GREMLIN Database
ILVE2 - Branched-chain-amino-acid aminotransferase 2
UniProt: P39576 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 363 (295)
Sequences: 5170 (2936)
Seq/√Len: 171.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
246_E277_S4.4041.00
178_K312_E3.8751.00
246_E275_Q3.7461.00
279_R285_E3.5011.00
94_E110_E3.4711.00
69_T199_A3.0881.00
247_I269_L3.0411.00
49_I123_I2.9741.00
336_D340_G2.8941.00
340_G345_A2.8111.00
263_N267_A2.6591.00
97_N110_E2.5531.00
115_E119_Q2.5251.00
101_D107_Q2.3731.00
271_H350_F2.3721.00
119_Q122_A2.3681.00
337_T346_V2.3471.00
340_G346_V2.3281.00
230_Y280_K2.3281.00
79_S85_L2.3111.00
91_K263_N2.3111.00
248_V279_R2.2691.00
258_E263_N2.2521.00
298_A310_V2.2461.00
266_I276_V2.2281.00
109_D112_Q2.2011.00
272_W333_K2.1921.00
52_Y58_D2.1821.00
96_L142_I2.1351.00
272_W337_T2.1131.00
312_E319_T2.0311.00
105_I142_I2.0251.00
119_Q123_I2.0181.00
116_G159_L2.0151.00
332_K336_D1.9801.00
100_N142_I1.9121.00
138_I163_L1.8761.00
63_V69_T1.8681.00
242_K330_I1.8611.00
271_H349_E1.8571.00
94_E98_Q1.8421.00
267_A271_H1.8271.00
180_A215_K1.7851.00
80_E345_A1.7131.00
179_I221_L1.6861.00
247_I274_L1.6721.00
105_I157_Y1.6711.00
91_K94_E1.6621.00
90_E114_L1.6441.00
141_F160_L1.6401.00
79_S83_H1.6381.00
70_V100_N1.6001.00
245_G296_E1.5971.00
265_V301_T1.5811.00
115_E118_K1.5741.00
122_A125_K1.5281.00
77_Y306_V1.5161.00
98_Q101_D1.4541.00
234_V300_G1.4511.00
184_E211_V1.4461.00
70_V96_L1.4431.00
239_I298_A1.4381.00
44_W108_I1.4351.00
187_R190_K1.4281.00
46_D158_K1.4141.00
51_P54_P1.4111.00
181_V283_I1.4041.00
262_R278_E1.3971.00
333_K337_T1.3871.00
274_L330_I1.3821.00
116_G161_I1.3741.00
93_M114_L1.3711.00
230_Y282_A1.3651.00
337_T340_G1.3571.00
179_I234_V1.3561.00
85_L353_T1.3441.00
90_E94_E1.3361.00
243_I296_E1.3321.00
231_I241_F1.3321.00
238_N259_G1.3281.00
89_P114_L1.3151.00
269_L334_L1.3041.00
93_M117_L1.3021.00
327_T332_K1.2951.00
251_M280_K1.2771.00
54_P58_D1.2651.00
98_Q258_E1.2621.00
97_N107_Q1.2531.00
104_C214_E1.2521.00
113_V159_L1.2411.00
64_Y143_I1.2401.00
133_G136_L1.2361.00
300_G310_V1.2351.00
88_R264_S1.2341.00
281_I285_E1.2311.00
70_V99_S1.2271.00
97_N113_V1.2161.00
93_M113_V1.2101.00
152_A155_H1.1971.00
185_F190_K1.1961.00
120_L124_D1.1921.00
221_L286_V1.1841.00
266_I270_K1.1831.00
242_K247_I1.1741.00
98_Q195_N1.1571.00
178_K218_S1.1561.00
111_E115_E1.1511.00
76_A121_V1.1501.00
250_P281_I1.1491.00
242_K296_E1.1431.00
265_V334_L1.1421.00
221_L239_I1.1401.00
86_L118_K1.1381.00
270_K278_E1.1341.00
211_V215_K1.1271.00
61_A147_P1.1221.00
265_V307_I1.1181.00
117_L138_I1.1131.00
312_E321_S1.1011.00
121_V136_L1.0971.00
88_R91_K1.0911.00
176_P311_G1.0851.00
177_V218_S1.0801.00
329_E332_K1.0761.00
50_I53_Q1.0711.00
240_F299_F1.0711.00
287_I320_L1.0691.00
118_K122_A1.0661.00
39_A156_T1.0611.00
120_L161_I1.0601.00
117_L161_I1.0561.00
76_A136_L1.0561.00
249_T262_R1.0530.99
112_Q115_E1.0480.99
240_F266_I1.0450.99
267_A350_F1.0420.99
229_K284_D1.0410.99
142_I159_L1.0390.99
243_I248_V1.0370.99
325_G328_G1.0350.99
348_D352_W1.0330.99
49_I120_L1.0300.99
108_I159_L1.0270.99
187_R191_G1.0270.99
70_V142_I1.0240.99
57_M61_A1.0210.99
91_K260_I1.0160.99
243_I289_A1.0080.99
