GREMLIN Database
MCPB - Methyl-accepting chemotaxis protein McpB
UniProt: P39215 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 662 (617)
Sequences: 7605 (6588)
Seq/√Len: 265.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
333_S338_G6.1821.00
328_T352_R4.1061.00
16_K335_D3.8641.00
319_T324_D3.4601.00
14_S304_R3.3271.00
34_F38_R3.3051.00
335_D338_G3.1961.00
317_S347_M2.6711.00
472_G475_K2.5691.00
318_K339_E2.4931.00
113_Y181_A2.4881.00
499_A520_R2.4871.00
328_T349_Q2.4761.00
466_V547_S2.4381.00
303_V307_T2.4321.00
328_T345_N2.3941.00
201_E272_E2.3661.00
205_F265_A2.3591.00
482_R486_G2.3121.00
256_T263_K2.3031.00
12_S15_K2.3001.00
552_K556_Q2.2571.00
456_I561_G2.2411.00
249_D270_M2.2371.00
282_T286_I2.2351.00
473_K543_E2.2171.00
566_D570_E2.2081.00
286_I290_A2.2041.00
198_V202_G2.1411.00
142_Q146_K2.1401.00
36_S284_G2.1191.00
526_S530_A2.1131.00
478_T541_V2.0801.00
469_G543_E2.0751.00
499_A517_E2.0651.00
521_K524_V2.0401.00
313_L317_S2.0401.00
473_K539_E2.0191.00
304_R308_K2.0171.00
159_A162_D2.0141.00
143_D146_K1.9971.00
428_I586_L1.9921.00
476_D479_S1.9891.00
442_G572_F1.9831.00
134_D137_Q1.9781.00
168_T183_D1.9691.00
642_A645_L1.9691.00
345_N348_G1.9641.00
623_D626_A1.9531.00
563_V567_N1.9161.00
320_I347_M1.9131.00
420_Q423_Q1.8971.00
441_T444_K1.8961.00
314_V339_E1.8941.00
444_K448_Q1.8881.00
480_I536_L1.8861.00
556_Q559_Q1.8821.00
479_S482_R1.8781.00
483_V529_S1.8771.00
319_T327_E1.8701.00
157_Y168_T1.8661.00
471_E548_L1.8611.00
339_E342_E1.8581.00
317_S344_F1.8501.00
474_S544_I1.8471.00
567_N570_E1.8381.00
517_E520_R1.8311.00
100_S104_S1.8211.00
448_Q451_G1.8121.00
367_A371_Q1.8081.00
314_V343_S1.7981.00
299_I303_V1.7981.00
591_S594_E1.7591.00
239_G254_Y1.7511.00
406_S409_H1.7501.00
317_S340_L1.7381.00
485_N530_A1.7251.00
231_A235_A1.7201.00
619_A623_D1.7071.00
608_S612_D1.6831.00
472_G476_D1.6701.00
616_E619_A1.6671.00
203_Y217_K1.6671.00
33_E288_L1.6661.00
442_G575_I1.6591.00
595_Q598_D1.6551.00
438_I574_S1.6451.00
349_Q353_S1.6431.00
612_D615_K1.6351.00
560_S563_V1.6331.00
228_D231_A1.6291.00
534_E538_Q1.6271.00
40_A280_V1.6211.00
331_I345_N1.6201.00
450_V569_K1.6181.00
374_A378_Q1.6091.00
227_G231_A1.6051.00
116_A120_T1.6011.00
379_T383_T1.6001.00
559_Q563_V1.5881.00
467_V548_L1.5831.00
430_K434_Q1.5811.00
466_V546_T1.5811.00
453_M456_I1.5811.00
28_P291_S1.5801.00
402_E405_E1.5801.00
318_K322_R1.5781.00
370_E374_A1.5711.00
601_Q605_A1.5591.00
318_K346_E1.5531.00
437_E441_T1.5521.00
619_A622_Q1.5471.00
528_D532_E1.5451.00
449_T568_T1.5441.00
164_S187_D1.5381.00
147_A150_E1.5321.00
203_Y216_H1.5281.00
570_E574_S1.5271.00
630_E633_A1.5221.00
64_T68_G1.5211.00
