GREMLIN Database
DLTD - Protein DltD
UniProt: P39578 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 392 (377)
Sequences: 343 (275)
Seq/√Len: 14.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
256_G264_N7.8061.00
257_S264_N5.2901.00
355_H358_D4.3771.00
72_L125_I4.1981.00
268_K271_K3.8201.00
145_Y150_G3.7130.99
312_V376_V3.6800.99
244_N371_K3.5960.99
376_V380_I3.4430.99
249_Q252_K3.2730.99
189_A197_K3.1590.98
381_D385_K2.9820.97
257_S268_K2.9060.97
331_R335_Y2.8610.97
124_F298_M2.8050.96
260_F316_V2.7040.95
39_S94_Y2.6060.94
263_D363_K2.5770.94
331_R334_Y2.5560.93
267_Y274_V2.5430.93
248_D371_K2.5000.93
339_N343_R2.4760.92
318_G322_D2.4380.92
78_F250_S2.4320.92
261_H359_P2.3960.91
135_G290_P2.3220.90
335_Y356_E2.3120.89
251_G370_W2.2750.89
119_G306_G2.2090.87
310_M350_A2.1820.86
170_R294_D2.1570.86
339_N351_D2.1430.85
266_V366_I2.1140.84
78_F246_L2.1020.84
302_L309_P2.1010.84
106_H117_L2.0880.84
318_G357_Y2.0570.83
292_Y334_Y2.0460.82
84_F91_F1.9970.81
169_K386_T1.9800.80
236_K279_G1.9680.80
6_F10_I1.8960.77
74_R366_I1.8710.76
261_H319_K1.8370.75
254_H263_D1.8160.74
64_L91_F1.8150.74
331_R356_E1.8150.74
299_L347_F1.7990.73
72_L99_G1.7820.72
279_G282_K1.7740.72
92_T110_F1.7710.72
331_R357_Y1.7550.71
8_P347_F1.7520.71
352_F361_F1.7160.69
126_V312_V1.6970.69
241_S259_D1.6890.68
50_G148_L1.6770.68
223_E227_P1.6670.67
37_K58_L1.6560.67
101_S136_S1.6470.66
355_H375_Y1.6340.66
316_V331_R1.6090.64
122_I307_A1.5670.62
252_K336_K1.5550.62
132_I279_G1.5530.61
292_Y320_W1.5380.61
102_Q368_I1.5300.60
83_Y89_E1.5190.60
253_R329_K1.4710.57
271_K343_R1.4690.57
155_F205_A1.4440.56
138_E162_E1.4420.56
63_Y94_Y1.4360.55
302_L307_A1.4260.55
129_Q370_W1.4150.54
266_V362_M1.4050.54
107_S111_A1.4010.53
71_E97_G1.3980.53
124_F295_F1.3960.53
253_R256_G1.3870.53
31_I124_F1.3830.52
109_N112_A1.3820.52
258_N264_N1.3520.51
116_Q272_P1.3510.51
116_Q329_K1.3440.50
47_M238_K1.3440.50
142_A145_Y1.3250.49
244_N378_K1.3200.49
243_L247_A1.3180.49
243_L324_T1.3070.48
50_G53_L1.3040.48
69_S258_N1.3010.48
358_D371_K1.2960.48
21_A262_I1.2880.47
106_H260_F1.2850.47
23_P63_Y1.2810.47
327_P330_G1.2770.47
67_Y110_F1.2760.47
119_G204_A1.2650.46
121_K327_P1.2580.46
368_I376_V1.2530.45
311_F347_F1.2520.45
127_S130_W1.2510.45
341_Q347_F1.2390.45
102_Q121_K1.2320.44
79_H296_E1.2230.44
218_Y380_I1.2230.44
364_D367_H1.2150.43
219_Y295_F1.2140.43
