GREMLIN Database
YWLF - Putative sugar phosphate isomerase YwlF
UniProt: P39156 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 149 (142)
Sequences: 3517 (2132)
Seq/√Len: 178.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_D140_K3.4311.00
135_Q139_G3.3581.00
21_L122_K2.5981.00
16_N19_K2.3451.00
25_L122_K2.2681.00
17_E114_P2.1351.00
4_A32_M2.0861.00
90_T119_E2.0511.00
84_C106_A2.0481.00
32_M53_K2.0061.00
94_K98_E1.9481.00
98_E130_T1.8941.00
4_A59_V1.8811.00
6_A50_V1.8751.00
36_C39_G1.8051.00
85_A96_T1.7711.00
19_K23_D1.7651.00
88_H92_S1.7381.00
14_I117_A1.7161.00
67_G110_R1.6931.00
17_E118_R1.6881.00
113_G116_L1.6661.00
48_F144_Y1.6651.00
11_G65_I1.6541.00
13_H38_S1.6201.00
53_K58_E1.5961.00
13_H109_E1.5801.00
64_L76_A1.4721.00
42_D136_T1.4481.00
2_K28_E1.4461.00
30_I59_V1.4451.00
20_E23_D1.4361.00
122_K126_T1.4291.00
20_E24_E1.4291.00
25_L126_T1.4001.00
4_A53_K1.3971.00
55_V79_V1.3921.00
51_A82_I1.3841.00
89_D92_S1.3651.00
48_F52_E1.3621.00
47_A72_M1.3621.00
98_E127_T1.3601.00
91_F95_A1.3341.00
64_L72_M1.3201.00
64_L106_A1.3101.00
102_T124_W1.2951.00
12_V16_N1.2931.00
15_R31_D1.2821.00
48_F79_V1.2761.00
10_G110_R1.2711.00
52_E56_S1.2671.00
94_K119_E1.2671.00
21_L25_L1.2481.00
23_D29_Y1.2371.00
21_L118_R1.2321.00
63_I121_A1.2211.00
55_V82_I1.1931.00
139_G143_D1.1911.00
70_I85_A1.1581.00
78_K142_S1.1521.00
115_G118_R1.1411.00
50_V62_G1.1361.00
90_T123_I1.1261.00
84_C104_I1.1261.00
95_A98_E1.1171.00
76_A84_C1.0951.00
73_S106_A1.0891.00
5_I19_K1.0861.00
96_T124_W1.0811.00
91_F111_V1.0691.00
47_A64_L1.0541.00
96_T102_T1.0511.00
73_S86_L1.0501.00
40_S136_T1.0391.00
66_C72_M1.0381.00
18_I121_A1.0351.00
123_I127_T1.0341.00
61_R124_W1.0240.99
87_A105_L1.0210.99
94_K123_I1.0080.99
4_A57_G1.0020.99
120_I123_I1.0010.99
61_R97_R0.9970.99
6_A32_M0.9940.99
93_A120_I0.9790.99
82_I104_I0.9740.99
57_G60_D0.9700.99
50_V64_L0.9600.99
51_A104_I0.9330.99
41_V46_Y0.9210.99
72_M106_A0.9200.99
14_I109_E0.9170.99
14_I114_P0.9100.99
79_V144_Y0.9060.99
132_G135_Q0.9010.99
105_L120_I0.8990.99
88_H112_I0.8860.98
87_A120_I0.8850.98
101_D129_F0.8820.98
12_V36_C0.8820.98
7_S34_C0.8570.98
51_A55_V0.8430.98
91_F113_G0.8430.98
107_M112_I0.8380.98
4_A60_D0.8350.98
73_S84_C0.8340.98
49_P53_K0.8310.98
17_E20_E0.8280.98
108_G111_V0.8280.98
131_G135_Q0.8270.98
30_I53_K0.8190.97
139_G142_S0.8190.97
138_I142_S0.8170.97