352_R356_S1.5121.00
545_D549_H1.5121.00
318_K343_S1.5081.00
556_Q560_S1.5071.00
199_G202_G1.5061.00
473_K476_D1.5031.00
191_E194_K1.4961.00
153_V169_I1.4961.00
574_S577_S1.4891.00
636_E640_S1.4881.00
188_K191_E1.4771.00
33_E37_Y1.4741.00
469_G472_G1.4731.00
119_G136_R1.4711.00
403_K609_G1.4661.00
212_T224_K1.4621.00
320_I348_G1.4581.00
612_D616_E1.4561.00
609_G612_D1.4531.00
581_E584_G1.4531.00
467_V547_S1.4521.00
248_E269_Y1.4521.00
204_A266_G1.4411.00
155_D210_N1.4331.00
367_A370_E1.4331.00
602_H605_A1.4321.00
91_N94_E1.4321.00
313_L340_L1.4251.00
451_G455_S1.4201.00
412_N416_E1.4181.00
414_M600_S1.4161.00
426_S430_K1.4131.00
459_S553_E1.4121.00
279_S283_T1.4091.00
433_I437_E1.4071.00
434_Q437_E1.4031.00
340_L344_F1.3961.00
156_P165_M1.3961.00
629_E633_A1.3931.00
252_M265_A1.3891.00
191_E195_Q1.3881.00
328_T348_G1.3861.00
310_L340_L1.3831.00
453_M561_G1.3761.00
290_A294_A1.3731.00
377_G381_K1.3671.00
281_L285_M1.3661.00
440_G444_K1.3641.00
52_A56_V1.3561.00
353_S357_A1.3511.00
528_D531_K1.3511.00
187_D191_E1.3461.00
317_S343_S1.3401.00
92_Q96_K1.3391.00
149_G174_K1.3261.00
591_S595_Q1.3261.00
114_G173_L1.3221.00
594_E598_D1.3211.00
242_Q270_M1.3211.00
199_G272_E1.3191.00
584_G588_T1.3181.00
531_K535_K1.3171.00
462_Q465_A1.3151.00
399_E402_E1.3091.00
580_N584_G1.3081.00
152_V170_A1.3071.00
283_T286_I1.3071.00
371_Q374_A1.3061.00
427_D430_K1.3031.00
470_L547_S1.3021.00
470_L540_I1.2981.00
144_A170_A1.2981.00
577_S581_E1.2961.00
458_Q462_Q1.2921.00
22_I296_G1.2841.00
460_V558_V1.2791.00
496_L504_R1.2761.00
633_A636_E1.2701.00
324_D327_E1.2691.00
626_A629_E1.2681.00
486_G489_D1.2671.00
448_Q567_N1.2661.00
293_V297_I1.2651.00
305_S308_K1.2621.00
250_K269_Y1.2541.00
430_K433_I1.2451.00
524_V528_D1.2441.00
588_T591_S1.2421.00
423_Q427_D1.2381.00
447_Q451_G1.2381.00
141_Y145_M1.2381.00
270_M274_K1.2371.00
454_N458_Q1.2351.00
14_S18_I1.2351.00
13_I337_L1.2331.00
47_E51_N1.2231.00
109_V182_M1.2231.00
572_F575_I1.2191.00
331_I341_G1.2181.00
313_L341_G1.2161.00
11_P19_V1.2141.00
37_Y281_L1.2141.00
157_Y183_D1.2111.00
492_N520_R1.2111.00
203_Y267_T1.1991.00
29_I32_L1.1991.00
331_I335_D1.1961.00
549_H552_K1.1951.00
626_A630_E1.1911.00
465_A469_G1.1911.00
72_K75_T1.1891.00
11_P15_K1.1841.00
402_E406_S1.1801.00
35_S39_S1.1771.00
142_Q145_M1.1751.00
495_A520_R1.1751.00
409_H413_L1.1741.00
467_V551_F1.1731.00
452_Q560_S1.1721.00
232_K237_D1.1711.00
313_L344_F1.1701.00
320_I325_L1.1631.00
139_P143_D1.1611.00
444_K447_Q1.1601.00
230_V233_M1.1601.00
437_E440_G1.1601.00
282_T285_M1.1531.00
380_S383_T1.1491.00
535_K539_E1.1461.00
96_K100_S1.1451.00
25_L28_P1.1441.00
461_Q555_N1.1431.00
