ILVE2 - BACSU - GREMLIN Contacts

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ILVE2 - Branched-chain-amino-acid aminotransferase 2

UniProt:	P39576	Sequences: MTKQTIRVELTSTKKPKPDPNQLSFGRVFTDHMFVMDYAADKGWYDPRIIPYQPLSMDPAAMVYHYGQTVFEGLKAYVSEDDHVLLFRPEKNMERLNQSNDRLCIPQIDEEQVLEGLKQLVAIDKDWIPNAEGTSLYIRPFIIATEPFLGVAASHTYKLLIILSPVGSYYKEGIKPVKIAVESEFVRAVKGGTGNAKTAGNYASSLKAQQVAEEKGFSQVLWLDGIEKKYIEEVGSMNIFFKINGEIVTPMLNGSILEGITRNSVIALLKHWGLQVSERKIAIDEVIQAHKDGILEEAFGTGTAAVISPVGELIWQDETLSINNGETGEIAKKLYDTITGIQKGAVADEFGWTTEVAALTESK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	363 (295)
Sequences:	5170 (2936)
Seq/√Len:	171.0

ECOLI - ILVE PABC
BACSU - ILVE2 ILVE1 PABC DAAA
HALSA - Q9HNF8 Q9HS64

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
246_E	277_S	4.404	1.00
178_K	312_E	3.875	1.00
246_E	275_Q	3.746	1.00
279_R	285_E	3.501	1.00
94_E	110_E	3.471	1.00
69_T	199_A	3.088	1.00
247_I	269_L	3.041	1.00
49_I	123_I	2.974	1.00
336_D	340_G	2.894	1.00
340_G	345_A	2.811	1.00
263_N	267_A	2.659	1.00
97_N	110_E	2.553	1.00
115_E	119_Q	2.525	1.00
101_D	107_Q	2.373	1.00
271_H	350_F	2.372	1.00
119_Q	122_A	2.368	1.00
337_T	346_V	2.347	1.00
340_G	346_V	2.328	1.00
230_Y	280_K	2.328	1.00
79_S	85_L	2.311	1.00
91_K	263_N	2.311	1.00
248_V	279_R	2.269	1.00
258_E	263_N	2.252	1.00
298_A	310_V	2.246	1.00
266_I	276_V	2.228	1.00
109_D	112_Q	2.201	1.00
272_W	333_K	2.192	1.00
52_Y	58_D	2.182	1.00
96_L	142_I	2.135	1.00
272_W	337_T	2.113	1.00
312_E	319_T	2.031	1.00
105_I	142_I	2.025	1.00
119_Q	123_I	2.018	1.00
116_G	159_L	2.015	1.00
332_K	336_D	1.980	1.00
100_N	142_I	1.912	1.00
138_I	163_L	1.876	1.00
63_V	69_T	1.868	1.00
242_K	330_I	1.861	1.00
271_H	349_E	1.857	1.00
94_E	98_Q	1.842	1.00
267_A	271_H	1.827	1.00
180_A	215_K	1.785	1.00
80_E	345_A	1.713	1.00
179_I	221_L	1.686	1.00
247_I	274_L	1.672	1.00
105_I	157_Y	1.671	1.00
91_K	94_E	1.662	1.00
90_E	114_L	1.644	1.00
141_F	160_L	1.640	1.00
79_S	83_H	1.638	1.00
70_V	100_N	1.600	1.00
245_G	296_E	1.597	1.00
265_V	301_T	1.581	1.00
115_E	118_K	1.574	1.00
122_A	125_K	1.528	1.00
77_Y	306_V	1.516	1.00
98_Q	101_D	1.454	1.00
234_V	300_G	1.451	1.00
184_E	211_V	1.446	1.00
70_V	96_L	1.443	1.00
239_I	298_A	1.438	1.00
44_W	108_I	1.435	1.00
187_R	190_K	1.428	1.00
46_D	158_K	1.414	1.00
51_P	54_P	1.411	1.00
