GREMLIN Database
XYLB - Xylulose kinase
UniProt: P39211 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 499 (473)
Sequences: 12511 (8517)
Seq/√Len: 391.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
191_N201_A4.2031.00
108_Q142_E3.9041.00
20_N24_K3.4851.00
16_T57_A3.3371.00
111_R142_E3.2961.00
411_Q415_D2.8561.00
183_H186_R2.8551.00
381_H476_F2.8411.00
123_I190_S2.8341.00
420_R463_Y2.8211.00
381_H385_E2.8191.00
327_I367_H2.7401.00
31_K56_E2.7111.00
94_L147_L2.7071.00
182_L207_L2.6901.00
36_I96_N2.6731.00
29_T60_E2.6441.00
168_V206_P2.6251.00
31_K60_E2.6201.00
447_S450_E2.5971.00
407_D460_A2.5961.00
356_L368_F2.5911.00
446_E450_E2.5521.00
396_T422_I2.5481.00
209_E212_D2.5381.00
95_R144_E2.4991.00
51_V164_R2.4701.00
18_L61_L2.4441.00
89_Q152_A2.4071.00
48_E164_R2.4031.00
88_D150_K2.3961.00
381_H473_K2.3831.00
188_E201_A2.3771.00
194_C201_A2.3141.00
183_H190_S2.2421.00
191_N195_N2.2281.00
469_V473_K2.1791.00
153_V169_I2.1741.00
237_G242_C2.1481.00
162_R236_G2.1101.00
7_I54_T2.1001.00
17_I431_A2.0921.00
418_N469_V2.0481.00
13_A30_S2.0471.00
332_N367_H2.0281.00
218_L221_V2.0131.00
303_S372_I2.0051.00
316_S319_Q1.9681.00
111_R115_K1.9661.00
48_E92_Q1.9601.00
119_H122_D1.9491.00
263_G300_A1.9291.00
34_P49_D1.9101.00
335_L478_L1.9091.00
4_V439_A1.9031.00
364_N367_H1.9021.00
319_Q322_Q1.8951.00
425_E457_R1.8891.00
39_K42_Y1.8791.00
336_Y356_L1.8781.00
326_A366_K1.8761.00
399_S410_L1.8521.00
5_I58_L1.8501.00
219_P229_E1.8471.00
60_E64_I1.8411.00
476_F480_K1.8291.00
166_T233_V1.8161.00
5_I16_T1.8071.00
9_L14_V1.7991.00
138_L142_E1.7621.00
415_D465_K1.7361.00
307_F372_I1.7301.00
234_Y441_G1.7231.00
3_Y26_C1.7091.00
208_V212_D1.7061.00
119_H192_D1.6901.00
422_I461_A1.6781.00
123_I192_D1.6711.00
86_L140_V1.6681.00
110_I114_E1.6551.00
88_D92_Q1.6481.00
91_R163_F1.6471.00
254_K396_T1.6461.00
3_Y18_L1.6401.00
119_H123_I1.6341.00
170_H208_V1.6291.00
213_C216_S1.6241.00
420_R461_A1.6041.00
378_F475_L1.6031.00
107_P111_R1.5871.00
85_V157_P1.5801.00
86_L203_I1.5751.00
305_D309_R1.5701.00
213_C234_Y1.5561.00
353_R360_D1.5451.00
4_V444_W1.5401.00
323_G366_K1.5341.00
323_G326_A1.5061.00
252_S270_E1.5011.00
315_E319_Q1.4961.00
146_E149_K1.4891.00
29_T61_L1.4871.00
29_T57_A1.4841.00
385_E480_K1.4831.00
228_L231_T1.4791.00
46_N49_D1.4711.00
62_V69_A1.4481.00
118_D122_D1.4451.00
425_E459_A1.4281.00
162_R214_V1.4261.00
370_R374_E1.4131.00
408_T412_M1.4061.00
320_L369_L1.3841.00
27_A61_L1.3831.00
