GREMLIN Database
GERBC - Spore germination protein B3
UniProt: P39571 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 374 (358)
Sequences: 2225 (1921)
Seq/√Len: 101.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
272_H359_K5.1071.00
274_S361_D4.3111.00
103_E107_R4.2911.00
224_E318_K4.1381.00
103_E134_R3.5771.00
46_K138_A3.5461.00
309_E313_K3.5421.00
39_E109_Q3.3711.00
100_L133_A3.1781.00
136_N139_D3.0191.00
276_K363_S2.8501.00
193_A219_F2.8371.00
305_E364_F2.7671.00
251_F304_F2.6831.00
110_N214_N2.5781.00
271_F330_L2.5771.00
320_Q353_F2.5171.00
138_A142_T2.5141.00
309_E362_I2.4641.00
44_Q73_H2.4581.00
271_F356_T2.4461.00
216_L219_F2.4211.00
49_Y84_V2.3511.00
275_V312_V2.3501.00
319_L353_F2.3491.00
47_L80_A2.3471.00
270_V357_D2.3341.00
278_K367_I2.3321.00
324_K354_S2.2871.00
207_G216_L2.2451.00
227_T315_V2.1821.00
270_V359_K2.1761.00
132_A207_G2.1441.00
178_R189_Y2.1441.00
48_T137_A2.0561.00
206_A225_T2.0561.00
316_M358_F2.0471.00
106_M132_A2.0201.00
218_G323_Y2.0071.00
116_N120_R1.9941.00
319_L328_V1.9821.00
101_L114_V1.9751.00
348_H351_E1.9561.00
319_L327_P1.9521.00
46_K73_H1.8721.00
72_S83_D1.8561.00
298_H301_E1.8341.00
37_I105_L1.8191.00
190_L228_L1.8161.00
38_D137_A1.8151.00
273_I330_L1.8051.00
34_G154_S1.8031.00
272_H361_D1.7961.00
32_A91_V1.7961.00
206_A228_L1.7931.00
341_Y345_V1.7861.00
44_Q75_K1.7661.00
130_L178_R1.7611.00
102_G137_A1.7511.00
263_V272_H1.7421.00
131_M194_V1.7381.00
331_S349_W1.7281.00
178_R191_I1.7011.00
81_V93_S1.6511.00
38_D102_G1.6251.00
40_T73_H1.6161.00
35_L96_L1.6071.00
251_F279_G1.5841.00
36_A137_A1.5831.00
268_K357_D1.5761.00
82_S252_E1.5661.00
277_T364_F1.5621.00
193_A216_L1.5451.00
132_A209_I1.5391.00
262_P269_P1.5381.00
227_T308_L1.5351.00
185_N346_K1.5241.00
264_I269_P1.5161.00
106_M209_I1.5051.00
271_F334_I1.4971.00
278_K365_K1.4911.00
188_S325_T1.4861.00
157_L194_V1.4671.00
221_S224_E1.4641.00
274_S363_S1.4401.00
139_D142_T1.4331.00
101_L106_M1.4311.00
134_R195_K1.4281.00
300_L366_I1.4191.00
302_N305_E1.4171.00
71_T138_A1.4091.00
34_G141_F1.4041.00
307_K310_R1.3961.00
46_K71_T1.3951.00
101_L111_V1.3911.00
299_R303_I1.3841.00
102_G105_L1.3811.00
307_K311_D1.3650.99
208_I327_P1.3560.99
316_M360_Y1.3540.99
74_G80_A1.3500.99
312_V360_Y1.3500.99
305_E309_E1.3460.99
188_S350_D1.3450.99
260_I271_F1.3440.99
35_L118_F1.3400.99
301_E305_E1.3340.99
131_M161_T1.3250.99
218_G325_T1.3220.99
233_G258_T1.3130.99
349_W353_F1.3090.99
75_K79_E1.2950.99
46_K136_N1.2850.99
231_V273_I1.2840.99
10_M14_L1.2810.99
126_R176_I1.2730.99
40_T46_K1.2590.99
97_K158_I1.2470.99
317_D320_Q1.2360.99
315_V319_L1.2340.99
29_L92_Y1.2030.99
293_S296_Y1.2030.99
258_T275_V1.2020.99
67_F153_P1.2010.99
45_Y105_L1.1950.99
231_V328_V1.1940.99
265_E270_V1.1880.99
320_Q349_W1.1850.98
30_S51_N1.1770.98
334_I341_Y1.1740.98
74_G79_E1.1690.98