181_V	283_I	1.404	1.00
262_R	278_E	1.397	1.00
333_K	337_T	1.387	1.00
274_L	330_I	1.382	1.00
116_G	161_I	1.374	1.00
93_M	114_L	1.371	1.00
230_Y	282_A	1.365	1.00
337_T	340_G	1.357	1.00
179_I	234_V	1.356	1.00
85_L	353_T	1.344	1.00
90_E	94_E	1.336	1.00
243_I	296_E	1.332	1.00
231_I	241_F	1.332	1.00
238_N	259_G	1.328	1.00
89_P	114_L	1.315	1.00
269_L	334_L	1.304	1.00
93_M	117_L	1.302	1.00
327_T	332_K	1.295	1.00
251_M	280_K	1.277	1.00
54_P	58_D	1.265	1.00
98_Q	258_E	1.262	1.00
97_N	107_Q	1.253	1.00
104_C	214_E	1.252	1.00
113_V	159_L	1.241	1.00
64_Y	143_I	1.240	1.00
133_G	136_L	1.236	1.00
300_G	310_V	1.235	1.00
88_R	264_S	1.234	1.00
281_I	285_E	1.231	1.00
70_V	99_S	1.227	1.00
97_N	113_V	1.216	1.00
93_M	113_V	1.210	1.00
152_A	155_H	1.197	1.00
185_F	190_K	1.196	1.00
120_L	124_D	1.192	1.00
221_L	286_V	1.184	1.00
266_I	270_K	1.183	1.00
242_K	247_I	1.174	1.00
98_Q	195_N	1.157	1.00
178_K	218_S	1.156	1.00
111_E	115_E	1.151	1.00
76_A	121_V	1.150	1.00
250_P	281_I	1.149	1.00
242_K	296_E	1.143	1.00
265_V	334_L	1.142	1.00
221_L	239_I	1.140	1.00
86_L	118_K	1.138	1.00
270_K	278_E	1.134	1.00
211_V	215_K	1.127	1.00
61_A	147_P	1.122	1.00
265_V	307_I	1.118	1.00
117_L	138_I	1.113	1.00
312_E	321_S	1.101	1.00
121_V	136_L	1.097	1.00
88_R	91_K	1.091	1.00
176_P	311_G	1.085	1.00
177_V	218_S	1.080	1.00
329_E	332_K	1.076	1.00
50_I	53_Q	1.071	1.00
240_F	299_F	1.071	1.00
287_I	320_L	1.069	1.00
118_K	122_A	1.066	1.00
39_A	156_T	1.061	1.00
120_L	161_I	1.060	1.00
117_L	161_I	1.056	1.00
76_A	136_L	1.056	1.00
249_T	262_R	1.053	0.99
112_Q	115_E	1.048	0.99
240_F	266_I	1.045	0.99
267_A	350_F	1.042	0.99
229_K	284_D	1.041	0.99
142_I	159_L	1.039	0.99
243_I	248_V	1.037	0.99
325_G	328_G	1.035	0.99
348_D	352_W	1.033	0.99
49_I	120_L	1.030	0.99
108_I	159_L	1.027	0.99
187_R	191_G	1.027	0.99
70_V	142_I	1.024	0.99
57_M	61_A	1.021	0.99
91_K	260_I	1.016	0.99
243_I	289_A	1.008	0.99
252_L	258_E	1.008	0.99
210_Q	214_E	1.006	0.99
86_L	117_L	1.000	0.99
333_K	336_D	0.997	0.99
172_E	175_K	0.996	0.99
225_G	228_K	0.980	0.99
93_M	110_E	0.969	0.99
114_L	118_K	0.968	0.99
78_V	134_T	0.965	0.99
298_A	313_L	0.958	0.99
248_V	285_E	0.953	0.99
86_L	89_P	0.951	0.99
108_I	112_Q	0.947	0.99
224_D	255_S	0.943	0.99
68_Q	144_A	0.942	0.99
335_Y	339_T	0.942	0.99
269_L	274_L	0.939	0.99
186_V	189_V	0.938	0.99
