GREMLIN Database
DLTB - Protein DltB
UniProt: P39580 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 395 (367)
Sequences: 3596 (2849)
Seq/√Len: 148.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
307_K315_I4.4771.00
200_Y247_M3.7461.00
270_S275_D3.7391.00
235_S380_C3.7061.00
340_Y382_G3.4501.00
200_Y243_A3.3771.00
193_K262_E3.2601.00
344_L378_F3.1231.00
71_L142_E3.0821.00
155_F253_S3.0231.00
129_V133_M2.8991.00
19_P40_I2.8931.00
22_I36_F2.7241.00
322_M339_L2.6521.00
243_A247_M2.6171.00
199_L203_I2.6001.00
60_T150_L2.5601.00
127_K158_T2.5551.00
42_L60_T2.5521.00
38_S150_L2.5121.00
86_A132_I2.5081.00
106_P332_P2.5011.00
166_R290_D2.4761.00
66_L86_A2.3251.00
231_M380_C2.2981.00
194_I248_F2.2671.00
26_N36_F2.2631.00
336_I385_I2.2331.00
271_K275_D2.1891.00
261_P283_S2.1811.00
268_F383_F2.1641.00
189_T254_Y2.0941.00
288_F324_M2.0551.00
254_Y259_K2.0301.00
193_K250_V2.0281.00
59_F90_S2.0211.00
63_Q90_S2.0141.00
62_W89_A2.0121.00
19_P256_M2.0051.00
292_V323_L1.9991.00
315_I319_L1.9731.00
169_R286_F1.8961.00
9_F252_V1.8611.00
232_Y377_H1.8331.00
340_Y344_L1.7901.00
372_I376_F1.7741.00
282_M286_F1.7701.00
79_S138_G1.7651.00
326_V335_I1.7551.00
130_Q152_F1.7471.00
186_L259_K1.7311.00
61_I146_L1.7141.00
148_R175_Q1.7111.00
318_F339_L1.7061.00
288_F320_L1.7011.00
271_K368_T1.6981.00
101_P112_P1.6911.00
271_K371_A1.6831.00
69_G82_V1.6601.00
37_I151_Y1.6461.00
84_C88_I1.6461.00
133_M137_D1.6451.00
213_I387_S1.6411.00
145_P148_R1.6371.00
274_K349_N1.6241.00
186_L254_Y1.6231.00
34_N148_R1.6171.00
341_H379_V1.6101.00
272_N348_Y1.6071.00
297_V300_M1.6051.00
262_E265_N1.5921.00
128_G153_I1.5881.00
297_V316_G1.5791.00
215_N230_Y1.5281.00
190_G251_G1.5221.00
336_I391_F1.5131.00
303_K313_S1.5011.00
304_K313_S1.5001.00
274_K348_Y1.4921.00
173_D259_K1.4721.00
66_L82_V1.4701.00
313_S349_N1.4631.00
294_M301_T1.4631.00
24_G255_I1.4461.00
201_K241_D1.4431.00
67_I135_A1.4391.00
102_F106_P1.4241.00
194_I255_I1.4221.00
375_T379_V1.4081.00
223_K226_G1.4081.00
74_R79_S1.4061.00
63_Q128_G1.4041.00
62_W66_L1.4031.00
333_Q388_G1.3871.00
70_Y82_V1.3751.00
379_V383_F1.3691.00
67_I70_Y1.3661.00
63_Q86_A1.3601.00
321_F345_M1.3561.00
146_L150_L1.3541.00
65_L69_G1.3401.00
4_Y9_F1.3341.00
318_F342_A1.3171.00
167_Y171_V1.3111.00
294_M297_V1.3061.00
379_V382_G1.3011.00
273_I344_L1.2981.00
83_F87_V1.2941.00
216_L387_S1.2891.00
64_V68_S1.2861.00
285_S317_Y1.2821.00
101_P114_N1.2801.00
87_V92_L1.2711.00
276_F383_F1.2701.00
231_M384_Y1.2631.00
303_K315_I1.2541.00
246_T250_V1.2471.00
101_P113_H1.2361.00
42_L154_L1.2351.00
170_F174_E1.2251.00
276_F379_V1.2211.00
322_M335_I1.2181.00
273_I375_T1.2181.00
341_H382_G1.2121.00
285_S289_R1.2051.00
297_V301_T1.2041.00
212_F387_S1.2021.00
143_Q175_Q1.2011.00
265_N282_M1.1951.00
139_L168_R1.1831.00
50_L54_I1.1831.00
373_V377_H1.1791.00
187_L255_I1.1711.00
238_L268_F1.1691.00
96_L115_L1.1641.00
314_N350_F1.1621.00