439_A445_F1.3751.00
48_E52_Q1.3731.00
407_D423_K1.3711.00
322_Q326_A1.3691.00
323_G365_R1.3641.00
166_T215_G1.3621.00
27_A64_I1.3561.00
324_V408_T1.3541.00
81_M238_A1.3541.00
139_W143_H1.3481.00
471_K475_L1.3461.00
259_I413_Q1.3451.00
89_Q153_V1.3441.00
36_I49_D1.3411.00
407_D462_F1.3411.00
74_G438_A1.3401.00
51_V55_I1.3341.00
467_Q470_Q1.3321.00
87_L155_L1.3241.00
377_T412_M1.3111.00
336_Y340_L1.3091.00
106_T110_I1.3061.00
255_T394_V1.3021.00
321_L325_E1.2981.00
216_S230_K1.2971.00
173_Y187_K1.2951.00
297_T379_S1.2941.00
160_Y164_R1.2941.00
257_C413_Q1.2941.00
396_T420_R1.2891.00
7_I58_L1.2891.00
200_S203_I1.2881.00
388_R419_T1.2871.00
423_K462_F1.2861.00
68_Q71_D1.2841.00
377_T416_I1.2621.00
194_C204_C1.2601.00
14_V54_T1.2581.00
418_N472_Y1.2581.00
119_H196_Q1.2531.00
410_L462_F1.2491.00
336_Y372_I1.2451.00
208_V214_V1.2431.00
21_Q444_W1.2371.00
377_T413_Q1.2341.00
18_L67_V1.2311.00
108_Q138_L1.2261.00
83_G97_A1.2221.00
471_K474_T1.2181.00
237_G437_L1.2171.00
162_R170_H1.2101.00
141_K148_F1.2081.00
134_L197_I1.2001.00
357_I482_I1.1991.00
14_V53_Q1.1971.00
120_L128_V1.1951.00
385_E476_F1.1871.00
321_L407_D1.1851.00
52_Q56_E1.1841.00
213_C232_K1.1831.00
144_E147_L1.1811.00
168_V208_V1.1731.00
19_V25_V1.1711.00
91_R169_I1.1711.00
115_K196_Q1.1701.00
56_E60_E1.1571.00
318_E321_L1.1531.00
7_I16_T1.1511.00
382_E480_K1.1501.00
334_L363_H1.1441.00
311_F368_F1.1441.00
173_Y207_L1.1271.00
148_F151_T1.1261.00
86_L151_T1.1251.00
467_Q471_K1.1251.00
251_S452_A1.1231.00
319_Q323_G1.1221.00
46_N96_N1.1211.00
381_H417_F1.1211.00
412_M416_I1.1201.00
192_D195_N1.1191.00
44_E96_N1.1151.00
107_P110_I1.1121.00
146_E150_K1.1111.00
109_C128_V1.1101.00
321_L406_N1.1081.00
251_S254_K1.1061.00
385_E388_R1.1041.00
155_L169_I1.0951.00
405_K427_E1.0951.00
50_W157_P1.0941.00
299_A303_S1.0931.00
359_M363_H1.0921.00
418_N473_K1.0921.00
213_C441_G1.0871.00
251_S449_E1.0831.00
299_A302_Y1.0821.00
254_K398_V1.0791.00
170_H214_V1.0791.00
473_K477_D1.0771.00
151_T203_I1.0771.00
54_T161_V1.0741.00
67_V71_D1.0721.00
35_L45_Q1.0711.00
95_R147_L1.0691.00
469_V472_Y1.0681.00
436_M455_F1.0631.00
398_V422_I1.0561.00
173_Y182_L1.0551.00
384_I417_F1.0481.00
86_L137_M1.0441.00
3_Y67_V1.0431.00
303_S336_Y1.0421.00
77_Y162_R1.0421.00
363_H367_H1.0351.00
74_G442_S1.0321.00
465_K469_V1.0291.00
440_F451_C1.0281.00
194_C199_I1.0281.00
47_P85_V1.0261.00
19_V435_A1.0251.00
104_R139_W1.0191.00
4_V442_S1.0141.00
108_Q143_H1.0111.00
322_Q325_E1.0081.00
