GREMLIN Database
GAL1 - Galactokinase
UniProt: P39574 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 390 (371)
Sequences: 2815 (2015)
Seq/√Len: 104.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
197_E289_K4.3241.00
64_R114_D3.8311.00
301_K326_W3.4591.00
23_F50_G3.3301.00
234_A271_A3.1631.00
307_L313_V3.1581.00
56_A114_D3.1241.00
292_N295_E3.0301.00
279_H283_K2.9291.00
207_A351_D2.8521.00
51_T132_S2.7881.00
228_R232_N2.7571.00
61_G81_D2.7381.00
64_R77_E2.7381.00
150_D153_E2.7221.00
334_S347_S2.7201.00
284_T296_I2.6811.00
205_G351_D2.6281.00
359_Q363_D2.5941.00
251_K254_D2.5391.00
62_L77_E2.4951.00
10_A16_K2.3541.00
58_R114_D2.3451.00
24_A384_A2.3341.00
18_G57_E2.3331.00
15_E56_A2.3051.00
272_K310_D2.2511.00
237_D267_N2.2461.00
214_N374_D2.2071.00
273_H306_S2.1851.00
366_Q372_R2.1831.00
138_G154_L2.1441.00
169_N225_N2.1391.00
142_Q148_E2.1251.00
295_E298_Q2.1041.00
286_H290_E2.0911.00
217_R339_A2.0911.00
53_A136_L2.0721.00
8_I11_S2.0191.00
55_V140_V2.0061.00
287_M292_N1.9951.00
305_L309_D1.9681.00
139_V384_A1.9311.00
8_I12_V1.9301.00
22_F143_S1.9281.00
38_N231_C1.9251.00
270_R312_E1.9211.00
223_S226_T1.9111.00
298_Q302_E1.9011.00
39_G246_A1.8771.00
111_H145_F1.8681.00
350_K353_F1.8491.00
100_Y104_Q1.8461.00
363_D367_E1.8461.00
61_G79_S1.7811.00
233_D237_D1.7791.00
105_R160_H1.7611.00
305_L326_W1.7551.00
99_I141_L1.7541.00
117_F133_I1.7421.00
287_M295_E1.7231.00
265_E269_R1.7151.00
230_E270_R1.7141.00
283_K295_E1.7141.00
55_V144_Y1.7101.00
233_D236_L1.7051.00
276_Y310_D1.6861.00
211_A347_S1.6821.00
69_N118_S1.6371.00
334_S345_T1.6271.00
9_F56_A1.6041.00
155_V179_G1.6011.00
135_L179_G1.6001.00
95_P137_M1.5921.00
177_A181_G1.5821.00
98_V138_G1.5801.00
62_L79_S1.5771.00
53_A115_I1.5641.00
209_V357_F1.5391.00
211_A345_T1.5341.00
252_P279_H1.5021.00
105_R153_E1.4881.00
318_L345_T1.4871.00
355_D358_I1.4811.00
182_K198_Y1.4711.00
207_A354_V1.4661.00
324_A364_R1.4641.00
34_H37_Y1.4591.00
188_L285_A1.4561.00
21_F54_A1.4491.00
382_E385_R1.4431.00
7_G11_S1.4321.00
318_L336_M1.4281.00
355_D359_Q1.4071.00
192_D249_D1.3961.00
349_V357_F1.3961.00
269_R312_E1.3871.00
182_K185_H1.3821.00
41_H282_I1.3801.00
57_E111_H1.3661.00
184_H202_N1.3550.99
256_D259_S1.3480.99
218_T221_D1.3430.99
213_T321_L1.3350.99
160_H164_H1.3310.99
168_V339_A1.3270.99
68_D116_V1.3260.99
353_F356_D1.3170.99
266_T269_R1.3170.99
233_D267_N1.2970.99
58_R112_G1.2860.99
5_L116_V1.2780.99
297_G333_G1.2720.99
29_N44_P1.2550.99
119_G132_S1.2460.99
281_A285_A1.2400.99
6_K10_A1.2380.99
320_E324_A1.2380.99
176_F189_L1.2340.99
8_I116_V1.2210.99
65_M95_P1.2210.99
35_T248_G1.2150.99
39_G248_G1.2130.99
212_N374_D1.2080.99
107_Y149_V1.2020.99
63_V113_F1.2000.99
285_A289_K1.1990.99
6_K17_E1.1970.99
182_K382_E1.1950.99
320_E369_T1.1940.99
358_I362_G1.1910.99
255_F268_R1.1910.99
354_V358_I1.1900.99
332_I350_K1.1810.99
79_S82_D1.1800.99
35_T38_N1.1720.99
230_E266_T1.1610.98
244_I250_I1.1570.98
