GREMLIN Database
GERBA - Spore germination protein B1
UniProt: P39569 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 483 (469)
Sequences: 2258 (1875)
Seq/√Len: 86.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
164_K194_F7.3051.00
235_V245_S7.1801.00
413_S425_V5.8681.00
170_K201_N4.8011.00
185_A190_V4.6261.00
102_A117_T4.6191.00
168_L197_L4.1581.00
216_E274_R3.5911.00
368_Q372_Q3.5621.00
247_L254_A3.3311.00
163_I177_A3.1131.00
300_I411_M3.0941.00
226_I257_V3.0651.00
97_V103_I2.9691.00
163_I179_A2.9611.00
181_I184_I2.9581.00
207_E251_T2.9331.00
178_V194_F2.9331.00
152_L247_L2.9031.00
294_Y426_Y2.8161.00
333_A380_M2.8151.00
139_I155_R2.8041.00
89_T92_E2.7551.00
146_R149_T2.7541.00
103_I114_A2.6991.00
171_R183_D2.6741.00
204_N240_L2.6631.00
410_V425_V2.6531.00
11_L39_C2.5931.00
87_V114_A2.5621.00
187_D477_E2.5221.00
181_I239_L2.4591.00
434_M444_I2.4591.00
171_R478_D2.4561.00
152_L179_A2.4561.00
229_T235_V2.4411.00
104_L115_F2.3901.00
93_I103_I2.3411.00
160_N183_D2.3051.00
86_V111_G2.2231.00
190_V244_V2.2211.00
414_A422_V2.2181.00
19_G162_V2.2141.00
192_E196_R2.2071.00
162_V182_Q2.2031.00
410_V429_V2.1821.00
158_D171_R2.1731.00
166_M198_K2.1711.00
128_P140_G2.1351.00
337_I407_R2.1321.00
193_V257_V2.1311.00
76_S86_V2.1241.00
21_N162_V2.1161.00
137_P272_S2.1091.00
333_A411_M2.0221.00
265_I289_I2.0091.00
193_V244_V1.9921.00
196_R217_D1.9431.00
87_V92_E1.9401.00
280_L405_I1.8941.00
238_S256_I1.8891.00
168_L176_I1.8821.00
24_M43_I1.8291.00
95_Q173_K1.8271.00
28_T37_K1.8041.00
127_E140_G1.8031.00
44_D146_R1.7981.00
166_M194_F1.7971.00
202_I214_L1.7971.00
420_Y424_M1.7871.00
105_L112_G1.7741.00
156_T236_E1.7611.00
176_I248_V1.7431.00
182_Q187_D1.7161.00
330_F415_T1.6861.00
297_G414_A1.6861.00
20_Q164_K1.6831.00
191_K195_K1.6801.00
40_L104_L1.6791.00
200_V211_L1.6571.00
192_E195_K1.6511.00
179_A254_A1.6451.00
145_L177_A1.6371.00
450_Q455_L1.6341.00
96_L114_A1.6231.00
8_Q37_K1.6171.00
193_V246_I1.6161.00
288_S393_T1.6111.00
15_K26_F1.6061.00
96_L101_Q1.5991.00
271_Y457_D1.5961.00
101_Q118_K1.5751.00
12_D16_K1.5671.00
288_S342_L1.5511.00
20_Q182_Q1.5461.00
172_T204_N1.5331.00
166_M178_V1.5301.00
203_D470_R1.5291.00
88_S111_G1.5281.00
208_S248_V1.5031.00
178_V244_V1.4991.00
289_I403_L1.4941.00
259_A264_F1.4941.00
187_D191_K1.4770.99
167_T175_K1.4600.99
221_S225_T1.4570.99
165_E175_K1.4560.99
83_H116_D1.4430.99
296_P387_T1.4420.99
149_T163_I1.4320.99
93_I112_G1.4280.99
18_L98_F1.4250.99