343_R349_V1.2120.43
202_K272_P1.2120.43
299_L346_G1.2060.43
287_A333_D1.2030.43
58_L384_Y1.1980.42
10_I332_T1.1970.42
253_R276_K1.1900.42
241_S329_K1.1830.42
66_I93_P1.1710.41
117_L251_G1.1700.41
174_F307_A1.1620.40
299_L369_G1.1550.40
251_G360_Y1.1530.40
104_L153_L1.1510.40
97_G130_W1.1500.40
211_M267_Y1.1440.40
335_Y353_S1.1370.39
103_S128_P1.1330.39
297_M359_P1.1320.39
59_K329_K1.1310.39
157_D160_D1.1290.39
96_V360_Y1.1290.39
108_L144_N1.1230.38
128_P338_V1.1220.38
204_A268_K1.1210.38
223_E229_R1.1190.38
361_F383_F1.1180.38
98_K335_Y1.1150.38
19_A23_P1.1040.37
47_M94_Y1.1040.37
320_W370_W1.0870.37
14_I237_D1.0850.36
263_D268_K1.0800.36
148_L212_L1.0770.36
23_P171_M1.0760.36
115_D249_Q1.0740.36
260_F339_N1.0720.36
319_K359_P1.0710.36
8_P346_G1.0680.36
119_G165_K1.0670.36
78_F247_A1.0660.36
79_H93_P1.0640.35
106_H251_G1.0640.35
10_I232_S1.0630.35
54_Q57_M1.0620.35
263_D352_F1.0580.35
216_D311_F1.0540.35
81_S95_L1.0520.35
67_Y99_G1.0510.35
11_L326_F1.0460.35
280_K284_R1.0440.34
84_F299_L1.0420.34
17_A59_K1.0410.34
281_N324_T1.0410.34
308_E363_K1.0360.34
213_E236_K1.0350.34
224_S227_P1.0350.34
74_R341_Q1.0320.34
79_H286_Y1.0300.34
15_L19_A1.0290.34
141_F145_Y1.0290.34
101_S171_M1.0220.33
66_I380_I1.0220.33
62_T173_R1.0200.33
36_V72_L1.0100.33
16_F19_A1.0090.33
108_L338_V1.0070.33
123_V310_M1.0070.33
36_V167_M1.0050.33
177_V307_A1.0040.32
364_D373_W0.9960.32
366_I369_G0.9960.32
143_P174_F0.9880.32
154_A196_W0.9870.32
331_R358_D0.9770.31
89_E384_Y0.9760.31
280_K324_T0.9720.31
148_L216_D0.9680.31
312_V351_D0.9650.31
361_F375_Y0.9640.31
181_A264_N0.9620.30
5_F9_I0.9610.30
266_V369_G0.9610.30
122_I298_M0.9600.30
8_P63_Y0.9540.30
65_P94_Y0.9490.30
295_F333_D0.9470.30
160_D164_K0.9460.30
326_F337_K0.9430.30
53_L112_A0.9420.30
302_L311_F0.9400.29
162_E254_H0.9380.29
189_A201_L0.9310.29
296_E300_D0.9310.29
114_M368_I0.9290.29
359_P374_V0.9250.29
222_T312_V0.9210.29
130_W291_E0.9200.29
67_Y298_M0.9200.29
19_A267_Y0.9160.28
320_W337_K0.9150.28
341_Q366_I0.9120.28
362_M366_I0.9110.28
154_A190_M0.9080.28
74_R123_V0.9030.28
286_Y365_T0.9020.28
57_M94_Y0.8990.28
282_K385_K0.8980.28
128_P135_G0.8960.28
296_E311_F0.8960.28
201_L204_A0.8960.28
99_G314_I0.8940.27
185_E249_Q0.8910.27
244_N374_V0.8880.27
63_Y100_G0.8880.27
290_P316_V0.8870.27
82_N309_P0.8860.27
18_G145_Y0.8860.27
292_Y337_K0.8840.27
153_L167_M0.8830.27
192_N262_I0.8810.27
