GREMLIN Database
GERBB - Spore germination protein B2
UniProt: P39570 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 368 (354)
Sequences: 23799 (15069)
Seq/√Len: 800.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
299_I311_L4.2121.00
49_G226_T3.5511.00
132_I317_A3.3221.00
355_L359_Q3.0311.00
213_Q216_K2.9671.00
210_D213_Q2.8511.00
299_I302_L2.8461.00
9_T209_R2.8121.00
14_L220_L2.6821.00
10_F220_L2.5841.00
164_S235_I2.4841.00
254_S257_H2.4791.00
304_N310_L2.4571.00
133_Y137_G2.4301.00
13_T208_M2.4301.00
309_W312_T2.3821.00
302_L311_L2.3391.00
169_Q172_F2.3091.00
216_K220_L2.2361.00
76_S81_K2.2151.00
10_F14_L2.1751.00
151_P155_I2.1381.00
254_S258_A2.1281.00
76_S84_G2.1101.00
9_T12_Q2.0921.00
244_E258_A2.0891.00
125_F324_Y2.0841.00
140_Y144_K2.0491.00
75_N87_L2.0021.00
314_M318_T1.9881.00
290_K294_I1.9611.00
14_L224_T1.9591.00
50_V54_I1.9381.00
345_V349_P1.9031.00
241_T244_E1.8941.00
257_H262_P1.8891.00
12_Q147_A1.8861.00
106_L127_F1.8731.00
206_P294_I1.8551.00
331_V334_Y1.8201.00
92_C316_A1.7951.00
33_A41_G1.7811.00
125_F321_I1.7711.00
300_F315_L1.7571.00
88_N292_A1.7521.00
129_A317_A1.7451.00
61_P357_W1.7401.00
219_A223_A1.7311.00
66_N77_I1.7291.00
44_M187_L1.7271.00
48_Q191_T1.7261.00
129_A321_I1.7251.00
17_I221_G1.6911.00
349_P352_V1.6861.00
304_N308_A1.6761.00
309_W314_M1.6661.00
207_F287_G1.6631.00
12_Q143_A1.6521.00
332_F336_T1.6501.00
155_I159_M1.6251.00
171_D174_R1.6181.00
56_V222_I1.6151.00
56_V218_V1.6111.00
172_F175_P1.6071.00
110_V123_V1.6071.00
8_L12_Q1.5941.00
248_V254_S1.5831.00
331_V335_G1.5761.00
168_F238_G1.5731.00
40_S184_F1.5581.00
293_H301_H1.5571.00
116_K119_P1.5511.00
103_A128_L1.5351.00
161_L231_I1.5241.00
330_D333_Y1.5141.00
80_G83_I1.5111.00
223_A227_L1.5101.00
311_L315_L1.5051.00
125_F129_A1.5031.00
10_F216_K1.4811.00
311_L314_M1.4641.00
73_K77_I1.4631.00
298_E301_H1.4601.00
132_I313_A1.4501.00
136_G310_L1.4491.00
61_P64_Q1.4471.00
79_A355_L1.4471.00
79_A83_I1.4451.00
166_R171_D1.4451.00
166_R169_Q1.4431.00
165_F235_I1.4191.00
28_T105_I1.4151.00
124_V324_Y1.4001.00
250_W254_S1.4001.00
57_L219_A1.3991.00
68_G73_K1.3881.00
354_F358_I1.3871.00
333_Y336_T1.3801.00
164_S239_C1.3601.00
348_I352_V1.3371.00
160_L164_S1.3371.00
121_A125_F1.3301.00
21_L225_S1.3271.00
13_T217_A1.3271.00
5_E307_N1.3111.00
287_G292_A1.3111.00
210_D216_K1.3051.00
69_K206_P1.2951.00
42_W234_L1.2941.00
154_L158_M1.2931.00
119_P122_V1.2921.00
349_P353_W1.2821.00
63_L74_L1.2801.00
273_L276_T1.2681.00
144_K148_Y1.2561.00
227_L231_I1.2531.00
335_G338_L1.2501.00
7_K209_R1.2481.00
132_I319_F1.2461.00
167_L170_L1.2431.00
11_M15_I1.2431.00
58_L350_F1.2411.00
204_L283_A1.2391.00
234_L238_G1.2351.00
132_I136_G1.2331.00
211_P215_K1.2251.00
166_R170_L1.2171.00
85_F89_L1.2111.00
351_F355_L1.2111.00
136_G314_M1.2071.00
168_F172_F1.2061.00