243_R263_E1.4220.99
446_P449_A1.4010.99
7_L105_L1.3840.99
24_M41_L1.3830.99
432_H436_L1.3670.99
301_S422_V1.3640.99
226_I255_L1.3570.99
279_S283_L1.3570.99
52_L102_A1.3550.99
195_K199_S1.3480.99
283_L287_S1.3370.99
246_I257_V1.3350.99
292_T394_V1.3140.99
172_T240_L1.3140.99
45_G149_T1.3110.99
221_S432_H1.3080.99
167_T173_K1.3060.99
156_T240_L1.3040.99
328_P331_V1.2950.99
11_L15_K1.2910.99
45_G150_A1.2910.99
26_F39_C1.2880.98
470_R478_D1.2840.98
48_E119_S1.2800.98
340_I388_A1.2770.98
194_F198_K1.2710.98
371_V382_I1.2650.98
7_L107_D1.2650.98
52_L117_T1.2610.98
145_L247_L1.2600.98
184_I470_R1.2570.98
11_L28_T1.2540.98
235_V254_A1.2480.98
339_T365_V1.2420.98
127_E138_K1.2380.98
9_N12_D1.2350.98
85_S92_E1.2340.98
287_S338_F1.2190.98
133_V267_S1.2180.98
47_T52_L1.2060.98
341_E408_I1.2010.98
141_F152_L1.1880.97
129_S138_K1.1790.97
125_L139_I1.1720.97
160_N182_Q1.1710.97
330_F412_I1.1630.97
103_I112_G1.1520.97
189_V244_V1.1440.97
14_L24_M1.1430.97
165_E177_A1.1400.97
245_S256_I1.1400.97
10_N105_L1.1320.97
225_T274_R1.1260.96
149_T179_A1.1250.96
337_I404_R1.1250.96
26_F41_L1.1230.96
185_A244_V1.1170.96
50_K54_Q1.1150.96
71_S74_D1.1150.96
433_L444_I1.1130.96
7_L39_C1.1040.96
409_G413_S1.1030.96
337_I384_V1.1010.96
45_G146_R1.0970.96
186_P441_Q1.0950.96
73_E76_S1.0940.96
327_F331_V1.0890.96
195_K198_K1.0890.96
139_I154_E1.0840.96
166_M197_L1.0820.96
99_S157_S1.0810.96
13_T17_T1.0810.96
256_I263_E1.0790.95
139_I250_G1.0670.95
101_Q116_D1.0660.95
235_V256_I1.0590.95
411_M415_T1.0550.95
176_I246_I1.0510.95
321_S378_A1.0490.95
132_V352_K1.0490.95
193_V439_F1.0470.95
244_V257_V1.0430.95
171_R470_R1.0430.95
183_D187_D1.0420.95
294_Y410_V1.0400.94
31_F38_A1.0390.94
120_V144_K1.0390.94
30_A37_K1.0390.94
46_L150_A1.0370.94
186_P475_D1.0310.94
329_P380_M1.0280.94
20_Q162_V1.0220.94
216_E225_T1.0200.94
39_C105_L1.0200.94
334_F411_M1.0190.94
209_G213_Q1.0130.94
134_E269_D1.0120.94
245_S254_A1.0110.94
126_D140_G1.0110.94
206_P210_T1.0100.94
139_I151_L1.0090.94
223_F406_I1.0060.93
156_T181_I1.0050.93
22_D164_K1.0030.93
196_R215_I0.9990.93
260_T263_E0.9920.93
241_E271_Y0.9900.93
142_I148_N0.9870.93
179_A239_L0.9850.93
337_I408_I0.9800.93
28_T39_C0.9760.92
447_I459_V0.9740.92
390_A393_T0.9730.92
406_I429_V0.9700.92
265_I286_Y0.9690.92
152_L235_V0.9660.92
27_Y84_H0.9660.92
347_G355_G0.9660.92
262_D447_I0.9640.92
264_F399_Y0.9640.92
11_L41_L0.9630.92
192_E217_D0.9570.92
223_F432_H0.9510.91
297_G410_V0.9500.91