71_E130_W0.8790.27
63_Y125_I0.8760.27
253_R336_K0.8750.27
116_Q288_V0.8750.27
12_A383_F0.8740.27
102_Q376_V0.8730.27
14_I133_K0.8600.26
70_S97_G0.8570.26
187_Y246_L0.8570.26
261_H352_F0.8540.26
53_L94_Y0.8540.26
285_S292_Y0.8530.26
278_K323_Y0.8520.26
170_R320_W0.8520.26
141_F216_D0.8520.26
49_Q144_N0.8520.26
122_I302_L0.8510.26
102_Q214_K0.8510.26
362_M370_W0.8500.26
201_L316_V0.8470.25
107_S308_E0.8460.25
241_S244_N0.8450.25
15_L275_P0.8440.25
47_M50_G0.8440.25
181_A191_V0.8430.25
140_H174_F0.8420.25
136_S214_K0.8420.25
94_Y101_S0.8400.25
298_M311_F0.8370.25
69_S127_S0.8370.25
180_D183_L0.8370.25
166_K314_I0.8340.25
129_Q251_G0.8330.25
199_N275_P0.8330.25
345_K362_M0.8330.25
34_K225_S0.8330.25
93_P347_F0.8310.25
314_I326_F0.8300.25
98_K144_N0.8300.25
111_A302_L0.8280.25
161_P165_K0.8270.25
121_K384_Y0.8250.25
58_L249_Q0.8210.24
68_G71_E0.8190.24
6_F11_L0.8190.24
227_P310_M0.8190.24
199_N202_K0.8180.24
50_G94_Y0.8160.24
183_L307_A0.8150.24
246_L374_V0.8140.24
100_G347_F0.8140.24
102_Q112_A0.8140.24
53_L124_F0.8110.24
306_G344_A0.8100.24
251_G384_Y0.8090.24
286_Y324_T0.8070.24
164_K384_Y0.8060.24
14_I241_S0.8050.24
258_N372_G0.8040.24
240_W331_R0.8030.24
350_A379_A0.8010.24
83_Y106_H0.8000.24
161_P164_K0.8000.24
13_F236_K0.7980.23
271_K329_K0.7960.23
352_F379_A0.7930.23
129_Q369_G0.7920.23
249_Q283_G0.7910.23
322_D331_R0.7900.23
129_Q360_Y0.7890.23
85_Q350_A0.7890.23
288_V333_D0.7860.23
75_L134_R0.7850.23
127_S372_G0.7820.23
41_T136_S0.7800.23
39_S47_M0.7790.23
14_I338_V0.7780.23
88_N245_K0.7770.23
70_S131_F0.7770.23
229_R232_S0.7770.23
214_K217_L0.7740.23
25_S34_K0.7730.23
228_K271_K0.7730.23
271_K380_I0.7720.22
106_H211_M0.7720.22
109_N167_M0.7720.22
268_K272_P0.7710.22
67_Y122_I0.7710.22
255_S276_K0.7700.22
18_G236_K0.7650.22
43_L99_G0.7630.22
23_P26_W0.7630.22
93_P311_F0.7610.22
170_R315_P0.7560.22
117_L317_N0.7560.22
91_F384_Y0.7520.22
54_Q342_I0.7510.22
98_K143_P0.7440.21
375_Y378_K0.7440.21
154_A307_A0.7420.21
236_K271_K0.7420.21
239_S332_T0.7410.21
262_I279_G0.7400.21
321_Y331_R0.7380.21
14_I38_E0.7380.21
241_S253_R0.7380.21
185_E268_K0.7370.21
335_Y339_N0.7370.21
193_G313_T0.7350.21
180_D213_E0.7350.21
115_D119_G0.7340.21
97_G127_S0.7320.21
69_S291_E0.7320.21
277_L323_Y0.7290.21
90_G257_S0.7270.21
210_S312_V0.7270.21
76_D100_G0.7240.21
147_A380_I0.7230.21
6_F23_P0.7220.21
34_K38_E0.7220.21
30_F242_E0.7210.21