43_A47_S1.1611.00
158_T165_D1.1451.00
68_S72_A1.1431.00
306_I315_I1.1431.00
54_I58_L1.1401.00
80_G136_R1.1351.00
134_E291_Y1.1351.00
321_F342_A1.1310.99
250_V262_E1.1280.99
185_D189_T1.1270.99
321_F324_M1.1260.99
46_F50_L1.1230.99
119_L160_S1.1220.99
238_L383_F1.1170.99
340_Y385_I1.1080.99
303_K307_K1.1070.99
143_Q148_R1.1020.99
266_K269_I1.0960.99
16_L256_M1.0950.99
87_V133_M1.0950.99
42_L57_C1.0890.99
293_F297_V1.0850.99
235_S376_F1.0850.99
20_T255_I1.0780.99
274_K278_N1.0780.99
91_I129_V1.0740.99
381_F385_I1.0730.99
95_F103_L1.0610.99
212_F230_Y1.0610.99
212_F216_L1.0610.99
321_F341_H1.0570.99
271_K372_I1.0560.99
127_K165_D1.0560.99
36_F40_I1.0550.99
305_W314_N1.0490.99
204_I208_I1.0470.99
216_L231_M1.0440.99
101_P105_H1.0440.99
340_Y378_F1.0430.99
296_F319_L1.0420.99
70_Y79_S1.0390.99
46_F53_V1.0380.99
71_L141_K1.0320.99
128_G149_L1.0310.99
27_G33_Y1.0290.99
101_P104_S1.0280.99
103_L326_V1.0280.99
198_F248_F1.0210.99
95_F100_W1.0200.99
208_I233_G1.0200.99
91_I292_V1.0190.99
222_N227_N1.0150.99
351_F355_N1.0120.99
190_G255_I1.0100.99
336_I339_L1.0080.99
58_L89_A1.0010.99
270_S285_S1.0010.99
376_F380_C1.0000.99
320_L324_M1.0000.99
96_L113_H0.9970.99
96_L100_W0.9970.99
377_H381_F0.9920.99
232_Y380_C0.9910.99
317_Y345_M0.9880.99
165_D261_P0.9850.99
91_I323_L0.9830.99
283_S286_F0.9830.99
210_T214_M0.9830.99
293_F300_M0.9810.99
218_A221_H0.9800.99
169_R261_P0.9740.98
382_G385_I0.9720.98
138_G141_K0.9700.98
59_F128_G0.9680.98
49_D53_V0.9630.98
368_T372_I0.9580.98
76_K79_S0.9510.98
273_I341_H0.9490.98
88_I92_L0.9490.98
39_I43_A0.9480.98
216_L230_Y0.9460.98
294_M316_G0.9450.98
300_M316_G0.9440.98
147_H151_Y0.9390.98
131_L144_L0.9380.98
121_I125_T0.9370.98
364_N367_T0.9350.98
216_L388_G0.9330.98
332_P335_I0.9320.98
228_L377_H0.9270.98
69_G72_A0.9260.98
20_T24_G0.9260.98
27_G31_Q0.9230.98
100_W115_L0.9170.98
367_T371_A0.9130.98
188_Y192_H0.9120.98
237_Y387_S0.9060.98
60_T63_Q0.9050.98
99_I330_L0.9000.97
314_N349_N0.9000.97
182_E187_L0.8990.97
296_F316_G0.8960.97
318_F346_T0.8880.97
344_L382_G0.8850.97
100_W104_S0.8830.97
225_L229_L0.8800.97
68_S144_L0.8770.97
22_I26_N0.8740.97
81_F84_C0.8720.97
294_M300_M0.8690.97
151_Y174_E0.8680.97
67_I131_L0.8670.97
376_F379_V0.8630.97
59_F63_Q0.8610.97
183_Y186_L0.8500.96
59_F125_T0.8500.96
127_K253_S0.8490.96
84_C87_V0.8460.96
324_M345_M0.8400.96
63_Q66_L0.8400.96
224_I228_L0.8390.96
324_M337_Y0.8370.96
48_H55_A0.8290.96
273_I379_V0.8210.96
20_T187_L0.8210.96
337_Y383_F0.8210.96
104_S110_H0.8200.96
59_F93_P0.8190.96
342_A346_T0.8190.96
270_S279_R0.8160.95
140_L167_Y0.8150.95
236_M376_F0.8050.95
158_T260_S0.8050.95
212_F233_G0.8040.95
378_F382_G0.8030.95
34_N258_I0.8020.95
83_F133_M0.7990.95
187_L191_I0.7930.95
35_M147_H0.7920.95
194_I252_V0.7910.95
208_I236_M0.7900.95
158_T161_S0.7860.94
209_N213_I0.7850.94
211_Y233_G0.7840.94
82_V85_G0.7830.94
165_D170_F0.7820.94
