GREMLIN Database
MENA - 1,4-dihydroxy-2-naphthoate octaprenyltransferase
UniProt: P39582 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 311 (275)
Sequences: 9277 (6660)
Seq/√Len: 401.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_F102_P3.7671.00
76_Y102_P3.7231.00
69_A113_Y3.2671.00
227_K231_T3.1251.00
18_M104_T3.0401.00
103_K107_Q3.0051.00
76_Y106_L2.9731.00
21_I99_G2.8351.00
101_K104_T2.7301.00
24_Q99_G2.3111.00
210_E213_K2.2771.00
42_T56_F2.2241.00
209_I213_K2.2201.00
86_A91_I2.1831.00
72_L112_S2.0911.00
290_T294_N2.0831.00
279_M282_N2.0671.00
110_L114_G2.0401.00
272_K276_Q2.0341.00
121_V129_W2.0331.00
65_W115_I2.0261.00
58_A119_L1.9291.00
66_I116_A1.9251.00
22_L104_T1.9171.00
31_L64_L1.8881.00
81_R217_R1.8731.00
129_W133_L1.8631.00
269_Q273_G1.8561.00
128_S131_L1.8401.00
289_S293_T1.8371.00
107_Q111_A1.8151.00
224_M228_G1.8051.00
228_G231_T1.8031.00
268_V272_K1.7961.00
77_Y147_G1.7761.00
288_K292_Q1.7391.00
287_M291_A1.7311.00
289_S292_Q1.7221.00
20_Q24_Q1.7101.00
231_T235_A1.7101.00
183_N186_S1.6731.00
213_K222_I1.6631.00
58_A122_Y1.6541.00
39_L60_L1.6421.00
76_Y105_I1.6331.00
264_V267_P1.6301.00
287_M290_T1.6191.00
100_M105_I1.5981.00
121_V132_A1.5621.00
172_L190_S1.5551.00
156_P223_L1.5471.00
72_L108_L1.5431.00
131_L176_F1.5341.00
68_I112_S1.5251.00
241_Y263_S1.5131.00
287_M294_N1.5111.00
153_A217_R1.5051.00
148_G155_T1.5001.00
221_A229_A1.4921.00
289_S294_N1.4781.00
22_L108_L1.4701.00
113_Y139_M1.4661.00
33_A200_I1.4431.00
293_T297_F1.4401.00
65_W116_A1.4371.00
294_N298_G1.4311.00
271_V275_V1.4261.00
78_D154_Y1.4191.00
209_I226_H1.4041.00
106_L110_L1.4031.00
65_W112_S1.3881.00
238_A242_I1.3771.00
83_L96_V1.3711.00
133_L137_V1.3641.00
52_D55_L1.3561.00
102_P106_L1.3461.00
268_V271_V1.3451.00
283_M287_M1.3421.00
290_T298_G1.3421.00
266_K273_G1.3371.00
260_V263_S1.3321.00
209_I222_I1.3241.00
22_L26_T1.3081.00
291_A295_T1.3031.00
141_I165_C1.2951.00
72_L109_A1.2951.00
73_F109_A1.2941.00
26_T72_L1.2901.00
26_T112_S1.2901.00
265_P269_Q1.2881.00
23_W26_T1.2731.00
270_A273_G1.2711.00
291_A294_N1.2681.00
103_K106_L1.2591.00
118_L122_Y1.2511.00
26_T68_I1.2491.00
159_E219_T1.2341.00
81_R154_Y1.2331.00
95_I105_I1.2261.00
192_P243_W1.2181.00
25_L105_I1.2171.00
266_K269_Q1.2161.00
208_D212_D1.2071.00
120_G135_G1.1941.00
226_H230_V1.1891.00
85_T211_E1.1841.00
19_G23_W1.1781.00
288_K291_A1.1751.00
79_F83_L1.1741.00
195_I236_S1.1731.00
272_K275_V1.1731.00
62_S119_L1.1671.00
265_P272_K1.1531.00
26_T108_L1.1531.00
38_V63_C1.1511.00
41_G45_A1.1461.00
57_L61_F1.1301.00
199_A236_S1.1281.00
228_G232_L1.1181.00
267_P270_A1.1141.00
218_K223_L1.1051.00
23_W28_P1.0941.00
51_V56_F1.0871.00
266_K270_A1.0861.00
286_A297_F1.0831.00
290_T295_T1.0711.00
108_L112_S1.0711.00
274_F277_N1.0681.00
84_D215_G1.0681.00
267_P271_V1.0641.00
61_F119_L1.0641.00
25_L72_L1.0611.00
269_Q272_K1.0571.00
187_I191_I1.0551.00
175_F186_S1.0541.00
42_T178_Q1.0531.00
136_L140_A1.0491.00
283_M286_A1.0391.00
