1.00
78_D	154_Y	1.419	1.00
209_I	226_H	1.404	1.00
106_L	110_L	1.403	1.00
65_W	112_S	1.388	1.00
238_A	242_I	1.377	1.00
83_L	96_V	1.371	1.00
133_L	137_V	1.364	1.00
52_D	55_L	1.356	1.00
102_P	106_L	1.346	1.00
268_V	271_V	1.345	1.00
283_M	287_M	1.342	1.00
290_T	298_G	1.342	1.00
266_K	273_G	1.337	1.00
260_V	263_S	1.332	1.00
209_I	222_I	1.324	1.00
22_L	26_T	1.308	1.00
291_A	295_T	1.303	1.00
141_I	165_C	1.295	1.00
72_L	109_A	1.295	1.00
73_F	109_A	1.294	1.00
26_T	72_L	1.290	1.00
26_T	112_S	1.290	1.00
265_P	269_Q	1.288	1.00
23_W	26_T	1.273	1.00
270_A	273_G	1.271	1.00
291_A	294_N	1.268	1.00
103_K	106_L	1.259	1.00
118_L	122_Y	1.251	1.00
26_T	68_I	1.249	1.00
159_E	219_T	1.234	1.00
81_R	154_Y	1.233	1.00
95_I	105_I	1.226	1.00
192_P	243_W	1.218	1.00
25_L	105_I	1.217	1.00
266_K	269_Q	1.216	1.00
208_D	212_D	1.207	1.00
120_G	135_G	1.194	1.00
226_H	230_V	1.189	1.00
85_T	211_E	1.184	1.00
19_G	23_W	1.178	1.00
288_K	291_A	1.175	1.00
79_F	83_L	1.174	1.00
195_I	236_S	1.173	1.00
272_K	275_V	1.173	1.00
62_S	119_L	1.167	1.00
265_P	272_K	1.153	1.00
26_T	108_L	1.153	1.00
38_V	63_C	1.151	1.00
41_G	45_A	1.146	1.00
57_L	61_F	1.130	1.00
199_A	236_S	1.128	1.00
228_G	232_L	1.118	1.00
267_P	270_A	1.114	1.00
218_K	223_L	1.105	1.00
23_W	28_P	1.094	1.00
51_V	56_F	1.087	1.00
266_K	270_A	1.086	1.00
286_A	297_F	1.083	1.00
290_T	295_T	1.071	1.00
108_L	112_S	1.071	1.00
274_F	277_N	1.068	1.00
84_D	215_G	1.068	1.00
267_P	271_V	1.064	1.00
61_F	119_L	1.064	1.00
25_L	72_L	1.061	1.00
269_Q	272_K	1.057	1.00
187_I	191_I	1.055	1.00
175_F	186_S	1.054	1.00
42_T	178_Q	1.053	1.00
136_L	140_A	1.049	1.00
283_M	286_A	1.039	1.00
143_Y	147_G	1.037	1.00
76_Y	109_A	1.035	1.00
271_V	274_F	1.032	1.00
231_T	234_A	1.031	1.00
205_N	221_A	1.027	1.00
54_L	58_A	1.027	1.00
254_S	257_L	1.014	1.00
58_A	123_I	1.014	1.00
280_P	283_M	1.012	1.00
70_T	142_G	1.008	1.00
38_V	59_M	1.007	1.00
191_I	243_W	1.007	1.00
182_I	186_S	1.003	1.00
206_I	229_A	1.001	1.00
288_K	294_N	1.001	1.00
144_L	161_F	0.999	1.00
220_L	224_M	0.999	1.00
165_C	190_S	0.998	1.00
257_L	261_F	0.996	1.00
209_I	221_A	0.980	1.00
79_F	95_I	0.980	1.00
184_M	187_I	0.978	1.00
167_G	197_V	0.975	1.00
182_I	187_I	0.973	1.00
294_N	297_F	0.972	1.00
287_M	293_T	0.970	1.00
253_A	256_W	0.967	1.00
66_I	135_G	0.963	1.00
292_Q	297_F	0.961	1.00
285_V	289_S	0.960	1.00
248_V	258_F	0.960	1.00
94_A	98_H	0.960	1.00
72_L	100_M	0.958	1.00
256_W	260_V	0.955	1.00
153_A	159_E	0.950	1.00
281_M	285_V	0.948	1.00
162_S	201_N	0.939	1.00
264_V	268_V	0.926	1.00
53_L	57_L	0.917	1.00
262_L	265_P	0.916	1.00
117_I	121_V	0.911	1.00
202_L	232_L	0.910	1.00
181_K	185_Q	0.908	1.00
282_N	285_V	0.903	1.00
78_D	81_R	0.901	1.00
297_F	302_S	0.895	1.00
297_F	300_L	0.893	1.00
130_W	134_I	0.889	1.00
286_A	292_Q	0.888	1.00
18_M	21_I	0.888	1.00
227_K	230_V	0.884	1.00