215_K	319_T	0.938	0.99
248_V	277_S	0.936	0.99
73_G	302_G	0.935	0.99
187_R	192_G	0.931	0.99
268_L	272_W	0.919	0.99
63_V	199_A	0.915	0.99
234_V	237_M	0.914	0.99
241_F	298_A	0.914	0.99
247_I	330_I	0.912	0.99
329_E	333_K	0.906	0.98
55_L	160_L	0.905	0.98
42_K	123_I	0.904	0.98
284_D	288_Q	0.902	0.98
268_L	337_T	0.896	0.98
297_E	328_G	0.895	0.98
39_A	45_Y	0.891	0.98
143_I	160_L	0.889	0.98
79_S	353_T	0.888	0.98
178_K	311_G	0.888	0.98
91_K	267_A	0.882	0.98
145_T	158_K	0.881	0.98
60_A	162_I	0.877	0.98
89_P	93_M	0.874	0.98
322_I	325_G	0.867	0.98
42_K	51_P	0.859	0.98
42_K	45_Y	0.859	0.98
146_E	156_T	0.857	0.98
277_S	285_E	0.856	0.98
241_F	281_I	0.852	0.98
44_W	49_I	0.850	0.98
254_G	280_K	0.844	0.98
120_L	163_L	0.842	0.98
65_H	141_F	0.841	0.98
74_L	117_L	0.838	0.97
237_M	305_A	0.834	0.97
103_L	198_T	0.834	0.97
39_A	42_K	0.830	0.97
287_I	318_E	0.826	0.97
245_G	275_Q	0.825	0.97
267_A	270_K	0.821	0.97
184_E	193_T	0.819	0.97
209_Q	213_E	0.809	0.97
177_V	308_S	0.808	0.97
179_I	310_V	0.804	0.97
71_F	202_Y	0.802	0.97
173_G	176_P	0.801	0.97
99_S	196_A	0.801	0.97
193_T	200_G	0.800	0.97
270_K	275_Q	0.798	0.97
251_M	279_R	0.795	0.96
179_I	300_G	0.793	0.96
264_S	338_I	0.792	0.96
74_L	89_P	0.792	0.96
241_F	286_V	0.784	0.96
175_K	326_E	0.782	0.96
58_D	147_P	0.782	0.96
93_M	97_N	0.781	0.96
224_D	228_K	0.781	0.96
241_F	289_A	0.776	0.96
271_H	337_T	0.775	0.96
259_G	262_R	0.774	0.96
208_A	222_W	0.774	0.96
178_K	217_F	0.772	0.96
110_E	114_L	0.770	0.96
181_V	318_E	0.767	0.96
97_N	101_D	0.766	0.96
349_E	353_T	0.765	0.96
249_T	278_E	0.765	0.96
186_V	228_K	0.763	0.96
145_T	156_T	0.763	0.96
180_A	217_F	0.762	0.96
323_N	328_G	0.761	0.96
208_A	220_V	0.759	0.95
224_D	230_Y	0.757	0.95
244_N	296_E	0.756	0.95
187_R	193_T	0.756	0.95
96_L	108_I	0.753	0.95
221_L	313_L	0.750	0.95
188_A	191_G	0.749	0.95
101_D	207_K	0.749	0.95
348_D	351_G	0.748	0.95
70_V	103_L	0.748	0.95
236_S	304_A	0.747	0.95
135_S	343_K	0.739	0.95
39_A	43_G	0.739	0.95
185_F	188_A	0.739	0.95
306_V	339_T	0.736	0.95
59_P	160_L	0.735	0.95
240_F	301_T	0.734	0.95
79_S	82_D	0.734	0.95
90_E	111_E	0.730	0.94
84_V	125_K	0.729	0.94
65_H	162_I	0.729	0.94
307_I	331_A	0.729	0.94
269_L	276_V	0.728	0.94
94_E	97_N	0.728	0.94
240_F	249_T	0.727	0.94
137_Y	140_P	0.725	0.94
211_V	214_E	0.725	0.94
198_T	203_A	0.721	0.94