376_I403_G1.0041.00
251_S395_H1.0001.00
33_Y53_Q1.0001.00
478_L481_N0.9991.00
323_G369_L0.9981.00
74_G234_Y0.9961.00
253_G395_H0.9921.00
336_Y371_A0.9901.00
60_E63_S0.9881.00
378_F416_I0.9861.00
3_Y71_D0.9851.00
458_E461_A0.9821.00
436_M451_C0.9821.00
111_R114_E0.9811.00
16_T61_L0.9811.00
43_S101_N0.9791.00
110_I113_T0.9771.00
120_L180_L0.9711.00
137_M154_F0.9711.00
134_L180_L0.9661.00
255_T267_S0.9641.00
403_G409_W0.9641.00
466_A469_V0.9601.00
49_D52_Q0.9581.00
54_T58_L0.9561.00
354_G359_M0.9541.00
182_L186_R0.9541.00
325_E408_T0.9531.00
108_Q111_R0.9531.00
439_A444_W0.9521.00
122_D274_R0.9511.00
163_F169_I0.9511.00
75_I231_T0.9471.00
29_T64_I0.9461.00
55_I59_A0.9451.00
59_A63_S0.9391.00
5_I18_L0.9311.00
466_A472_Y0.9291.00
78_S430_P0.9291.00
256_L400_I0.9281.00
86_L154_F0.9241.00
147_L150_K0.9231.00
381_H416_I0.9231.00
145_P149_K0.9221.00
216_S232_K0.9221.00
378_F476_F0.9221.00
327_I331_A0.9211.00
370_R408_T0.9201.00
92_Q164_R0.9151.00
187_K209_E0.9121.00
77_Y161_V0.9111.00
330_G333_G0.9101.00
445_F451_C0.9101.00
73_D442_S0.9081.00
470_Q474_T0.9051.00
359_M368_F0.9011.00
122_D185_T0.9011.00
140_V147_L0.8971.00
62_V72_I0.8961.00
396_T461_A0.8961.00
234_Y442_S0.8961.00
19_V432_M0.8941.00
317_F320_L0.8921.00
265_I384_I0.8901.00
18_L72_I0.8881.00
151_T154_F0.8861.00
171_T176_A0.8811.00
95_R140_V0.8811.00
20_N26_C0.8791.00
411_Q465_K0.8781.00
397_V417_F0.8741.00
174_S285_H0.8741.00
176_A189_W0.8701.00
82_H178_G0.8691.00
159_D171_T0.8691.00
5_I72_I0.8681.00
84_L154_F0.8671.00
470_Q473_K0.8661.00
185_T272_K0.8661.00
138_L141_K0.8641.00
417_F420_R0.8641.00
263_G380_L0.8611.00
440_F448_L0.8611.00
167_G218_L0.8601.00
9_L161_V0.8591.00
335_L357_I0.8541.00
188_E206_P0.8521.00
189_W204_C0.8511.00
404_A427_E0.8511.00
450_E454_Q0.8491.00
31_K57_A0.8481.00
134_L181_L0.8471.00
117_G196_Q0.8451.00
152_A202_D0.8421.00
173_Y209_E0.8391.00
356_L372_I0.8381.00
111_R138_L0.8381.00
156_L179_T0.8341.00
109_C130_E0.8341.00
4_V74_G0.8331.00
70_K228_L0.8321.00
243_G400_I0.8291.00
76_S234_Y0.8261.00
113_T128_V0.8251.00
32_R305_D0.8251.00
268_Y290_S0.8241.00
77_Y165_M0.8241.00
318_E322_Q0.8221.00
312_A365_R0.8221.00
28_E428_Q0.8221.00
314_N320_L0.8201.00
171_T205_P0.8151.00
216_S229_E0.8151.00
81_M294_M0.8141.00
58_L62_V0.8091.00
240_N264_V0.8091.00
208_V235_A0.8081.00
270_E290_S0.8081.00
170_H206_P0.8071.00
308_K317_F0.8061.00
321_L324_V0.8061.00
474_T477_D0.8031.00
103_T129_L0.8021.00
219_P230_K0.8011.00