262_P337_Q1.1610.98
259_K274_S1.1540.98
32_A93_S1.1440.98
78_L82_S1.1360.98
78_L252_E1.1290.98
78_L117_H1.1280.98
104_K137_A1.1260.98
186_G331_S1.1230.98
227_T319_L1.1160.98
78_L282_T1.1140.98
290_N293_S1.1140.98
304_F364_F1.1130.98
74_G83_D1.1130.98
277_T308_L1.1020.98
318_K322_E1.1010.98
195_K204_D1.0990.98
168_G235_I1.0990.98
297_L301_E1.0970.97
17_L20_C1.0970.97
279_G304_F1.0940.97
13_M16_A1.0850.97
343_N346_K1.0780.97
48_T71_T1.0760.97
134_R219_F1.0750.97
96_L124_L1.0730.97
50_Q153_P1.0710.97
119_I179_A1.0700.97
33_R52_L1.0690.97
37_I77_I1.0680.97
133_A140_V1.0660.97
208_I323_Y1.0610.97
72_S84_V1.0590.97
228_L232_M1.0510.97
280_I368_N1.0470.97
228_L327_P1.0400.97
48_T69_N1.0390.96
262_P338_H1.0360.96
332_D335_R1.0330.96
87_K200_K1.0290.96
36_A136_N1.0280.96
111_V178_R1.0210.96
6_K17_L1.0170.96
40_T43_H1.0140.96
306_K309_E1.0090.96
239_V252_E1.0070.96
99_I128_S1.0070.96
76_T248_P1.0030.96
231_V312_V1.0000.96
95_H125_R1.0000.96
330_L358_F0.9970.96
261_K272_H0.9960.96
106_M207_G0.9960.96
120_R370_G0.9940.95
221_S225_T0.9930.95
100_L131_M0.9920.95
195_K202_K0.9910.95
334_I342_W0.9900.95
303_I306_K0.9880.95
210_K217_V0.9870.95
224_E314_Q0.9830.95
313_K360_Y0.9820.95
262_P271_F0.9770.95
112_D214_N0.9700.95
178_R182_Y0.9680.95
334_I338_H0.9680.95
90_P123_E0.9640.95
99_I118_F0.9580.94
186_G329_F0.9500.94
306_K310_R0.9480.94
313_K317_D0.9460.94
54_P150_Q0.9450.94
210_K325_T0.9450.94
320_Q354_S0.9450.94
27_E126_R0.9420.94
350_D353_F0.9340.94
103_E219_F0.9280.94
131_M192_Q0.9240.93
104_K107_R0.9190.93
220_L224_E0.9160.93
264_I338_H0.9120.93
284_D289_E0.9070.93
332_D336_I0.9060.93
121_D282_T0.9040.93
269_P356_T0.8900.92
110_N209_I0.8890.92
72_S80_A0.8880.92
75_K248_P0.8860.92
67_F152_M0.8840.92
231_V258_T0.8830.92
191_I209_I0.8790.92
102_G133_A0.8780.91
302_N306_K0.8750.91
333_H336_I0.8720.91
217_V325_T0.8680.91
249_I300_L0.8650.91
24_K29_L0.8550.90
187_Y329_F0.8540.90
37_I47_L0.8540.90
99_I130_L0.8520.90
14_L18_C0.8450.90
106_M216_L0.8420.90
188_S353_F0.8400.90
57_E66_E0.8320.89
106_M110_N0.8300.89
133_A137_A0.8250.89
87_K202_K0.8240.89
190_L327_P0.8230.89
50_Q67_F0.8220.89
210_K350_D0.8170.88
261_K274_S0.8130.88
101_L132_A0.8130.88
352_I355_E0.8120.88
275_V362_I0.8110.88
227_T230_W0.8100.88
338_H341_Y0.8010.87
140_V194_V0.7980.87
227_T312_V0.7960.87
6_K14_L0.7960.87
298_H302_N0.7950.87
260_I273_I0.7950.87
281_L291_S0.7920.87
209_I216_L0.7920.87
310_R314_Q0.7900.87
262_P333_H0.7850.86
208_I220_L0.7820.86
174_L177_G0.7820.86
175_R178_R0.7820.86
28_Q159_D0.7800.86
107_R209_I0.7800.86
35_L99_I0.7780.86
36_A48_T0.7780.86
132_A216_L0.7750.85
160_L203_Y0.7710.85
76_T283_E0.7700.85
35_L49_Y0.7680.85
308_L312_V0.7660.85
243_T248_P0.7650.85
102_G132_A0.7630.85
240_M311_D0.7620.85
333_H337_Q0.7600.84
72_S87_K0.7590.84
78_L283_E0.7580.84
296_Y299_R0.7550.84