101_Q114_A0.9490.91
282_R457_D0.9490.91
391_S400_N0.9480.91
120_V154_E0.9460.91
8_Q12_D0.9440.91
337_I344_R0.9420.91
261_V444_I0.9410.91
171_R181_I0.9400.91
340_I359_G0.9390.91
155_R174_K0.9310.91
174_K248_V0.9260.90
191_K194_F0.9220.90
93_I105_L0.9210.90
128_P230_E0.9190.90
150_A154_E0.9180.90
178_V193_V0.9180.90
300_I333_A0.9160.90
305_F416_A0.9160.90
157_S175_K0.9160.90
213_Q464_T0.9050.89
47_T117_T0.9050.89
303_V329_P0.8990.89
29_F57_I0.8980.89
13_T90_M0.8960.89
57_I61_Q0.8960.89
262_D458_T0.8940.89
85_S96_L0.8920.89
152_L161_L0.8920.89
131_E234_R0.8890.88
207_E272_S0.8870.88
280_L341_E0.8850.88
23_D153_R0.8830.88
38_A104_L0.8820.88
213_Q461_R0.8760.88
226_I439_F0.8740.88
41_L105_L0.8740.88
347_G356_Q0.8730.87
121_A150_A0.8720.87
237_S241_E0.8700.87
358_I388_A0.8690.87
18_L21_N0.8650.87
227_L263_E0.8640.87
223_F429_V0.8580.87
350_L392_F0.8570.86
462_I467_L0.8550.86
207_E210_T0.8530.86
288_S390_A0.8500.86
200_V203_D0.8500.86
95_Q167_T0.8490.86
399_Y402_P0.8470.86
171_R184_I0.8450.86
7_L10_N0.8430.86
155_R250_G0.8430.86
154_E249_D0.8420.86
92_E95_Q0.8420.86
14_L41_L0.8420.86
223_F433_L0.8370.85
259_A263_E0.8360.85
344_R347_G0.8350.85
122_T147_T0.8340.85
87_V103_I0.8330.85
124_S142_I0.8310.85
130_S253_F0.8300.85
25_M44_D0.8300.85
260_T264_F0.8280.85
90_M105_L0.8260.84
144_K175_K0.8260.84
291_I386_V0.8250.84
87_V93_I0.8230.84
146_R175_K0.8230.84
330_F411_M0.8210.84
41_L97_V0.8200.84
229_T245_S0.8190.84
133_V268_P0.8180.84
56_V115_F0.8170.84
352_K358_I0.8150.84
261_V399_Y0.8130.83
234_R268_P0.8100.83
54_Q58_S0.8060.83
404_R408_I0.8040.83
293_I406_I0.8040.83
410_V413_S0.8030.83
171_R203_D0.8030.83
223_F443_Y0.8020.83
321_S379_L0.7890.82
222_I432_H0.7890.82
130_S354_I0.7880.82
123_R143_E0.7880.82
227_L259_A0.7860.81
17_T94_E0.7850.81
184_I203_D0.7830.81
397_Y400_N0.7790.81
141_F235_V0.7770.81
190_V193_V0.7760.81
347_G357_T0.7750.80
423_I427_L0.7740.80
410_V414_A0.7740.80
397_Y401_F0.7730.80
18_L94_E0.7710.80
453_Q469_R0.7700.80
45_G120_V0.7700.80
469_R472_T0.7700.80
261_V393_T0.7690.80
186_P476_P0.7660.80
144_K147_T0.7660.80
216_E219_P0.7640.79
70_C73_E0.7600.79
434_M448_M0.7560.79
264_F404_R0.7530.78
359_G379_L0.7520.78
279_S462_I0.7520.78
445_I454_D0.7500.78
453_Q456_K0.7480.78
238_S263_E0.7480.78
178_V185_A0.7470.78
412_I415_T0.7450.78
341_E344_R0.7440.78
322_R325_V0.7420.77
71_S75_L0.7400.77
128_P253_F0.7380.77
210_T237_S0.7380.77
330_F334_F0.7380.77
296_P337_I0.7370.77
451_P454_D0.7350.77