217_L231_T0.8001.00
267_S387_F0.8001.00
81_M175_D0.7991.00
72_I231_T0.7981.00
109_C135_P0.7951.00
9_L54_T0.7931.00
373_M412_M0.7921.00
187_K289_D0.7861.00
87_L91_R0.7851.00
416_I472_Y0.7841.00
73_D444_W0.7831.00
386_L389_E0.7821.00
481_N484_T0.7821.00
182_L187_K0.7821.00
185_T271_E0.7811.00
171_T207_L0.7791.00
399_S413_Q0.7781.00
333_G475_L0.7731.00
257_C263_G0.7711.00
94_L150_K0.7701.00
327_I332_N0.7691.00
474_T478_L0.7671.00
255_T397_V0.7651.00
257_C380_L0.7631.00
422_I458_E0.7621.00
137_M181_L0.7611.00
306_W309_R0.7611.00
475_L478_L0.7601.00
47_P96_N0.7601.00
185_T274_R0.7591.00
100_W262_S0.7591.00
19_V426_N0.7591.00
188_E191_N0.7581.00
264_V296_V0.7571.00
158_K236_G0.7571.00
44_E104_R0.7541.00
123_I183_H0.7531.00
307_F368_F0.7521.00
330_G370_R0.7521.00
324_V370_R0.7511.00
399_S423_K0.7501.00
227_L230_K0.7491.00
445_F454_Q0.7491.00
62_V67_V0.7481.00
307_F369_L0.7471.00
22_N454_Q0.7451.00
327_I366_K0.7441.00
373_M406_N0.7441.00
107_P143_H0.7421.00
192_D196_Q0.7411.00
324_V327_I0.7411.00
377_T409_W0.7401.00
300_A376_I0.7391.00
174_S237_G0.7381.00
75_I217_L0.7351.00
91_R152_A0.7341.00
107_P142_E0.7331.00
55_I221_V0.7331.00
6_G76_S0.7321.00
33_Y45_Q0.7321.00
382_E476_F0.7301.00
217_L228_L0.7271.00
11_T99_L0.7271.00
87_L169_I0.7271.00
31_K53_Q0.7261.00
38_E42_Y0.7261.00
195_N201_A0.7231.00
48_E160_Y0.7231.00
247_A256_L0.7211.00
315_E365_R0.7191.00
32_R308_K0.7191.00
247_A400_I0.7181.00
74_G232_K0.7181.00
378_F472_Y0.7181.00
420_R464_P0.7171.00
153_V203_I0.7171.00
458_E464_P0.7171.00
404_A410_L0.7151.00
138_L198_G0.7141.00
14_V33_Y0.7131.00
480_K484_T0.7121.00
69_A72_I0.7101.00
25_V28_E0.7091.00
52_Q55_I0.7081.00
58_L61_L0.7061.00
49_D53_Q0.7051.00
449_E452_A0.7051.00
55_I164_R0.7051.00
325_E407_D0.7041.00
305_D317_F0.7041.00
88_D94_L0.7041.00
54_T57_A0.7031.00
395_H419_T0.7021.00
249_I254_K0.7021.00
21_Q73_D0.7021.00
411_Q462_F0.7011.00
110_I351_S0.7011.00
162_R166_T0.7011.00
87_L153_V0.7001.00
333_G370_R0.6991.00
399_S421_V0.6981.00
9_L53_Q0.6961.00
183_H188_E0.6951.00
86_L94_L0.6941.00
221_V230_K0.6941.00
249_I256_L0.6910.99
217_L227_L0.6900.99
332_N363_H0.6880.99
381_H480_K0.6880.99
333_G374_E0.6880.99
190_S193_I0.6870.99
325_E411_Q0.6870.99
307_F311_F0.6870.99
51_V221_V0.6850.99
4_V73_D0.6840.99
79_G175_D0.6790.99
124_T193_I0.6770.99
295_G383_S0.6760.99
243_G430_P0.6750.99
87_L160_Y0.6740.99
87_L163_F0.6730.99
210_S236_G0.6690.99
160_Y163_F0.6670.99
275_D279_K0.6670.99
85_V97_A0.6650.99