222_N230_Y0.7780.94
215_N222_N0.7780.94
140_L168_R0.7780.94
208_I212_F0.7770.94
22_I40_I0.7760.94
87_V129_V0.7750.94
28_K31_Q0.7750.94
275_D278_N0.7720.94
275_D279_R0.7690.94
35_M39_I0.7690.94
285_S320_L0.7680.94
19_P36_F0.7640.94
102_F332_P0.7640.94
106_P335_I0.7640.94
277_W328_H0.7620.93
286_F289_R0.7600.93
43_A46_F0.7600.93
305_W350_F0.7590.93
149_L153_I0.7590.93
63_Q132_I0.7580.93
300_M337_Y0.7580.93
42_L150_L0.7530.93
71_L144_L0.7510.93
381_F384_Y0.7430.93
165_D169_R0.7410.93
23_L33_Y0.7380.92
74_R138_G0.7370.92
227_N384_Y0.7330.92
219_I222_N0.7310.92
83_F136_R0.7300.92
195_F199_L0.7290.92
331_A391_F0.7270.92
213_I217_P0.7270.92
236_M240_F0.7270.92
326_V331_A0.7230.92
217_P389_K0.7190.91
15_I23_L0.7190.91
57_C61_I0.7150.91
235_S383_F0.7140.91
34_N147_H0.7130.91
293_F316_G0.7120.91
209_N237_Y0.7120.91
344_L348_Y0.7120.91
305_W353_K0.7110.91
33_Y178_W0.7110.91
314_N346_T0.7090.91
273_I348_Y0.7080.91
253_S258_I0.7040.91
201_K205_G0.7040.91
193_K247_M0.7010.90
301_T313_S0.7010.90
340_Y381_F0.7010.90
108_P112_P0.7010.90
317_Y342_A0.7000.90
60_T149_L0.6990.90
8_L47_S0.6980.90
102_F330_L0.6980.90
320_L345_M0.6970.90
348_Y352_E0.6950.90
199_L204_I0.6950.90
63_Q149_L0.6950.90
102_F335_I0.6930.90
368_T371_A0.6930.90
318_F343_V0.6920.90
10_F194_I0.6920.90
83_F132_I0.6900.90
292_V326_V0.6890.90
285_S290_D0.6860.89
301_T316_G0.6830.89
294_M337_Y0.6810.89
86_A129_V0.6740.89
153_I158_T0.6740.89
297_V337_Y0.6730.88
165_D260_S0.6730.88
341_H383_F0.6720.88
365_R368_T0.6720.88
111_P114_N0.6710.88
52_G55_A0.6700.88
41_I45_I0.6690.88
246_T249_A0.6680.88
28_K33_Y0.6680.88
204_I240_F0.6670.88
232_Y235_S0.6660.88
366_W369_I0.6650.88
24_G187_L0.6630.88
100_W113_H0.6610.88
189_T192_H0.6610.88
278_N285_S0.6590.87
161_S234_Y0.6510.87
70_Y83_F0.6510.87
345_M348_Y0.6510.87
235_S239_F0.6480.87
384_Y388_G0.6470.86
74_R78_N0.6460.86
75_Q78_N0.6440.86
194_I251_G0.6440.86
128_G132_I0.6440.86
268_F379_V0.6370.86
374_I378_F0.6370.86
301_T304_K0.6360.85
285_S321_F0.6350.85
66_L70_Y0.6320.85
318_F322_M0.6320.85
228_L384_Y0.6310.85
285_S345_M0.6290.85
207_A210_T0.6280.85
352_E356_K0.6260.85
303_K306_I0.6260.85
42_L46_F0.6250.84
87_V91_I0.6240.84
17_L21_I0.6230.84
67_I132_I0.6230.84
166_R286_F0.6210.84
353_K356_K0.6180.84
78_N81_F0.6180.84
76_K80_G0.6160.84
370_L374_I0.6150.84
155_F260_S0.6140.83
317_Y349_N0.6130.83
247_M262_E0.6130.83
285_S341_H0.6120.83
143_Q171_V0.6110.83
351_F371_A0.6100.83
18_L21_I0.6090.83
234_Y238_L0.6090.83
190_G254_Y0.6090.83
15_I19_P0.6070.83
138_G142_E0.6070.83
161_S245_Y0.6060.83
59_F124_L0.6050.83
193_K254_Y0.6040.82
60_T146_L0.6020.82
250_V259_K0.6010.82
338_G342_A0.6010.82
293_F301_T0.6000.82
26_N32_A0.5990.82
155_F258_I0.5990.82
274_K321_F0.5990.82
137_D295_R0.5960.82
67_I86_A0.5950.82
107_Q110_H0.5940.81
49_D52_G0.5930.81
37_I256_M0.5920.81
77_A80_G0.5920.81
369_I373_V0.5910.81
313_S317_Y0.5900.81
304_K307_K0.5890.81