265_P	268_V	0.882	1.00
286_A	290_T	0.881	1.00
96_V	105_I	0.872	1.00
35_F	39_L	0.871	1.00
292_Q	295_T	0.870	1.00
206_I	228_G	0.866	1.00
295_T	299_F	0.860	1.00
230_V	234_A	0.857	1.00
78_D	217_R	0.849	1.00
290_T	293_T	0.849	1.00
175_F	179_T	0.848	1.00
292_Q	298_G	0.848	1.00
172_L	186_S	0.847	1.00
183_N	187_I	0.846	1.00
34_S	67_Q	0.846	1.00
225_G	229_A	0.845	1.00
119_L	123_I	0.841	1.00
72_L	105_I	0.839	1.00
33_A	37_P	0.837	1.00
279_M	283_M	0.835	1.00
292_Q	296_F	0.832	1.00
270_A	274_F	0.831	1.00
35_F	60_L	0.829	1.00
131_L	173_I	0.828	1.00
293_T	299_F	0.827	1.00
297_F	301_L	0.827	1.00
254_S	258_F	0.824	1.00
130_W	133_L	0.821	1.00
278_E	282_N	0.821	1.00
140_A	144_L	0.816	1.00
293_T	298_G	0.816	1.00
43_V	46_M	0.814	1.00
191_I	195_I	0.807	1.00
81_R	215_G	0.801	1.00
76_Y	95_I	0.799	1.00
62_S	120_G	0.795	1.00
80_K	84_D	0.794	1.00
239_V	243_W	0.786	1.00
104_T	107_Q	0.786	1.00
287_M	297_F	0.779	1.00
234_A	238_A	0.774	1.00
291_A	297_F	0.772	1.00
67_Q	71_N	0.770	1.00
286_A	293_T	0.766	1.00
159_E	205_N	0.762	1.00
78_D	146_T	0.760	1.00
270_A	275_V	0.760	1.00
267_P	272_K	0.757	1.00
25_L	100_M	0.757	1.00
286_A	294_N	0.754	1.00
167_G	193_I	0.752	1.00
244_V	260_V	0.750	1.00
114_G	118_L	0.747	1.00
206_I	226_H	0.746	1.00
193_I	197_V	0.745	1.00
146_T	154_Y	0.743	1.00
80_K	102_P	0.739	1.00
68_I	72_L	0.739	1.00
55_L	123_I	0.737	1.00
210_E	214_K	0.734	1.00
293_T	300_L	0.732	1.00
212_D	219_T	0.728	1.00
43_V	302_S	0.727	1.00
282_N	286_A	0.726	1.00
201_N	204_N	0.723	1.00
129_W	132_A	0.721	1.00
42_T	51_V	0.721	1.00
54_L	57_L	0.720	1.00
166_M	197_V	0.720	1.00
257_L	260_V	0.718	1.00
100_M	108_L	0.718	1.00
94_A	99_G	0.717	1.00
61_F	65_W	0.715	1.00
75_E	78_D	0.713	1.00
210_E	226_H	0.711	1.00
291_A	300_L	0.708	1.00
36_V	298_G	0.708	1.00
106_L	109_A	0.707	1.00
98_H	104_T	0.704	1.00
95_I	100_M	0.700	1.00
163_G	168_S	0.699	1.00
93_G	98_H	0.697	1.00
77_Y	146_T	0.696	1.00
247_L	256_W	0.694	1.00
284_I	288_K	0.693	1.00
205_N	219_T	0.691	1.00
283_M	290_T	0.689	1.00
291_A	298_G	0.686	1.00
294_N	301_L	0.685	1.00
134_I	169_V	0.685	1.00
168_S	190_S	0.682	0.99
291_A	302_S	0.680	0.99
118_L	121_V	0.679	0.99
111_A	115_I	0.679	0.99
286_A	291_A	0.670	0.99
30_T	71_N	0.670	0.99
264_V	270_A	0.669	0.99
52_D	178_Q	0.666	0.99
81_R	84_D	0.662	0.99
259_V	263_S	0.661	0.99
73_F	143_Y	0.659	0.99
42_T	59_M	0.652	0.99
115_I	119_L	0.652	0.99
266_K	272_K	0.651	0.99
264_V	272_K	0.650	0.99
70_T	146_T	0.646	0.99
199_A	237_F	0.643	0.99
256_W	259_V	0.639	0.99
200_I	204_N	0.639	0.99
109_A	113_Y	0.637	0.99
206_I	230_V	0.637	0.99
292_Q	299_F	0.636	0.99
120_G	132_A	0.635	0.99
73_F	77_Y	0.635	0.99
85_T	88_S	0.634	0.99
74_N	146_T	0.633	0.99
204_N	207_R	0.626	0.99
288_K	295_T	0.623	0.99
266_K	271_V	0.622	0.99
69_A	112_S	0.621	0.99
267_P	274_F	0.620	0.99
158_G	162_S	0.620	0.99
75_E	94_A	0.617	0.99