246_A249_D1.1540.98
35_T278_N1.1530.98
151_A179_G1.1500.98
362_G373_A1.1440.98
28_V346_I1.1440.98
205_G352_E1.1440.98
325_A345_T1.1360.98
101_E160_H1.1250.98
314_T336_M1.1220.98
42_V173_M1.1220.98
142_Q147_P1.1170.98
283_K286_H1.1120.98
9_F114_D1.1110.98
168_V219_L1.1090.98
320_E368_K1.1070.98
234_A267_N1.1060.98
325_A357_F1.1040.98
65_M78_C1.0980.98
63_V78_C1.0940.98
307_L318_L1.0930.98
187_M198_Y1.0920.98
356_D360_K1.0910.98
63_V112_G1.0810.97
12_V66_Y1.0810.97
159_Q170_C1.0690.97
316_P368_K1.0690.97
229_Q233_D1.0630.97
135_L158_A1.0600.97
259_S268_R1.0550.97
67_S70_F1.0530.97
48_T381_G1.0510.97
258_H261_L1.0510.97
215_K315_C1.0460.97
307_L311_Y1.0400.97
105_R157_M1.0360.97
10_A15_E1.0290.97
23_F385_R1.0270.97
328_H360_K1.0260.97
176_F180_M1.0260.97
55_V113_F1.0230.96
53_A117_F1.0200.96
17_E54_A1.0190.96
237_D263_Q1.0190.96
29_N33_E1.0170.96
5_L54_A1.0160.96
139_V151_A1.0140.96
316_P320_E0.9970.96
211_A334_S0.9960.96
299_L303_S0.9950.96
117_F137_M0.9940.96
135_L154_L0.9910.96
101_E164_H0.9900.96
216_K219_L0.9890.96
286_H289_K0.9850.96
263_Q267_N0.9800.96
61_G80_L0.9800.96
205_G350_K0.9800.96
142_Q154_L0.9720.95
268_R272_K0.9710.95
360_K364_R0.9700.95
163_N166_I0.9680.95
28_V337_T0.9670.95
294_D298_Q0.9590.95
24_A178_I0.9580.95
84_R165_F0.9540.95
131_A170_C0.9530.95
98_V161_A0.9460.95
78_C96_K0.9420.94
134_E175_Q0.9410.94
272_K276_Y0.9400.94
161_A170_C0.9400.94
226_T230_E0.9340.94
230_E267_N0.9340.94
53_A140_V0.9310.94
102_F147_P0.9280.94
5_L118_S0.9230.94
68_D118_S0.9200.94
58_R63_V0.9180.94
54_A116_V0.9130.93
95_P133_I0.9090.93
135_L178_I0.9080.93
138_G158_A0.9080.93
57_E145_F0.9070.93
211_A321_L0.9070.93
156_K159_Q0.9060.93
136_L140_V0.9050.93
47_L381_G0.9050.93
18_G56_A0.9030.93
152_L156_K0.9030.93
101_E104_Q0.9020.93
206_L332_I0.9000.93
190_N248_G0.9000.93
213_T318_L0.8960.93
33_E307_L0.8920.93
237_D262_I0.8880.93
215_K218_T0.8850.92
159_Q172_I0.8780.92
66_Y116_V0.8760.92
281_A284_T0.8680.92
41_H248_G0.8660.92
139_V154_L0.8650.92
95_P117_F0.8650.92
324_A328_H0.8650.92
121_I178_I0.8640.91
321_L345_T0.8640.91
176_F196_Y0.8590.91
50_G121_I0.8490.91
242_L261_L0.8480.91
183_K382_E0.8440.90
215_K219_L0.8430.90
5_L8_I0.8420.90
318_L339_A0.8360.90
230_E312_E0.8320.90
258_H262_I0.8320.90
142_Q145_F0.8300.90
315_C345_T0.8300.90
168_V220_A0.8260.90
142_Q151_A0.8230.89
48_T379_D0.8230.89
362_G372_R0.8210.89
245_A249_D0.8200.89
274_A313_V0.8180.89
124_G131_A0.8130.89
331_V353_F0.8130.89
161_A166_I0.8090.89
315_C318_L0.8080.88
39_G192_D0.8070.88
189_L198_Y0.8070.88
338_G342_G0.8070.88
151_A154_L0.8040.88
153_E156_K0.8030.88
104_Q160_H0.8020.88
41_H278_N0.8000.88
325_A334_S0.7940.88
55_V115_I0.7940.88
214_N219_L0.7940.88
279_H282_I0.7920.87
63_V141_L0.7920.87
24_A136_L0.7900.87
155_V180_M0.7890.87
305_L308_K0.7890.87
88_E93_N0.7880.87
284_T300_M0.7880.87
172_I176_F0.7870.87
308_K319_D0.7870.87
142_Q149_V0.7860.87
113_F141_L0.7860.87
