GREMLIN Database
TLPA - Methyl-accepting chemotaxis protein TlpA
UniProt: P39216 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 662 (617)
Sequences: 7608 (6594)
Seq/√Len: 265.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
332_S337_G6.4791.00
327_T351_R4.2971.00
16_R334_D3.8791.00
318_K323_D3.4441.00
334_D337_G3.3711.00
34_V38_Q3.3531.00
14_A303_R3.3301.00
316_A346_M2.7581.00
112_F180_A2.7141.00
471_I474_K2.6541.00
498_A519_R2.6461.00
317_E338_V2.5531.00
200_E271_E2.5251.00
465_V546_S2.4801.00
455_I560_G2.4081.00
481_R485_G2.3831.00
302_I306_T2.3571.00
248_K269_A2.3521.00
285_I289_I2.3451.00
327_T348_H2.3081.00
327_T344_N2.2871.00
551_Q555_K2.2851.00
204_F264_S2.2791.00
477_T540_V2.2451.00
312_I316_A2.2391.00
12_S15_R2.2181.00
281_I285_I2.1921.00
472_K542_E2.1701.00
255_T262_K2.1581.00
303_R307_K2.1281.00
167_T182_D2.1281.00
520_K523_V2.1221.00
525_S529_A2.1121.00
468_G542_E2.1071.00
498_A516_E2.0901.00
479_I535_L2.0831.00
472_K538_E2.0781.00
427_I585_L2.0531.00
197_I201_G2.0431.00
469_L546_S2.0371.00
319_I346_M2.0311.00
441_G571_F2.0191.00
441_G574_I2.0171.00
516_E519_R2.0021.00
141_K145_A1.9981.00
565_D569_Q1.9951.00
36_A283_A1.9941.00
473_S543_I1.9731.00
622_D625_A1.9611.00
419_E422_R1.9591.00
562_V566_E1.9461.00
142_E145_A1.9451.00
475_D478_N1.9441.00
230_D234_K1.9391.00
470_E547_L1.9351.00
344_N347_A1.9351.00
115_G119_D1.9351.00
440_K443_T1.9191.00
318_K326_E1.9011.00
99_K103_Q1.8981.00
555_K558_E1.8921.00
478_N481_R1.8701.00
590_A593_E1.8551.00
443_T447_K1.8401.00
482_V528_S1.8401.00
156_Y167_T1.8391.00
316_A343_F1.8351.00
298_I302_I1.8311.00
313_V338_V1.8291.00
313_V342_S1.8281.00
559_T562_V1.8261.00
338_V341_E1.8191.00
366_S370_E1.8161.00
484_N529_A1.7881.00
405_T408_E1.7821.00
449_A568_K1.7651.00
202_Y216_S1.7591.00
369_E373_A1.7251.00
436_E440_K1.7181.00
615_E618_D1.7181.00
447_K450_G1.7111.00
198_G201_G1.7101.00
558_E562_V1.7041.00
533_E537_S1.7031.00
448_T567_T1.7011.00
466_V546_S1.7001.00
466_V547_L1.6981.00
316_A339_L1.6981.00
238_G253_F1.6821.00
437_V573_H1.6811.00
158_S161_S1.6801.00
573_H576_Q1.6721.00
611_A615_E1.6451.00
555_K559_T1.6411.00
607_N611_A1.6331.00
429_E433_D1.6291.00
133_N136_E1.6271.00
33_S37_Y1.6201.00
628_E632_A1.6181.00
190_T193_K1.6111.00
465_V545_T1.6111.00
278_R282_M1.6041.00
330_I344_N1.5971.00
641_A644_L1.5961.00
154_E209_N1.5911.00
450_G454_T1.5801.00
378_T382_T1.5801.00
471_I475_D1.5571.00
163_K186_D1.5541.00
601_E604_A1.5531.00
40_A279_V1.5461.00
202_Y215_Y1.5401.00
33_S287_L1.5381.00
432_A436_E1.5291.00
108_V181_I1.5251.00
571_F574_I1.5181.00
348_H352_S1.5111.00
156_Y182_D1.5081.00
401_E404_E1.5041.00