87_F	264_S	0.721	0.94
120_L	123_I	0.721	0.94
328_G	331_A	0.719	0.94
73_G	137_Y	0.719	0.94
68_Q	206_L	0.716	0.94
323_N	326_E	0.716	0.94
76_A	86_L	0.712	0.94
297_E	331_A	0.708	0.93
150_G	206_L	0.706	0.93
89_P	117_L	0.703	0.93
209_Q	219_Q	0.701	0.93
86_L	138_I	0.699	0.93
188_A	193_T	0.698	0.93
231_I	281_I	0.698	0.93
48_R	56_S	0.698	0.93
102_R	196_A	0.698	0.93
332_K	335_Y	0.695	0.93
248_V	281_I	0.694	0.93
49_I	116_G	0.692	0.93
172_E	218_S	0.692	0.93
78_V	84_V	0.691	0.93
298_A	322_I	0.688	0.92
253_N	280_K	0.686	0.92
183_S	211_V	0.686	0.92
302_G	305_A	0.685	0.92
61_A	199_A	0.685	0.92
249_T	299_F	0.683	0.92
124_D	163_L	0.680	0.92
219_Q	235_G	0.678	0.92
330_I	333_K	0.678	0.92
62_M	144_A	0.678	0.92
44_W	116_G	0.674	0.92
307_I	334_L	0.674	0.92
239_I	250_P	0.672	0.92
309_P	328_G	0.669	0.91
109_D	113_V	0.669	0.91
285_E	289_A	0.668	0.91
47_P	116_G	0.667	0.91
268_L	334_L	0.666	0.91
143_I	158_K	0.666	0.91
121_V	138_I	0.665	0.91
76_A	138_I	0.664	0.91
62_M	152_A	0.663	0.91
192_G	201_N	0.662	0.91
90_E	110_E	0.659	0.91
132_E	345_A	0.658	0.91
61_A	145_T	0.655	0.90
188_A	192_G	0.654	0.90
240_F	262_R	0.654	0.90
228_K	280_K	0.653	0.90
70_V	198_T	0.652	0.90
175_K	218_S	0.650	0.90
236_S	300_G	0.649	0.90
84_V	121_V	0.649	0.90
321_S	324_N	0.647	0.90
217_F	319_T	0.644	0.90
45_Y	160_L	0.642	0.90
66_Y	137_Y	0.641	0.90
49_I	119_Q	0.639	0.89
153_A	210_Q	0.639	0.89
141_F	199_A	0.639	0.89
347_A	350_F	0.639	0.89
249_T	252_L	0.636	0.89
117_L	140_P	0.636	0.89
55_L	59_P	0.634	0.89
197_K	257_L	0.632	0.89
195_N	258_E	0.630	0.89
286_V	313_L	0.630	0.89
209_Q	235_G	0.630	0.89
247_I	299_F	0.628	0.89
229_K	282_A	0.626	0.88
283_I	286_V	0.624	0.88
80_E	85_L	0.623	0.88
240_F	278_E	0.622	0.88
105_I	144_A	0.621	0.88
64_Y	69_T	0.620	0.88
262_R	299_F	0.619	0.88
219_Q	237_M	0.618	0.88
170_Y	236_S	0.616	0.88
187_R	194_G	0.613	0.87
350_F	353_T	0.613	0.87
103_L	203_A	0.606	0.87
270_K	276_V	0.606	0.87
249_T	256_I	0.605	0.87
174_I	332_K	0.604	0.87
245_G	274_L	0.604	0.87
108_I	116_G	0.603	0.87
134_T	168_S	0.603	0.87
61_A	143_I	0.603	0.87
167_G	170_Y	0.603	0.87
324_N	327_T	0.603	0.87
86_L	121_V	0.603	0.87
168_S	173_G	0.600	0.86
197_K	202_Y	0.597	0.86
306_V	342_Q	0.596	0.86
195_N	254_G	0.596	0.86
337_T	341_I	0.594	0.86
97_N	108_I	0.593	0.86
66_Y	139_R	0.592	0.86