209_G214_L0.7350.77
406_I409_G0.7350.77
372_Q378_A0.7320.77
264_F362_G0.7260.76
133_V269_D0.7260.76
227_L264_F0.7250.76
199_S437_K0.7240.76
144_K249_D0.7240.76
93_I97_V0.7230.76
135_R140_G0.7230.76
172_T206_P0.7220.76
22_D149_T0.7220.76
38_A106_A0.7200.75
384_V408_I0.7200.75
88_S92_E0.7200.75
273_Q401_F0.7190.75
206_P240_L0.7180.75
357_T363_G0.7180.75
203_D471_P0.7150.75
122_T144_K0.7150.75
99_S118_K0.7100.74
235_V422_V0.7100.74
329_P359_G0.7060.74
317_S379_L0.7030.74
152_L236_E0.7030.74
51_M117_T0.7020.73
292_T403_L0.7010.73
205_L211_L0.7010.73
321_S363_G0.6990.73
237_S266_H0.6980.73
304_S329_P0.6960.73
149_T177_A0.6950.73
135_R212_E0.6940.73
336_M380_M0.6940.73
202_I205_L0.6920.72
157_S249_D0.6920.72
445_I449_A0.6920.72
60_L104_L0.6920.72
118_K146_R0.6910.72
142_I147_T0.6910.72
86_V113_L0.6890.72
126_D129_S0.6880.72
368_Q385_S0.6870.72
456_K469_R0.6800.71
189_V439_F0.6790.71
184_I211_L0.6770.71
339_T386_V0.6770.71
280_L338_F0.6760.71
164_K178_V0.6750.71
13_T16_K0.6740.70
151_L154_E0.6740.70
29_F38_A0.6730.70
261_V289_I0.6710.70
15_K41_L0.6700.70
24_M181_I0.6690.70
359_G437_K0.6690.70
408_I412_I0.6670.70
306_H419_M0.6660.70
326_P345_E0.6640.69
259_A394_V0.6640.69
224_P264_F0.6640.69
298_L302_L0.6630.69
326_P369_A0.6630.69
262_D286_Y0.6620.69
179_A247_L0.6620.69
43_I46_L0.6620.69
158_D478_D0.6610.69
322_R368_Q0.6610.69
327_F375_I0.6580.69
202_I208_S0.6570.68
208_S255_L0.6560.68
227_L238_S0.6540.68
183_D477_E0.6540.68
260_T441_Q0.6520.68
25_M42_Y0.6520.68
441_Q474_N0.6520.68
257_V439_F0.6520.68
187_D190_V0.6510.68
21_N24_M0.6490.68
264_F396_S0.6490.68
205_L210_T0.6480.67
139_I236_E0.6470.67
361_I388_A0.6470.67
342_L359_G0.6460.67
456_K462_I0.6440.67
119_S126_D0.6430.67
324_N385_S0.6420.67
20_Q194_F0.6410.67
387_T411_M0.6380.66
49_N144_K0.6370.66
99_S175_K0.6340.66
131_E288_S0.6340.66
189_V441_Q0.6330.66
265_I399_Y0.6310.65
333_A384_V0.6300.65
14_L39_C0.6290.65
268_P272_S0.6290.65
217_D438_S0.6290.65
44_D83_H0.6270.65
40_L102_A0.6270.65
315_A354_I0.6270.65
228_S253_F0.6270.65
227_L256_I0.6260.65
14_L26_F0.6260.65
69_E74_D0.6260.65
266_H282_R0.6250.65
371_V378_A0.6250.65
457_D467_L0.6230.64
456_K467_L0.6230.64
74_D78_F0.6230.64
145_L249_D0.6210.64
412_I416_A0.6190.64
292_T391_S0.6180.64
83_H156_T0.6170.64
95_Q287_S0.6160.64
306_H418_G0.6140.63
222_I405_I0.6130.63
215_I439_F0.6120.63
348_L353_P0.6120.63
329_P364_V0.6110.63
298_L447_I0.6090.63
294_Y422_V0.6090.63
231_R256_I0.6090.63
74_D77_A0.6080.63