143_Y147_G1.0371.00
76_Y109_A1.0351.00
271_V274_F1.0321.00
231_T234_A1.0311.00
205_N221_A1.0271.00
54_L58_A1.0271.00
254_S257_L1.0141.00
58_A123_I1.0141.00
280_P283_M1.0121.00
70_T142_G1.0081.00
38_V59_M1.0071.00
191_I243_W1.0071.00
182_I186_S1.0031.00
206_I229_A1.0011.00
288_K294_N1.0011.00
144_L161_F0.9991.00
220_L224_M0.9991.00
165_C190_S0.9981.00
257_L261_F0.9961.00
209_I221_A0.9801.00
79_F95_I0.9801.00
184_M187_I0.9781.00
167_G197_V0.9751.00
182_I187_I0.9731.00
294_N297_F0.9721.00
287_M293_T0.9701.00
253_A256_W0.9671.00
66_I135_G0.9631.00
292_Q297_F0.9611.00
285_V289_S0.9601.00
248_V258_F0.9601.00
94_A98_H0.9601.00
72_L100_M0.9581.00
256_W260_V0.9551.00
153_A159_E0.9501.00
281_M285_V0.9481.00
162_S201_N0.9391.00
264_V268_V0.9261.00
53_L57_L0.9171.00
262_L265_P0.9161.00
117_I121_V0.9111.00
202_L232_L0.9101.00
181_K185_Q0.9081.00
282_N285_V0.9031.00
78_D81_R0.9011.00
297_F302_S0.8951.00
297_F300_L0.8931.00
130_W134_I0.8891.00
286_A292_Q0.8881.00
18_M21_I0.8881.00
227_K230_V0.8841.00
265_P268_V0.8821.00
286_A290_T0.8811.00
96_V105_I0.8721.00
35_F39_L0.8711.00
292_Q295_T0.8701.00
206_I228_G0.8661.00
295_T299_F0.8601.00
230_V234_A0.8571.00
78_D217_R0.8491.00
290_T293_T0.8491.00
175_F179_T0.8481.00
292_Q298_G0.8481.00
172_L186_S0.8471.00
183_N187_I0.8461.00
34_S67_Q0.8461.00
225_G229_A0.8451.00
119_L123_I0.8411.00
72_L105_I0.8391.00
33_A37_P0.8371.00
279_M283_M0.8351.00
292_Q296_F0.8321.00
270_A274_F0.8311.00
35_F60_L0.8291.00
131_L173_I0.8281.00
293_T299_F0.8271.00
297_F301_L0.8271.00
254_S258_F0.8241.00
130_W133_L0.8211.00
278_E282_N0.8211.00
140_A144_L0.8161.00
293_T298_G0.8161.00
43_V46_M0.8141.00
191_I195_I0.8071.00
81_R215_G0.8011.00
76_Y95_I0.7991.00
62_S120_G0.7951.00
80_K84_D0.7941.00
239_V243_W0.7861.00
104_T107_Q0.7861.00
287_M297_F0.7791.00
234_A238_A0.7741.00
291_A297_F0.7721.00
67_Q71_N0.7701.00
286_A293_T0.7661.00
159_E205_N0.7621.00
78_D146_T0.7601.00
270_A275_V0.7601.00
267_P272_K0.7571.00
25_L100_M0.7571.00
286_A294_N0.7541.00
167_G193_I0.7521.00
244_V260_V0.7501.00
114_G118_L0.7471.00
206_I226_H0.7461.00
193_I197_V0.7451.00
146_T154_Y0.7431.00
80_K102_P0.7391.00
68_I72_L0.7391.00
55_L123_I0.7371.00
210_E214_K0.7341.00
293_T300_L0.7321.00
212_D219_T0.7281.00
43_V302_S0.7271.00
282_N286_A0.7261.00
201_N204_N0.7231.00
129_W132_A0.7211.00
42_T51_V0.7211.00
54_L57_L0.7201.00
166_M197_V0.7201.00
257_L260_V0.7181.00
100_M108_L0.7181.00
94_A99_G0.7171.00
61_F65_W0.7151.00
75_E78_D0.7131.00
210_E226_H0.7111.00
291_A300_L0.7081.00
36_V298_G0.7081.00
106_L109_A0.7071.00
98_H104_T0.7041.00
95_I100_M0.7001.00
163_G168_S0.6991.00
93_G98_H0.6971.00
77_Y146_T0.6961.00
247_L256_W0.6941.00
284_I288_K0.6931.00
205_N219_T0.6911.00
283_M290_T0.6891.00
291_A298_G0.6861.00
294_N301_L0.6851.00
134_I169_V0.6851.00
168_S190_S0.6820.99
291_A302_S0.6800.99
118_L121_V0.6790.99
111_A115_I0.6790.99
286_A291_A0.6700.99
30_T71_N0.6700.99
264_V270_A0.6690.99
52_D178_Q0.6660.99
81_R84_D0.6620.99
