GREMLIN Database
YWLG - UPF0340 protein YwlG
UniProt: P39157 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 180 (175)
Sequences: 557 (399)
Seq/√Len: 30.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
84_A117_S5.0681.00
134_D159_H4.7341.00
36_V53_I4.3511.00
123_T143_P4.0181.00
72_C76_L3.7121.00
97_A120_L3.2861.00
141_L165_T2.8561.00
81_V120_L2.7241.00
150_V162_L2.6211.00
21_L128_A2.5931.00
14_E151_S2.4810.99
67_H86_T2.4460.99
11_M155_L2.3820.99
82_V92_L2.1090.98
37_A49_I2.1000.98
90_F127_D2.0610.98
154_S159_H2.0090.97
22_K88_K1.9030.96
4_L155_L1.9010.96
26_L92_L1.8600.96
5_K55_S1.7900.94
26_L124_I1.7420.94
173_V178_E1.6960.93
25_Q127_D1.6500.92
50_A110_Y1.6390.91
11_M160_V1.6320.91
41_I135_T1.6270.91
134_D161_T1.5920.90
58_A62_E1.5640.89
141_L145_A1.5570.89
136_F159_H1.5240.88
69_A82_V1.5080.87
5_K56_G1.4930.87
19_A164_R1.4830.87
83_E118_P1.4310.85
14_E150_V1.4010.83
26_L86_T1.3810.82
15_F150_V1.3710.82
79_A170_I1.3470.81
80_L140_H1.3470.81
19_A24_D1.3120.79
87_A94_T1.3110.79
86_T90_F1.3090.79
33_T107_M1.2970.78
22_K84_A1.2840.77
136_F161_T1.2750.77
136_F145_A1.2670.76
72_C81_V1.2560.76
96_S169_L1.2560.76
15_F162_L1.2450.75
141_L163_A1.2440.75
40_R43_T1.2360.75
51_E113_K1.2310.74
136_F163_A1.2280.74
72_C108_A1.2230.74
87_A121_V1.2020.72
54_Y58_A1.1880.72
12_L60_L1.1830.71
96_S146_V1.1810.71
57_L68_L1.1710.70
15_F19_A1.1530.69
15_F18_Q1.1410.68
39_S43_T1.1320.68
15_F27_F1.1320.68
101_P109_S1.1290.68
145_A163_A1.1240.67
81_V108_A1.1200.67
67_H85_E1.1140.67
69_A124_I1.1110.66
84_A94_T1.1020.66
76_L81_V1.0940.65
31_C107_M1.0930.65
7_T152_Q1.0840.64
13_S63_K1.0760.64
28_V80_L1.0720.63
65_G128_A1.0680.63
83_E115_M1.0670.63
61_R66_I1.0500.62
110_Y114_Q1.0240.60
10_T152_Q1.0200.60
148_V164_R1.0080.59
53_I57_L1.0080.59
50_A107_M0.9840.57
134_D154_S0.9830.57
39_S44_S0.9810.57
70_F107_M0.9790.56
85_E116_K0.9750.56
58_A61_R0.9640.55
26_L90_F0.9640.55
50_A101_P0.9610.55
115_M118_P0.9580.55
96_S178_E0.9510.54
100_V169_L0.9430.54
122_E168_K0.9430.54
9_K59_E0.9390.53
130_I162_L0.9370.53
8_W56_G0.9340.53
62_E116_K0.9230.52
100_V109_S0.9170.52
55_S114_Q0.9140.51
90_F94_T0.9100.51
21_L25_Q0.9060.51
23_Q65_G0.8980.50
41_I134_D0.8960.50
85_E89_L0.8910.49
93_P168_K0.8900.49
45_G107_M0.8890.49
127_D142_K0.8880.49
10_T151_S0.8880.49
93_P125_Q0.8870.49
11_M150_V0.8800.49
8_W60_L0.8780.48
50_A54_Y0.8780.48
153_N161_T0.8760.48
67_H89_L0.8730.48
35_E149_R0.8720.48
145_A165_T0.8710.48
12_L57_L0.8600.47
45_G50_A0.8440.46
45_G100_V0.8440.46
23_Q66_I0.8350.45
143_P168_K0.8340.45
7_T49_I0.8340.45
54_Y114_Q0.8320.45
27_F66_I0.8280.44
27_F61_R0.8270.44
100_V176_V0.8260.44
61_R70_F0.8240.44
60_L66_I0.8230.44
81_V112_F0.8210.44
29_L70_F0.8140.43
84_A88_K0.8130.43
154_S157_S0.8070.43
15_F148_V0.7970.42
50_A56_G0.7930.42
82_V86_T0.7890.41
52_S148_V0.7790.41
4_L52_S0.7780.41