134_R193_A0.7520.84
230_W277_T0.7520.84
308_L364_F0.7520.84
78_L121_D0.7500.84
341_Y344_K0.7460.83
339_P342_W0.7440.83
178_R209_I0.7410.83
177_G181_V0.7410.83
98_V131_M0.7380.83
318_K323_Y0.7360.82
230_W235_I0.7350.82
85_S122_D0.7290.82
263_V270_V0.7260.82
34_G50_Q0.7260.82
111_V209_I0.7250.81
25_D95_H0.7250.81
278_K368_N0.7240.81
34_G98_V0.7230.81
70_V84_V0.7220.81
349_W354_S0.7200.81
50_Q125_R0.7180.81
35_L47_L0.7170.81
111_V242_T0.7140.80
229_S234_T0.7130.80
23_V31_F0.7120.80
5_S17_L0.7110.80
339_P343_N0.7100.80
316_M320_Q0.7100.80
188_S327_P0.7090.80
252_E282_T0.7080.80
6_K10_M0.7080.80
79_E241_P0.7070.80
316_M328_V0.7060.80
129_Y158_I0.7060.80
31_F92_Y0.7050.80
49_Y93_S0.7040.80
184_Q332_D0.7020.79
230_W308_L0.7010.79
309_E360_Y0.6990.79
103_E193_A0.6940.79
227_T311_D0.6940.79
96_L128_S0.6930.78
189_Y329_F0.6900.78
36_A138_A0.6880.78
345_V352_I0.6870.78
9_V12_F0.6870.78
76_T241_P0.6870.78
320_Q356_T0.6840.78
324_K351_E0.6790.77
253_I279_G0.6790.77
40_T44_Q0.6780.77
181_V187_Y0.6760.77
53_L56_S0.6750.77
37_I99_I0.6750.77
226_Q311_D0.6710.76
25_D89_P0.6680.76
130_L191_I0.6670.76
5_S16_A0.6660.76
49_Y81_V0.6650.76
169_K226_Q0.6650.76
83_D86_I0.6650.76
251_F366_I0.6650.76
265_E295_S0.6630.75
264_I341_Y0.6610.75
137_A141_F0.6600.75
118_F175_R0.6550.74
93_S99_I0.6550.74
86_I169_K0.6540.74
18_C22_D0.6540.74
111_V214_N0.6510.74
289_E296_Y0.6500.74
23_V150_Q0.6490.74
319_L323_Y0.6480.74
36_A102_G0.6470.74
243_T246_G0.6460.73
5_S295_S0.6450.73
173_P182_Y0.6450.73
155_E159_D0.6440.73
105_L114_V0.6440.73
14_L314_Q0.6400.73
133_A205_G0.6390.73
312_V315_V0.6370.72
173_P177_G0.6370.72
37_I45_Y0.6370.72
176_I180_S0.6360.72
209_I214_N0.6350.72
226_Q230_W0.6330.72
277_T303_I0.6330.72
50_Q69_N0.6330.72
220_L318_K0.6290.71
249_I284_D0.6280.71
193_A207_G0.6270.71
27_E156_K0.6250.71
84_V183_S0.6240.71
14_L47_L0.6240.71
5_S18_C0.6190.70
18_C21_W0.6180.70
156_K160_L0.6170.70
173_P181_V0.6160.70
190_L206_A0.6140.70
262_P339_P0.6130.70
40_T104_K0.6120.69
257_K362_I0.6120.69
22_D28_Q0.6120.69
102_G216_L0.6120.69
294_K298_H0.6110.69
253_I256_S0.6100.69
101_L115_L0.6100.69
327_P353_F0.6100.69
269_P334_I0.6100.69
48_T133_A0.6080.69
14_L17_L0.6070.69
316_M353_F0.6060.69
32_A84_V0.6060.69
315_V318_K0.6060.69
103_E135_G0.6050.69
220_L228_L0.6030.68
135_G205_G0.6030.68
177_G223_D0.6020.68
155_E158_I0.6020.68
260_I356_T0.6000.68
73_H77_I0.6000.68
220_L315_V0.5990.68
262_P330_L0.5980.68
31_F67_F0.5970.68
347_G351_E0.5960.67
48_T104_K0.5950.67
168_G205_G0.5950.67
76_T250_T0.5920.67
7_F303_I0.5920.67
11_F302_N0.5910.67
87_K197_E0.5910.67
36_A142_T0.5900.67
275_V288_N0.5890.66
276_K365_K0.5890.66
78_L122_D0.5860.66
10_M13_M0.5850.66
230_W311_D0.5840.66
228_L315_V0.5840.66
107_R216_L0.5840.66
33_R176_I0.5820.66
186_G189_Y0.5820.66
134_R216_L0.5820.66
226_Q328_V0.5810.65