440_F447_S0.6640.99
88_D152_A0.6640.99
327_I330_G0.6630.99
439_A443_G0.6620.99
239_D261_T0.6620.99
227_L231_T0.6610.99
412_M472_Y0.6590.99
98_I104_R0.6580.99
128_V180_L0.6570.99
48_E93_V0.6550.99
89_Q150_K0.6540.99
269_E273_E0.6540.99
374_E412_M0.6530.99
216_S219_P0.6530.99
153_V163_F0.6510.99
17_I25_V0.6500.99
339_Y343_E0.6500.99
214_V235_A0.6490.99
337_T355_S0.6490.99
112_M197_I0.6480.99
397_V419_T0.6460.99
263_G413_Q0.6450.99
463_Y466_A0.6450.99
278_G294_M0.6440.99
229_E232_K0.6440.99
343_E346_P0.6430.99
138_L148_F0.6400.99
277_K389_E0.6400.99
120_L193_I0.6370.99
174_S210_S0.6370.99
448_L452_A0.6340.99
159_D169_I0.6330.99
472_Y475_L0.6320.99
397_V421_V0.6320.99
48_E96_N0.6300.99
257_C397_V0.6290.99
19_V431_A0.6290.99
352_I355_S0.6290.99
118_D121_L0.6280.99
158_K175_D0.6250.99
213_C442_S0.6250.99
304_L321_L0.6220.99
266_L292_Y0.6220.99
423_K459_A0.6210.99
336_Y375_G0.6210.99
56_E59_A0.6200.99
466_A470_Q0.6190.99
132_F178_G0.6170.99
79_G157_P0.6160.99
396_T419_T0.6160.99
418_N466_A0.6130.99
84_L133_T0.6120.99
141_K198_G0.6110.99
80_Q100_W0.6110.99
321_L408_T0.6100.99
406_N409_W0.6100.99
137_M203_I0.6090.99
338_P375_G0.6070.99
436_M440_F0.6060.99
473_K476_F0.6060.99
331_A370_R0.6050.99
331_A335_L0.6050.99
370_R412_M0.6050.99
193_I197_I0.6040.99
324_V369_L0.6030.99
238_A241_A0.6030.99
55_I58_L0.6020.99
286_G289_D0.6000.99
112_M135_P0.6000.99
259_I399_S0.5990.99
317_F321_L0.5980.99
333_G367_H0.5980.99
91_R153_V0.5970.99
138_L197_I0.5950.98
335_L378_F0.5950.98
181_L204_C0.5920.98
81_M178_G0.5910.98
206_P212_D0.5900.98
105_T135_P0.5900.98
148_F152_A0.5890.98
195_N200_S0.5890.98
334_L371_A0.5890.98
332_N362_A0.5890.98
28_E64_I0.5880.98
120_L197_I0.5860.98
347_H382_E0.5860.98
44_E95_R0.5830.98
72_I227_L0.5830.98
297_T383_S0.5820.98
173_Y286_G0.5820.98
394_V419_T0.5800.98
126_N132_F0.5800.98
426_N432_M0.5780.98
312_A315_E0.5760.98
410_L423_K0.5750.98
232_K442_S0.5750.98
440_F445_F0.5740.98
328_P331_A0.5730.98
455_F458_E0.5730.98
12_S15_K0.5720.98
98_I140_V0.5710.98
75_I233_V0.5700.98
106_T130_E0.5700.98
374_E378_F0.5700.98
135_P180_L0.5690.98
148_F198_G0.5670.98
116_F193_I0.5660.98
221_V227_L0.5660.98
324_V373_M0.5660.98
4_V445_F0.5660.98
92_Q150_K0.5650.98
327_I370_R0.5640.98
46_N52_Q0.5640.98
257_C265_I0.5640.98
244_A266_L0.5620.98
376_I409_W0.5610.98
347_H480_K0.5610.98
199_I204_C0.5610.98
477_D480_K0.5590.98
240_N258_S0.5580.98
331_A367_H0.5570.98
24_K425_E0.5560.98
349_D352_I0.5550.98
328_P471_K0.5550.98
