GREMLIN Database
CSPC - Cold shock protein CspC
UniProt: P39158 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 66 (62)
Sequences: 4101 (1565)
Seq/√Len: 198.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_V63_V3.6611.00
52_E61_A3.2781.00
50_D62_N2.7701.00
48_S64_Q2.2551.00
11_A42_D2.0741.00
21_E46_K2.0691.00
5_T46_K2.0201.00
3_Q48_S2.0091.00
3_Q46_K1.8531.00
34_Q64_Q1.8481.00
20_R24_D1.7461.00
53_Q58_A1.6851.00
54_G57_G1.6311.00
42_D45_Q1.6131.00
32_A61_A1.5871.00
28_V41_L1.5661.00
11_A38_F1.5491.00
20_R23_G1.4951.00
54_G59_Q1.4711.00
34_Q62_N1.4301.00
20_R49_F1.3351.00
11_A40_S1.3071.00
26_V51_V1.3011.00
33_I38_F1.2241.00
5_T19_E1.2171.00
33_I39_K1.2091.00
3_Q21_E1.2001.00
54_G58_A1.1491.00
9_F30_F1.1471.00
30_F39_K1.1191.00
51_V58_A1.0961.00
24_D58_A1.0661.00
32_A52_E0.9760.99
4_G18_I0.9620.99
41_L47_V0.9450.99
18_I49_F0.9380.99
52_E59_Q0.9120.99
32_A62_N0.8700.99
49_F60_A0.8270.98
33_I36_D0.8200.98
4_G60_A0.8070.98
8_W28_V0.8040.98
19_E44_G0.7880.98
18_I60_A0.7860.98
30_F33_I0.7810.98
10_N27_F0.7550.97
35_S39_K0.6920.95
13_K37_G0.6850.95
5_T21_E0.6750.94
36_D64_Q0.6580.94
30_F56_R0.6560.93
7_K25_D0.6550.93
20_R51_V0.6450.93
18_I47_V0.6420.93
13_K25_D0.6310.92
33_I63_V0.6310.92
17_F44_G0.6270.92
7_K13_K0.6240.92
43_E59_Q0.6190.91
14_G25_D0.6160.91
24_D53_Q0.5970.90
33_I41_L0.5970.90
4_G49_F0.5880.89
30_F38_F0.5830.89
41_L45_Q0.5810.89
40_S45_Q0.5760.88
12_E59_Q0.5700.88
32_A49_F0.5670.87
35_S38_F0.5640.87
26_V52_E0.5640.87
8_W13_K0.5630.87
8_W43_E0.5620.87
50_D61_A0.5600.87
36_D39_K0.5600.87
51_V61_A0.5590.87
12_E45_Q0.5580.87
16_G28_V0.5570.86
18_I28_V0.5450.85
26_V60_A0.5440.85
38_F42_D0.5340.84
27_F45_Q0.5340.84
14_G33_I0.5250.83
15_F41_L0.5200.82
10_N15_F0.5180.82
17_F29_H0.5150.82
55_A58_A0.5120.82
7_K34_Q0.5100.81
4_G31_S0.5100.81
19_E26_V0.5090.81
15_F26_V0.5060.81
36_D47_V0.5020.80
53_Q59_Q0.5010.80
15_F35_S0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2lxjA 1 1 99.8 0.146 Contact Map
1c9oA 2 1 99.7 0.155 Contact Map
3camA 2 1 99.7 0.158 Contact Map
3a0jA 1 1 99.7 0.167 Contact Map
1g6pA 1 0.9848 99.7 0.18 Contact Map
3i2zB 2 1 99.7 0.183 Contact Map
2lssA 1 1 99.7 0.187 Contact Map
2mqhA 1 0.9697 99.7 0.191 Contact Map
3uljA 3 1 99.7 0.194 Contact Map
1h95A 1 1 99.7 0.206 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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