199_S285_A0.7850.87
244_I254_D0.7850.87
104_Q164_H0.7840.87
315_C320_E0.7830.87
357_F361_V0.7790.87
172_I191_C0.7760.86
132_S178_I0.7690.86
215_K317_E0.7680.86
102_F157_M0.7680.86
219_L222_S0.7650.86
294_D350_K0.7640.86
48_T378_A0.7620.85
254_D257_A0.7620.85
185_H200_K0.7610.85
31_I284_T0.7590.85
93_N96_K0.7580.85
274_A307_L0.7580.85
364_R367_E0.7570.85
153_E157_M0.7560.85
237_D242_L0.7530.85
9_F116_V0.7530.85
27_R36_D0.7530.85
63_V99_I0.7530.85
31_I44_P0.7520.85
113_F145_F0.7490.84
60_D112_G0.7470.84
42_V172_I0.7470.84
206_L350_K0.7460.84
168_V225_N0.7460.84
277_E280_R0.7440.84
242_L250_I0.7430.84
63_V80_L0.7430.84
155_V159_Q0.7420.84
106_G109_V0.7410.84
15_E114_D0.7400.84
102_F107_Y0.7400.84
360_K363_D0.7360.83
49_M378_A0.7360.83
365_Y371_L0.7350.83
7_G10_A0.7310.83
45_C208_L0.7300.83
27_R174_D0.7290.83
58_R64_R0.7270.83
152_L155_V0.7250.82
152_L180_M0.7250.82
130_S343_G0.7230.82
366_Q373_A0.7210.82
276_Y306_S0.7190.82
45_C380_I0.7180.82
328_H331_V0.7170.82
231_C235_L0.7160.82
358_I375_F0.7140.81
207_A377_V0.7100.81
292_N298_Q0.7060.81
131_A158_A0.7050.81
273_H303_S0.7040.81
39_G249_D0.7000.80
134_E158_A0.6990.80
316_P369_T0.6980.80
133_I137_M0.6980.80
226_T229_Q0.6960.80
13_F66_Y0.6960.80
109_V147_P0.6940.80
226_T339_A0.6920.79
356_D359_Q0.6900.79
304_H322_V0.6870.79
33_E44_P0.6860.79
211_A325_A0.6820.78
219_L223_S0.6810.78
227_R312_E0.6810.78
324_A329_E0.6800.78
127_L210_I0.6790.78
322_V326_W0.6790.78
41_H281_A0.6770.78
139_V142_Q0.6760.78
17_E20_R0.6760.78
266_T270_R0.6750.78
139_V179_G0.6720.77
158_A161_A0.6710.77
280_R306_S0.6690.77
89_D93_N0.6680.77
128_S175_Q0.6650.77
76_K92_A0.6630.76
128_S335_R0.6590.76
43_F285_A0.6590.76
175_Q224_Y0.6590.76
8_I68_D0.6570.76
273_H337_T0.6560.76
69_N123_N0.6550.76
170_C219_L0.6540.75
59_N111_H0.6530.75
266_T312_E0.6500.75
89_D92_A0.6490.75
277_E303_S0.6460.75
173_M181_G0.6430.74
115_I140_V0.6410.74
256_D260_S0.6410.74
134_E161_A0.6400.74
23_F52_Y0.6360.73
35_T40_G0.6330.73
35_T41_H0.6330.73
209_V349_V0.6320.73
217_R344_C0.6310.73
30_L296_I0.6310.73
303_S306_S0.6310.73
235_L247_L0.6310.73
28_V44_P0.6300.73
324_A360_K0.6290.73
250_I255_F0.6290.73
354_V377_V0.6280.73
134_E170_C0.6280.73
27_R128_S0.6280.73
180_M196_Y0.6250.72
22_F136_L0.6250.72
7_G363_D0.6220.72
337_T346_I0.6220.72
30_L300_M0.6220.72
211_A361_V0.6190.71
328_H364_R0.6190.71
316_P319_D0.6180.71
5_L52_Y0.6170.71
28_V45_C0.6160.71
364_R368_K0.6160.71
22_F53_A0.6130.71
128_S224_Y0.6070.70
351_D354_V0.6060.70
47_L127_L0.6050.70
322_V334_S0.6050.70
300_M346_I0.6040.70
102_F141_L0.6040.70
213_T345_T0.6030.69
171_G174_D0.6020.69
57_E144_Y0.6010.69
51_T117_F0.6010.69
177_A189_L0.6010.69
320_E323_F0.6000.69
319_D322_V0.6000.69
307_L336_M0.5990.69
65_M115_I0.5980.69
35_T235_L0.5970.69
300_M333_G0.5970.69
252_P276_Y0.5970.69
154_L179_G0.5960.69
162_E171_G0.5940.68
313_V318_L0.5930.68
58_R61_G0.5930.68
26_G121_I0.5920.68
44_P173_M0.5920.68
129_S162_E0.5910.68