275_D389_E0.5550.98
85_V93_V0.5540.98
246_G429_G0.5530.98
179_T189_W0.5520.98
254_K452_A0.5520.98
412_M475_L0.5520.98
25_V426_N0.5510.98
148_F200_S0.5510.98
83_G99_L0.5500.98
330_G367_H0.5500.98
440_F443_G0.5490.97
347_H483_Y0.5490.97
328_P332_N0.5480.97
48_E51_V0.5480.97
82_H100_W0.5440.97
211_H441_G0.5440.97
404_A423_K0.5430.97
42_Y98_I0.5410.97
263_G297_T0.5400.97
82_H262_S0.5380.97
104_R143_H0.5380.97
431_A434_A0.5360.97
174_S241_A0.5350.97
47_P97_A0.5340.97
331_A374_E0.5340.97
245_I436_M0.5320.97
343_E349_D0.5310.97
378_F478_L0.5310.97
11_T100_W0.5310.97
43_S99_L0.5310.97
290_S448_L0.5300.97
330_G475_L0.5300.97
248_G452_A0.5300.97
195_N198_G0.5300.97
173_Y210_S0.5290.97
413_Q417_F0.5290.97
210_S237_G0.5290.97
155_L163_F0.5290.97
50_W97_A0.5280.97
86_L95_R0.5280.97
411_Q414_A0.5280.97
451_C455_F0.5280.97
53_Q56_E0.5280.97
93_V96_N0.5270.97
269_E293_T0.5270.97
218_L230_K0.5270.97
337_T483_Y0.5250.97
267_S394_V0.5240.97
407_D411_Q0.5230.97
78_S434_A0.5230.97
168_V216_S0.5220.97
341_V361_G0.5220.97
337_T343_E0.5220.97
333_G478_L0.5210.97
300_A303_S0.5210.97
178_G238_A0.5200.97
115_K138_L0.5190.96
261_T302_Y0.5190.96
445_F455_F0.5190.96
473_K480_K0.5190.96
380_L413_Q0.5180.96
447_S451_C0.5170.96
346_P349_D0.5170.96
265_I383_S0.5170.96
321_L373_M0.5160.96
254_K395_H0.5160.96
425_E458_E0.5160.96
6_G431_A0.5150.96
82_H238_A0.5130.96
159_D205_P0.5130.96
211_H440_F0.5130.96
305_D308_K0.5120.96
320_L324_V0.5110.96
432_M436_M0.5110.96
239_D402_G0.5110.96
172_E235_A0.5110.96
209_E286_G0.5100.96
228_L232_K0.5100.96
167_G220_H0.5100.96
452_A455_F0.5090.96
297_T380_L0.5070.96
17_I432_M0.5060.96
301_G305_D0.5060.96
62_V68_Q0.5060.96
87_L152_A0.5050.96
258_S264_V0.5040.96
244_A284_N0.5040.96
45_Q80_Q0.5030.96
414_A421_V0.5030.96
258_S400_I0.5030.96
80_Q238_A0.5030.96
388_R393_S0.5020.96
45_Q99_L0.5020.96
185_T188_E0.5020.96
334_L475_L0.5020.96
310_T364_N0.5010.96
323_G327_I0.5000.96
158_K171_T0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ll3A 2 0.978 100 0.103 Contact Map
3hz6A 1 0.9659 100 0.118 Contact Map
3qdkA 2 0.994 100 0.12 Contact Map
3ifrA 2 0.9699 100 0.121 Contact Map
2itmA 2 0.9519 100 0.123 Contact Map
3wxlA 2 0.976 100 0.134 Contact Map
3ezwA 3 0.9739 100 0.139 Contact Map
3l0qA 2 0.98 100 0.143 Contact Map
2d4wA 2 0.976 100 0.144 Contact Map
3g25A 3 0.9719 100 0.146 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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