204_D222_A0.5800.65
92_Y97_K0.5800.65
279_G364_F0.5790.65
7_F11_F0.5790.65
86_I222_A0.5790.65
100_L137_A0.5770.65
60_Q63_G0.5770.65
115_L223_D0.5770.65
208_I325_T0.5740.65
16_A302_N0.5730.64
245_K324_K0.5720.64
45_Y114_V0.5700.64
50_Q141_F0.5700.64
51_N70_V0.5700.64
82_S85_S0.5680.64
291_S296_Y0.5680.64
26_I89_P0.5680.64
279_G301_E0.5660.63
50_Q152_M0.5650.63
98_V157_L0.5650.63
82_S121_D0.5650.63
88_D160_L0.5650.63
290_N317_D0.5640.63
229_S233_G0.5640.63
210_K213_S0.5640.63
8_S16_A0.5630.63
315_V327_P0.5610.63
98_V154_S0.5600.63
131_M157_L0.5600.63
31_F175_R0.5590.62
140_V322_E0.5560.62
102_G136_N0.5560.62
269_P341_Y0.5540.62
9_V16_A0.5540.62
279_G366_I0.5540.62
89_P150_Q0.5540.62
34_G155_E0.5540.62
223_D311_D0.5530.62
217_V323_Y0.5520.62
89_P336_I0.5510.61
221_S274_S0.5510.61
269_P345_V0.5510.61
48_T138_A0.5510.61
71_T197_E0.5510.61
266_N276_K0.5500.61
26_I66_E0.5500.61
265_E268_K0.5500.61
29_L94_D0.5480.61
274_S277_T0.5480.61
116_N283_E0.5460.61
177_G353_F0.5440.60
77_I341_Y0.5430.60
231_V316_M0.5420.60
241_P248_P0.5420.60
192_Q203_Y0.5400.60
189_Y331_S0.5400.60
21_W342_W0.5400.60
52_L151_P0.5400.60
132_A191_I0.5400.60
134_R221_S0.5390.60
152_M155_E0.5390.60
104_K197_E0.5380.60
249_I279_G0.5380.60
45_Y273_I0.5370.59
309_E361_D0.5350.59
218_G353_F0.5340.59
334_I339_P0.5340.59
280_I367_I0.5330.59
113_Q304_F0.5320.59
304_F366_I0.5320.59
27_E53_L0.5320.59
36_A50_Q0.5300.58
129_Y172_I0.5280.58
6_K13_M0.5280.58
107_R295_S0.5270.58
5_S130_L0.5260.58
187_Y332_D0.5250.58
252_E280_I0.5240.58
85_S91_V0.5230.57
361_D364_F0.5230.57
39_E45_Y0.5220.57
234_T344_K0.5220.57
143_K201_A0.5210.57
340_D344_K0.5210.57
88_D145_N0.5200.57
35_L81_V0.5200.57
44_Q47_L0.5200.57
242_T303_I0.5200.57
189_Y192_Q0.5190.57
100_L140_V0.5190.57
8_S267_G0.5190.57
181_V242_T0.5180.57
229_S371_T0.5180.57
48_T141_F0.5170.57
48_T102_G0.5150.56
42_D259_K0.5150.56
260_I333_H0.5150.56
6_K16_A0.5140.56
49_Y124_L0.5130.56
350_D362_I0.5120.56
85_S90_P0.5120.56
52_L125_R0.5080.55
54_P89_P0.5070.55
6_K109_Q0.5060.55
254_K280_I0.5060.55
33_R203_Y0.5050.55
94_D229_S0.5040.55
30_S329_F0.5040.55
235_I256_S0.5040.55
230_W240_M0.5030.55
106_M111_V0.5030.55
52_L152_M0.5030.55
168_G226_Q0.5020.54
119_I126_R0.5020.54
37_I101_L0.5020.54
171_M228_L0.5010.54
173_P366_I0.5010.54
52_L156_K0.5000.54
18_C210_K0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3n54B 5 0.8235 100 0.17 Contact Map
3zbiC 1 0.0722 45.3 0.958 Contact Map
2jnaA 2 0.2406 18 0.966 Contact Map
4n4rB 1 0.377 13.9 0.967 Contact Map
4fybB 1 0.377 9.9 0.969 Contact Map
3utkA 1 0.2166 9 0.97 Contact Map
3wfdC 1 0.3396 8.9 0.97 Contact Map
4n6kA 1 0.6658 8.8 0.97 Contact Map
4inwA 1 0.1658 8.5 0.97 Contact Map
2nocA 1 0.2326 6.3 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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