247_A374_V0.7190.21
36_V125_I0.7180.20
83_Y326_F0.7180.20
268_K275_P0.7170.20
65_P100_G0.7160.20
232_S235_V0.7160.20
267_Y365_T0.7130.20
285_S329_K0.7100.20
249_Q253_R0.7070.20
14_I385_K0.7060.20
43_L143_P0.7060.20
313_T353_S0.7040.20
339_N353_S0.7010.20
69_S130_W0.7000.20
251_G267_Y0.6990.20
102_Q135_G0.6980.20
125_I137_D0.6960.20
70_S367_H0.6920.20
291_E372_G0.6920.20
130_W372_G0.6920.20
118_K305_A0.6910.20
152_D283_G0.6890.19
54_Q67_Y0.6870.19
242_E385_K0.6870.19
136_S174_F0.6830.19
50_G376_V0.6830.19
246_L249_Q0.6820.19
249_Q359_P0.6810.19
208_Y211_M0.6770.19
355_H361_F0.6750.19
125_I129_Q0.6740.19
40_A302_L0.6740.19
166_K281_N0.6720.19
23_P121_K0.6720.19
73_S187_Y0.6710.19
97_G131_F0.6700.19
138_E174_F0.6700.19
108_L302_L0.6690.19
8_P12_A0.6690.19
105_I342_I0.6670.19
20_I52_Y0.6670.19
244_N248_D0.6660.19
236_K254_H0.6650.19
26_W279_G0.6640.19
43_L223_E0.6630.19
39_S171_M0.6630.19
160_D304_D0.6630.19
242_E245_K0.6620.19
373_W377_D0.6600.18
10_I42_A0.6590.18
99_G156_N0.6570.18
154_A322_D0.6560.18
26_W265_P0.6550.18
78_F298_M0.6550.18
114_M305_A0.6510.18
172_L377_D0.6510.18
48_F149_Q0.6480.18
165_K190_M0.6480.18
6_F74_R0.6470.18
92_T280_K0.6460.18
22_I245_K0.6460.18
73_S102_Q0.6450.18
80_P292_Y0.6430.18
213_E278_K0.6420.18
292_Y323_Y0.6410.18
183_L191_V0.6380.18
255_S369_G0.6360.18
252_K283_G0.6360.18
9_I292_Y0.6360.18
266_V370_W0.6330.18
187_Y295_F0.6320.18
370_W373_W0.6310.18
341_Q345_K0.6290.17
94_Y100_G0.6280.17
101_S140_H0.6270.17
70_S291_E0.6270.17
186_L222_T0.6270.17
93_P100_G0.6240.17
122_I348_Q0.6230.17
17_A202_K0.6220.17
203_P268_K0.6220.17
7_G383_F0.6220.17
43_L101_S0.6200.17
74_R370_W0.6180.17
63_Y212_L0.6160.17
171_M174_F0.6150.17
67_Y307_A0.6140.17
240_W357_Y0.6130.17
322_D335_Y0.6130.17
11_L267_Y0.6120.17
112_A167_M0.6120.17
10_I386_T0.6100.17
8_P66_I0.6090.17
11_L336_K0.6090.17
122_I342_I0.6090.17
136_S338_V0.6070.17
156_N169_K0.6050.17
207_V340_K0.6050.17
84_F87_N0.6030.17
260_F317_N0.6030.17
144_N334_Y0.6010.17
88_N306_G0.6000.17
156_N322_D0.5990.17
145_Y175_K0.5980.17
91_F166_K0.5970.17
239_S269_K0.5930.16
170_R289_S0.5910.16
97_G367_H0.5870.16
50_G54_Q0.5830.16
70_S364_D0.5820.16
127_S291_E0.5800.16
367_H372_G0.5790.16
295_F338_V0.5790.16
295_F376_V0.5780.16
87_N382_E0.5780.16
15_L45_P0.5780.16
183_L186_L0.5770.16
98_K101_S0.5760.16
108_L308_E0.5740.16
32_T218_Y0.5700.16
274_V282_K0.5700.16