63_I105_L0.8150.97
18_I118_R0.8140.97
31_D35_D0.8050.97
5_I22_M0.8000.97
17_E21_L0.8000.97
21_L24_E0.7970.97
107_M121_A0.7950.97
6_A46_Y0.7930.97
42_D140_K0.7920.97
7_S11_G0.7900.97
97_R124_W0.7860.97
5_I29_Y0.7800.97
50_V104_I0.7740.96
7_S16_N0.7730.96
32_M59_V0.7720.96
97_R127_T0.7670.96
112_I120_I0.7650.96
51_A79_V0.7590.96
18_I65_I0.7560.96
119_E122_K0.7530.96
16_N20_E0.7470.96
34_C46_Y0.7460.96
99_H137_R0.7400.95
43_Y134_H0.7390.95
30_I35_D0.7380.95
112_I117_A0.7140.94
3_V27_I0.7090.94
4_A50_V0.6950.94
6_A64_L0.6940.94
119_E123_I0.6910.93
52_E144_Y0.6910.93
75_S141_I0.6860.93
5_I65_I0.6830.93
89_D116_L0.6820.93
23_D28_E0.6810.93
134_H137_R0.6810.93
74_I102_T0.6710.92
54_V81_G0.6680.92
72_M75_S0.6670.92
2_K30_I0.6640.92
42_D45_D0.6620.92
7_S12_V0.6620.92
53_K59_V0.6610.92
129_F135_Q0.6600.92
3_V125_L0.6590.92
34_C41_V0.6550.91
112_I116_L0.6530.91
99_H134_H0.6500.91
70_I96_T0.6460.91
90_T120_I0.6450.91
70_I73_S0.6430.91
99_H133_R0.6400.91
133_R137_R0.6250.89
92_S108_G0.6170.89
136_T139_G0.6150.89
30_I58_E0.6140.89
93_A105_L0.6110.88
61_R101_D0.6030.88
114_P118_R0.6030.88
6_A15_R0.6010.88
95_A99_H0.6000.87
90_T94_K0.5980.87
69_G86_L0.5960.87
22_M25_L0.5940.87
66_C73_S0.5940.87
45_D49_P0.5930.87
70_I86_L0.5920.87
92_S111_V0.5910.87
78_K141_I0.5880.86
88_H107_M0.5880.86
44_P140_K0.5750.85
34_C40_S0.5730.85
62_G104_I0.5730.85
47_A51_A0.5660.84
10_G67_G0.5650.84
47_A66_C0.5600.84
135_Q138_I0.5580.83
2_K60_D0.5570.83
101_D142_S0.5550.83
9_H42_D0.5530.83
7_S31_D0.5520.83
101_D135_Q0.5490.82
48_F142_S0.5480.82
57_G61_R0.5480.82
83_R142_S0.5450.82
55_V80_K0.5450.82
52_E55_V0.5430.82
116_L120_I0.5390.81
70_I92_S0.5300.80
70_I74_I0.5270.80
13_H17_E0.5200.79
75_S79_V0.5160.78
22_M121_A0.5150.78
64_L104_I0.5140.78
24_E118_R0.5060.77
86_L92_S0.5060.77
54_V79_V0.5050.77
25_L118_R0.5050.77
53_K56_S0.5040.77
5_I63_I0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3s5pA 4 0.8859 100 0.022 Contact Map
3he8A 2 0.9933 100 0.027 Contact Map
4lflB 3 0.9933 100 0.027 Contact Map
3ph3A 2 0.9866 100 0.028 Contact Map
2vvrA 2 0.9799 100 0.033 Contact Map
2vvpA 2 0.9933 100 0.037 Contact Map
3sgwA 4 1 100 0.039 Contact Map
3k7pA 4 0.9933 100 0.041 Contact Map
1o1xA 3 0.9597 100 0.051 Contact Map
4lflA 2 0.9463 100 0.065 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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