244_I247_L0.5900.68
154_L157_M0.5890.68
33_E313_V0.5880.68
214_N371_L0.5880.68
211_A375_F0.5870.67
207_A379_D0.5830.67
242_L258_H0.5820.67
217_R222_S0.5820.67
60_D111_H0.5810.67
166_I170_C0.5800.67
224_Y339_A0.5800.67
91_W94_Y0.5790.66
322_V325_A0.5770.66
208_L346_I0.5760.66
213_T336_M0.5750.66
150_D156_K0.5750.66
251_K275_V0.5740.66
7_G15_E0.5720.65
335_R341_F0.5720.65
155_V158_A0.5710.65
155_V173_M0.5700.65
262_I267_N0.5690.65
59_N291_N0.5680.65
307_L339_A0.5670.65
101_E105_R0.5660.65
301_K305_L0.5660.65
140_V348_I0.5650.64
271_A275_V0.5650.64
252_P256_D0.5650.64
184_H379_D0.5640.64
20_R144_Y0.5630.64
46_A178_I0.5630.64
130_S171_G0.5630.64
10_A14_G0.5630.64
250_I275_V0.5620.64
269_R310_D0.5610.64
323_F326_W0.5610.64
216_K221_D0.5600.64
35_T224_Y0.5600.64
20_R143_S0.5580.64
313_V336_M0.5570.63
331_V357_F0.5560.63
345_T357_F0.5560.63
52_Y118_S0.5560.63
76_K83_I0.5550.63
156_K179_G0.5550.63
36_D42_V0.5540.63
162_E175_Q0.5520.63
313_V341_F0.5520.63
235_L243_D0.5510.63
314_T319_D0.5500.62
206_L293_I0.5490.62
215_K314_T0.5490.62
34_H311_Y0.5490.62
171_G175_Q0.5470.62
188_L282_I0.5450.62
47_L51_T0.5450.62
100_Y103_Q0.5440.62
338_G343_G0.5440.62
85_Y96_K0.5440.62
10_A17_E0.5440.62
325_A361_V0.5440.62
284_T288_F0.5430.61
210_I376_Y0.5430.61
223_S230_E0.5420.61
93_N165_F0.5410.61
85_Y88_E0.5400.61
115_I137_M0.5400.61
131_A217_R0.5400.61
374_D378_A0.5390.61
168_V217_R0.5380.61
136_L384_A0.5360.60
6_K16_K0.5350.60
6_K11_S0.5340.60
187_M199_S0.5330.60
58_R111_H0.5330.60
283_K299_L0.5310.60
41_H188_L0.5310.60
217_R223_S0.5290.59
61_G111_H0.5290.59
233_D300_M0.5290.59
185_H198_Y0.5280.59
89_D96_K0.5280.59
302_E305_L0.5260.59
24_A53_A0.5260.59
210_I337_T0.5260.59
223_S339_A0.5240.59
40_G97_G0.5220.58
282_I286_H0.5220.58
33_E346_I0.5220.58
36_D171_G0.5220.58
119_G123_N0.5210.58
188_L197_E0.5200.58
134_E159_Q0.5200.58
207_A352_E0.5200.58
27_R224_Y0.5180.58
164_H169_N0.5180.58
22_F144_Y0.5170.58
124_G339_A0.5160.58
129_S171_G0.5160.58
151_A180_M0.5140.57
163_N224_Y0.5140.57
365_Y370_G0.5140.57
171_G338_G0.5140.57
29_N307_L0.5120.57
128_S171_G0.5110.57
158_A170_C0.5100.57
27_R175_Q0.5090.57
47_L346_I0.5080.56
36_D175_Q0.5080.56
235_L242_L0.5080.56
8_I66_Y0.5070.56
99_I113_F0.5060.56
362_G375_F0.5040.56
139_V385_R0.5030.56
314_T345_T0.5030.56
27_R37_Y0.5020.56
215_K221_D0.5010.55
29_N337_T0.5010.55
271_A306_S0.5000.55
227_R311_Y0.5000.55
274_A281_A0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pieA 1 0.9872 100 0.245 Contact Map
3v2uC 2 0.9795 100 0.292 Contact Map
2a2cA 1 0.9718 100 0.301 Contact Map
1wuuA 2 0.959 100 0.31 Contact Map
2cz9A 1 0.8872 100 0.365 Contact Map
1kvkA 2 0.8462 100 0.486 Contact Map
4n3oA 2 0.8051 100 0.507 Contact Map
3k85A 3 0.7513 100 0.51 Contact Map
1kkhA 1 0.7923 100 0.525 Contact Map
2hfsA 1 0.8231 100 0.56 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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