222_I277_P0.6080.63
192_E215_I0.6080.63
411_M414_A0.6080.63
273_Q398_A0.6070.62
295_L386_V0.6070.62
14_L105_L0.6040.62
297_G400_N0.6040.62
343_I361_I0.6040.62
131_E321_S0.6030.62
225_T366_I0.6020.62
296_P383_V0.6010.62
125_L151_L0.6010.62
133_V137_P0.6000.61
155_R231_R0.6000.61
181_I197_L0.6000.61
56_V111_G0.6000.61
374_Q449_A0.6000.61
121_A147_T0.5990.61
337_I411_M0.5990.61
307_T329_P0.5990.61
178_V190_V0.5990.61
188_Y191_K0.5990.61
152_L354_I0.5980.61
290_L294_Y0.5980.61
359_G364_V0.5980.61
322_R377_S0.5960.61
350_L354_I0.5950.61
370_A376_V0.5950.61
310_L313_R0.5940.61
390_A450_Q0.5930.61
229_T395_P0.5910.60
405_I478_D0.5910.60
155_R236_E0.5910.60
291_I295_L0.5900.60
238_S243_R0.5890.60
260_T359_G0.5890.60
300_I305_F0.5880.60
170_K478_D0.5880.60
298_L419_M0.5880.60
438_S442_D0.5870.60
309_L397_Y0.5870.60
347_G353_P0.5860.60
83_H144_K0.5850.60
164_K182_Q0.5850.60
218_E225_T0.5850.60
474_N477_E0.5840.59
144_K154_E0.5830.59
343_I381_V0.5830.59
72_I111_G0.5830.59
457_D461_R0.5830.59
219_P465_M0.5820.59
88_S91_K0.5820.59
350_L363_G0.5820.59
40_L115_F0.5800.59
292_T296_P0.5800.59
455_L458_T0.5800.59
300_I415_T0.5790.59
196_R438_S0.5780.59
106_A469_R0.5770.59
227_L234_R0.5760.58
409_G429_V0.5760.58
411_M417_L0.5740.58
345_E349_R0.5730.58
45_G154_E0.5730.58
29_F40_L0.5730.58
259_A339_T0.5720.58
337_I400_N0.5710.58
145_L175_K0.5700.58
345_E369_A0.5700.58
430_I434_M0.5700.58
72_I86_V0.5690.57
243_R266_H0.5680.57
128_P272_S0.5670.57
297_G337_I0.5660.57
310_L353_P0.5650.57
365_V433_L0.5650.57
422_V425_V0.5650.57
84_H113_L0.5640.57
212_E228_S0.5640.57
340_I347_G0.5630.57
14_L18_L0.5630.57
275_W363_G0.5620.57
46_L154_E0.5620.57
424_M428_F0.5620.57
315_A340_I0.5620.57
346_A388_A0.5610.56
375_I382_I0.5610.56
270_D345_E0.5600.56
96_L168_L0.5600.56
222_I337_I0.5600.56
461_R464_T0.5590.56
166_M246_I0.5580.56
186_P474_N0.5570.56
122_T142_I0.5570.56
22_D165_E0.5560.56
44_D49_N0.5560.56
18_L97_V0.5560.56
94_E97_V0.5560.56
57_I241_E0.5550.56
71_S300_I0.5550.56
140_G253_F0.5550.56
213_Q216_E0.5540.55
358_I382_I0.5530.55
16_K19_G0.5520.55
377_S418_G0.5520.55
266_H271_Y0.5510.55
18_L24_M0.5500.55
171_R240_L0.5500.55
138_K253_F0.5490.55
297_G397_Y0.5480.55
245_S257_V0.5470.55
219_P274_R0.5470.55
260_T303_V0.5460.54
201_N470_R0.5450.54
220_F466_F0.5450.54
37_K107_D0.5450.54
321_S377_S0.5450.54
137_P398_A0.5430.54
326_P418_G0.5420.54
160_N171_R0.5420.54
18_L158_D0.5420.54
452_G456_K0.5410.54
288_S357_T0.5410.54