67_G	199_A	0.592	0.86
243_I	246_E	0.591	0.85
75_K	303_T	0.591	0.85
289_A	296_E	0.590	0.85
74_L	138_I	0.588	0.85
115_E	122_A	0.586	0.85
117_L	120_L	0.586	0.85
262_R	266_I	0.584	0.85
52_Y	60_A	0.584	0.85
346_V	349_E	0.584	0.85
56_S	59_P	0.578	0.84
137_Y	303_T	0.576	0.84
49_I	124_D	0.576	0.84
323_N	327_T	0.576	0.84
43_G	52_Y	0.575	0.84
73_G	304_A	0.575	0.84
64_Y	141_F	0.574	0.84
69_T	141_F	0.573	0.84
66_Y	151_V	0.570	0.83
242_K	245_G	0.568	0.83
346_V	351_G	0.568	0.83
274_L	333_K	0.567	0.83
340_G	343_K	0.565	0.83
217_F	312_E	0.563	0.83
152_A	213_E	0.563	0.83
47_P	112_Q	0.561	0.82
249_T	266_I	0.560	0.82
233_E	257_L	0.559	0.82
148_F	152_A	0.558	0.82
269_L	272_W	0.557	0.82
74_L	93_M	0.557	0.82
347_A	351_G	0.557	0.82
139_R	202_Y	0.555	0.82
243_I	288_Q	0.553	0.81
306_V	335_Y	0.553	0.81
55_L	158_K	0.553	0.81
196_A	200_G	0.552	0.81
100_N	105_I	0.548	0.81
93_M	109_D	0.547	0.81
73_G	139_R	0.547	0.81
77_Y	135_S	0.544	0.80
146_E	152_A	0.541	0.80
339_T	343_K	0.541	0.80
74_L	86_L	0.540	0.80
150_G	169_Y	0.536	0.79
245_G	270_K	0.536	0.79
45_Y	57_M	0.534	0.79
243_I	285_E	0.534	0.79
266_I	278_E	0.533	0.79
107_Q	159_L	0.532	0.79
200_G	204_S	0.529	0.79
68_Q	157_Y	0.528	0.78
183_S	287_I	0.528	0.78
242_K	331_A	0.528	0.78
185_F	211_V	0.527	0.78
241_F	248_V	0.525	0.78
117_L	121_V	0.525	0.78
328_G	332_K	0.525	0.78
177_V	300_G	0.525	0.78
110_E	117_L	0.524	0.78
286_V	298_A	0.524	0.78
66_Y	149_L	0.523	0.78
189_V	225_G	0.521	0.78
97_N	109_D	0.520	0.77
169_Y	305_A	0.519	0.77
236_S	301_T	0.516	0.77
62_M	148_F	0.516	0.77
210_Q	213_E	0.515	0.77
170_Y	177_V	0.512	0.76
179_I	219_Q	0.510	0.76
88_R	304_A	0.509	0.76
147_P	156_T	0.509	0.76
48_R	330_I	0.508	0.76
98_Q	263_N	0.507	0.76
170_Y	173_G	0.506	0.75
62_M	68_Q	0.504	0.75
80_E	83_H	0.500	0.75

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2coiA	2	0.9559	100	0.187	Contact Map
5bwxA	2	0.9614	100	0.195	Contact Map
3dtgA	2	0.9835	100	0.204	Contact Map
3uzoA	2	0.9091	100	0.255	Contact Map
4dqnA	2	0.9146	100	0.266	Contact Map
3u0gA	5	0.8347	100	0.323	Contact Map
1iyeA	5	0.8237	100	0.327	Contact Map
2eiyA	5	0.8264	100	0.332	Contact Map
4chiA	2	0.8595	100	0.344	Contact Map
4cmfA	4	0.8567	100	0.348	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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