468_G471_I1.4971.00
618_D622_D1.4841.00
351_R355_H1.4831.00
227_D230_D1.4811.00
317_E342_S1.4791.00
469_L539_I1.4781.00
309_L339_L1.4731.00
312_I339_L1.4651.00
64_D68_S1.4641.00
339_L343_F1.4591.00
629_E632_A1.4571.00
611_A614_K1.4531.00
472_K475_D1.4491.00
28_P290_A1.4451.00
198_G271_E1.4441.00
226_G230_D1.4401.00
152_V168_I1.4401.00
187_D190_T1.4381.00
148_G173_V1.4381.00
155_P164_M1.4371.00
316_A342_S1.4351.00
366_S369_E1.4331.00
319_I347_A1.4271.00
413_M599_A1.4241.00
203_A265_G1.4211.00
452_M560_G1.4201.00
251_M264_S1.4191.00
593_E597_A1.4191.00
425_A429_E1.4181.00
25_L28_P1.4161.00
618_D621_Q1.4151.00
113_S172_T1.4081.00
327_T347_A1.4041.00
452_M455_I1.4031.00
594_E597_A1.3991.00
317_E345_H1.3941.00
373_A377_Q1.3881.00
247_K268_Y1.3871.00
211_K223_E1.3871.00
527_D531_E1.3861.00
461_A464_Q1.3861.00
411_N415_D1.3811.00
600_Q604_A1.3751.00
566_E569_Q1.3741.00
433_D436_E1.3701.00
140_Y144_M1.3701.00
544_H548_N1.3581.00
530_K534_S1.3571.00
289_I293_A1.3551.00
95_K99_K1.3481.00
118_G135_L1.3481.00
292_G296_T1.3441.00
22_L295_M1.3441.00
635_E639_S1.3441.00
402_K608_D1.3431.00
458_S552_S1.3411.00
52_A56_V1.3401.00
495_L503_R1.3301.00
138_D142_E1.3281.00
429_E432_A1.3261.00
527_D530_K1.3241.00
580_Q583_S1.3181.00
453_N457_H1.3051.00
190_T194_G1.3031.00
280_L284_S1.3011.00
632_A635_E1.3001.00
485_G488_D1.2971.00
241_E269_A1.2971.00
376_D380_R1.2961.00
408_E412_E1.2961.00
608_D611_A1.2941.00
330_I334_D1.2841.00
625_A628_E1.2811.00
243_T248_K1.2801.00
143_A169_A1.2801.00
583_S587_N1.2791.00
446_Q450_G1.2781.00
47_Q51_S1.2761.00
398_S401_E1.2741.00
40_A44_L1.2691.00
244_Y249_K1.2681.00
459_V557_V1.2661.00
284_S288_A1.2581.00
523_V527_D1.2571.00
494_A519_R1.2531.00
202_Y266_T1.2511.00
13_I336_L1.2491.00
14_A18_I1.2461.00
625_A629_E1.2421.00
242_Y249_K1.2381.00
29_I32_L1.2381.00
583_S586_Q1.2361.00
151_I169_A1.2361.00
422_R426_V1.2341.00
576_Q580_Q1.2331.00
143_A178_V1.2311.00
249_K268_Y1.2271.00
451_Q559_T1.2271.00
370_E373_A1.2271.00
379_S382_T1.2221.00
443_T446_Q1.2211.00
330_I340_S1.2211.00
426_V429_E1.2181.00
590_A594_E1.2141.00
460_K554_N1.2101.00
323_D326_E1.2071.00
11_S19_I1.2071.00
304_S307_K1.2021.00
232_L264_S1.2001.00
315_S328_I1.1981.00
569_Q572_K1.1981.00
412_E415_D1.1911.00
491_N519_R1.1911.00
282_M285_I1.1891.00
269_A273_H1.1881.00
519_R523_V1.1881.00
312_I340_S1.1871.00
484_N533_E1.1851.00
100_Q103_Q1.1851.00
466_V550_L1.1831.00
401_E405_T1.1791.00
324_L354_I1.1781.00
312_I343_F1.1761.00
621_Q625_A1.1751.00
71_E75_A1.1751.00
439_S443_T1.1681.00
453_N565_D1.1681.00
66_K70_T1.1541.00
38_Q42_A1.1531.00
548_N551_Q1.1511.00
418_A422_R1.1511.00