320_I344_F1.1431.00
285_M289_I1.1411.00
75_T151_I1.1381.00
458_Q461_Q1.1371.00
244_T249_D1.1371.00
553_E556_Q1.1371.00
316_S329_I1.1341.00
454_N566_D1.1331.00
38_R42_G1.1311.00
451_G454_N1.1311.00
71_A75_T1.1301.00
21_F299_I1.1271.00
461_Q465_A1.1271.00
18_I22_I1.1271.00
319_T347_M1.1231.00
362_V369_S1.1201.00
66_D70_K1.1181.00
232_K236_N1.1181.00
443_E573_Q1.1171.00
549_H553_E1.1161.00
289_I293_V1.1151.00
359_Q363_N1.1021.00
243_Y250_K1.1011.00
520_R524_V1.1001.00
480_I537_I1.0991.00
622_Q626_A1.0991.00
620_S623_D1.0981.00
297_I301_F1.0981.00
144_A179_V1.0971.00
476_D532_E1.0961.00
508_S519_V1.0951.00
250_K267_T1.0931.00
74_V171_Q1.0931.00
531_K534_E1.0921.00
485_N534_E1.0911.00
419_Q423_Q1.0901.00
605_A609_G1.0901.00
200_K272_E1.0901.00
527_A531_K1.0891.00
538_Q542_A1.0881.00
468_K472_G1.0871.00
584_G587_Q1.0851.00
400_Q404_V1.0801.00
243_Y252_M1.0791.00
314_V318_K1.0781.00
638_I645_L1.0781.00
480_I529_S1.0731.00
414_M596_L1.0711.00
525_Q528_D1.0701.00
325_L351_L1.0691.00
41_S45_D1.0691.00
325_L355_I1.0681.00
40_A44_L1.0651.00
71_A153_V1.0641.00
121_Y124_A1.0621.00
356_S360_D1.0621.00
465_A468_K1.0601.00
320_I351_L1.0591.00
525_Q532_E1.0561.00
489_D500_I1.0481.00
45_D49_M1.0461.00
637_E640_S1.0441.00
17_L21_F1.0421.00
154_T157_Y1.0401.00
410_Q413_L1.0391.00
587_Q591_S1.0381.00
439_A442_G1.0361.00
115_G135_P1.0361.00
329_I345_N1.0351.00
70_K73_A1.0341.00
344_F348_G1.0341.00
30_L34_F1.0341.00
624_I627_S1.0331.00
316_S344_F1.0321.00
464_E551_F1.0311.00
170_A179_V1.0281.00
38_R41_S1.0261.00
631_Q635_M1.0251.00
466_V550_M1.0191.00
638_I642_A1.0171.00
542_A546_T1.0161.00
56_V60_N1.0121.00
376_A383_T1.0091.00
348_G352_R1.0071.00
312_R330_E1.0061.00
295_G299_I1.0061.00
369_S376_A1.0051.00
25_L295_G1.0031.00
60_N257_N1.0031.00
296_G300_L1.0031.00
517_E521_K1.0031.00
245_L250_K1.0021.00
322_R346_E1.0001.00
464_E555_N0.9991.00
93_E97_A0.9981.00
635_M645_L0.9971.00
611_A615_K0.9961.00
439_A576_F0.9961.00
470_L544_I0.9931.00
598_D602_H0.9921.00
29_I288_L0.9921.00
26_I30_L0.9901.00
314_V340_L0.9881.00
94_E97_A0.9871.00
323_G347_M0.9861.00
228_D232_K0.9861.00
341_G345_N0.9821.00
323_G340_L0.9811.00
416_E420_Q0.9801.00
315_Q318_K0.9791.00
151_I171_Q0.9781.00
495_A519_V0.9781.00
449_T565_T0.9751.00
33_E284_G0.9721.00
475_K545_D0.9721.00
74_V182_M0.9701.00
340_L347_M0.9691.00
425_S428_I0.9641.00
334_K338_G0.9621.00
278_K281_L0.9611.00
278_K282_T0.9611.00
547_S551_F0.9551.00
570_E573_Q0.9551.00
459_S462_Q0.9551.00
376_A380_S0.9551.00
360_D363_N0.9541.00
493_L500_I0.9531.00
563_V566_D0.9531.00
155_D208_T0.9501.00
316_S327_E0.9501.00
20_S302_I0.9491.00
51_N54_N0.9481.00
231_A234_Y0.9451.00
537_I541_V0.9411.00