353_W357_W1.1951.00
18_S224_T1.1901.00
59_F71_L1.1811.00
298_E302_L1.1781.00
132_I314_M1.1661.00
144_K147_A1.1621.00
17_I201_I1.1581.00
107_G123_V1.1541.00
169_Q173_I1.1541.00
68_G77_I1.1491.00
46_L230_S1.1441.00
79_A351_F1.1441.00
348_I354_F1.1431.00
302_L305_K1.1421.00
180_G183_S1.1391.00
8_L143_A1.1371.00
327_D330_D1.1271.00
242_V245_A1.1261.00
122_V126_I1.1221.00
16_M204_L1.1121.00
75_N83_I1.1071.00
145_V149_I1.1071.00
318_T322_T1.1071.00
309_W313_A1.1051.00
337_L341_A1.1021.00
123_V126_I1.0991.00
283_A287_G1.0981.00
287_G290_K1.0961.00
118_T122_V1.0921.00
270_D277_W1.0891.00
156_I269_F1.0841.00
15_I147_A1.0831.00
308_A311_L1.0821.00
168_F171_D1.0731.00
159_M163_F1.0701.00
273_L287_G1.0671.00
8_L13_T1.0621.00
75_N348_I1.0601.00
314_M317_A1.0581.00
34_A41_G1.0571.00
186_S190_K1.0481.00
134_H145_V1.0441.00
115_L118_T1.0441.00
170_L173_I1.0441.00
302_L310_L1.0401.00
82_F86_L1.0401.00
40_S177_F1.0341.00
117_N120_M1.0331.00
126_I130_V1.0331.00
239_C255_L1.0291.00
248_V251_P1.0271.00
168_F173_I1.0251.00
205_V214_V1.0251.00
158_M162_M1.0221.00
308_A312_T1.0181.00
102_Q277_W1.0131.00
101_F193_L1.0081.00
276_T283_A1.0051.00
270_D274_Q1.0021.00
316_A319_F1.0021.00
129_A133_Y1.0011.00
7_K140_Y1.0001.00
154_L228_F0.9981.00
133_Y136_G0.9971.00
167_L171_D0.9851.00
130_V275_L0.9851.00
287_G293_H0.9831.00
181_Y185_F0.9811.00
11_M147_A0.9791.00
345_V348_I0.9791.00
99_V320_F0.9771.00
329_N334_Y0.9691.00
350_F353_W0.9671.00
305_K310_L0.9671.00
107_G124_V0.9671.00
270_D273_L0.9591.00
18_S225_S0.9571.00
268_R272_F0.9561.00
167_L172_F0.9551.00
303_K307_N0.9511.00
300_F311_L0.9461.00
264_I268_R0.9441.00
42_W237_I0.9421.00
49_G195_F0.9381.00
336_T339_G0.9361.00
135_V279_A0.9341.00
199_E203_Y0.9331.00
345_V352_V0.9291.00
289_F293_H0.9291.00
226_T230_S0.9251.00
92_C289_F0.9251.00
167_L173_I0.9221.00
137_G141_S0.9211.00
340_Y343_L0.9191.00
161_L235_I0.9171.00
283_A286_L0.9141.00
160_L256_I0.9061.00
277_W280_Q0.9061.00
78_V352_V0.9041.00
110_V114_L0.9041.00
12_Q144_K0.9031.00
14_L217_A0.8991.00
53_I57_L0.8951.00
344_I349_P0.8941.00
33_A37_G0.8941.00
10_F217_A0.8921.00
161_L165_F0.8911.00
355_L358_I0.8911.00
220_L224_T0.8911.00
329_N332_F0.8871.00
175_P178_E0.8871.00
128_L320_F0.8861.00
161_L232_T0.8731.00
348_I355_L0.8711.00
7_K139_V0.8691.00
352_V355_L0.8651.00
103_A278_T0.8621.00
326_K330_D0.8601.00
128_L317_A0.8551.00
41_G233_L0.8541.00
290_K293_H0.8511.00
169_Q175_P0.8491.00
329_N333_Y0.8491.00
308_A313_A0.8491.00
346_I353_W0.8461.00
346_I349_P0.8451.00
313_A317_A0.8421.00
11_M144_K0.8361.00
106_L271_L0.8351.00
271_L274_Q0.8311.00
166_R172_F0.8311.00
224_T228_F0.8261.00
241_T258_A0.8261.00
171_D175_P0.8251.00
54_I58_L0.8251.00
288_S292_A0.8241.00
250_W253_I0.8231.00
72_F76_S0.8231.00
296_L300_F0.8181.00
131_A278_T0.8181.00
273_L277_W0.8171.00