252_L258_E1.0080.99
210_Q214_E1.0060.99
86_L117_L1.0000.99
333_K336_D0.9970.99
172_E175_K0.9960.99
225_G228_K0.9800.99
93_M110_E0.9690.99
114_L118_K0.9680.99
78_V134_T0.9650.99
298_A313_L0.9580.99
248_V285_E0.9530.99
86_L89_P0.9510.99
108_I112_Q0.9470.99
224_D255_S0.9430.99
68_Q144_A0.9420.99
335_Y339_T0.9420.99
269_L274_L0.9390.99
186_V189_V0.9380.99
215_K319_T0.9380.99
248_V277_S0.9360.99
73_G302_G0.9350.99
187_R192_G0.9310.99
268_L272_W0.9190.99
63_V199_A0.9150.99
234_V237_M0.9140.99
241_F298_A0.9140.99
247_I330_I0.9120.99
329_E333_K0.9060.98
55_L160_L0.9050.98
42_K123_I0.9040.98
284_D288_Q0.9020.98
268_L337_T0.8960.98
297_E328_G0.8950.98
39_A45_Y0.8910.98
143_I160_L0.8890.98
79_S353_T0.8880.98
178_K311_G0.8880.98
91_K267_A0.8820.98
145_T158_K0.8810.98
60_A162_I0.8770.98
89_P93_M0.8740.98
322_I325_G0.8670.98
42_K51_P0.8590.98
42_K45_Y0.8590.98
146_E156_T0.8570.98
277_S285_E0.8560.98
241_F281_I0.8520.98
44_W49_I0.8500.98
254_G280_K0.8440.98
120_L163_L0.8420.98
65_H141_F0.8410.98
74_L117_L0.8380.97
237_M305_A0.8340.97
103_L198_T0.8340.97
39_A42_K0.8300.97
287_I318_E0.8260.97
245_G275_Q0.8250.97
267_A270_K0.8210.97
184_E193_T0.8190.97
209_Q213_E0.8090.97
177_V308_S0.8080.97
179_I310_V0.8040.97
71_F202_Y0.8020.97
173_G176_P0.8010.97
99_S196_A0.8010.97
193_T200_G0.8000.97
270_K275_Q0.7980.97
251_M279_R0.7950.96
179_I300_G0.7930.96
264_S338_I0.7920.96
74_L89_P0.7920.96
241_F286_V0.7840.96
175_K326_E0.7820.96
58_D147_P0.7820.96
93_M97_N0.7810.96
224_D228_K0.7810.96
241_F289_A0.7760.96
271_H337_T0.7750.96
259_G262_R0.7740.96
208_A222_W0.7740.96
178_K217_F0.7720.96
110_E114_L0.7700.96
181_V318_E0.7670.96
97_N101_D0.7660.96
349_E353_T0.7650.96
249_T278_E0.7650.96
186_V228_K0.7630.96
145_T156_T0.7630.96
180_A217_F0.7620.96
323_N328_G0.7610.96
208_A220_V0.7590.95
224_D230_Y0.7570.95
244_N296_E0.7560.95
187_R193_T0.7560.95
96_L108_I0.7530.95
221_L313_L0.7500.95
188_A191_G0.7490.95
101_D207_K0.7490.95
348_D351_G0.7480.95
70_V103_L0.7480.95
236_S304_A0.7470.95
135_S343_K0.7390.95
39_A43_G0.7390.95
185_F188_A0.7390.95
306_V339_T0.7360.95
59_P160_L0.7350.95
240_F301_T0.7340.95
79_S82_D0.7340.95
90_E111_E0.7300.94
84_V125_K0.7290.94
65_H162_I0.7290.94
307_I331_A0.7290.94
269_L276_V0.7280.94
94_E97_N0.7280.94
240_F249_T0.7270.94
137_Y140_P0.7250.94
211_V214_E0.7250.94
198_T203_A0.7210.94
87_F264_S0.7210.94
120_L123_I0.7210.94
328_G331_A0.7190.94
73_G137_Y0.7190.94
68_Q206_L0.7160.94
323_N326_E0.7160.94
76_A86_L0.7120.94
297_E331_A0.7080.93
150_G206_L0.7060.93
89_P117_L0.7030.93
209_Q219_Q0.7010.93
86_L138_I0.6990.93
188_A193_T0.6980.93
231_I281_I0.6980.93
48_R56_S0.6980.93
102_R196_A0.6980.93
332_K335_Y0.6950.93
248_V281_I0.6940.93
49_I116_G0.6920.93
172_E218_S0.6920.93
78_V84_V0.6910.93
298_A322_I0.6880.92
253_N280_K0.6860.92
183_S211_V0.6860.92
302_G305_A0.6850.92
61_A199_A0.6850.92
249_T299_F0.6830.92
124_D163_L0.6800.92
219_Q235_G0.6780.92
330_I333_K0.6780.92
62_M144_A0.6780.92
44_W116_G0.6740.92
307_I334_L0.6740.92
239_I250_P0.6720.92
309_P328_G0.6690.91
109_D113_V0.6690.91
285_E289_A0.6680.91
47_P116_G0.6670.91
268_L334_L0.6660.91
143_I158_K0.6660.91
121_V138_I0.6650.91
76_A138_I0.6640.91