21_F298_I1.1481.00
91_K95_K1.1481.00
438_S441_G1.1471.00
37_Y280_L1.1441.00
457_H461_A1.1421.00
35_S39_S1.1411.00
186_D190_T1.1401.00
552_S555_K1.1401.00
537_S541_K1.1401.00
436_E439_S1.1381.00
41_V45_D1.1381.00
467_K471_I1.1371.00
11_S15_R1.1371.00
614_K618_D1.1361.00
199_K271_E1.1351.00
231_K235_D1.1331.00
457_H460_K1.1331.00
526_A530_K1.1291.00
318_K346_M1.1281.00
319_I343_F1.1261.00
71_E152_V1.1231.00
450_G453_N1.1231.00
524_Q531_E1.1211.00
569_Q573_H1.1201.00
74_L170_R1.1201.00
475_D531_E1.1171.00
548_N552_S1.1171.00
530_K533_E1.1171.00
442_E572_K1.1151.00
120_F123_Y1.1121.00
479_I536_I1.1101.00
45_D49_T1.1081.00
413_M595_L1.1071.00
319_I324_L1.1061.00
352_S356_G1.1021.00
313_V317_E1.0911.00
463_E550_L1.0901.00
281_I284_S1.0901.00
207_S211_K1.0891.00
18_I22_L1.0841.00
295_M299_Y1.0801.00
141_K144_M1.0781.00
155_P207_S1.0751.00
409_Q412_E1.0741.00
204_F215_Y1.0741.00
534_S538_E1.0741.00
464_Q468_G1.0731.00
169_A178_V1.0721.00
319_I350_L1.0661.00
277_S280_L1.0651.00
460_K464_Q1.0641.00
75_A150_T1.0631.00
333_K337_G1.0621.00
507_Y518_V1.0611.00
328_I344_N1.0601.00
465_V549_V1.0581.00
96_Q99_K1.0541.00
361_V368_S1.0541.00
321_E349_S1.0531.00
604_A607_N1.0531.00
322_G339_L1.0521.00
438_S575_S1.0511.00
277_S281_I1.0501.00
413_M416_G1.0481.00
572_K576_Q1.0441.00
25_L294_G1.0361.00
587_N590_A1.0341.00
474_K544_H1.0331.00
112_F182_D1.0321.00
72_K75_A1.0311.00
315_S343_F1.0251.00
114_S134_A1.0231.00
541_K545_T1.0211.00
560_G567_T1.0211.00
343_F347_A1.0211.00
447_K563_M1.0201.00
153_T156_Y1.0201.00
324_L350_L1.0181.00
562_V565_D1.0181.00
358_K362_E1.0151.00
357_I364_V1.0131.00
294_G298_I1.0101.00
411_N414_N1.0091.00
314_A317_E1.0071.00
455_I557_V1.0041.00
33_S283_A1.0041.00
488_D499_I1.0041.00
17_L21_F1.0011.00
524_Q527_D1.0011.00
619_G622_D0.9981.00
20_S301_V0.9981.00
579_N583_S0.9971.00
373_A376_D0.9971.00
136_E141_K0.9961.00
137_R159_I0.9931.00
249_K266_T0.9911.00
316_A319_I0.9881.00
311_R314_A0.9871.00
636_E639_S0.9871.00
26_I30_T0.9851.00
343_F346_M0.9841.00
464_Q467_K0.9831.00
30_T34_V0.9831.00
302_I305_I0.9811.00
456_D561_L0.9801.00
469_L543_I0.9801.00
74_L181_I0.9801.00
339_L346_M0.9791.00
135_L140_Y0.9791.00
463_E554_N0.9791.00
479_I528_S0.9791.00
347_A351_R0.9781.00
424_A427_I0.9771.00
536_I540_V0.9771.00
399_Q403_I0.9751.00
139_W156_Y0.9751.00
308_P332_S0.9741.00
29_I287_L0.9721.00
16_R304_S0.9691.00
340_S344_N0.9691.00
231_K236_K0.9681.00
130_S134_A0.9671.00
462_A553_V0.9651.00
313_V339_L0.9651.00
421_A424_A0.9641.00
322_G346_M0.9631.00
288_A292_G0.9611.00
399_Q613_S0.9601.00
459_V550_L0.9581.00
492_L499_I0.9581.00
586_Q590_A0.9571.00
543_I546_S0.9571.00