299_I303_K0.8151.00
283_A290_K0.8131.00
43_L46_L0.8101.00
271_L275_L0.8031.00
279_A286_L0.8021.00
274_Q278_T0.8011.00
277_W284_C0.7971.00
98_I101_F0.7971.00
347_T351_F0.7961.00
264_I267_E0.7951.00
282_F286_L0.7931.00
170_L174_R0.7931.00
141_S144_K0.7921.00
110_V271_L0.7901.00
310_L314_M0.7881.00
111_G120_M0.7861.00
330_D336_T0.7821.00
61_P65_K0.7811.00
317_A321_I0.7811.00
270_D276_T0.7791.00
121_A124_V0.7781.00
62_F74_L0.7721.00
278_T281_Q0.7721.00
235_I238_G0.7691.00
143_A147_A0.7691.00
87_L348_I0.7691.00
345_V353_W0.7681.00
208_M214_V0.7671.00
91_I95_F0.7671.00
7_K11_M0.7661.00
136_G304_N0.7621.00
21_L221_G0.7621.00
53_I219_A0.7611.00
350_F357_W0.7601.00
103_A107_G0.7591.00
329_N336_T0.7581.00
139_V283_A0.7561.00
52_F198_F0.7541.00
353_W356_S0.7531.00
202_F218_V0.7511.00
33_A191_T0.7501.00
296_L299_I0.7481.00
39_P237_I0.7431.00
338_L342_F0.7421.00
36_T186_S0.7421.00
60_L64_Q0.7391.00
277_W287_G0.7371.00
141_S145_V0.7361.00
348_I358_I0.7361.00
312_T316_A0.7341.00
282_F285_M0.7321.00
22_I25_G0.7321.00
346_I354_F0.7301.00
276_T279_A0.7291.00
306_N310_L0.7261.00
327_D331_V0.7251.00
26_V232_T0.7241.00
169_Q174_R0.7241.00
354_F357_W0.7241.00
274_Q277_W0.7231.00
334_Y338_L0.7231.00
30_P233_L0.7221.00
147_A151_P0.7151.00
290_K303_K0.7141.00
287_G291_G0.7131.00
246_K249_T0.7131.00
110_V127_F0.7101.00
309_W316_A0.7081.00
286_L290_K0.7071.00
181_Y184_F0.7031.00
215_K218_V0.7021.00
32_S35_E0.7021.00
312_T315_L0.7011.00
138_G141_S0.7001.00
273_L283_A0.7001.00
165_F231_I0.6981.00
273_L280_Q0.6951.00
326_K331_V0.6941.00
348_I353_W0.6941.00
72_F88_N0.6941.00
42_W46_L0.6931.00
48_Q192_L0.6911.00
256_I260_E0.6901.00
89_L296_L0.6891.00
321_I325_P0.6881.00
232_T236_V0.6861.00
247_T250_W0.6841.00
351_F354_F0.6841.00
329_N335_G0.6831.00
34_A37_G0.6831.00
266_I269_F0.6781.00
268_R271_L0.6771.00
309_W315_L0.6761.00
276_T280_Q0.6741.00
62_F78_V0.6741.00
286_L293_H0.6731.00
310_L313_A0.6731.00
271_L276_T0.6711.00
170_L238_G0.6681.00
63_L202_F0.6671.00
277_W281_Q0.6671.00
63_L214_V0.6661.00
183_S186_S0.6661.00
43_L184_F0.6661.00
285_M289_F0.6661.00
150_F153_T0.6651.00
129_A132_I0.6641.00
212_K216_K0.6631.00
19_S150_F0.6611.00
56_V198_F0.6611.00
231_I235_I0.6601.00
43_L47_L0.6591.00
42_W230_S0.6571.00
284_C288_S0.6521.00
266_I273_L0.6501.00
46_L50_V0.6491.00
105_I109_V0.6441.00
47_L188_F0.6431.00
255_L258_A0.6411.00
281_Q288_S0.6411.00
196_S199_E0.6411.00
346_I350_F0.6401.00
135_V283_A0.6371.00
80_G84_G0.6371.00
273_L279_A0.6351.00
258_A262_P0.6341.00
297_T300_F0.6321.00
348_I351_F0.6301.00
265_F269_F0.6271.00
177_F184_F0.6261.00
309_W320_F0.6241.00
92_C96_I0.6241.00
275_L279_A0.6241.00
98_I102_Q0.6241.00
313_A316_A0.6241.00
75_N84_G0.6221.00
339_G342_F0.6211.00
106_L110_V0.6181.00
65_K356_S0.6181.00
18_S150_F0.6171.00
286_L292_A0.6161.00
131_A282_F0.6151.00