296_F300_M0.5880.81
321_F349_N0.5880.81
234_Y268_F0.5870.81
34_N178_W0.5850.80
347_C351_F0.5840.80
77_A81_F0.5830.80
235_S268_F0.5820.80
135_A142_E0.5820.80
83_F137_D0.5810.80
80_G84_C0.5810.80
130_Q287_W0.5810.80
172_K176_K0.5790.80
268_F276_F0.5790.80
127_K260_S0.5770.80
316_G337_Y0.5770.80
246_T260_S0.5760.79
264_F267_P0.5760.79
228_L232_Y0.5740.79
81_F85_G0.5730.79
38_S41_I0.5710.79
295_R301_T0.5710.79
231_M385_I0.5700.79
345_M349_N0.5690.79
197_G251_G0.5690.79
285_S324_M0.5670.78
63_Q124_L0.5670.78
54_I57_C0.5650.78
63_Q153_I0.5640.78
184_A188_Y0.5630.78
297_V304_K0.5630.78
187_L190_G0.5620.78
369_I372_I0.5620.78
265_N275_D0.5600.77
331_A335_I0.5590.77
229_L233_G0.5590.77
15_I40_I0.5570.77
133_M287_W0.5570.77
133_M139_L0.5560.77
19_P37_I0.5550.77
278_N289_R0.5540.77
182_E186_L0.5540.77
209_N212_F0.5530.77
143_Q167_Y0.5530.77
130_Q166_R0.5520.76
215_N226_G0.5520.76
304_K315_I0.5510.76
49_D56_L0.5500.76
18_L22_I0.5490.76
349_N383_F0.5490.76
297_V302_K0.5470.76
66_L85_G0.5450.76
241_D245_Y0.5450.76
38_S147_H0.5440.75
40_I43_A0.5430.75
69_G81_F0.5430.75
61_I65_L0.5420.75
348_Y351_F0.5400.75
16_L255_I0.5380.75
232_Y236_M0.5370.75
127_K130_Q0.5370.75
7_F14_G0.5370.75
97_S124_L0.5360.74
67_I71_L0.5360.74
5_S9_F0.5360.74
122_S126_F0.5350.74
155_F170_F0.5350.74
101_P115_L0.5340.74
21_I25_L0.5340.74
333_Q391_F0.5330.74
147_H150_L0.5330.74
75_Q220_T0.5330.74
273_I345_M0.5330.74
89_A93_P0.5320.74
164_I320_L0.5320.74
131_L135_A0.5320.74
81_F92_L0.5310.74
284_L288_F0.5290.73
20_T252_V0.5280.73
41_I44_L0.5270.73
154_L158_T0.5270.73
292_V324_M0.5260.73
98_K126_F0.5260.73
239_F243_A0.5250.73
272_N275_D0.5240.73
131_L149_L0.5240.73
119_L129_V0.5230.73
348_Y371_A0.5230.73
231_M235_S0.5220.72
351_F356_K0.5220.72
317_Y320_L0.5220.72
323_L345_M0.5220.72
350_F353_K0.5210.72
189_T193_K0.5210.72
148_R171_V0.5190.72
231_M388_G0.5180.72
10_F17_L0.5170.72
56_L154_L0.5170.72
306_I313_S0.5170.72
213_I216_L0.5160.72
58_L72_A0.5150.71
334_Y383_F0.5150.71
90_S93_P0.5140.71
189_T259_K0.5140.71
135_A144_L0.5130.71
48_H324_M0.5110.71
297_V383_F0.5110.71
166_R289_R0.5100.71
186_L257_G0.5090.71
232_Y376_F0.5090.71
313_S350_F0.5090.71
389_K392_H0.5050.70
194_I198_F0.5040.70
134_E167_Y0.5040.70
64_V149_L0.5030.70
96_L103_L0.5030.70
167_Y172_K0.5020.70
117_S161_S0.5020.70
68_S71_L0.5010.69
152_F158_T0.5010.69
203_I207_A0.5010.69
62_W85_G0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4o6yA 2 0.2127 3.8 0.978 Contact Map
2i2jA 1 0.0532 3.4 0.978 Contact Map
4a2nB 1 0.1722 1.9 0.981 Contact Map
2rddB 1 0.0937 1.5 0.982 Contact Map
3si5X 1 0.0304 1.4 0.983 Contact Map
2f3yB 1 0.0456 1.2 0.983 Contact Map
1g92A 1 0.0633 1.1 0.983 Contact Map
4ue9B 1 0.0861 0.9 0.984 Contact Map
2ooaA 1 0.0911 0.9 0.984 Contact Map
3dvkB 1 0.0582 0.9 0.985 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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