156_P208_T0.9381.00
309_P333_S0.9381.00
363_N367_A0.9371.00
137_Q142_Q0.9371.00
36_S40_A0.9361.00
448_Q564_V0.9341.00
354_L358_I0.9341.00
73_A76_F0.9331.00
233_M265_A0.9321.00
605_A608_S0.9251.00
113_Y183_D0.9231.00
344_F347_M0.9221.00
138_R160_A0.9201.00
573_Q577_S0.9191.00
523_A526_S0.9171.00
311_K314_V0.9171.00
411_L607_V0.9151.00
374_A377_G0.9151.00
455_S557_E0.9141.00
455_S458_Q0.9131.00
64_T259_L0.9131.00
347_M351_L0.9101.00
300_L304_R0.9101.00
615_K619_A0.9091.00
158_V163_G0.9081.00
68_G71_A0.9031.00
460_V551_F0.9021.00
624_I631_Q0.9011.00
421_V579_T0.9011.00
436_T440_G0.9001.00
346_E349_Q0.8971.00
634_S638_I0.8961.00
205_F216_H0.8961.00
50_G54_N0.8961.00
312_R315_Q0.8921.00
439_A443_E0.8911.00
251_K270_M0.8911.00
468_K552_K0.8911.00
317_S320_I0.8911.00
115_G140_W0.8871.00
140_W157_Y0.8871.00
541_V548_L0.8871.00
248_E271_D0.8861.00
480_I530_A0.8831.00
312_R316_S0.8821.00
456_I558_V0.8821.00
174_K177_S0.8811.00
303_V306_I0.8801.00
591_S598_D0.8781.00
290_A297_I0.8761.00
421_V593_V0.8711.00
412_N415_N0.8711.00
309_P337_L0.8711.00
469_G546_T0.8691.00
400_Q614_S0.8671.00
164_S185_T0.8661.00
331_I342_E0.8651.00
532_E535_K0.8651.00
138_R159_A0.8651.00
464_E552_K0.8631.00
613_V617_S0.8631.00
639_S643_T0.8631.00
480_I526_S0.8621.00
56_V266_G0.8611.00
422_S425_S0.8611.00
413_L416_E0.8561.00
125_P128_K0.8551.00
101_Q104_S0.8541.00
275_D279_S0.8541.00
429_T433_I0.8541.00
120_T134_D0.8531.00
463_A554_V0.8531.00
423_Q426_S0.8501.00
136_R141_Y0.8501.00
53_K57_D0.8501.00
378_Q381_K0.8501.00
453_M565_T0.8481.00
16_K305_S0.8451.00
474_S480_I0.8451.00
412_N604_S0.8451.00
158_V165_M0.8440.99
633_A637_E0.8430.99
376_A379_T0.8430.99
358_I365_V0.8410.99
413_L417_G0.8400.99
356_S359_Q0.8400.99
631_Q638_I0.8360.99
588_T592_T0.8360.99
641_S644_T0.8330.99
123_Q127_E0.8330.99
561_G568_T0.8330.99
200_K275_D0.8320.99
457_N562_L0.8310.99
539_E543_E0.8300.99
123_Q126_K0.8290.99
134_D138_R0.8290.99
232_K235_A0.8230.99
369_S372_L0.8230.99
365_V368_S0.8230.99
140_W179_V0.8210.99
37_Y277_S0.8200.99
418_L596_L0.8190.99
45_D274_K0.8190.99
13_I336_E0.8160.99
426_S594_E0.8160.99
205_F267_T0.8150.99
279_S282_T0.8120.99
432_S579_T0.8120.99
405_E409_H0.8120.99
433_I587_Q0.8110.99
11_P334_K0.8090.99
408_S413_L0.8090.99
319_T322_R0.8090.99
544_I547_S0.8080.99
15_K19_V0.8070.99
464_E547_S0.8060.99
338_G341_G0.8060.99
459_S557_E0.8030.99
575_I578_M0.8030.99
61_T64_T0.8020.99
331_I338_G0.8020.99
133_Y138_R0.8000.99
133_Y140_W0.8000.99
617_S638_I0.7990.99
59_F62_T0.7990.99
307_T311_K0.7980.99
476_D539_E0.7980.99
413_L599_R0.7980.99
69_E72_K0.7970.99
257_N260_T0.7950.99
37_Y41_S0.7900.99
12_S339_E0.7900.99