170_L175_P0.6151.00
333_Y337_L0.6151.00
267_E270_D0.6151.00
332_F335_G0.6141.00
55_I350_F0.6111.00
283_A292_A0.6091.00
214_V218_V0.6091.00
285_M316_A0.6061.00
315_L319_F0.6041.00
352_V356_S0.6041.00
251_P255_L0.6021.00
348_I356_S0.5981.00
56_V60_L0.5981.00
224_T227_L0.5961.00
45_I194_Y0.5951.00
17_I21_L0.5941.00
109_V253_I0.5911.00
20_T200_I0.5901.00
82_F85_F0.5901.00
229_Y233_L0.5891.00
149_I276_T0.5881.00
14_L17_I0.5871.00
48_Q195_F0.5861.00
148_Y152_I0.5861.00
71_L199_E0.5851.00
166_R175_P0.5851.00
84_G88_N0.5831.00
220_L223_A0.5831.00
104_R334_Y0.5801.00
318_T321_I0.5791.00
107_G110_V0.5781.00
331_V338_L0.5761.00
271_L287_G0.5751.00
33_A187_L0.5741.00
40_S176_V0.5731.00
302_L313_A0.5731.00
287_G294_I0.5711.00
284_C291_G0.5691.00
179_G182_Q0.5681.00
210_D215_K0.5681.00
247_T254_S0.5661.00
168_F175_P0.5661.00
232_T252_T0.5651.00
20_T281_Q0.5651.00
304_N307_N0.5641.00
53_I222_I0.5621.00
100_C103_A0.5611.00
42_W45_I0.5601.00
90_Y94_Y0.5591.00
102_Q105_I0.5581.00
32_S36_T0.5581.00
173_I238_G0.5581.00
267_E271_L0.5571.00
168_F174_R0.5571.00
45_I233_L0.5571.00
246_K251_P0.5541.00
44_M184_F0.5531.00
270_D278_T0.5531.00
347_T354_F0.5521.00
66_N78_V0.5511.00
289_F312_T0.5511.00
185_F189_P0.5501.00
72_F84_G0.5481.00
71_L203_Y0.5471.00
13_T204_L0.5471.00
330_D335_G0.5471.00
15_I150_F0.5461.00
73_K76_S0.5451.00
223_A226_T0.5401.00
316_A320_F0.5401.00
36_T190_K0.5391.00
251_P256_I0.5371.00
69_K73_K0.5371.00
252_T256_I0.5361.00
274_Q281_Q0.5361.00
314_M319_F0.5341.00
39_P242_V0.5331.00
244_E247_T0.5311.00
239_C259_L0.5301.00
11_M14_L0.5301.00
122_V125_F0.5301.00
173_I177_F0.5281.00
269_F274_Q0.5281.00
37_G44_M0.5281.00
68_G206_P0.5281.00
272_F276_T0.5251.00
173_I176_V0.5231.00
17_I217_A0.5231.00
74_L202_F0.5221.00
345_V351_F0.5211.00
137_G306_N0.5211.00
86_L90_Y0.5201.00
281_Q287_G0.5191.00
208_M217_A0.5191.00
136_G308_A0.5181.00
179_G183_S0.5181.00
270_D287_G0.5171.00
83_I86_L0.5161.00
146_Y279_A0.5141.00
304_N312_T0.5141.00
344_I348_I0.5131.00
269_F276_T0.5131.00
60_L218_V0.5121.00
287_G303_K0.5121.00
269_F273_L0.5121.00
309_W322_T0.5111.00
112_F257_H0.5101.00
148_Y151_P0.5091.00
330_D334_Y0.5091.00
11_M151_P0.5081.00
267_E274_Q0.5081.00
351_F358_I0.5041.00
155_I158_M0.5021.00
22_I153_T0.5021.00
331_V336_T0.5021.00
6_H209_R0.5021.00
136_G313_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.962 100 0.281 Contact Map
3giaA 1 0.9837 100 0.317 Contact Map
4djkA 2 0.9484 100 0.356 Contact Map
3dh4A 3 0.9511 98.7 0.838 Contact Map
2xq2A 2 0.9511 98.6 0.845 Contact Map
2jlnA 1 0.9429 98.3 0.858 Contact Map
4xp4A 1 0.962 97.7 0.879 Contact Map
4us3A 1 0.9592 97.5 0.883 Contact Map
2a65A 2 0.9538 97.4 0.886 Contact Map
4wgvA 2 0.9293 97.4 0.886 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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