122_R125_Y0.9561.00
452_M564_T0.9561.00
377_Q380_R0.9551.00
230_D233_Y0.9551.00
468_G545_T0.9521.00
311_R329_E0.9491.00
479_I529_A0.9481.00
587_N591_T0.9481.00
346_M350_L0.9421.00
375_A382_T0.9381.00
612_I616_S0.9361.00
133_N137_R0.9341.00
458_S556_E0.9331.00
150_T170_R0.9311.00
247_K270_N0.9301.00
409_Q413_M0.9261.00
139_W167_T0.9241.00
359_D363_H0.9211.00
299_Y303_R0.9171.00
359_D362_E0.9161.00
308_P336_L0.9141.00
167_T180_A0.9131.00
328_I340_S0.9131.00
540_V547_L0.9111.00
318_K321_E0.9111.00
70_T73_S0.9101.00
137_R158_S0.9081.00
140_Y178_V0.9081.00
68_S71_E0.9071.00
231_K234_K0.9071.00
597_A601_E0.9061.00
467_K551_Q0.9061.00
330_I337_G0.9061.00
64_D258_T0.9061.00
158_S182_D0.9051.00
556_E559_T0.9051.00
415_D419_E0.9041.00
362_E366_S0.9031.00
425_A593_E0.9021.00
404_E408_E0.9011.00
604_A608_D0.8971.00
250_K269_A0.8961.00
590_A597_A0.8951.00
368_S371_L0.8951.00
119_D133_N0.8941.00
375_A379_S0.8941.00
479_I525_S0.8941.00
32_L36_A0.8911.00
148_G171_Q0.8901.00
355_H359_D0.8891.00
406_T605_A0.8881.00
412_E598_G0.8841.00
158_S165_V0.8841.00
157_E164_M0.8841.00
60_D256_S0.8831.00
274_D278_R0.8821.00
632_A636_E0.8811.00
229_V232_L0.8801.00
139_W182_D0.8791.00
92_T96_Q0.8791.00
494_A518_V0.8751.00
445_V448_T0.8741.00
412_E416_G0.8731.00
516_E520_K0.8731.00
531_E534_S0.8731.00
150_T168_I0.8731.00
438_S442_E0.8691.00
623_I626_S0.8691.00
417_L592_V0.8691.00
56_V265_G0.8671.00
445_V564_T0.8651.00
56_V60_D0.8631.00
69_T72_K0.8621.00
417_L595_L0.8621.00
78_S170_R0.8611.00
353_L357_I0.8591.00
122_R126_A0.8581.00
546_S550_L0.8561.00
345_H348_H0.8521.00
435_T439_S0.8521.00
256_S259_T0.8501.00
463_E551_Q0.8491.00
622_D626_S0.8481.00
462_A550_L0.8451.00
538_E542_E0.8430.99
296_T300_F0.8430.99
431_S578_T0.8430.99
311_R315_S0.8420.99
522_A525_S0.8400.99
462_A466_V0.8380.99
242_Y251_M0.8350.99
227_D231_K0.8340.99
22_L26_I0.8340.99
447_K566_E0.8340.99
630_Q637_I0.8330.99
352_S355_H0.8280.99
637_I644_L0.8270.99
11_S333_K0.8270.99
132_F137_R0.8240.99
163_K184_K0.8230.99
315_S326_E0.8230.99
434_S578_T0.8220.99
454_T556_E0.8200.99
518_V524_Q0.8200.99
444_L566_E0.8180.99
623_I630_Q0.8180.99
330_I341_E0.8160.99
337_G340_S0.8150.99
420_L578_T0.8140.99
199_K274_D0.8130.99
420_L592_V0.8130.99
637_I640_S0.8120.99
110_A124_P0.8120.99
423_A587_N0.8100.99
435_T582_A0.8100.99
153_T169_A0.8090.99
364_V367_S0.8080.99
51_S54_E0.8070.99
135_L138_D0.8020.99
610_T614_K0.8020.99
114_S120_F0.7990.99
413_M602_I0.7970.99
445_V571_F0.7960.99
553_V560_G0.7960.99
278_R281_I0.7950.99
428_T432_A0.7950.99
75_A170_R0.7940.99
279_V283_A0.7930.99
204_F266_T0.7920.99
80_W83_A0.7910.99
153_T167_T0.7910.99