241_E244_V0.5410.54
350_L375_I0.5410.54
139_I174_K0.5390.53
205_L248_V0.5390.53
241_E266_H0.5380.53
400_N404_R0.5380.53
209_G212_E0.5380.53
264_F337_I0.5380.53
451_P472_T0.5370.53
461_R467_L0.5370.53
47_T187_D0.5370.53
189_V193_V0.5370.53
454_D470_R0.5370.53
308_G435_R0.5370.53
259_A262_D0.5360.53
467_L471_P0.5350.53
442_D449_A0.5350.53
332_E345_E0.5350.53
200_V205_L0.5350.53
289_I394_V0.5350.53
183_D309_L0.5340.53
447_I458_T0.5320.53
192_E199_S0.5320.53
193_V348_L0.5310.52
176_I211_L0.5310.52
184_I478_D0.5300.52
77_A262_D0.5300.52
301_S414_A0.5300.52
202_I464_T0.5290.52
105_L113_L0.5290.52
29_F61_Q0.5270.52
135_R208_S0.5260.52
12_D15_K0.5260.52
309_L388_A0.5260.52
176_I208_S0.5260.52
31_F61_Q0.5250.52
92_E96_L0.5250.52
200_V214_L0.5250.52
99_S197_L0.5240.51
170_K187_D0.5240.51
189_V192_E0.5230.51
141_F254_A0.5220.51
284_L365_V0.5220.51
27_Y142_I0.5220.51
410_V426_Y0.5210.51
296_P411_M0.5210.51
410_V422_V0.5200.51
263_E347_G0.5200.51
363_G366_I0.5190.51
222_I231_R0.5190.51
354_I358_I0.5190.51
88_S110_R0.5190.51
126_D416_A0.5170.51
106_A109_Y0.5170.51
294_Y407_R0.5160.50
185_A189_V0.5150.50
172_T359_G0.5150.50
303_V315_A0.5150.50
241_E457_D0.5140.50
91_K173_K0.5140.50
8_Q28_T0.5140.50
120_V146_R0.5140.50
325_V377_S0.5130.50
151_L155_R0.5130.50
399_Y403_L0.5130.50
58_S62_K0.5120.50
384_V411_M0.5110.50
349_R369_A0.5110.50
29_F52_L0.5100.50
184_I201_N0.5100.50
384_V391_S0.5100.50
269_D315_A0.5100.50
17_T159_P0.5090.49
353_P359_G0.5080.49
82_F334_F0.5080.49
340_I384_V0.5080.49
186_P190_V0.5070.49
142_I291_I0.5070.49
269_D394_V0.5060.49
134_E357_T0.5060.49
279_S388_A0.5050.49
397_Y404_R0.5050.49
229_T239_L0.5050.49
183_D476_P0.5050.49
462_I466_F0.5050.49
289_I363_G0.5040.49
322_R329_P0.5040.49
344_R406_I0.5040.49
426_Y429_V0.5040.49
293_I403_L0.5040.49
232_P236_E0.5040.49
184_I471_P0.5030.49
142_I175_K0.5030.49
471_P474_N0.5020.48
48_E126_D0.5020.48
189_V475_D0.5020.48
17_T90_M0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hh1A 2 0.2112 33.9 0.98 Contact Map
3kpeA 3 0.1014 16.5 0.983 Contact Map
4g3oA 1 0.0911 11.6 0.984 Contact Map
4p0zA 1 0.2174 10.7 0.984 Contact Map
1ez3A 1 0.2277 9.6 0.985 Contact Map
4bemA 3 0.1656 9.1 0.985 Contact Map
1qzmA 1 0.1615 9.1 0.985 Contact Map
2qwvA 2 0.3168 7.4 0.985 Contact Map
2xquA 3 0.1677 6.2 0.986 Contact Map
1mhqA 1 0.2505 6.1 0.986 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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