623_D627_S0.7880.99
316_S320_I0.7870.99
131_E135_P0.7860.99
493_L521_K0.7850.99
449_T456_I0.7820.99
366_A370_E0.7820.99
583_A587_Q0.7810.99
526_S536_L0.7770.99
452_Q455_S0.7770.99
46_Q50_G0.7770.99
141_Y179_V0.7760.99
22_I26_I0.7760.99
372_L376_A0.7750.99
74_V78_S0.7730.99
280_V284_G0.7730.99
544_I548_L0.7730.99
170_A181_A0.7730.99
554_V561_G0.7720.99
406_S410_Q0.7720.99
133_Y136_R0.7710.99
110_A159_A0.7700.99
404_V610_I0.7700.99
103_V112_I0.7690.99
432_S582_I0.7680.99
607_V610_I0.7680.99
424_T588_T0.7670.99
159_A166_V0.7650.99
154_T170_A0.7650.99
607_V611_A0.7650.99
149_G172_E0.7630.99
409_H412_N0.7630.99
337_L341_G0.7600.99
590_N594_E0.7600.99
360_D364_N0.7600.99
417_G592_T0.7590.99
542_A545_D0.7580.99
329_I341_G0.7570.99
357_A360_D0.7560.99
74_V169_I0.7560.99
445_F567_N0.7550.99
311_K315_Q0.7540.99
143_D170_A0.7530.99
291_S295_G0.7530.99
410_Q414_M0.7510.99
49_M53_K0.7500.99
348_G351_L0.7500.99
353_S356_S0.7470.99
463_A551_F0.7460.99
407_S606_A0.7430.99
631_Q645_L0.7430.99
97_A101_Q0.7420.99
519_V525_Q0.7420.99
446_V449_T0.7420.99
576_F580_N0.7410.99
557_E560_S0.7410.99
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585_K588_T0.5340.91
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287_V291_S0.5320.91
98_K101_Q0.5320.91
22_I28_P0.5290.91
307_T310_L0.5280.91
439_A456_I0.5260.91
319_T350_S0.5260.91
554_V558_V0.5230.91
213_Y216_H0.5230.91
609_G613_V0.5210.90
435_S582_I0.5200.90
417_G589_M0.5200.90
492_N495_A0.5200.90
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133_Y137_Q0.5190.90
254_Y265_A0.5180.90
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417_G599_R0.5160.90
435_S442_G0.5150.90
447_Q569_K0.5150.90
631_Q634_S0.5140.90
519_V529_S0.5140.90
307_T337_L0.5130.90
490_Q518_E0.5120.90
435_S446_V0.5120.90
621_I628_A0.5120.90
442_G456_I0.5110.90
246_N249_D0.5110.90
454_N457_N0.5100.89
404_V411_L0.5100.89
314_V337_L0.5100.89
317_S348_G0.5090.89
18_I23_A0.5070.89
271_D278_K0.5060.89
345_N352_R0.5050.89
112_I115_G0.5050.89
473_K536_L0.5040.89
307_T314_V0.5040.89
115_G133_Y0.5030.89
141_Y166_V0.5030.89
91_N95_I0.5030.89
52_A253_T0.5030.89
132_G136_R0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zx6A 2 0.4577 100 0.511 Contact Map
2ch7A 2 0.4668 100 0.587 Contact Map
1qu7A 2 0.3399 100 0.618 Contact Map
3g67A 2 0.3157 100 0.672 Contact Map
4i3mA 2 0.2221 99.9 0.794 Contact Map
3lifA 1 0.355 99.9 0.809 Contact Map
3c8cA 2 0.3505 99.9 0.821 Contact Map
3li9A 2 0.3369 99.9 0.822 Contact Map
3libA 3 0.3505 99.9 0.823 Contact Map
3lidA 2 0.3701 99.9 0.823 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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