59_E63_K0.7680.40
81_V146_V0.7660.40
98_V176_V0.7520.39
91_R125_Q0.7460.38
33_T46_S0.7440.38
169_L173_V0.7420.38
81_V97_A0.7380.38
130_I150_V0.7340.37
45_G101_P0.7280.37
125_Q143_P0.7270.37
86_T92_L0.7270.37
67_H90_F0.7150.36
11_M152_Q0.7110.36
44_S109_S0.7100.35
96_S114_Q0.7090.35
61_R64_T0.7060.35
33_T101_P0.7000.35
13_S60_L0.7000.35
54_Y107_M0.6970.35
108_A141_L0.6950.34
54_Y115_M0.6900.34
39_S157_S0.6890.34
54_Y110_Y0.6880.34
65_G85_E0.6870.34
8_W33_T0.6860.34
28_V128_A0.6840.34
106_A127_D0.6830.34
98_V160_V0.6830.34
169_L178_E0.6820.33
45_G110_Y0.6810.33
82_V91_R0.6800.33
16_Q64_T0.6800.33
9_K56_G0.6770.33
72_C97_A0.6750.33
92_L121_V0.6740.33
33_T110_Y0.6710.33
18_Q97_A0.6710.33
41_I149_R0.6700.33
29_L57_L0.6700.33
68_L83_E0.6690.33
94_T119_V0.6670.32
9_K33_T0.6570.32
48_D51_E0.6540.31
45_G109_S0.6520.31
76_L100_V0.6410.31
101_P106_A0.6390.30
31_C150_V0.6370.30
109_S113_K0.6330.30
39_S102_K0.6180.29
57_L60_L0.6150.29
56_G60_L0.6140.29
22_K25_Q0.6140.29
58_A115_M0.6130.29
68_L118_P0.6120.29
93_P97_A0.6100.29
8_W31_C0.6090.28
26_L67_H0.6060.28
87_A119_V0.6000.28
11_M130_I0.5970.28
23_Q59_E0.5960.28
51_E124_I0.5960.28
136_F165_T0.5950.28
69_A136_F0.5940.28
96_S120_L0.5930.27
70_F110_Y0.5910.27
19_A23_Q0.5900.27
5_K9_K0.5880.27
97_A115_M0.5870.27
35_E41_I0.5870.27
9_K13_S0.5870.27
130_I160_V0.5870.27
11_M162_L0.5860.27
43_T102_K0.5830.27
8_W155_L0.5820.27
6_Q9_K0.5790.27
70_F108_A0.5780.27
14_E90_F0.5750.26
38_G167_P0.5730.26
31_C135_T0.5730.26
97_A168_K0.5730.26
80_L106_A0.5670.26
86_T89_L0.5640.26
5_K23_Q0.5630.26
26_L80_L0.5570.25
136_F154_S0.5570.25
38_G50_A0.5560.25
36_V50_A0.5530.25
31_C54_Y0.5520.25
16_Q21_L0.5490.25
19_A69_A0.5480.25
52_S56_G0.5460.25
6_Q10_T0.5460.25
49_I141_L0.5460.25
87_A92_L0.5450.25
14_E98_V0.5430.24
7_T10_T0.5420.24
106_A112_F0.5410.24
9_K116_K0.5380.24
126_A160_V0.5370.24
12_L20_E0.5370.24
70_F111_A0.5350.24
23_Q148_V0.5340.24
107_M169_L0.5340.24
10_T17_D0.5330.24
10_T14_E0.5320.24
8_W15_F0.5300.24
5_K59_E0.5290.24
31_C66_I0.5280.24
72_C145_A0.5280.24
97_A121_V0.5270.23
12_L150_V0.5250.23
45_G61_R0.5240.23
127_D165_T0.5230.23
29_L72_C0.5230.23
43_T46_S0.5170.23
39_S117_S0.5160.23
48_D178_E0.5150.23
81_V169_L0.5100.23
101_P108_A0.5090.22
123_T145_A0.5040.22
106_A170_I0.5030.22
92_L127_D0.5030.22
5_K168_K0.5010.22
25_Q88_K0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1v8dA 5 0.9833 100 0.048 Contact Map
4a2aA 1 0.95 31.3 0.963 Contact Map
2qfyA 2 0.3167 21.9 0.966 Contact Map
2jrxA 2 0.4167 20.9 0.966 Contact Map
2jpqA 2 0.4167 19.8 0.967 Contact Map
3wqtA 2 0.9222 19.2 0.967 Contact Map
2jr2A 2 0.3778 14.4 0.969 Contact Map
2xdqA 1 0.95 13.5 0.969 Contact Map
3pvjA 3 0.3333 12.6 0.969 Contact Map
4umxA 2 0.3056 12.4 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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