24_S31_I0.5680.16
65_P93_P0.5680.16
180_D306_G0.5670.16
253_R264_N0.5670.16
18_G213_E0.5650.16
151_L205_A0.5640.16
55_D328_K0.5630.16
105_I143_P0.5630.16
206_K339_N0.5630.16
42_A348_Q0.5620.15
252_K358_D0.5610.15
101_S146_S0.5600.15
227_P312_V0.5600.15
111_A144_N0.5570.15
98_K331_R0.5550.15
166_K358_D0.5530.15
173_R242_E0.5520.15
32_T245_K0.5520.15
108_L167_M0.5510.15
317_N377_D0.5510.15
74_R100_G0.5500.15
128_P317_N0.5500.15
203_P269_K0.5490.15
92_T260_F0.5490.15
256_G259_D0.5480.15
59_K118_K0.5480.15
236_K252_K0.5470.15
320_W377_D0.5470.15
174_F177_V0.5470.15
66_I123_V0.5460.15
49_Q154_A0.5460.15
140_H143_P0.5450.15
121_K146_S0.5440.15
261_H379_A0.5430.15
378_K382_E0.5430.15
24_S214_K0.5420.15
100_G243_L0.5410.15
264_N312_V0.5400.15
234_S345_K0.5400.15
299_L330_G0.5390.15
350_A375_Y0.5380.15
20_I42_A0.5370.15
121_K251_G0.5370.15
123_V312_V0.5360.15
315_P370_W0.5350.15
47_M148_L0.5340.15
195_T319_K0.5340.15
332_T335_Y0.5340.15
55_D209_Y0.5330.15
102_Q293_G0.5320.15
255_S297_M0.5310.15
15_L189_A0.5300.15
48_F100_G0.5300.15
208_Y268_K0.5290.15
98_K102_Q0.5280.15
308_E355_H0.5270.15
63_Y341_Q0.5250.14
84_F331_R0.5240.14
109_N353_S0.5240.14
203_P252_K0.5230.14
258_N294_D0.5230.14
98_K334_Y0.5230.14
253_R386_T0.5220.14
57_M377_D0.5210.14
40_A243_L0.5210.14
107_S167_M0.5170.14
325_G373_W0.5170.14
203_P206_K0.5160.14
123_V365_T0.5150.14
69_S372_G0.5150.14
361_F372_G0.5140.14
59_K313_T0.5130.14
12_A323_Y0.5130.14
38_E58_L0.5130.14
96_V171_M0.5130.14
66_I83_Y0.5090.14
164_K331_R0.5090.14
97_G291_E0.5090.14
311_F341_Q0.5070.14
122_I231_I0.5050.14
103_S235_V0.5050.14
112_A353_S0.5050.14
131_F367_H0.5050.14
7_G42_A0.5040.14
227_P264_N0.5040.14
362_M369_G0.5020.14
77_E250_S0.5020.14
158_Q233_Q0.5020.14
62_T192_N0.5020.14
168_M290_P0.5010.14
95_L129_Q0.5000.14
279_G358_D0.5000.14
292_Y353_S0.5000.14
126_V344_A0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bmaA 6 0.9158 100 0.146 Contact Map
4jggA 1 0.4311 97.8 0.935 Contact Map
1k7cA 1 0.4923 96.3 0.948 Contact Map
3p94A 4 0.4949 95.8 0.95 Contact Map
4jhlA 5 0.4949 95.6 0.951 Contact Map
4q7qA 1 0.4847 94.9 0.953 Contact Map
3milA 2 0.477 94.6 0.954 Contact Map
1fxwF 1 0.4923 94.4 0.954 Contact Map
4rw0A 1 0.4362 94 0.955 Contact Map
1ivnA 2 0.4439 93.9 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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