368_S375_A0.7900.99
448_T452_M0.7900.99
53_K57_Q0.7890.99
45_D273_H0.7880.99
289_I296_T0.7880.99
177_G180_A0.7860.99
470_E544_H0.7860.99
458_S461_A0.7840.99
81_A85_K0.7840.99
65_D68_S0.7810.99
473_S479_I0.7810.99
416_G598_G0.7800.99
611_A618_D0.7800.99
154_E207_S0.7800.99
564_T567_T0.7790.99
634_M637_I0.7790.99
11_S14_A0.7770.99
478_N482_V0.7770.99
479_I482_V0.7760.99
306_T310_R0.7750.99
344_N348_H0.7750.99
439_S442_E0.7730.99
26_I291_I0.7720.99
211_K214_A0.7710.99
131_D137_R0.7690.99
492_L520_K0.7680.99
445_V567_T0.7670.99
541_K544_H0.7650.99
308_P337_G0.7650.99
451_Q454_T0.7640.99
488_D492_L0.7630.99
15_R19_I0.7600.99
434_S441_G0.7600.99
403_I609_I0.7600.99
114_S140_Y0.7600.99
475_D538_E0.7590.99
377_Q381_A0.7590.99
316_A350_L0.7580.99
310_R313_V0.7580.99
448_T455_I0.7560.99
355_H358_K0.7550.99
408_E411_N0.7550.99
399_Q413_M0.7540.99
402_K605_A0.7520.99
139_W158_S0.7520.99
356_G359_D0.7510.99
290_A294_G0.7510.99
410_I606_S0.7510.99
454_T457_H0.7490.99
11_S16_R0.7480.99
139_W178_V0.7470.99
637_I641_A0.7460.99
13_I335_E0.7460.99
437_V440_K0.7450.99
463_E546_S0.7440.99
470_E474_K0.7430.99
336_L340_S0.7380.99
411_N603_S0.7370.99
525_S535_L0.7350.99
406_T413_M0.7340.99
138_D141_K0.7330.99
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342_S347_A0.5170.90
232_L235_D0.5170.90
113_S177_G0.5170.90
367_S378_T0.5170.90
91_K94_L0.5160.90
438_S578_T0.5150.90
41_V277_S0.5150.90
455_I459_V0.5150.90
476_I536_I0.5150.90
306_T313_V0.5140.90
407_T413_M0.5140.90
434_S437_V0.5130.90
97_E100_Q0.5130.90
147_K171_Q0.5120.90
454_T458_S0.5120.90
589_N593_E0.5120.90
123_Y127_D0.5120.90
456_D558_E0.5120.90
219_K222_T0.5120.90
461_A549_V0.5110.90
326_E346_M0.5100.89
232_L238_G0.5100.89
421_A589_N0.5090.89
427_I431_S0.5090.89
201_G271_E0.5080.89
213_I261_W0.5080.89
263_I268_Y0.5070.89
115_G121_T0.5070.89
14_A302_I0.5060.89
270_N277_S0.5060.89
25_L291_I0.5060.89
455_I553_V0.5050.89
122_R127_D0.5050.89
409_Q434_S0.5050.89
345_H349_S0.5040.89
360_S363_H0.5030.89
136_E159_I0.5030.89
371_L379_S0.5020.89
140_Y182_D0.5010.89
623_I631_L0.5000.89
420_L427_I0.5000.89
312_I315_S0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zx6A 2 0.4577 100 0.513 Contact Map
2ch7A 2 0.4668 100 0.588 Contact Map
1qu7A 2 0.3414 100 0.621 Contact Map
3g67A 2 0.3157 100 0.671 Contact Map
4i3mA 2 0.2221 99.9 0.795 Contact Map
3lifA 1 0.355 99.9 0.814 Contact Map
3lidA 2 0.3686 99.9 0.825 Contact Map
3c8cA 2 0.3505 99.9 0.826 Contact Map
3li9A 2 0.3369 99.9 0.826 Contact Map
3libA 3 0.3505 99.9 0.827 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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