259_V263_S0.6610.99
73_F143_Y0.6590.99
42_T59_M0.6520.99
115_I119_L0.6520.99
266_K272_K0.6510.99
264_V272_K0.6500.99
70_T146_T0.6460.99
199_A237_F0.6430.99
256_W259_V0.6390.99
200_I204_N0.6390.99
109_A113_Y0.6370.99
206_I230_V0.6370.99
292_Q299_F0.6360.99
120_G132_A0.6350.99
73_F77_Y0.6350.99
85_T88_S0.6340.99
74_N146_T0.6330.99
204_N207_R0.6260.99
288_K295_T0.6230.99
266_K271_V0.6220.99
69_A112_S0.6210.99
267_P274_F0.6200.99
158_G162_S0.6200.99
75_E94_A0.6170.99
44_L175_F0.6160.99
46_M51_V0.6160.99
171_V174_S0.6120.99
45_A175_F0.6120.99
248_V255_P0.6100.99
167_G194_A0.6100.99
286_A289_S0.6080.99
275_V278_E0.6080.99
278_E281_M0.6060.99
69_A143_Y0.6040.99
40_L189_I0.6040.99
253_A257_L0.6030.99
104_T108_L0.6020.99
159_E217_R0.6000.99
271_V276_Q0.5990.99
290_T297_F0.5990.99
287_M295_T0.5980.99
248_V257_L0.5960.99
159_E201_N0.5960.99
172_L175_F0.5940.99
289_S299_F0.5940.99
67_Q204_N0.5930.99
198_G236_S0.5930.99
294_N299_F0.5880.99
263_S266_K0.5860.98
185_Q250_T0.5840.98
285_V288_K0.5830.98
96_V99_G0.5830.98
80_K83_L0.5820.98
243_W246_G0.5800.98
268_V275_V0.5800.98
128_S134_I0.5780.98
93_G96_V0.5750.98
76_Y79_F0.5750.98
46_M178_Q0.5730.98
30_T204_N0.5720.98
40_L193_I0.5680.98
234_A271_V0.5670.98
294_N300_L0.5660.98
169_V173_I0.5640.98
196_L240_A0.5640.98
245_V249_I0.5640.98
245_V248_V0.5640.98
264_V271_V0.5630.98
92_G99_G0.5620.98
61_F115_I0.5590.98
292_Q300_L0.5570.98
188_L250_T0.5560.98
261_F265_P0.5560.98
22_L100_M0.5550.98
284_I287_M0.5550.98
287_M292_Q0.5540.98
113_Y116_A0.5540.98
299_F302_S0.5530.98
291_A301_L0.5520.98
170_F173_I0.5520.98
69_A109_A0.5520.98
134_I138_G0.5510.98
202_L229_A0.5490.98
159_E198_G0.5480.98
30_T67_Q0.5470.98
75_E212_D0.5470.98
22_L25_L0.5470.98
66_I142_G0.5460.98
65_W119_L0.5430.98
266_K274_F0.5420.97
283_M288_K0.5410.97
175_F183_N0.5390.97
131_L134_I0.5380.97
59_M177_I0.5370.97
252_A255_P0.5350.97
195_I238_A0.5350.97
100_M104_T0.5350.97
87_E211_E0.5350.97
68_I108_L0.5340.97
218_K222_I0.5320.97
156_P220_L0.5310.97
234_A275_V0.5310.97
54_L122_Y0.5300.97
224_M232_L0.5290.97
217_R222_I0.5280.97
28_P31_L0.5280.97
289_S296_F0.5230.97
93_G162_S0.5230.97
117_I132_A0.5230.97
230_V233_L0.5230.97
39_L56_F0.5210.97
201_N205_N0.5200.97
233_L237_F0.5160.97
157_F224_M0.5160.97
117_I120_G0.5150.97
141_I161_F0.5140.97
163_G167_G0.5130.97
30_T207_R0.5100.96
27_R208_D0.5080.96
292_Q302_S0.5040.96
148_G156_P0.5040.96
82_G153_A0.5020.96
73_F110_L0.5010.96
288_K293_T0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4od4A 1 0.8489 100 0.357 Contact Map
4tq3A 1 0.8939 100 0.365 Contact Map
2cfqA 1 0.6367 14.9 0.952 Contact Map
2xq2A 2 0.7653 12.6 0.953 Contact Map
3ze3A 4 0.3473 11.3 0.954 Contact Map
4xnjA 1 0.6206 8.3 0.957 Contact Map
3p8lA 2 0.7814 7.1 0.958 Contact Map
2h8oA 2 0.7653 6.7 0.959 Contact Map
3o7qA 1 0.836 6.2 0.959 Contact Map
4lfgA 2 0.8006 4.9 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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