44_L	175_F	0.616	0.99
46_M	51_V	0.616	0.99
171_V	174_S	0.612	0.99
45_A	175_F	0.612	0.99
248_V	255_P	0.610	0.99
167_G	194_A	0.610	0.99
286_A	289_S	0.608	0.99
275_V	278_E	0.608	0.99
278_E	281_M	0.606	0.99
69_A	143_Y	0.604	0.99
40_L	189_I	0.604	0.99
253_A	257_L	0.603	0.99
104_T	108_L	0.602	0.99
159_E	217_R	0.600	0.99
271_V	276_Q	0.599	0.99
290_T	297_F	0.599	0.99
287_M	295_T	0.598	0.99
248_V	257_L	0.596	0.99
159_E	201_N	0.596	0.99
172_L	175_F	0.594	0.99
289_S	299_F	0.594	0.99
67_Q	204_N	0.593	0.99
198_G	236_S	0.593	0.99
294_N	299_F	0.588	0.99
263_S	266_K	0.586	0.98
185_Q	250_T	0.584	0.98
285_V	288_K	0.583	0.98
96_V	99_G	0.583	0.98
80_K	83_L	0.582	0.98
243_W	246_G	0.580	0.98
268_V	275_V	0.580	0.98
128_S	134_I	0.578	0.98
93_G	96_V	0.575	0.98
76_Y	79_F	0.575	0.98
46_M	178_Q	0.573	0.98
30_T	204_N	0.572	0.98
40_L	193_I	0.568	0.98
234_A	271_V	0.567	0.98
294_N	300_L	0.566	0.98
169_V	173_I	0.564	0.98
196_L	240_A	0.564	0.98
245_V	249_I	0.564	0.98
245_V	248_V	0.564	0.98
264_V	271_V	0.563	0.98
92_G	99_G	0.562	0.98
61_F	115_I	0.559	0.98
292_Q	300_L	0.557	0.98
188_L	250_T	0.556	0.98
261_F	265_P	0.556	0.98
22_L	100_M	0.555	0.98
284_I	287_M	0.555	0.98
287_M	292_Q	0.554	0.98
113_Y	116_A	0.554	0.98
299_F	302_S	0.553	0.98
291_A	301_L	0.552	0.98
170_F	173_I	0.552	0.98
69_A	109_A	0.552	0.98
134_I	138_G	0.551	0.98
202_L	229_A	0.549	0.98
159_E	198_G	0.548	0.98
30_T	67_Q	0.547	0.98
75_E	212_D	0.547	0.98
22_L	25_L	0.547	0.98
66_I	142_G	0.546	0.98
65_W	119_L	0.543	0.98
266_K	274_F	0.542	0.97
283_M	288_K	0.541	0.97
175_F	183_N	0.539	0.97
131_L	134_I	0.538	0.97
59_M	177_I	0.537	0.97
252_A	255_P	0.535	0.97
195_I	238_A	0.535	0.97
100_M	104_T	0.535	0.97
87_E	211_E	0.535	0.97
68_I	108_L	0.534	0.97
218_K	222_I	0.532	0.97
156_P	220_L	0.531	0.97
234_A	275_V	0.531	0.97
54_L	122_Y	0.530	0.97
224_M	232_L	0.529	0.97
217_R	222_I	0.528	0.97
28_P	31_L	0.528	0.97
289_S	296_F	0.523	0.97
93_G	162_S	0.523	0.97
117_I	132_A	0.523	0.97
230_V	233_L	0.523	0.97
39_L	56_F	0.521	0.97
201_N	205_N	0.520	0.97
233_L	237_F	0.516	0.97
157_F	224_M	0.516	0.97
117_I	120_G	0.515	0.97
141_I	161_F	0.514	0.97
163_G	167_G	0.513	0.97
30_T	207_R	0.510	0.96
27_R	208_D	0.508	0.96
292_Q	302_S	0.504	0.96
148_G	156_P	0.504	0.96
82_G	153_A	0.502	0.96
73_F	110_L	0.501	0.96
288_K	293_T	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4od4A	1	0.8489	100	0.357	Contact Map
4tq3A	1	0.8939	100	0.365	Contact Map
2cfqA	1	0.6367	14.9	0.952	Contact Map
2xq2A	2	0.7653	12.6	0.953	Contact Map
3ze3A	4	0.3473	11.3	0.954	Contact Map
4xnjA	1	0.6206	8.3	0.957	Contact Map
3p8lA	2	0.7814	7.1	0.958	Contact Map
2h8oA	2	0.7653	6.7	0.959	Contact Map
3o7qA	1	0.836	6.2	0.959	Contact Map
4lfgA	2	0.8006	4.9	0.961	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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