62_M152_A0.6630.91
192_G201_N0.6620.91
90_E110_E0.6590.91
132_E345_A0.6580.91
61_A145_T0.6550.90
188_A192_G0.6540.90
240_F262_R0.6540.90
228_K280_K0.6530.90
70_V198_T0.6520.90
175_K218_S0.6500.90
236_S300_G0.6490.90
84_V121_V0.6490.90
321_S324_N0.6470.90
217_F319_T0.6440.90
45_Y160_L0.6420.90
66_Y137_Y0.6410.90
49_I119_Q0.6390.89
153_A210_Q0.6390.89
141_F199_A0.6390.89
347_A350_F0.6390.89
249_T252_L0.6360.89
117_L140_P0.6360.89
55_L59_P0.6340.89
197_K257_L0.6320.89
195_N258_E0.6300.89
286_V313_L0.6300.89
209_Q235_G0.6300.89
247_I299_F0.6280.89
229_K282_A0.6260.88
283_I286_V0.6240.88
80_E85_L0.6230.88
240_F278_E0.6220.88
105_I144_A0.6210.88
64_Y69_T0.6200.88
262_R299_F0.6190.88
219_Q237_M0.6180.88
170_Y236_S0.6160.88
187_R194_G0.6130.87
350_F353_T0.6130.87
103_L203_A0.6060.87
270_K276_V0.6060.87
249_T256_I0.6050.87
174_I332_K0.6040.87
245_G274_L0.6040.87
108_I116_G0.6030.87
134_T168_S0.6030.87
61_A143_I0.6030.87
167_G170_Y0.6030.87
324_N327_T0.6030.87
86_L121_V0.6030.87
168_S173_G0.6000.86
197_K202_Y0.5970.86
306_V342_Q0.5960.86
195_N254_G0.5960.86
337_T341_I0.5940.86
97_N108_I0.5930.86
66_Y139_R0.5920.86
67_G199_A0.5920.86
243_I246_E0.5910.85
75_K303_T0.5910.85
289_A296_E0.5900.85
74_L138_I0.5880.85
115_E122_A0.5860.85
117_L120_L0.5860.85
262_R266_I0.5840.85
52_Y60_A0.5840.85
346_V349_E0.5840.85
56_S59_P0.5780.84
137_Y303_T0.5760.84
49_I124_D0.5760.84
323_N327_T0.5760.84
43_G52_Y0.5750.84
73_G304_A0.5750.84
64_Y141_F0.5740.84
69_T141_F0.5730.84
66_Y151_V0.5700.83
242_K245_G0.5680.83
346_V351_G0.5680.83
274_L333_K0.5670.83
340_G343_K0.5650.83
217_F312_E0.5630.83
152_A213_E0.5630.83
47_P112_Q0.5610.82
249_T266_I0.5600.82
233_E257_L0.5590.82
148_F152_A0.5580.82
269_L272_W0.5570.82
74_L93_M0.5570.82
347_A351_G0.5570.82
139_R202_Y0.5550.82
243_I288_Q0.5530.81
306_V335_Y0.5530.81
55_L158_K0.5530.81
196_A200_G0.5520.81
100_N105_I0.5480.81
93_M109_D0.5470.81
73_G139_R0.5470.81
77_Y135_S0.5440.80
146_E152_A0.5410.80
339_T343_K0.5410.80
74_L86_L0.5400.80
150_G169_Y0.5360.79
245_G270_K0.5360.79
45_Y57_M0.5340.79
243_I285_E0.5340.79
266_I278_E0.5330.79
107_Q159_L0.5320.79
200_G204_S0.5290.79
68_Q157_Y0.5280.78
183_S287_I0.5280.78
242_K331_A0.5280.78
185_F211_V0.5270.78
241_F248_V0.5250.78
117_L121_V0.5250.78
328_G332_K0.5250.78
177_V300_G0.5250.78
110_E117_L0.5240.78
286_V298_A0.5240.78
66_Y149_L0.5230.78
189_V225_G0.5210.78
97_N109_D0.5200.77
169_Y305_A0.5190.77
236_S301_T0.5160.77
62_M148_F0.5160.77
210_Q213_E0.5150.77
170_Y177_V0.5120.76
179_I219_Q0.5100.76
88_R304_A0.5090.76
147_P156_T0.5090.76
48_R330_I0.5080.76
98_Q263_N0.5070.76
170_Y173_G0.5060.75
62_M68_Q0.5040.75
80_E83_H0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2coiA 2 0.9559 100 0.187 Contact Map
5bwxA 2 0.9614 100 0.195 Contact Map
3dtgA 2 0.9835 100 0.204 Contact Map
3uzoA 2 0.9091 100 0.255 Contact Map
4dqnA 2 0.9146 100 0.266 Contact Map
3u0gA 5 0.8347 100 0.323 Contact Map
1iyeA 5 0.8237 100 0.327 Contact Map
2eiyA 5 0.8264 100 0.332 Contact Map
4chiA 2 0.8595 100 0.344 Contact Map
4cmfA 4 0.8567 100 0.348 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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